The Energy Blueprint
Human Optimization - Cellular Hydration 180g
£32.00
£43.00
The hidden, evidence-based answer to a longer, healthier life? Optimal Cellular Hydration
Hydration is much more important than you realize… it's the unlikely key to a LONGER LIFE
Research tells us that hydration equals optimal energy, mood, cognition, and skin health.
But one surprising benefit you may not know—hydration equals a longer, more vibrant life.
Introducing Cellular Hydration.
An advanced cellular-level hydration formula that supports energy, brain health, physical performance, and longevity.
The Science-Backed Benefits of Cellular Hydration
Cellular hydration isn’t just wellness lingo…it’s backed by science
Hydration at the cellular level has been connected with:
Increased energy at the cellular level [1]
Boosted brain function [2]
Better mental health and mood [3]
Enhanced heart and vascular health [4, 5]
Superior muscle performance [6]
Deep nourishment from over 70 naturally-derived trace minerals [7]
Accelerated anti-aging [8]
Exercise performance enhancement [9]
Positive changes to gut health and your good bacteria [10]
Improved mitochondrial function [11]
And a longer, healthier life! [12]
The Longevity-Hydration Link
New research shows hydration is a powerful key to “slow down aging and prolong a disease-free life.”
What if there was a magic elixir that could lower your risk of chronic disease and dying early…
Would you drink it?
A drink you could sip on every day that would…
Lower your risk of disease
Give you more energy
Better performance
Better mood and brain function
And slow down the aging process
It turns out that hydration – true, cellular hydration – is a major key to health and longevity.
With Hydrate, you can create cellular hydration and all the benefits it provides in mere seconds.
According to New Research… Staying Well-Hydrated Is Closely Linked to Longevity
According to a National Institutes of Health study published in 2023, “Adults who stay well-hydrated appear to be healthier, develop fewer chronic conditions, such as heart and lung disease, and live longer than those who may not get sufficient fluids” [12].
The study analyzed data from 11,255 adults over a 30-year period for links between hydration status and health conditions.
They found something remarkable: Adults with low hydration status had a whopping 64% higher risk of developing heart failure, stroke, atrial fibrillation, peripheral artery disease, chronic lung disease, diabetes, dementia and other diseases.
They found that those with poor hydration status had poorer lung function, more inflammation, and poorer metabolic and cardiovascular health. They even found that hydration status was an indicator of aging faster biologically than chronologically!
“The results suggest that proper hydration may slow down aging and prolong a disease-free life.”
– Natalia Dmitrieva, Ph.D., a study author and researcher in the Laboratory of Cardiovascular Regenerative Medicine at the National Heart, Lung, and Blood Institute, part of NIH
Poor Hydration is Rampant
Optimal hydration isn’t just for athletes sweating a lot or after the sauna.
The research is clear: Hydration leads to a long life & healthy aging and is important for EVERYONE.
As we age, our ability to sense thirst decreases. Paired with changes in our body’s water and sodium balance, adults tend to become dehydrated.
Electrolytes aren’t just for athletes. They’re for people who want a long, healthy life
Large-scale research shows that roughly 1 in 3 older adults is dehydrated, and a much larger percentage may have more subtle issues of poor hydration that don’t qualify as full-blown “dehydration.” [13]
Not only that, younger and younger populations are suffering from the negative effects of dehydration: In the United States, over 50% of children between the ages of 6 to 19 are dehydrated. [14]
Hydrate is safe, supportive, and, according to science, needed by people of every age.
Cellular Hydration’s Ingredients Support Longevity Better Than Any Other Formula
Hydration isn’t simply a matter of drinking more fluids. It’s a cellular process.
But most electrolyte formulas don’t perform at the cellular level.
Hydrate is much more than electrolytes—it’s cellular hydration with every sip.
Potassium A Cellular Hydration Superstar
We use 200%-1,000% more potassium than typical electrolyte formulas and sports drinks.
Why?
Potassium deficiency is rampant and is a major contributor to poor health and dehydration at the deepest levels.
Study after study reveals that Western dietary habits leave us deficient in potassium and over-exposed to sodium, a silent imbalance that can lead to high blood pressure, acidic systemic pH, and cellular dehydration.
Hydrate contains four types of potassium—potassium citrate, potassium chloride, potassium bicarbonate, and dipotassium phosphate—formulated to mimic the potassium contained in a whole food diet.
Potassium regulates cellular hydration
Your cells contain 30 times more potassium than the extracellular space! Deep hydration demands adequate potassium [23].
Balanced potassium & sodium lead to less risk of high blood pressure, heart disease, stroke, and other health risks like kidney stones
Potassium supports optimal blood pressure, proper nervous system function, bone density, and reduction of kidney stone formation. In a study of 57 people with kidney stones, 75% of those given potassium citrate experienced disease remission, and reduced stone formation was found in ALL patients [24, 25, 26].
Multiple studies show the benefits of increasing potassium and decreasing salt. People who eat high ratios of salt to potassium increase their risk of death by 46% [27]!
Potassium contributes to an alkalized body
Our modern foods and lifestyles leave us with an acidic systemic pH.
Potassium-rich foods and supplements, like Hydrate, are the solution to keep us easily alkalized and at less risk of negative health outcomes from metabolic acidosis, such as hypertension, type 2 diabetes, and even anxiety. An alkalized body also means improved sports performance [28, 29]!
In a market flooded with electrolyte formulas, Cellular Hydration stands out
Longevity-supporting and performance-enhancing water you can make in seconds
Achieve the perfect pH with bicarbonate and other key alkalizing cofactors like citrate, malate, and potassium
Plus, benefit from the performance-enhancing benefits of bicarbonate!
A little-known fact is that body pH regulation is a critically important aspect of health. Unfortunately, our modern foods and lifestyles promote an acidic systemic pH and a higher risk of negative health outcomes, such as hypertension, type 2 diabetes, and even anxiety [28].
But with adequate amounts of nutrients and cofactors, your body can masterfully regulate pH.
Bicarbonate, citrate, malate, and potassium are powerful pH cofactors and play unique roles in keeping your body within an ideal alkaline pH…something no other electrolyte formula offers [30, 31, 32].
As an added bonus, an alkalized body also means improved sports performance and greater amount of lean muscle mass, especially in older individuals [29, 33].
Bicarbonate
Bicarbonate, found in Hydrate as sodium bicarbonate and potassium bicarbonate, is the chief alkalizing substance your body uses to create an optimal pH. Research tells us that a diet rich in fruits and especially vegetables supplies most of our bicarbonate, but your body also creates its own bicarbonate as part of pH buffering. Unfortunately, our current diet and lifestyle patterns skew us toward acidic states that sometimes need outside assistance from supplemental bicarbonate [34].
Hydrate is the perfect way to introduce the extra bicarbonate you need not only for optimal pH but also for the added bonus of increased physical performance. Multiple studies have found benefits of bicarbonate for males and females and in many different forms of exercise, such as endurance, high-intensity training, and even hands-on activities such as karate or judo [32].
Citrate & Malate
Both citrate and malate, found in Hydrate as magnesium malate and potassium citrate, are technically known as anions. Your body transforms these compounds into alkalizing bicarbonate during the process of digestion [35]!
Along with Hydrate, you’ll find these anions in fruits and especially vegetables. On top of their ability to create an alkaline environment, they also support your body in maintaining adequate calcium stores and, thus, better bone health and less risk of detrimental fractures [36].
Potassium
Hydrate’s special mixture of potassium promotes pH balance in multiple ways—the alkalizing ions of potassium citrate, the direct buffering of potassium bicarbonate, and the powerful action of potassium itself.
The Longevity Power of Taurine
L-taurine is best known as a non-structural amino acid, but it plays crucial roles in optimal hydration due to its function as an osmoprotectant, meaning it guards against the negative effects of dehydration and electrolyte imbalance [37]. Additionally, it’s particularly beneficial to the heart, muscle tissue, and brain and is neuroprotective [38, 39].
But new research reveals that taurine slows or even reverses aging at the cellular, mitochondrial, and genetic levels, likely due to its role in combating oxidative stress, mitochondrial dysfunction, and cell deterioration and protection against telomerase deficiency, DNA damage, and inflammation [40, 41].
It’s even been shown to protect against skin aging (aka, wrinkles!) in animal models [42] As one study succinctly stated,
“Taurine supplementation extends healthy lifespan.”
The 500 milligrams of taurine in each serving of Hydrate also supports digestive health, specifically the lining of the small intestine, as well as the balance of the gut microbiota and bile acid composition needed for optimal fat digestion [43, 44, 45].
Creatine... Not Just for Athletes
You probably think of creatine as a supplement just for athletes—that’s a common and unfortunate misconception!
Creatine monohydrate is the most extensively researched compound of all time. It’s a powerful sports supplement—for many athletes, it’s a highly effective performance aid as well as a promoter of lean body mass—but it’s also extremely useful for longevity and hydration.
Creatine is a hyper-hydrator that leads to greater fluid volume inside the cell. It may also help with thermoregulation, meaning that, in hot or humid environments, creatine allows the body to adapt to higher temperatures and avoid dehydration and heat illness [46, 47].
Along with this, creatine has been well-researched for its ability to help older adults maintain muscle mass and bone vitality. Studies show anti-inflammatory and anti-aging properties, along with a lower risk of falls with creatine use [48].
Creatine also has special neuroprotective qualities and is particularly supportive of brain and cognitive function. One study called it “more than a supplement for athletes” due to its ability to reduce mental fatigue, protect the brain from neurotoxicity, and even improve some neurological disorders like depression and bipolar disorder [49].
All in all, a master ingredient for hydration, performance, and longevity.
Fulvic Acid & Trace Minerals: Naturally-derived microminerals
Fulvic acid, a crucial element in humus, the nutrient-rich layer of the earth, is created by microbes breaking down plant matter. This compound combines with minerals to form a complex molecular compound. Termed ‘nature’s miracle molecule,’ fulvic acid activates soil nutrients for plant cell utilization, fostering strong and healthy growth.
Fulvic acid has recently risen in popularity as a supplement due to studies showing its usefulness in inflammatory conditions, skin disease, metabolic disorders, immune strengthening, wound healing, and digestive function [50].Fulvic acid broadens the mineral profile you receive in each dose of Hydrate. Evidence also shows that it further enhances the absorption of key minerals into the cell.
This ingredient is strictly sourced from a pristine area of Northwest New Mexico and contains a thoroughly tested array of naturally occurring fulvic ionic macro and micro trace minerals and elements.
Skip the artificial fluorescent green-colored ”ades” for a hydration formula that PERFORMS
Replenishing minerals after a sweaty workout or sauna session keeps you feeling and thinking your best.
Any sports drink can provide a little extra sodium, potassium, and magnesium (and a LOT of food coloring, sugar, and added ingredients)…
But Hydrate isn't just any sports drink.
It offers extra minerals—in the forms and amounts that actually make a difference—along with science-backed, pH-balancing ingredients like taurine for anti-aging and cardio-protection, creatine for hyper-hydration, muscle-mass promotion, and more complete recovery, and potassium, citrate, malate, and sodium bicarbonate, for alkalized performance enhancement.
