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Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*

Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*

Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*

Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.

Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.

FibroVera is a proprietary blend of microbial and botanical components selected to support uterine and breast health. Reproductive health is an important topic for men and women alike. For women however, understanding and feeling confident about the body and the ebb and flow of the menstrual cycle is almost always a daily concern. FibroVera is a gentle option that offers the opportunity of bringing balance back to women’s hormone levels. FibroVera is an all-natural unique blend of hormone balancing botanicals and enzymes designed to help women support health concerns stemming from hormonal irregularities. FibroVera provides fibrinolytic (fibrin eating) enzymes and cofactors that are specifically selected to promote normal fibrin activity. Healthy hormone levels will naturally promote normal fibrin activity as well as support normal premenstrual symptoms. FibroVera is intended to modulate the hormonal response, restoring inherent processes in a woman's body. Each component was carefully selected using only well researched and clinically supported ingredients. Dr. Andrew L. Rubman is a naturopathic physician and founder of the Southbury Clinic for Traditional Medicines in Connecticut. He is a member of the American Association of Naturopathic Physicians and was inducted into the association's elite Founder's Club. He is also a Fellow of the International Association for Medical Preventics and a member of the National Center for Homeopathy, the Orthomolecular Medical Society, and the National Science Honor Society. His most current project has landed him as the primary formulator of Fibrovera AHS, a unique blend of botanical components clinically documented to restore hormonal balance in woman. Hormone modulating ingredients, combined with fibrinolytic enzymes, provides women with a direct defense against uterine and breast abnormalities. Like us on Facebook and stay up to date on all specials and product giveaways.   Estrogen Dominance The phenomenon of Estrogen Dominance has been widely discussed with its relationship to fibroid growth. It is a prime contributor to the deregulation of normal function experienced by not only women approaching, transitioning, and resolving the challenge of menopause, but also those young women experiencing difficulty with menarche (the beginning of fertility). This imbalance is initially characterized by a number of factors: A decrease in DHEA due to stress, aging, poor diet, side effects of prescription drugs etc. A decrease in progesterone effect due to absolute decrease in synthesis secondary to inadequate cholesterol down-conversion and increasing insensitivity of progesterone receptors. The activation of a cross-conversion pathway that forces progesterone to act as a source for the synthesis of estrogens; decreasing both its bioavailability as a hormone, and as a substrate for the formation of adrenal cortical hormones. This concept, unfortunately like most of endocrinology, is difficult for the average person as well as many physicians to fully comprehend. Why is this concept important? It demonstrates that the best way to not only address conditions such as abnormal tissue growth and inflammation, is by providing the body with natural compounds that it can use to enhance processes that it already has in place to decrease symptoms and potentially undo tissue changes. The inclusion of a DHEA supplement may indirectly increase progesterone synthesis and act to alleviate the need for available progesterone scavenged to promote a significant source for the synthesis of estrogen; relying less on progesterone as source for estrogen conversion allowing progesterone to act freely opposing estrogen. [19],[20] This process is further supported by specifically including DIM in FibroVera, to discourage the aromatization of testosterone into estrogens. I have studied the emerging literature and incorporated it into treatment regimes for over a decade and now feel comfortable enough about its metabolism and effects to include it in an OTC formula. Yes, it is a steroidal hormone precursor, however at the dosage levels supplied; it can be regarded as underwriting the proper synthesis of the estrogens and testosterone as well as the balance and effects of a myriad of neurotransmitters in the central nervous system. It is included at synergistic dose levels to help the individual not only do better, but feel better as well. The peer-reviewed research supports the safety and efficacy of DHEA and this inspires our choice and confidence   Suggested Use Directions: Take 1 to 2 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. Warning:Do not take FibroVera without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is FibroVera safe? No serious or adverse side effects have been reported from taking FibroVera. If you are taking blood-thinning medication, you should consult with your physician before taking FibroVera. When is the best time to take FibroVera? For best results, take the product at least one hour prior to eating and/or two hours after a meal. Can I take FibroVera with other supplements? FibroVera can be used safely with other dietary supplements. How long does it take for FibroVera to work? For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, when one is addressing hormonal challenges with a product such as FibroVera, symptoms of hormonal change can occur in a matter of days. This is the first step in the process, and the most important, as hormonal imbalances left in their unbalanced state can lead to a variety of health concerns.   