The mineral-rich, alkalizing water you create with Hydrate amplifies performance with…
Supercharged Hydration
Research shows that mineral-rich, alkalizing water provides hydration that supports your health and keeps you performing at the highest level. One such study of 38 people found that, over a four week period, ingestion of mineral-rich, high alkaline water led to a more favorable bodywide pH and improved hydration status compared to non-mineralized water [51].
Superior Performance
Cellular hydration and alkaline pH mean Hydrate is an essential part of your workout. Studies show that high mineral water leads to increased muscle and cardiovascular function, deters metabolic acidosis, and assists in better metabolic function, i.e., it promotes more efficient metabolism so your exercise is energized and you leave the gym feeling your best [52, 53, 54, 55, 56, 57].
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Nishi SK, Babio N, Paz-Graniel I, et al. Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study. BMC Med. 2023;21(1):82.
Haghighatdoost F, Feizi A, Esmaillzadeh A, et al. Drinking plain water is associated with decreased risk of depression and anxiety in adults: Results from a large cross-sectional study. World J Psychiatry. 2018;8(3):88-96.
Santulli G, Kansakar U, Varzideh F, Mone P, Jankauskas SS, Lombardi A. Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview. Nutrients. 2023;15(19):4236.
Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ. 2013;346:f1378.
Cairns SP. Potassium effects on skeletal muscle contraction: are potassium-metabolic interactions required for fatigue?. Eur J Appl Physiol. 2023;123(11):2341-2343.
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Buford TW, Kreider RB, Stout JR, et al. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr. 2007;4:6.
Qian W, Li M, Yu L, Tian F, Zhao J, Zhai Q. Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis. Biomedicines. 2023;11(4):1048.
Jong CJ, Sandal P, Schaffer SW. The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant. Molecules. 2021;26(16):4913.
Dmitrieva NI, Gagarin A, Liu D, Wu CO, Boehm M. Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality. EBioMedicine. 2023;87:104404.
Li S, Xiao X, Zhang X. Hydration Status in Older Adults: Current Knowledge and Future Challenges. Nutrients. 2023;15(11):2609.
Kenney EL, Long MW, Cradock AL, Gortmaker SL. Prevalence of Inadequate Hydration Among US Children and Disparities by Gender and Race/Ethnicity: National Health and Nutrition Examination Survey, 2009-2012. Am J Public Health. 2015;105(8):e113-e118.
Armstrong LE, Ganio MS, Casa DJ, et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012;142(2):382-388.
Pross N, Demazières A, Girard N, et al. Influence of progressive fluid restriction on mood and physiological markers of dehydration in women. Br J Nutr. 2013;109(2):313-321.
Carlton A, Orr RM. The effects of fluid loss on physical performance: A critical review. Journal of Sport and Health Science. 2015;4(4):357-363.
Ganio MS, Armstrong LE, Casa DJ, et al. Mild dehydration impairs cognitive performance and mood of men. Br J Nutr. 2011;106(10):1535-1543.
Arca KN, Halker Singh RB. Dehydration and Headache. Curr Pain Headache Rep. 2021;25(8):56. Published 2021 Jul 15.
Spigt MG, Kuijper EC, Schayck CP, et al. Increasing the daily water intake for the prophylactic treatment of headache: a pilot trial. Eur J Neurol. 2005;12(9):715-718.
Palma L, Marques LT, Bujan J, Rodrigues LM. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol. 2015;8:413-421.
Adan A. Cognitive performance and dehydration. J Am Coll Nutr. 2012;31(2):71-78.
National Research Council (US) Subcommittee on the Tenth Edition of the Recommended Dietary Allowances. Recommended Dietary Allowances: 10th Edition. Washington (DC): National Academies Press (US); 1989. 11, Water and Electrolytes.
Kowey PR. The Role of Potassium. Women’s Health and Menopause. In: Lobo, R.A., Crosignani, P.G., Paoletti, R., Bruschi, F. (eds). Medical Science Symposia Series, vol 17. Springer, Boston, MA.
Kong SH, Kim JH, Hong AR, Lee JH, Kim SW, Shin CS. Dietary potassium intake is beneficial to bone health in a low calcium intake population: the Korean National Health and Nutrition Examination Survey (KNHANES) (2008-2011). Osteoporos Int. 2017;28(5):1577-1585.
Barcelo P, Wuhl O, Servitge E, Rousaud A, Pak CY. Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol. 1993;150(6):1761-1764.
Yang Q, Liu T, Kuklina EV, et al. Sodium and potassium intake and mortality among US adults: prospective data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2011;171(13):1183-1191.
McCarty MF. Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. Med Hypotheses. 2005;64(2):380-384.
Caciano SL, Inman CL, Gockel-Blessing EE, Weiss EP. Effects of dietary Acid load on exercise metabolism and anaerobic exercise performance. J Sports Sci Med. 2015;14(2):364-371.
Senewiratne NL, Woodall A, Can AS. Sodium Bicarbonate. [Updated 2023 Mar 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.
Green DA. The use of grocery store baking soda for chronic metabolic acidosis in a resource-poor setting. Clin Pediatr (Phila). 2011;50(4):375.
Grgic J, Pedisic Z, Saunders B, et al. International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance. J Int Soc Sports Nutr. 2021;18(1):61.
Dawson-Hughes B, Harris SS, Ceglia L. Alkaline diets favor lean tissue mass in older adults. Am J Clin Nutr. 2008;87(3):662-665.
Imenez Silva PH, Mohebbi N. Kidney metabolism and acid-base control: back to the basics. Pflugers Arch. 2022;474(8):919-934.
Demigné C, Sabboh H, Rémésy C, Meneton P. Protective effects of high dietary potassium: nutritional and metabolic aspects. J Nutr. 2004;134(11):2903-2906.
Sellmeyer DE, Schloetter M, Sebastian A. Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab. 2002;87(5):2008-2012.
Trachtman H, Barbour R, Sturman JA, Finberg L. Taurine and osmoregulation: taurine is a cerebral osmoprotective molecule in chronic hypernatremic dehydration. Pediatr Res. 1988;23(1):35-39.
Schaffer SW, Jong CJ, Ramila KC, Azuma J. Physiological roles of taurine in heart and muscle. J Biomed Sci. 2010;17 Suppl 1(Suppl 1):S2. Published 2010 Aug 24.
Kim HY, Kim HV, Yoon JH, et al. Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer’s disease. Sci Rep. 2014;4:7467.
Singh P, Gollapalli K, Mangiola S, et al. Taurine deficiency as a driver of aging. Science. 2023;380(6649):eabn9257.
Sheikh A, Iqbal M. Taurine as a potential anti-ageing therapy: the key to reversing the ageing process? Short communication. Ann Med Surg (Lond). 2023;85(7):3759-3760.
Yoshimura T, Manabe C, Inokuchi Y, Mutou C, Nagahama T, Murakami S. Protective effect of taurine on UVB-induced skin aging in hairless mice. Biomed Pharmacother. 2021;141:111898.
Wen C, Guo Q, Wang W, et al. Taurine Alleviates Intestinal Injury by Mediating Tight Junction Barriers in Diquat-Challenged Piglet Models. Front Physiol. 2020;11:449.
Qian W, Li M, Yu L, Tian F, Zhao J, Zhai Q. Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis. Biomedicines. 2023;11(4):1048.
Duszka K. Versatile Triad Alliance: Bile Acid, Taurine and Microbiota. Cells. 2022;11(15):2337.
Buford TW, Kreider RB, Stout JR, et al. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr. 2007;4:6.
Sobolewski EJ, Thompson BJ, Smith AE, Ryan ED. The Physiological Effects of Creatine Supplementation on Hydration: A Review. American Journal of Lifestyle Medicine. 2011;5(4):320-327.
Candow DG, Forbes SC, Chilibeck PD, Cornish SM, Antonio J, Kreider RB. Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation. J Clin Med. 2019;8(4):488.
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The Energy Blueprint
Human Optimization - Sleep 120 Capsules
£44.00
£59.00
Is It Memory Loss?
Or sleep loss?
Lack of sleep can lead to...
Impaired memory [1]
Decreased cognitive ability [2]
Poor mood [3]
Imbalanced immune function
Increased risk of infectious disease [4]
Vascular inflammation
Increased risk of cardiovascular disease [5]
Higher risk of sarcopenia - involuntary loss of muscle mass [6]
Emotional dysregulation [7]
Low libido [8]
Cravings & weight gain [9]
Metabolic syndrome [10]
Hormonal imbalances [11]
Decreased fertility & ability to conceive [12]
"In addition to elevated risks of chronic diseases, short sleep duration is strongly associated with decreases in cognitive performance...
...impairments in several cognitive domains can be observed even after short-term sleep restriction" [13].
Nature Journal, October 2021
Add 4 Pills To Your Night...And Extra Years To Your Life.
Sleep deprivation has deadly consequences, especially for women.
You might feel tired today, but over time, your health takes an enormous hit.
The most impactful illnesses and disasters of the 21st century are linked to lack of sleep.
Incredibly, a follow-up investigation of the space shuttle Challenger disaster named staff sleep loss as a possible cause [14].
The risk of obesity, metabolic syndrome, hypertension, heart attack, stroke, Alzheimer’s disease, and cancer, particularly the increasingly prevalent colorectal cancer, increase with suboptimal sleep [15, 16].
And women are affected more than men.
Females with disturbed sleep have greater chances of cardiovascular disease, increased insulin, hypertension, and inflammation compared to males [17].
Mental health also suffers—symptoms of depression, anxiety, psychosis, and stress perception worsen with sleep loss. Those with insomnia, for instance, have a two-fold risk of developing depression compared to those without the condition [18, 19].
Imagine 8 Restful Hours Instead Of 5 Restless Ones. A Calm Mind Instead Of Racing Thoughts.
The best part? No Rx hangover.
Human Optimization Lab's Sleep may support:
Non-habit forming REM sleep without the side effects of Rx drugs [20]
Healthier balance of non-REM and REM sleep patterns [21]
Sounder sleep versus waking up tired before your alarm clock [22, 23]
Increased sleep time [22]
Faster transition from awake to asleep—no more tossing & turning [22]
Alleviation of insomnia, specifically related to age [22, 24, 25]
Less chance of waking during the night [26]
Reduced symptoms of restless legs syndrome [27]
Antioxidant balance and anti-inflammatory effects [28]
Reduced anxiety [29]
Healthier circadian rhythms, even in the presence of unavoidable light at night [30]
Production of your body's own master antioxidant, melatonin [31]
Fewer obsessive thoughts that keep you awake [32]
Sleep's dream team:
Melatonin & your mitochondria
When you think of antioxidants, what comes to mind? Most of us imagine berries, dark chocolate, or vitamins C and E. But the real antioxidant all-star? Melatonin. Melatonin is an incredibly potent and unique antioxidant. Why? Unlike other antioxidants, it's created by your mitochondria and plays enormous roles in optimizing their function...and your energy levels [33].