Supplement Facts Fibrinolytic Enzyme Blend Hormonal changes can often trigger excessive fibrin fibrin production. The proprietary fibrinolytic enzyme blend in FibroVera has been added to support healthy fibrin levels. Fibrinolytic enzymes can enhance the normal process of fibrinolysis (fibrin dissolving). Serrapeptase and nattokinase are exceptional fibrinolytic enzymes. Bromelain, an enzyme derived from pineapple, has the potential to soften and digest necrotic (or dead) proteins. Papain, a protease enzyme derived from papaya, is often combined with bromelain to support healthy inflammatory levels. Coenzyme Blend Calcium and magnesium adequacy are essential to pain modulation, as well as cramping and other PMS symptoms, and have been added as active ingredients as well as coenzymes. High doses of systemic enzymes can deplete the body’s coenzyme resources. Coenzymes provide the “fuel” necessary to power the processes of enzymes. Magnesium is a very active coenzyme, and is also essential in proper absorption of calcium. Hormonal Support Blend FibroVera also contains a proprietary blend of hormone modulating compounds that work synergistically to restore hormonal equilibrium. P5P, a vitamin B6 derivative is used by the central nervous system in the synthesis of two important neurotransmitter. Serotonin deficiencies are related to depression, sleep disturbances, and even fatigue. GLA, or gamma-Linolenic acid, is an omega-6 fatty acid that has been shown to support a healthy inflammatory response. Diindolmethane, also known as DIM, is an extract derived from cruciferous vegetables. DIM has been shown to modulate estrogen metabolism. The inclusion of DHEA, Dehydroepiandrosterone, may indirectly increase progesterone synthesis, in turn supporting hormone balance. The female tonic Dong Quai produces a relaxing effect on the muscle of the uterus by decreasing sensitivity to inflammation, making it useful for painful menstruation and tenderness. Liver Cleansing Blend As the primary site of hormone metabolite processing, healthy liver function is essential. Milk Thistle Seed has been studied extensively for its use in supporting healthy liver function. In conjunction with Dandelion Root and Hyssop Flowers, it serves to increase the liver’s ability to bind hormonal metabolites to bile and effectively move them into the intestine for excretion. Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Propretary Blend Fibrovera AHS™ 730 mg † Fibrinolytic Enzyme Blend:Serrapeptase, Protease, Bromelain, Papain, Nattokinase NSK®     Cofactor Blend:Calcium Caprylate, Magnesium Ammoniate     Estromin® Hormonal Support Blend:P5P (Pyridoxal-5-Phosphate), GLA (Gamma- Linolenic Acid), DIM (Diindolylmethane), 5 HTP, DHEA (Dehydroepiandrosterone), Dong Quai Root (Angelica Sinesis)     Liver Cleanse:Milk Thistle Seed, Dandelion Root, Hyssop Flowers     * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Capsules), Maltodextrin Fibrovera™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed.   Frequently Asked Questions Will FibroVera help me when I become menopausal? The FibroVera formula was specifically formulated to help support many of the symptomatic challenges experienced by women in hormonal transitions. It is well to consider that many of the fluctuations preceding the cessation of menses may begin a full decade before. As many know, symptom clusters may persist many months and even years after the event. We believe that women experiencing difficulty associated with menopause will note substantial improvement with the consistent use of FibroVera. Can I take FibroVera if I am trying to conceive? FibroVera does not contain any ingredients that will negatively impact conception. However, if you become pregnant while taking FibroVera, or are nursing presently, discontinue use and ask your health care provider for advice on how to proceed. We are aware of the special concerns of pregnant women and our role in insuring safety. Unless drugs, OTCs, and supplements are specifically tested for their safety and efficacy while pregnant and nursing, they should not be used unless specifically evaluated and approved by your physician. Is FibroVera right for all women? FibroVera was designed with every woman in mind. FibroVera does not directly impact hormones. FibroVera provides the key ingredients that metabolize unwanted (non-beneficial) hormone metabolites while promoting the secretion and balance of good (beneficial) ones. FibroVera's ingredients are all natural components that work to replenish missing factors from diet, restoring the inherent processes in any woman's body. Can I take FibroVera with other supplements? FibroVera may be safely taken with Neprinol and other dietary supplements. Neprinol can increase the fibrinolytic (fibrin lysing) portion of FibroVera. Syntol can replenish beneficial flora in the body, and Devacor may reduce gastrointestinal stress induced by the process of digesting foods low in natural enzymes. If I am anemic, can I safely take FibroVera? Excessive blood loss can occur during menstruation. For many forms of anemia, we recommend your healthcare provider consider a heme-iron preparation, a B12 supplement, and folic acid with additional multi-B support to address this situation. If you believe that you are or may be anemic, please consult with your health care provider. Does FibroVera contain soy? Soy food products have been a dietary staple for many cultures for centuries and have undeniable benefits. However, we felt it was best not to include these components in the formula at this time. What can I expect from FibroVera? FibroVera has been designed to work as a part of a balanced food and supplement regimen to target those symptoms associated with hormonal imbalances complicated by inflammation and fibrous tissue changes. In the short term, usually within a few weeks, women should expect to feel and function better. Within a few months, they should notice a decrease in the effects of such issues as fibrous tissue abnormalities and endometriosis. FibroVera can be safely used without significant side effects or dangerous interactions with prescription drugs. Is FibroVera safe? No serious or adverse side effects have been reported from taking FibroVera. If you are taking blood-thinning medication, you should consult with your physician before taking FibroVera.