Ingredients Based On Science, Not Social Media.
Sleep is formulated with nutrients and doses proved effective in scientific studies…and only those nutrients.
We don’t believe in proprietary blends or hidden excipients.
Learn more about our transparent, evidence-based ingredients.
Magnesium (Magnesium Glycinate)
Magnesium aids sleep in multiple ways, yet aging is a risk factor for magnesium deficiency. Magnesium relieves muscle tension [35] and is an N-Methyl-D-aspartic acid (NMDA) antagonist and GABA agonist, meaning it gently reduces neuronal excitability and promotes neuronal relaxation.
Potassium (Potassium Glycinate)
Sleep is divided into two phases, non-rapid eye movement (NREM) and rapid eye movement (REM) and five separate stages! This organization is called sleep architecture, and potassium is best known for supporting these patterns thanks to its role in regulating the intricate physiology of potassium channels in the nervous system [36].
B6 (Pyridoxal 5’-Phosphate)
Pyridoxal 5′-phosphate (PLP), the biologically active form of vitamin B6, is a cofactor for kynurenine aminotransferase (KAT) and kynureninase (KYNU), two key enzymes in the conversion of kynurenine to tryptophan [38]. In turn, we use tryptophan to make both serotonin and melatonin [39].
Herbatonin® (Plant Melatonin)
Does melatonin leave you feeling drowsy throughout the morning? Interestingly, a double-blind, placebo-controlled study from MIT found 0.3 mg of melatonin to be the ideal dose for people with insomnia over 50 [24]. When compared to the pharmacological dose of 3 mg, the 0.3 physiological dose restored sleep efficiency without remaining elevated into the daytime.
L-Theanine
L-theanine is a non-protein amino acid abundant in green tea, well known for its relaxing effects and ability to cross the blood-brain barrier [40]. Once in the brain, l-theanine blocks glutamate receptors and enhances GABA and dopamine, resulting in reduced neuro-excitability and increased feelings of relaxation [41].
L-Tryptophan
L-tryptophan is an essential amino acid that plays an integral part in nervous system health and is the precursor to serotonin, a key hormone for mood regulation (43). Clinical studies of tryptophan-deficient diets show that low intake of this essential amino acid results in increased depression, anxiety, and poor emotional processing [44].
L-Serine
L-serine is a non-essential amino acid studied for its remarkable neuroprotective effects [47]. Researchers have hypothesized that dietary L-serine may be responsible for the large centenarian population in Ōgimi, Okinawa, due to their exceptionally high intake of L-serine through foods such as seaweed, tofu, and pork. [48]. The average Ōgimi woman eats over 8 grams of dietary L-serine daily, while her American counterpart only gets 2.5 grams [49].
5-HTP
5-HTP is an amino acid produced from tryptophan and is a metabolic intermediate to serotonin and melatonin. 5-HTP has been studied for its anti-depressant, anxiolytic, and sleep-promoting effects. Several neurodegenerative diseases have been associated with low levels of 5-HTP, including Parkinson’s, fibromyalgia, and Alzheimer's [54].
Myo-Inositol
Myo-inositol is a fascinating but commonly underconsumed compound primarily found in organ meats. It was once considered a B vitamin, but its classification changed when endogenous creation from glucose was discovered in the kidneys, liver, and brain.
Chamomile Extract (Matricaria Recutita)
For hundreds of years, chamomile has been one of the most trusted, aromatic sleep herbs. It's properties include anti-anxiety, stress relieving, and anti-insomnia. It's also beneficial to the immune and digestive systems and the liver [60].
What people say about Sleep
I have struggled with sleep most of my life, and for the last 10 years have tried many different supplements after finally stopping all sleep medications. Some of these supplements have helped, but I have been using Sleep and find that it combines all the different supplements I have tried into one! It works beautifully, it not only helps me ease into sleep quickly, but when I wake in the middle of the night, I can fall back to sleep. I wake up feeling relaxed but not groggy. I am loving this supplement!!
References
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Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021;4(1):1304.
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Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316.
Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001;86(10):4727-4730.
Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.
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Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2022;23(1):1.
Kukula-Koch W, Szwajgier D, Gaweł-Bęben K, Strzępek-Gomółka M, Głowniak K, Meissner HO. Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties. Molecules. 2021;26(19):6087.
Rao TP, Ozeki M, Juneja LR. In Search of a Safe Natural Sleep Aid. J Am Coll Nutr. 2015;34(5):436-447.
Ohashi M, Lee SI, Eto T, et al. Intake of L-serine before bedtime prevents the delay of the circadian phase in real life. J Physiol Anthropol. 2022;41(1):31.
Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181.
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Tan DX, Manchester LC, Qin L, Reiter RJ. Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics. Int J Mol Sci. 2016;17(12):2124.
Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020;35(2):86-95.
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Heizhati M, Zhang Y, Shao L, et al. Decreased serum potassium may disturb sleep homeostasis in essential hypertensives. Hypertens Res. 2019;42(2):174-181.
Deac OM, Mills JL, Shane B, et al. Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr. 2015;145(4):701-707.
Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2009;2:45-60.
Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007;74(1):39-45.
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Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362.
Kikuchi AM, Tanabe A, Iwahori Y. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. J Diet Suppl. 2021;18(3):316-333.
Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. 2016;8(1):56.
Hudson C, Hudson SP, Hecht T, MacKenzie J. Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. Nutr Neurosci. 2005;8(2):121-127.
Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316.
Ye L, Sun Y, Jiang Z, Wang G. L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury. Front Mol Neurosci. 2021;14:726665.
Cox PA, Metcalf JS. Traditional Food Items in Ogimi, Okinawa: l-Serine Content and the Potential for Neuroprotection. Curr Nutr Rep. 2017;6(1):24-31.
Yasuo S, Iwamoto A, Lee SI, et al. l-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans. J Nutr. 2017;147(12):2347-2355.
Bolsius YG, Zurbriggen MD, Kim JK, et al. The role of clock genes in sleep, stress and memory. Biochem Pharmacol. 2021;191:114493.
Yasuo S, Iwamoto A, Lee SI, et al. l-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans. J Nutr. 2017;147(12):2347-2355.
Ohashi M, Lee SI, Eto T, et al. Intake of L-serine before bedtime prevents the delay of the circadian phase in real life. J Physiol Anthropol. 2022;41(1):31.
Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181.
Meloni M, Figorilli M, Carta M, et al. Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease. Sleep Breath. 2022;26(3):1023-1031.
Sutanto C, Heng CW, Gan AX, Wang X, Fam J, Kim JE. The Impact of 5-Hydroxytryptophan Supplementation on Sleep Quality of Older Adults in Singapore: A Randomized Controlled Trial. Curr Dev Nutr. 2021;5(Suppl 2):372.
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The Energy Blueprint
Human Optimization - TWK10 EnergyBiotic 30 caps
£34.00
£47.00
Imagine a probiotic bacteria that doesn’t just improve your gut but skyrockets energy, shrinks fat, boosts muscle, and heals your gut at the same time!
Introducing TWK10 EnergyBiotic
The only probiotic strain scientifically proven to help you lose fat, lessen fatigue, increase energy, enhance muscle, and amplify exercise performance.
It’s not just a probiotic…it’s an EnergyBiotic!
TWK10 EnergyBiotic powers your performance
Whether you’re an athlete or just athletic…
Competing in or completing your first 5K…
Getting stage ready or gently strengthening your muscles…
We searched the scientific literature and found the most effective, advanced compound available to promote gut health and your unique performance goals.
TWK10 EnergyBiotic is the only probiotic backed by human studies to…
Increase energy and exercise performance by up to 42%! [1]
Balance body composition
Lower body fat
Enhance grip strength [2]
Optimize muscle growth and strength
Boost balance and walking speed
Decrease abdominal fat
Minimize inflammation [3]
Fight fatigue at the cellular level
Promote a healthy gut environment
Did you know low muscle strength is linked to a 134% increased risk of death from any cause? [4]
Aging doesn’t have to be a slow decline.
Disability, dysfunction, and premature death are not mandatory.
TWK10 EnergyBiotic is backed by multiple studies to strengthen your muscles, your mind, and burn fat at the same time.
“...TWK10 significantly elevated…exercise performance…and improved the fatigue-associated features correlated with better physiological adaptation. The change in body composition shifted in the healthy direction for TWK10 administration groups...which showed that body fat significantly decreased and muscle mass significantly increased.”
– “Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans,” Huang et al., 2019, Nutrients
TWK10 has postbiotic power, too
Postbiotics are one of the newest fields of gut microbiota study.
But…what are they?
Along with probiotics, postbiotics are gut-balancing compounds that create robust benefits for your digestive system, immune function, and, in the case of TWK10 EnergyBiotic, your performance. [8]
Research in healthy adults found that the postbiotic function of TWK10 led to...
A 33% increase in endurance [3]
Significant decreases in inflammation
Positive changes in body composition
Increased short-chain fatty acids* Known for their anti-obesity, anti-diabetes, liver protective, neuroprotective, immune balancing, anti-inflammatory, and cardiovascular protective qualities [9]
Beneficial shifts in the gut microbiome
Plus, animal studies using TWK10 have shown...
Lower body weight by up to 7.5% [10]
As much as a 4.81-fold improvement in exercise performance!
Up to 26.6% decrease in total cholesterol and lower triglycerides
1.72-fold increase in mitochondria-rich muscle fibers
Strengthened bone quality
Healthier vitamin D levels [11]
Improved learning and memory abilities
Improved learning and memory abilities
Increased liver and kidney function [12]
This might sound like a minor detail…but specificity matters.
L. plantarum TWK10 versus unspecified L. plantarum is the difference between a probiotic that works, backed by dozens of scientific studies…
…compared to one with questionable results. [13]
Consider this analogy: A Chihuahua and a Doberman are both canines but aren’t the same breed or “strain” of canine.
They are obviously very different in their behavior and efficacy in accomplishing certain objectives, e.g., being a lap dog versus a guard dog.
Comparing L. plantarum to L. plantarum TWK10 is like comparing a Chihuahua to a Doberman.
Only L. plantarum TWK10 can help you accomplish your goals to lose fat, build muscle, increase endurance, and enhance energy.
Huang W-C, Lee M-C, Lee C-C, Ng K-S, Hsu Y-J, Tsai T-Y, et al. Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans. Nutrients [Internet]. 2019;11. Available from: http://dx.doi.org/10.3390/nu11112836
Lee M-C, Tu Y-T, Lee C-C, Tsai S-C, Hsu H-Y, Tsai T-Y, et al. Lactobacillus plantarum TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial. Microorganisms [Internet]. 2021;9. Available from: http://dx.doi.org/10.3390/microorganisms9071466
Lee C-C, Liao Y-C, Lee M-C, Cheng Y-C, Chiou S-Y, Lin J-S, et al. Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans. Microorganisms [Internet]. 2022;10. Available from: http://dx.doi.org/10.3390/microorganisms10112181
Li R, Xia J, Zhang XI, Gathirua-Mwangi WG, Guo J, Li Y, et al. Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults. Med Sci Sports Exerc. 2018;50:458–67.
Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50:889–96.
Landi F, Calvani R, Cesari M, Tosato M, Martone AM, Bernabei R, et al. Sarcopenia as the Biological Substrate of Physical Frailty. Clin Geriatr Med. 2015;31:367–74.
Kojima G. Frailty as a Predictor of Nursing Home Placement Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. J Geriatr Phys Ther. 2018;41:42–8.
Vinderola G, Sanders ME, Salminen S. The Concept of Postbiotics. Foods [Internet]. 2022;11. Available from: http://dx.doi.org/10.3390/foods11081077
Xiong R-G, Zhou D-D, Wu S-X, Huang S-Y, Saimaiti A, Yang Z-J, et al. Health Benefits and Side Effects of Short-Chain Fatty Acids. Foods [Internet]. 2022;11. Available from: http://dx.doi.org/10.3390/foods11182863
Chen Y-M, Wei L, Chiu Y-S, Hsu Y-J, Tsai T-Y, Wang M-F, et al. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice. Nutrients. 2016;8:205.
Lee C-C, Liao Y-C, Lee M-C, Lin K-J, Hsu H-Y, Chiou S-Y, et al. Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice. Front Nutr. 2021;8:708096.
Chen Y-M, Liao C-C, Huang Y-C, Chen M-Y, Huang C-C, Chen W-C, et al. Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice. Food Sci Nutr. 2020;8:3525–34.
McFarland LV, Evans CT, Goldstein EJC. Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Front Med. 2018;5:124.
The Energy Blueprint
Human Optimization Lab - Molecular Hydrogen 30 Tablets (Rasberry Flavoured)
£27.00
£37.00
One Molecule. Hundreds Of Benefits. Over 2000 Scientific Studies.It’s not too good to be true—Molecular Hydrogen is the energy-boosting, brain-enhancing, performance-improving, pro-longevity antioxidant, anti-inflammatory, and anti-wrinkle supplement only researchers have heard of.Say Hello To HydrogenThe molecular answer to modern disease. You know the numbers… Every 33 seconds, someone in the United States dies from cardiovascular disease [1]. Every 52 seconds, someone dies from cancer [2].Statistically, one out of every three of your friends has metabolic syndrome and a higher risk of heart disease, diabetes, and stroke [3].The solution?One of the smallest compounds on Earth.Over 2000 studies prove molecular hydrogen’s powerful ability to support the underlying causes of modern disease.Benefit From...
Sharper brain function [4]
Sustained energy [5]
Balanced body composition [6]
Better Skin [7]
Boosted metabolism [8]
Improved immune function [9]
Faster recovery [10]
Powerful anti-aging [11]
Potent mitochondrial protection [12]
The vitality to do what you love
Most Antioxidants Have A Dark Side...Generally, antioxidants do a lot of good.
Research shows they fight aging, support our immune system, and help us avoid heart disease and cancer (13).But they also have a dark side.Why?Your body does best with balance. The right amount of stress—even oxidative stress—is a crucial trigger for powerful endogenous antioxidants like superoxide dismutase, catalase, and glutathione peroxidase.Most supplemental antioxidants disturb this delicate balance.But Molecular Hydrogen isn't most antioxidants.It acts as a master antioxidant by stimulating your body’s own internal defense system—your best source of optimized energy, performance, and recovery [14,15].Molecular Hydrogen Promotes Health In Three Primary Ways:
Unique antioxidant action: Directly and indirectly protects cells, proteins, and DNA from oxidative damage while elegantly influencing intracellular communication
Powerful anti-inflammatory: Reduces innate immune activation and promotes balance of pro- and anti-inflammatory cytokines at the genetic level (16, 17)
Dynamic apoptotic regulation: Adaptively balances programmed cell death and degradation—protects normal cells and may inhibit proliferation of malignant cells (18)
Blood Sugar Balance And Beauty
With zero side effectsSustained Energy
Molecular hydrogen positively impacts mitochondrial function and supports both acute and chronic fatigue [19]
Hydrogen’s ability to easily cross biological membranes, such as the double membrane surrounding mitochondria, allows easy entrance and quick action for those experiencing the increase in reactive oxygen and nitrogen species often associated with fatigue from disease states, stress, or high-intensity exercise [20].
In both animal and human studies, hydrogen has been shown to improve energy thanks to its antioxidant, anti-inflammatory, and even gene-level effects. It works within the mitochondria to quell hydroxyl radicals and block specific inflammatory pathways, such as the NLRP3 inflammasome.
Weight Loss & Improved Body Composition
Multiple studies have shown that supplemental hydrogen leads not only to weight loss but also improved body composition (fat-to-muscle ratio) [21,22].
In a study of middle-aged, overweight women, four weeks of hydrogen supplementation led to decreases in body fat percentage, serum triglycerides, and fasting serum insulin, likely due to hydrogen’s influence on obesity-associated mitochondrial dysfunction and inflammation.
The participants also experienced an increase in the endogenous antioxidant CoQ10 along with an improved lactate-to-pyruvate ratio, indicating positive mitochondrial outcomes [23].
Immune Balance
Investigations into the effects of hydrogen on autoimmune disease show a delay in the progression of experimental autoimmune encephalomyelitis, an experimental form of multiple sclerosis.
Disease severity, central nervous system infiltration, and demyelination were reduced when hydrogen was administered after the onset of the disease [24].
Supplemental hydrogen’s antioxidant and anti-inflammatory actions, specifically its ability to scavenge hydroxyl radicals, make it a promising therapy for those with rheumatoid arthritis (RA).
After 4 weeks of drinking hydrogen-enriched water, patients with RA had lower levels of oxidative marker 8-OHdG and decreased disease activity.
Those with early RA achieved disease remission (25,26).
Cognitive Performance
A small study of hydrogen supplementation’s effect on cognitive function in older women found that those who received hydrogen scored significantly better on tests of mental function, including improvements in word recall and word recognition.
The authors report that the average cognitive enhancement was significant enough for the group to progress from mild dementia at baseline to normal cognition at follow-up [27].
A second joint study examined memory-impaired animals and humans with mild cognitive decline. In mice, hydrogen water reduced oxidative stress, suppressed memory impairment and neurodegeneration, and even extended lifespan.
After one year of hydrogen water, human participants with the APOE4 genotype, a known risk factor for Alzheimer’s disease, scored significantly better on the Alzheimer’s Disease Assessment Scale, while the control group received slightly worse scores [28].
The Healing Power Of Hydrogen In Every Glass
Metabolic Protection
A randomized, double-blinded, placebo-controlled study of 30 men and 30 women with metabolic syndrome found that 24 weeks of hydrogen water consumption led to:
18.5 mg/dL reduction in total cholesterol
47 mg/dL reduction in triglycerides
18.4 mg/dL reduction in fasting glucose
12% reduction in HbA1c
Reduction of inflammatory markers TNF-a, IL-6, and CRP
Additionally, the antioxidant vitamins E and C significantly increased in the group drinking hydrogen water.
These effects are likely due to hydrogen’s antioxidant capabilities but may also be related to its positive influence on the electron transport chain, the series of biochemical steps leading to ATP production [29].
Skin Health
Hydrogen-rich water may be both internally and externally beneficial for the skin! One small Japanese study found that direct application of hydrogen water to the skin significantly decreased wrinkles, skin blotchiness, and modulated oiliness, meaning it reduced oiliness in participants with excessively oily skin and increased it in participants with dry skin.
The authors speculate that the potent antioxidant action of hydrogen water was responsible for mitigating reactive oxygen species damage that leads to skin aging [30].
Hydrogen also shows promise for those healing from skin damage due to radiation. In a recent animal study, radiation-induced skin wounds healed more quickly in the group sprayed with hydrogen water, likely due to lowered levels of malondialdehyde, a marker of oxidative stress, and IL-6, an inflammatory marker. Further, the wounds treated with hydrogen water had increased superoxide dismutase activity, an endogenous antioxidant enzyme [31].
Exercise Performance & Recovery
The influence of supplemental hydrogen on athletic performance reveals that even short-term supplementation may have positive benefits on endurance, fatigue, respiratory rate, heart rate, blood lactate levels, and perceived effort [32, 33, 34].
Additionally, hydrogen encourages recovery from soft tissue injuries [35].
Hydrogen’s unique role as a supporter of endogenous antioxidant production makes it particularly valuable to active people who want to achieve optimal health and improved performance. Research shows it balances exercise-induced oxidative stress and may even act as an alkalinizing agent capable of combating fatigue during high-intensity exercise [36].
How Did We Create Drinkable Hydrogen?
The answer is a simple (and very safe) chemical reaction—the form of magnesium used in Molecular Hydrogen reacts with water to produce hydrogen gas. For maximum benefit, begin drinking immediately after your tablet dissolves. It won’t be a struggle—Molecular Hydrogen is flavored with 100% natural raspberry powder.
Molecular Hydrogen: Supporting Metabolism For Over 2 Billion Years
(You read that right.)
According to the Hydrogen Hypothesis, hydrogen is the link between evolution and the development of our primary energy producers—mitochondria [37].
Billions of years ago, we evolved with a need for hydrogen. That requirement was fulfilled by the microscopic ancestors of present-day mitochondria.
How does evolution affect you today?
Research shows that molecular hydrogen has a profound positive impact on metabolism and mitochondrial health.
Supplemental Hydrogen Supports Mitochondrial Functions, Including:
Balanced cholesterol [38]
Metabolic stability [39, 40]
Optimal body composition
Liver capacity [41,42]
Cardiovascular fitness [43]
Healthy blood pressure [44]
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National Center for Chronic Disease Prevention and Health Promotion, Division for Heart Disease and Stroke Prevention. Heart Disease Facts. Last Reviewed: May 15, 2023.
Division of Cancer Prevention and Control, Centers for Disease Control and Prevention. An Update on Cancer Deaths in the United States. Page last reviewed: February 28, 2022.
Hirode G, Wong RJ. Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016. JAMA. 2020;323(24):2526-2528.
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LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896.
Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B. 2012;106:24-33.
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LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.
Diabetes Metab Syndr Obes. 2020;13:889-896.
Korovljev D, Trivic T, Drid P, Ostojic SM. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci. 2018;187(1):85-89.
Zhao M, Liu MD, Pu YY, et al. Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol. 2016;294:6-13.
Ishibashi T. Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.
Curr Pharm Des. 2013;19(35):6375-6381.
Ishibashi T, Sato B, Rikitake M, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27.
Korovljev D, Trivic T, Drid P, Stater V. Short-Term H2 Inhalation Improves Cognitive Function in Older Women: A Pilot Study. International Journal of Gerontology. 2020;14(2):149-150.
Nishimaki K, Asada T, Ohsawa I, et al. Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res. 2018;15(5):482-492.
LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896.
Tanaka Y, Miwa N. Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture. Hydrogen. 2022; 3(2):161-178.
Zhou P, Lin B, Wang P, Pan T, Wang S, Chen W, et al. The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats, Journal of Radiation Research. 2019;60(1):17–22.
Mikami T, Tano K, Lee H, et al. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Can J Physiol Pharmacol. 2019;97(9):857-862.
LeBaron TW, Larson AJ, Ohta S, et al. Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study. J Lifestyle Med. 2019;9(1):36-43.
Botek M, Krejci J, Mckune A, Sládečková B, Naumovski N. Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise. Int J Sports Med 2019;40(14):879-885.
Ostojic SM, Vukomanovic B, Calleja-Gonzalez J, Hoffman JR. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med. 2014;126(5):187-195.
Ostojic SM. Molecular hydrogen in sports medicine: new therapeutic perspectives. Int J Sports Med. 2015;36(4):273-279.
Martin W, Müller M. The hydrogen hypothesis for the first eukaryote. Nature. 1998;392(6671):37-41.
Todorovic N, Fernández-Landa J, Santibañez A, Kura B, Stajer V, Korovljev D, Ostojic SM. The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis. Pharmaceuticals. 2023; 16(2):142.
Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28(3):137-143.
Asada R, Tazawa K, Sato S, Miwa N. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. Med Gas Res. 2020;10(3):114-121.
Korovljev D, Stajer V, Ostojic J, LeBaron TW, Ostojic SM. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clin Res Hepatol Gastroenterol. 2019;43(6):688-693.
Kura B, Szantova M, LeBaron TW, Mojto V, Barancik M, Szeiffova Bacova B, Kalocayova B, Sykora M, Okruhlicova L, Tribulova N, et al. Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial. Antioxidants. 2022; 11(10):1935.
Saengsin K, Sittiwangkul R, Chattipakorn SC, Chattipakorn N. Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application. Cell Mol Life Sci. 2023;80(6):174.
Sugai K, Tamura T, Sano M, et al. Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension.
Sci Rep. 2020;10(1):20173.
The Energy Blueprint
The Energy Blueprint - Energenesis 432.5g
£89.00
£119.00
WHAT'S IN ENERGENESIS?
Energenesis is like a 5-star MEAL for your Mitochondria (LOADED with rare nutrients, energy boosters and powerful antioxidants, because your body needs a variety – each one works differently!) AND… we have gone to amazing lengths to source the highest quality ingredients, with unparalleled potency, purity, biological availability, and effectiveness…
If you want to see a breakdown of the exact ingredients and amounts, you can look in the right column of the image below…
It’s a potent cocktail of the most powerful mitochondrial regenerating ingredients designed to literally CHARGE your cells back up, so you can have the energy you had when you were young – ALL DAY ENERGY.
If you’ve been struggling with fatigue or low energy levels, it’s time to stop dragging yourself through the day with caffeine and stimulants…
It’s time to start building REAL ENERGY.
You can certainly use the information here to go out and buy all these compounds as separate supplements, but I strongly encourage you to simply get Energenesis. It’s obviously far more convenient to get everything in one formula rather than fiddling with 20 different bottles and 25 pills each day. Also, you don’t have to worry about dosing everything correctly.
And, on top of that, I’ve tried to make it a complete no brainer for you by making it way cheaper for you to order it this way (as opposed to buying 20+ different supplements).
Energenesis is simply the most powerful formula ever developed for that purpose.UNLIKE PREVIOUS GENERATION “ENERGY SUPPLEMENTS,” IT CONTAINS NO STIMULANTS, NO CAFFEINE, AND NO SUGAR. THIS ISN’T ABOUT GIVING YOU A FAKE ENERGY BOOST, WHILE ACTUALLY MAKING YOUR ENERGY LEVELS WORSE OVER TIME.
Energenesis builds REAL ENERGY!
This is not a supplement designed to fill to people’s desire for quick fixes and instant gratification through stimulants and temporary boosts of fake energy.
Energenesis is for people looking for REAL ANSWERS, who want to address ROOT CAUSES, and want to build real energy at the cellular level.
As a result, the energy your mitochondria produce naturally decreases over time, reducing your health and longevity — and ultimately, causing fatigue.
On top of that, stressors in our life — from psychological stress, to environmental toxins (like heavy metals and air pollutants), to a poor diet, to poor gut health, to chronic inflammation — all cause mitochondrial damage, dysfunction and shut down (they shift out of energy mode into a cell protection response).
Research is now showing that these three things — the loss of mitochondria, the damage/dysfunction of mitochondria, and the shut down of mitochondria — are the primary factors that drive low energy levels.
In other words, if you’ve got low energy levels, it likely simply means that your mitochondria have become weak, damaged, dysfunctional, and switched off over time.
ENERGENESIS INGREDIENTSWhat's Inside The Most Powerful Energy Supplement Ever CreatedMITOCHONDRIAL MEMBRANE SUPPORT COMPLEX
NT FACTOR PHOSPHOLIPIDS
NTFactor® is a digestion-resistant phospholipid complex that supplies the materials necessary to repair and regenerate damaged cell membranes directly to mitochondria, a treatment called lipid replacement therapy [1].
By supplying the bioactive phospholipids that mitochondria require to naturally replace damaged membrane components, NTFactor® is able to regenerate dysfunctional mitochondria, increase energy production, and enhance the energy levels of those using it.
Numerous studies have shown that NTFactor® reduces fatigue by 24–43 percent among those with chronic fatigue syndrome or conditions associated with fatigue, like general aging, obesity, lyme disease, and Gulf War Illness [2]. In older adults, NTFactor® restored mitochondrial function to a level matching healthy 29 year-olds [3].
ASTAXANTHIN
Astaxanthin is one of the most powerful membrane-specific antioxidants in existence. Not only is it 30–85 percent more potent than vitamin E and carotenoids like β-carotene, lycopene, and lutein [4], but it has a unique polar structure that allows it to cross through, protect, and stabilize the entire mitochondrial membrane [5].
Due to astaxanthin’s consistent and powerful ability to prevent oxidative damage and dysfunction to mitochondria [6–8], some researchers have even determined it to be “mitochondria-targeted antioxidant” [9].
Interventions have shown that astaxanthin supplementation increases muscular strength and power output in fatigued adults [10], enhances muscular endurance and recovery in recreational athletes [11,12], and reduces muscle damage and oxidative stress in elite soccer players [13].
MITOCHONDRIAL ENERGY PRODUCTION COFACTOR COMPLEX
ACETYL-L-CARNITINE
Acetyl-L-Carnitine (ALCAR) is a special form of carnitine that achieves two goals: (1) it supplies the carnitine your mitochondria need to produce energy, and (2) it provides an acetyl moiety that your mitochondria use to remain youthful and healthy.
The carnitine shuttle system is essential for bringing fatty acids into mitochondria to be used for energy production, and carnitine deficits (even mild ones) have been documented in those with chronic fatigue [14]. Moreover, over 20 percent of mitochondrial proteins rely on acetyl moieties to properly function, including those involved in antioxidant defenses and energy production [15,16].
For these reasons, some researchers have proposed that ALCAR should be considered a “mitochondrial rejuvenator” [17]. In chronically fatigued older adults, ALCAR supplementation led to profound benefits to their wellbeing — a 24 percent increase in physical function and close to a whopping 50 percent reduction in mental fatigue, physical fatigue, and overall fatigue severity [18].
CREATINE
Creatine is a molecule necessary for rapid and explosive energy production when energy needs cannot be immediately met by our mitochondria. Supplementation works by increasing the amount of available creatine within our muscles.
This not only increases muscular performance, but also helps stimulate mitochondrial energy production when faced with signals to do so (like being physically active) [24], enhance mitochondrial biogenesis and integrity [25], and protect mitochondria from oxidative damage [26,27].
Accordingly, creatine is one of the most extensively researched supplements for improving exercise performance, muscle strength, and power output in people of all ages [28–32].
COENZYME Q10
Coenzyme Q10 (CoQ10) is an essential component of mitochondrial energy production, serving as both an antioxidant and an energy-transferring molecule. As such, deficits in CoQ10 will not only lead to a cessation of energy production, but also an increase in oxidative damage.
Individuals with chronic fatigue regularly show deficiencies in CoQ10 concentrations throughout the body [33], as do those with conditions in which fatigue is a common symptom, like fibromyalgia [34–36], those who have survived heart attacks or heart failure [37,38], and multiple sclerosis [39,40].
Supplementation with CoQ10 improves fatigue, autonomic nervous system activity (the part of the nervous system involved in rest and recovery), and biochemical parameters of mitochondrial energy production in those with chronic fatigue [41–44], and reduces general fatigue and oxidative stress in healthy adults [45,46].
ALPHA-LIPOIC ACID (IDEALLY R-ALA)
Alpha-lipoic acid (ALA) is a mitochondrial molecule involved in energy metabolism and the antioxidant system. It is not only essential for mitochondria to create cellular energy, but also serves to function as an antioxidant, replenish other antioxidants, and stimulate the production of antioxidant enzymes like glutathione [47].
Accordingly, ALA has been heavily investigated as a mitochondrial rejunivator, able to help reverse age-related declines in mitochondrial energy production [48], particularly within the brian [49,50].
By improving mitochondrial function and protecting against oxidative stress, ALA has been shown to benefit metabolic health [51,52], as well as facilitate weight loss among those who are overweight [53–55].
ALA exists as either an S or R isomer, with unspecified ALA being a 50-50 ‘racemic’ solution of both. Most studies use the racemic solution, but only R-ALA has biological activity in the body and is more bioavailable [56], which is why we use it in Energenesis.
NAD+ REGENERATION COMPLEX
TAURINE
Taurine is an omnipresent amino acid within the body, essential for the development and function of our cardiovascular, muscular, nervous, and ocular systems [57]. It’s also essential for mitochondrial energy production and protein synthesis [58,59]
The highest amounts of taurine are in tissues with huge energy requirements and a lot of mitochondria, such as the retina, nerves, kidney, heart, and skeletal muscle [60]. If mitochondria don’t have enough taurine, energy production decreases and oxidative stress increases [61].
Insufficient taurine has been implicated in numerous chronic disease states [62,63], and several clinical trials have shown that supplementing with taurine reduces oxidative stress and inflammation in those with metabolic dysfunction [64–66].
Additionally, a meta-analysis reported that taurine supplementation improved endurance exercise performance, particularly power output and the amount of time that people could run before exhaustion [67].
MAGNESIUM
Magnesium is required for over 300 enzymes to function properly — muscle contractions, blood vessel regulation, insulin signaling, the synthesis of DNA and proteins, and nerve transmission all require magnesium [68].
One of the enzymes that relies on magnesium is ATP synthase, which is responsible for generating cellular energy (ATP) within mitochondria. Without magnesium, your mitochondria simply can’t function efficiently [69,70].
Energenesis provides two forms of magnesium, citrate and malate, which are both cofactors for mitochondrial energy production themselves.
B3 VARIANTS (NMN, NR, NIACIN & NIACINAMIDE)
Niacin is an essential component of energy-carrying molecules within the mitochondria, all of which are derivatives of nicotinamide adenine dinucleotide (NAD+). NAD+ is important for energy production, mitochondrial function, and cellular repair processes.
The primary route of NAD+ synthesis is through something called the salvage pathway, in which niacinamide serves as the starting molecule. We can also make NAD+ from nicotinic acid using an alternative pathway, which is why we’ve included both forms in Energenesis to ensure that NAD+ generation is not being impeded by a simple vitamin insufficiency.
MITOCHONDRIAL ENERGY PRODUCTION COFACTOR COMPLEX
POMEGRANATE
Pomegranate is a rich source of ellagitannins, potent antioxidant molecules that can be further metabolized into other antioxidant derivatives like ellagic acid and urolithins [71,72]. These substances have been heavily investigated for their mitochondrial and cardiovascular benefits.
Pomegranate ellagitannins and their derivatives have been shown to enhance mitochondrial function [73] and increase rates of mitophagy (mitochondria + autophagy) [74,75], which is a quality control pathway that preserves mitochondrial health by targeting damaged mitochondria for autophagic degradation, making anything that facilitates mitophagy absolutely vital for optimal health and disease prevention.
In recreational endurance athletes, supplementing with pomegranate extract for just two weeks increased the total time the athletes could cycle before complete exhaustion by 14 percent and increased the amount of time they could rely on their mitochondria to supply most of their energy by 10 percent [76].
Moreover, pomegranate supplementation has been shown to reduce blood lipid oxidation and the accumulation of plaque in arteries [77], particularly in people who have higher levels of oxidative stress [78,79].
GREEN TEA CATECHINS
Green tea (Camellia Sinensis) catechins are four phytochemical molecules, the most potent one being epigallocatechin-3-gallate (EGCG). It has been implicated in benefiting almost every organ system in the body in doses you can obtain easily from simply drinking green tea [87–89].
EGCG is neuroprotective [90,91], cardioprotective [92,93], anti-obesity [94–96], anti-carcinogenic [97,98], and anti-diabetic [99], all due primarily to its ability to stimulate mitochondrial biogenesis, enhance energy production, and protect mitochondria from oxidative stress [100,101].
Supplementation of EGCG plus resveratrol (another ingredient of Energenesis) has been shown to significantly increase mitochondrial function and the use of fatty acids for energy production [102], and several meta-analyses have concluded that EGCG reduces body weight and body fat [103–106], particularly abdominal fat [107].
GYNOSTEMMA
Gynostemma is a climbing vine native to SouthEast Asia and related to Panax Ginseng, containing many of the same bioactive molecules. Unlike ginseng, however, gynostemma also possesses an array of gypenosides that have been shown to upregulate several signaling molecule likes sirtuins and AMPK which facilitate mitochondrial function and biogenesis [108–110].
Clinical trials have shown that supplementation with gynostemma improves metabolic health through these mechanisms. A study of overweight men and women reported that supplementing with 450 mg of gynostemma daily for 12 weeks reduced total abdominal fat by 6%, visceral fat by 10%, and subcutaneous fat by 4% compared to a placebo [111].
Drinking 6 grams of gynostemma in the form of a tea lowered fasting glucose and insulin resistance each by 30% compared to a placebo after 12 weeks in adults with type 2 diabetes [112], and supplementing with 80 mL of gynostemma extract may improve liver health alongside dieting more than dieting alone in adults with fatty liver disease [113].
ASHWAGANDHA (SHODEN EXTRACT)
Ashwagandha (Withania somnifera) is a nightshade revered in Ayurvedic medicine for its physical- and mental-enhancing effects [114]. Today, it’s considered an adaptogen for similar reasons, able to increase a person’s resilience to stress and help reduce anxiety [115,116].
These effects are largely due to its constituent withanolide structures, which have several important neuroprotective effects within the brain, such as scavenging free radicals, reducing neuroinflammation, and promoting neurotransmitter signaling [117]. They also improve mitochondrial function and energy production [118].
In Energenesis, we use the most potent form of ashwagandha, a 35% withanolide concentrate called the Shoden extract. Just 240 mg of Shoden ashwagandha reduces stress and anxiety by 30% in mildly stressed adults [119], while a mere 60 mg can boost DHEA-S and testosterone by 15–18% in middle-aged men [120].
In another large randomized placebo-controlled trial of 150 men and women, supplementing 120 mg has been documented to improve physical and psychological quality of life by 8% and enhance sleep quality by 40% compared to placebo, including dramatically improving the time it took to fall asleep, total sleep time, and nightly awakenings [121].
Other studies have shown ashwagandha supplementation to reduce perceived stress, anxiety, and depression in mildly stressed healthy adults [122,123], adults battling chronic mental stress [124], and adults with an anxiety disorder [125].
PANAX GINSENG
Panax ginseng has been used medicinally for thousands of years in China, Korea, and Japan to alleviate physical and mental fatigue. While there are several types of ginseng on the market, panax ginseng is considered the “true” ginseng.
At a fundamental level, panax ginseng works to protect mitochondria from oxidative damage and improve energy production under conditions of oxidative stress [126,127]. A systematic review and meta-analysis of five studies in chronic fatigue patients found significant benefits of ginseng supplementation for reducing fatigue severity [128], with reductions of 20 percent after one month not being uncommon [129,130].
PQQ (PYRROLOQUINOLINE QUINONE)
Pyrroloquinoline Quinone (PQQ) is a potent stimulator of pathways involved in mitochondrial biogenesis and antioxidant defenses [131,132]. In particular, it stimulates pathways shared by exercise training and is believed to potentiate and enhance activity-induced benefits on mitochondria [133].
Supplementation has been shown to reduce fatigue and increase vigor by 20 percent in adults complaining of poor sleep and energy levels, as well as improve mood, sleep quality, and overall quality of life [134]. In another study of healthy adults, PQQ reduced inflammation and improved markers of mitochondrial respiration [135].
References
The Energy Blueprint
The Energy Blueprint - Longenesis 150caps
£89.00
£119.00
AGING IS A COMPLEX PROCESS
Aging is a complex process that is now understood by gerontologists (aging scientists) to be driven by at least 10 key mechanisms. These include:
1. Mitochondrial dysfunction
2. Inflammation (“Inflammaging”) and disrupted cell communication
3. Cellular senesence (“zombie” cells that secrete pro-inflammatory molecules that damage neighboring cells)
4. Protein accumulation inside and outside of cells that hinders cell functions
5. Epigenetic dysregulation (dysfunctional signaling leading to non-optimal changes in which changes are switched on or off)
6. Oxidative damage
7. Dysfunctional DNA methylation
8. Suppressed autophagy and mitophagy (the quality control process of maintaining healthy cells and mitochondria)
9. Reduced stem cell proliferation
10. Telomere shortening
(And other mechanisms, like DNA damage, glycation of tissues, and more).
"When designing Longenesis, our goal was to create the world’s most comprehensive formula using science-backed ingredients proven to impact on these mechanisms of aging."
For example, there are ingredients in the formula like ca-AKG proven to act on several of these mechanisms like improving mitochondrial health, reducing inflammation, reducing oxidative damage, and altering epigenetic signaling (gene expression). Or spermidine, which powerfully stimulates autophagy to allow the body to recycle and repair damaged cell parts. Or fisetin, which has been shown to powerfully clear away senescent cells. Or glucosamine sulfate, which has been shown to transiently challenge mitochondria (like exercise for mitochondria), making them larger and increasing their energy producing capacity – and which has been shown to actually translate into the hard outcomes of increased lifespans in animal models, and has been strongly associated with longer lifespans in humans.
All of this is just scratching the surface of the powerful ingredients in Longenesis, and the dozens of mechanisms through which these ingredients are provent to slow down the rate of cellular aging. (A more in-depth examination of the ingredients and the science behind them is below).
In addition, there is an enormous focus on safety in our formula. While there are certain ingredients that may enhance longevity, there side effect profile is highly questionable. Things like rapamycin, C60, and metformin (and many other new synethic compounds) fall into this category. In Longenesis, we’ve included only ingredients which have extremely good safety profiles and virtually no risk of harm – and which are natural (rather than synthetic lab-made molecules).
YOU CAN SLOW DOWN THE PROCESS OF CELLULAR AGING!
To do this you must:
Reduce the oxidative stress and inflammation that drives mitochondrial damage and dysfunction
Improve your stem cell production and proliferation
Clear senescent cells more effectively
Build up your internal antioxidant and detoxification defense systems
Optimize your genetic expression through proper epigenetic signaling
Reduce or eliminate chronic low-grade inflammation
Protect your telomeres
Restore proper DNA methylation
Rebuild your mitochondria
This is what Longenesis has been designed to do.
COMPLETE TRANSPARENCY ON THE LABEL
As always, we operate with complete transparency with the ingredients in our formulas. No “proprietary blends” to hide miniscule dosages of ingredients (as most manufacturers do). We proudly list out all our ingredients and their actual dosages, with nothing to hide.
While most manufacturers list out an impressive list of ingredients, what they don’t tell you is that they are typically using 1/5th, 1/10th, or even 1/20th of the proper clinically effective dosages of those ingredients that were actually used in the studies and shown to have benefits. As always, the dose makes the medicine! Just as there is a big difference in workouts between walking 20 steps vs. running a marathon, there is a big difference between using the proper 1,000 mg dose of a compound vs. using only 50 mg. These do not and will not have remotely the same benefit.
We encourage you to compare the ingredients, and the dosages of each ingredient to any other longevity formula on the market. You’ll quickly see that our formula is radically more comprehensive in terms of ingredients, and simultaneously uses much larger doses – the clinically effective dosages that are actually used in studies and proven to have benefits.
THE PERFECT FORMULATION
12 PREMIUM, CAREFULLY SOURCED, AND SCIENCE-BACKED INGREDIENTS IN THEIR OPTIMAL DOSAGES
ALPHA-KETOGLUTARATE
Alpha-ketoglutarate (AKG) is a key molecule in mitochondrial energy production that determines the overall rate of electron generation within the tricarboxylic acid (TCA) cycle. It is also essential for the function of several enzymes involved in gene expression and collagen synthesis. These unique roles have implicated AKG in healthy aging longevity [1].
In particular, AKG binds to the enzyme required for energy production (ATP synthase) and inhibits its function, thereby stressing mitochondria and causing adaptations that lead them to become more efficient energy producers [2]. It basically mimics energy restriction without dieting, causing delays in age-related diseases and increases in longevity.
GLYCINE
Glycine is a conditionally essential amino acid that wears many hats. It is necessary for protein synthesis, particularly that of collagen (the most abundant protein in the body), and an essential component of several biologically important compounds like porphyrins and heme, creatine, glutathione, and purines. It is also an important signaling molecule within the nervous and immune systems.
Mice consuming a diet of 8% glycine, about 1 g/kg body weight for a human, from young adulthood onward experience a 4–6% increase in average lifespan [13], and rats consuming a diet of 8% glycine from adolescence onwards experience a 30% increase in both average and maximal lifespan [14].
GLUCOSAMINE SULFATE
Glucosamine is a naturally occurring component of crustacean exoskeletons and fungi. Best known for reducing joint pain and improving mobility, few know of its profound mitochondrial benefits and lifespan-extending effects [25].
Several studies have associated glucosamine supplementation with 10–32% reductions in dying from all causes, cancer, or diseases of the cardiovascular, respiratory, and digestive systems, even after taking into account several known risk factors, such as age, sex, smoking, alcohol, physical activity, and metabolic health [26–29].
AC-11
AC-11 is a patented extract of Uncaria tomentosa, also known as cat’s claw, that enhances the body’s natural DNA repair mechanisms. DNA damage is a central feature of the aging process, and its reduction can help counteract virtually all age-related diseases [33].
Much of the DNA repair benefits are owed to the carboxy alkyl ester concentrates within AC-11, particularly quinic acid [34,35]. Supplementation of healthy men and women with 250 or 350 mg of AC-11 significantly increased DNA repair capacity by 12–15% [36].
QUERCETIN PHYTOSOME
Quercetin is a flavonoid with anti-inflammatory, antioxidant, and antiviral properties [41]. In particular, quercetin is able to inhibit the ability or respiratory viruses to enter cells and replicate, essentially reducing the risk of infection [42,43]. It also acts as a zinc ionophore, meaning that it carries zinc ions into cells so that the zinc can prevent viral replication [44].
Even in well-developed countries like the US, respiratory infections are still the 6th leading cause of death and 7th leading cause of lost life due to premature death — that’s more than diabetes, stroke, or breast cancer [45]. In 2020, thanks to the COVID-19 pandemic, respiratory infections became the 3rd leading cause of death after heart disease and cancer [46].
FISETIN
Fisetin is a naturally occurring flavonol found in fruits and vegetables best-known for its potent senolytic effects — it’s ability to kill off senescent cells that contribute to aging, disease, and dysfunction throughout the body.
Cellular senescence is a natural byproduct of aging. Senescent cells arise when damaged and dysfunctional cells resist removal by normal cell death processes and instead linger in a type of “zombie” state that harms neighboring normal cells.
PTEROSTILBENE
Pterostilbene is a natural molecule found in fruits, vegetables, and nuts, the best source being blueberries, and is a structural cousin to resveratrol. In supplemental doses, it confers a variety of health benefits that delay the aging process.
Two of the most pronounced effects of pterostilbene are its ability to suppress oxidative stress and inflammation, which it does through activation of AMPK (master autophagy controller), activation of Nrf2 (master of the antioxidant response to oxidant exposure), and suppression of NF-kB (master inflammatory signal) [54]. These, in turn, manifest as protection against metabolic, cardiovascular, and neurological diseases of aging.
LITHIUM
Lithium is a non-essential mineral found primarily in rocks. While best-known for its psychotropic effects and use as a psychiatric medication among those with bipolar disorder, schizophrenia, and depression, it can have a variety of anti-aging benefits when taken at much lower “microdoses”.
Through erosion, lithium can make its way into drinking water, where it correlates to longer lives and reduced premature mortality among those drinking it [103,104]. Other research has documented an increase in telomere-lengthening enzymes from lithium supplementation [105].
In mice, lithium helps offset diseases of aging [106], and psychiatric patients who take lithium show lesser signs of aging compared to those who don’t take it [107]. In older adults with mild cognitive impairment, using lithium for one year slowed the rate of cognitive decline and significantly reduced brain concentrations of tau proteins, a biomarker of Alzheimer’s disease [108].
LUTEIN AND ZEAXANTHIN
Lutein and zeaxanthin are carotenoids abundant in green leafy vegetables and egg yolk that preferentially accumulate in the retina and its supporting structures to protect the eyes against oxidative stress from light [61], which has massive implications for age-related vision loss.
Lutein and zeaxanthin protect the eyes in two ways [62–64]:
They situate themselves in front of delicate functional structures of the retina, such as photoreceptors, and directly absorb blue light (about 40%, on average) before it ever reaches the structures and has a chance to cause oxidative stress.
They are powerful antioxidant molecules that neutralize free radicals produced within the eye when blue light reacts with vitamin A derivatives, chromophores, and mitochondria.
There is strong evidence supporting lutein and zeaxanthin supplementation for the prevention and treatment of age-related eye diseases like macular degeneration (AMD) and cataracts.
SPERMIDINE
Spermidine is a naturally occurring polyamine that we synthesize and obtain from food. It regulates a variety of biological processes such as cell growth and proliferation, tissue regeneration, DNA and RNA stabilization, enzymatic modulation, and regulation of translation, among others.
The primary mechanism of action of spermidine is its ability to engage molecular pathways that are stimulated through calorie restriction, particularly the promotion of autophagy (the cleanup of old and damaged cells) [85,86]. While we make enough spermidine to satisfy our requirements in young adulthood, our ability declines with age, thus requiring sufficient dietary intake [87].
ERGOTHIONEINE
Ergothioneine is a naturally occurring amino acid that humans cannot synthesize and instead obtain exclusively through their diet. After consumption, it accumulates throughout the body, where it plays a role in many age-related diseases [94]. While levels increase through young adulthood, they begin to decline in old age [95–97].
The American biochemist Bruce Ames has conducted numerous studies looking at how nutrient insufficiencies over the lifetime contribute to mitochondrial decay and degenerative diseases, coining the term Triage Theory as a result [98,99]. Essentially, when nutrients are scarce, the body will prioritize their use for survival rather than long-term health.
References
The Energy Blueprint
The Energy Blueprint - Ultra Brain 150caps
£74.00
£99.00
WHAT YOU CAN EXPECT FROM ULTRABRAIN
Improved mood (combat depressed mood and increase joy)
Improved focus and cognitive performance
Improved brain energy levels
Decreased brain fog (improved clarity)
Decreased anxiety
Stimulant-free brain boosting action
Long-term decreased risk of neurodegenerative diseases
DO YOU HAVE ANY (OR ALL) OF THESE SYMPTOMS?Brain-Related fatigue - Feeling fatigued, exhausted, or sleepy after doing something mentally demanding
Chronic low-energy - waking up feeling groggy, feeling tired throughout the day, relying on caffeine or stimulants to keep you alert
Brain fog - a type of cognitive dysfunction that includes memory problems, lack of ability to concentrate, and lack of mental clarity
Anxiety or depression - persistent feelings of sadness, emptiness, guilt, hopelessness, worry, or pessimism
Sleep problems - racing thoughts at bedtime or inability to fall asleep quickly, waking up in the night - sometimes repeatedly, insomnia
Loss of resiliency - inability to handle and recover from stress
Whether you suffer from one or all of these issues, you must understand this critical truth: These symptoms are NOT a normal thing, and they're NOT just a normal part of aging!
HERE'S THE REALITY
These symptoms are present because you actually have damaged, inflamed, or dysfunctional neurons in your brain more specifically, you have:
Leaky blood-brain barrier – a shockingly common issue where the protective wall between your brain and bloodstream breaks down when it becomes leaky, things get into the brain that shouldn’t be there.
Mitochondrial dysfunction/shutdown – mitochondria are your cellular energy generators and danger sensors, but, mitochondria cannot be in both energy mode and cell defense mode. When your mitochondria are weak, they are constantly trying to sense danger and can’t produce energy.
Neuroinflammation – cells in your brain called microglia, which sort of function as your brain’s immune system, are activated too frequently and become stuck in the on position, as a result, they produce inflammatory compounds and oxidative damage.
LET'S FIX THE DAMAGED NEURONS IN YOUR BRAIN!
You CAN seal your blood-brain barrier, heal your mitochondria, and reduce the inflammation in your brain!
You CAN reverse your brain-related fatigue, brain fog, anxiety and depression, loss of resilience, and sleep issues!
To do this you must:
Nourish your imbalanced brain with a wide range of nutrients – nutrients that are scientifically proven to fix your neurons
Reverse cellular dysfunction
Reduce inflammation
Rewire your brain out of fatigue, stress, and depression mode
WHY THESE SPECIFIC NUTRIENTS?
The result is a very carefully curated formulation that meets these unparalleled standards:
Absolutely zero pseudo-sciences, facts, or false marketing. Pure science in every serving
Each ingredient is in its most potent, bioavailable form. Really nothing else can outperform these brain-boosting compounds.
Effective dosages in each and every serving. 6 capsules a day is everything you need to help reverse cellular dysfunction and supercharge your mental capacity
THE PERFECT FORMULATION
15 Premium, carefully sourced ingredients in effective dosages.
RHODIOLA ROSEA
Stabilizes mood
Reduces anxiety and depression
Improves cognitive performance
Reduces feelings of exhaustion, irritability, and burnout
Increases resilience (resistance to stress)
Functions as an antioxidant and anti-inflammatory
Fast-acting
Rhodiola is a neuroprotective, cognitive enhancing, and mood stabilizing herb that promotes neuronal regeneration, functions as an antioxidant and anti-inflammatory, facilitates neurotransmission, and regulates several key mediators of the stress response [1–3].
The effects are rapid. In adults with chronic work- and life-related stress, rhodiola significantly reduced feelings of exhaustion, irritability, and anxiety in as little as three days [4].
In a study of working adults suffering from burnout, a third of whom had been unsuccessfully treated for their stress in the past, rhodiola improved every aspect of quality of life and perceived stress after just 1 week, with further improvements seen after 12 weeks [5].
In adults with chronic fatigue syndrome, rhodiola improved every aspect of fatigue after just 1 week, with further improvements seen after 8 weeks [6]. Ultimately, 83% of the participants reported “very much” or “much” improved conditions, with every aspect of fatigue, stress, and global impairment being cut in half.
Improvements in perceived stress, mental fatigue, cognitive performance, anxiety, and depression have also been noted in medical students [7], military cadets [8], and adults with stress-related fatigue [9], mild anxiety [10], and mild-to-moderate depression [11,12].
LION'S MANE POWDER
Reduces anxiety and depression
Helps improve memory, concentration, and overall cognitive function
Promotes nerve growth and regeneration in the brain
Reduces inflammation
Stabilizes mood
Restores key neurotransmitters
Lion’s mane mushroom (Yamabushitake or Hericium erinaceus) is a medicinal mushroom that has been extensively studied for its neurohealth properties [13,14].
Stimulates the production of nerve growth factor [15–17], which promotes neuronal growth, development, and regeneration [18].
Stimulates the production of brain derived neurotrophic factor [19], which has neuroprotective effects, plays a role in neuronal development, and helps in the formation of neuronal connections important for memory and cognition [20].
Restores levels of serotonin, noradrenaline, and dopamine levels in the brain that can be suppressed due to chronic stress [19].
Reduces neuroinflammation [19,21]
Clinical trials have shown that lion’s manse improves cognitive function by 12% compared to placebo in older adults with mild cognitive impairment [22], and reduces symptoms of anxiety (by 27%) and depression (by 39%) in adults with obesity [23].
ALPHA-GPC
Protects neurons in the brain and supports neurotransmission
Increases dopamine and serotonin signaling in the brain
Decreases risk of vascular dementia
More effective than Alzheimer drug (Aricept) at improving cognition
Alpha-glycerophosphocholine (Alpha-GPC) is a highly bioavailable source of choline for the brain [24], which plays a critical role in neuronal plasticity, membrane stability, signaling events, and neurotransmission [25].
Having adequate brain choline concentrations is neuroprotective against a variety of brain diseases [26], and numerous clinical trials have found that alpha-GPC improves cognitive function and memory in individuals with neurodegenerative disorders, vascular dementia, and stroke — even being more effective than the standard drug therapy for Alzheimer’s disease [27].
CHOLINE (COGNIZIN®)
Promotes the health of cell membranes
Improves memory and overall brain cognition
Improves motor function
Increases focus and reduces impulsive behavior
Improves neuroplasticity (helps the brain adapt to new situations)
CDP-choline is a bioavailable source of choline for the brain and the direct precursor for the synthesis of phosphatidylcholine [28,29], one of the most abundant and important structural components of cell membranes. Supplementation has been confirmed in humans to increase phosphatidylcholine synthesis within the brain [30,31].
A Cochrane Systematic Review of 14 double-blind, placebo-controlled trials involving older adults with cognitive deficits like dementia reported that CDP-choline was able to improve memory, correct abnormal behaviors, and increase the global impression that physicians have towards the participants [32].
Other studies have found that CDP-choline slows the deterioration of cognition in those with Alzheimer’s disease [33,34], improves motor function and attention in adolescents [35], and improves attention in healthy women [36].
BACOPA
Enhances short-term and long-term memory
Enhances learning, visual processing, cognitive performance
Improves mood and reduces depression and anxiety
Reduces oxidative stress
Neuroprotective
Reduces β-amyloid deposits
Enhances communication between neurons
Increases blood flow
Bacopa monnieri is an Ayurvedic swamp plant (Brahmi) traditionally used for the enhancement of memory and cognition, as well as a general brain tonic. Its bioactive constituents, the bacosides, have numerous biological effects within the brain that facilitate this use [37–41]:
Reduces oxidative stress and increases antioxidant enzyme activity
Reduces inflammation
Neuroprotective
Reduces β-amyloid deposition
Increases the growth of nerve endings to enhance neuronal communication
Increase blood flow and the delivery of oxygen and nutrients
Numerous clinical trials have found that bacopa supplementation improves working memory, attention, learning rate, information processing, and a variety of other cognitive outcomes in healthy elderly adults [42–44], healthy middle-aged adults [45,46], young medical students [47], and adults with Alzheimer’s disease [48].
GINKGO BILOBA
Neuroprotective
Improves memory and cognitive performance
Works as an antioxidant
Counteracts cognitive impairment
Improves neuroplasticity
Preserves brain receptors in aging adults
Ginkgo biloba possesses neuroprotective and antioxidant effects that preserve brain receptors susceptible to age-related loss, counteract cognitive impairment, enhance neuronal plasticity, and improve memory [49].
A systematic review of 12 meta-analyses found that ginkgo biloba improves cognitive performance, activities of daily living, and clinical global impression in the treatment of dementia [50], provided that at least 240 mg was used daily for several months [51].
COFFEE FRUIT (COGNATIQ™)
Increases Brain-Derived Neurotrophic Factor (BDNF)
Powerful antioxidant
Improves neuroplasticity
Helps to grow new neurons and prevent neurodegeneration
Improves long-term memory
CognatiQ™ is a patented extract of the whole coffee fruit, including both the coffee bean and the fruiting body surrounding it, which contains many powerful antioxidant compounds [52,53].
Clinical studies in healthy adults have shown that CognatiQ™ nearly doubles concentrations of brain-derived neurotrophic factor (BDNF) after 1–2 hours [54,55], beating out other forms of coffee bioactives, caffeine, and the phytochemical-rich grape seed extract.
BDNF is a key protein involved in brain health, well established to be critical for:
Neuroplasticity (helps the brain adapt to new situations) [56].
Neurogenesis (the growth, regeneration and creation of new neurons and synapses) [57,58].
Long-term memory [59].
Prevention of neurodegeneration [60].
HUPERZINE A
Promotes learning
Used for centuries to treat brain-based illnesses
Improves cognition, especially in people with Alzheimer’s and vascular dementia
Naturally occurring acetylcholinesterase inhibitor (primary class of drugs for treating Alzheimer’s and dementia)
Huperzine-A is a naturally occurring acetylcholinesterase inhibitor, which functions to inhibit the enzyme that degrades acetylcholine, the neurotransmitter responsible for learning new information [61].
A meta-analysis of 20 randomized controlled trials found that huperzine A supplementation improves cognitive function, daily living activity, and global clinical assessments over 8–36 weeks [62]. Other meta-analyses have reported that huperzine A improves cognition in those with vascular dementia [63], as well as in those with major depression [64].
ACETYL-L CARNITINE
Improves brain function, especially memory and attention
Reduces oxidative stress
Protects against β-amyloid neurotoxicity
Reduces mental and physical fatigue
Reduces depression – more effective than antidepressant drugs! (And with far fewer side effects)
Reduces pain and increases nerve conduction
Prevents progression of brain-related disease
Acetyl-L-Carnitine (ALCAR) is a special form of carnitine that achieves two goals: (1) it supplies the carnitine your mitochondria need to produce energy, and (2) it provides an acetyl moiety that your mitochondria use to remain youthful and healthy.
ALCAR easily crosses the blood-brain barrier and preserves mitochondrial function within the brain that otherwise deteriorates with aging [65–69]. Notably, ALCAR concentrations slowly decline as cognitive impairment progresses, ultimately being 36% lower in Alzheimer’s patients than healthy adults [70].
A meta-analysis of 21 randomized controlled trials involving patients with mild cognitive impairment or Alzheimer’s disease found that ALCAR significantly improved cognitive function and prevented the progression of Alzheimer’s after as little as 3 months [71].
In elderly adults suffering from excessive fatigue, ALCAR improved cognitive function by 15%, reduced mental and physical fatigue by 43–52%, and improved the ability to function in daily life by 24% [72].
A meta-analysis of 12 randomized controlled trials found 3 g/d of ALCAR to significantly reduce depressive symptoms with an efficacy similar to antidepressant drugs, but with far less side effects [73].
SAFFRON EXTRACT
As effective as prescription drugs (with less side effects) in:
Reducing depression
Treating obsessive compulsive disorder (OCD)
Improving cognitive function
Antioxidant and anti-inflammatory
Neuroprotective
Saffron is one of the most well-researched antidepressant compounds available, with three separate meta-analyses of randomized controlled trials indicating that 30 mg/d has a potency comparable to prescription drugs but with less side effects [74–76].
Other studies have shown that saffron is as effective as prescription drugs for treating obsessive compulsive disorder (OCD) [77], and boosts cognitive function to the same extent as prescription drugs in those with Alzheimer’s disease [78,79].
L-THEANINE
L-theanine is a naturally occurring amino acid found in tea that alters neurotransmitter signaling within the brain. After consumption, it crosses the blood-brain barrier, interferes with excitatory glutamate signaling, stimulates dopamine release, and promotes inhibitory neurotransmission, thereby helping promote a state of relaxation [80,81].
Electroencephalography (EEG) studies have shown that theanine shifts brain waves towards alpha oscillatory patterns indicative of a relaxed state, particularly in those with high levels of baseline anxiety [82–86]. Accordingly, several studies have found that theanine supplementation improves feelings of relaxation, tension, calmness, and anxiety in the hours following [87,88].
AGMATINE SULFATE
Important neurotransmitter
Improves learning and memory
Reduces anxiety and depression
Protects neurons and enhances cell growth
Protects mitochondria
More effective at relieving pain than conventional medications
Agmatine is a neurotransmitter and neuromodulator (affects neurotransmission of entire neurons) that has anti-seizure, anti-pain, anti-anxiety, and antidepressant effects; modulates some of the processes involved in learning and memory; and interacts with the mechanisms of drug withdrawal [89].
Preliminary research has shown that agmatine supplementation causes a “total/incontrovertible remission of depression” without apparent adverse effects in those who were not responsive to conventional treatments [90].
In a randomized, double-blind, placebo-controlled study of individuals with back pain from herniated lumbar discs, agmatine reduced pain by 25–28% and improved parameters of general health by 65–76% after just two weeks [91].
POLYGALA TENUIFOLIA
Improves memory and combats forgetfulness
Supports neurotransmitters required for learning, memory, and mental health
Promotes growth of new neurons in the brain
Increases neuroplasticity and cognitive function
Polygala tenuifolia is one of the fundamental herbs used in traditional Chinese medicine, used to improve memory and combat forgetfulness with aging [92], which it does by:
Inhibiting the breakdown of acetylcholine, dopamine, serotonin, and noradrenaline, neurotransmitters required for learning new information, memory storage, and overall mental health [93,94].
Increasing the expression of brain derived neurotrophic factor (BDNF), which is fundamental for neuroplasticity and neurogenesis [95].
Promoting the growth of new neurons in the brain [96].
In a clinical trial of healthy adults, Polygala tenuifolia improved spatial, verbal, and working memories [97]. In a separate randomized, double-blind, placebo-controlled study of elderly adults, Polygala tenuifolia improved cognitive function by 5–10% [98].
N-ACETYL-L-TYROSINE
Critical for stress management
Boosts cognition, alertness, and information processing
Improves memory and mental health
L-tyrosine is a conditionally essential amino acid that serves as the precursor molecule from which we create the catecholamines: dopamine, adrenaline, and noradrenaline. Your brain needs a steady supply of tyrosine to make the catecholamines and keep your mental health at its peak [99,100], particularly if you are under a lot of stress [101].
Several clinical trials have shown that L-tyrosine supplementation boosts cognition, alertness, and memory in stressful and demanding situations in otherwise healthy adults [102,103], such as those who skimp on their sleep [104], undergo intense physical training [105], or those who endure extreme temperatures [106].
MAGNESIUM TAURATE
Over 300 enzymes require magnesium to function properly!
Required for optimal nerve transmission
Protects against cell death
Prevents mitochondrial dysfunction
Prevents migraines
Improves anxiety and depression
Slows development of and severity of Parkinson’s and Alzheimer’s
Reduces risk of stroke
Magnesium is required for over 300 enzymes to function properly [107]. Within the brain and nervous system, magnesium is required for optimal nerve transmission and protection against excitotoxicity (excessive excitation leading to cell death) [108,109].
A systematic review of magnesium’s role in neurological disorders found that it plays an important role in the prevention of migraines, treatment of anxiety and depression, severity of Parkinson’s disease, development of Alzheimer’s disease, and protection against stroke [110].
But, not all forms of magnesium are the same. Magnesium taurate demonstrates a superior ability to enter into the brain and increase the brain’s magnesium status compared to other forms [111,112].
References