FibroVera is a proprietary blend of microbial and botanical components selected to support uterine and breast health. Reproductive health is an important topic for men and women alike. For women however, understanding and feeling confident about the body and the ebb and flow of the menstrual cycle is almost always a daily concern. FibroVera is a gentle option that offers the opportunity of bringing balance back to women’s hormone levels. FibroVera is an all-natural unique blend of hormone balancing botanicals and enzymes designed to help women support health concerns stemming from hormonal irregularities. FibroVera provides fibrinolytic (fibrin eating) enzymes and cofactors that are specifically selected to promote normal fibrin activity. Healthy hormone levels will naturally promote normal fibrin activity as well as support normal premenstrual symptoms. FibroVera is intended to modulate the hormonal response, restoring inherent processes in a woman's body. Each component was carefully selected using only well researched and clinically supported ingredients. Dr. Andrew L. Rubman is a naturopathic physician and founder of the Southbury Clinic for Traditional Medicines in Connecticut. He is a member of the American Association of Naturopathic Physicians and was inducted into the association's elite Founder's Club. He is also a Fellow of the International Association for Medical Preventics and a member of the National Center for Homeopathy, the Orthomolecular Medical Society, and the National Science Honor Society. His most current project has landed him as the primary formulator of Fibrovera AHS, a unique blend of botanical components clinically documented to restore hormonal balance in woman. Hormone modulating ingredients, combined with fibrinolytic enzymes, provides women with a direct defense against uterine and breast abnormalities. Like us on Facebook and stay up to date on all specials and product giveaways.   Estrogen Dominance The phenomenon of Estrogen Dominance has been widely discussed with its relationship to fibroid growth. It is a prime contributor to the deregulation of normal function experienced by not only women approaching, transitioning, and resolving the challenge of menopause, but also those young women experiencing difficulty with menarche (the beginning of fertility). This imbalance is initially characterized by a number of factors: A decrease in DHEA due to stress, aging, poor diet, side effects of prescription drugs etc. A decrease in progesterone effect due to absolute decrease in synthesis secondary to inadequate cholesterol down-conversion and increasing insensitivity of progesterone receptors. The activation of a cross-conversion pathway that forces progesterone to act as a source for the synthesis of estrogens; decreasing both its bioavailability as a hormone, and as a substrate for the formation of adrenal cortical hormones. This concept, unfortunately like most of endocrinology, is difficult for the average person as well as many physicians to fully comprehend. Why is this concept important? It demonstrates that the best way to not only address conditions such as abnormal tissue growth and inflammation, is by providing the body with natural compounds that it can use to enhance processes that it already has in place to decrease symptoms and potentially undo tissue changes. The inclusion of a DHEA supplement may indirectly increase progesterone synthesis and act to alleviate the need for available progesterone scavenged to promote a significant source for the synthesis of estrogen; relying less on progesterone as source for estrogen conversion allowing progesterone to act freely opposing estrogen. [19],[20] This process is further supported by specifically including DIM in FibroVera, to discourage the aromatization of testosterone into estrogens. I have studied the emerging literature and incorporated it into treatment regimes for over a decade and now feel comfortable enough about its metabolism and effects to include it in an OTC formula. Yes, it is a steroidal hormone precursor, however at the dosage levels supplied; it can be regarded as underwriting the proper synthesis of the estrogens and testosterone as well as the balance and effects of a myriad of neurotransmitters in the central nervous system. It is included at synergistic dose levels to help the individual not only do better, but feel better as well. The peer-reviewed research supports the safety and efficacy of DHEA and this inspires our choice and confidence   Suggested Use Directions: Take 1 to 2 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. Warning:Do not take FibroVera without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is FibroVera safe? No serious or adverse side effects have been reported from taking FibroVera. If you are taking blood-thinning medication, you should consult with your physician before taking FibroVera. When is the best time to take FibroVera? For best results, take the product at least one hour prior to eating and/or two hours after a meal. Can I take FibroVera with other supplements? FibroVera can be used safely with other dietary supplements. How long does it take for FibroVera to work? For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, when one is addressing hormonal challenges with a product such as FibroVera, symptoms of hormonal change can occur in a matter of days. This is the first step in the process, and the most important, as hormonal imbalances left in their unbalanced state can lead to a variety of health concerns.   Supplement Facts Fibrinolytic Enzyme Blend Hormonal changes can often trigger excessive fibrin fibrin production. The proprietary fibrinolytic enzyme blend in FibroVera has been added to support healthy fibrin levels. Fibrinolytic enzymes can enhance the normal process of fibrinolysis (fibrin dissolving). Serrapeptase and nattokinase are exceptional fibrinolytic enzymes. Bromelain, an enzyme derived from pineapple, has the potential to soften and digest necrotic (or dead) proteins. Papain, a protease enzyme derived from papaya, is often combined with bromelain to support healthy inflammatory levels. Coenzyme Blend Calcium and magnesium adequacy are essential to pain modulation, as well as cramping and other PMS symptoms, and have been added as active ingredients as well as coenzymes. High doses of systemic enzymes can deplete the body’s coenzyme resources. Coenzymes provide the “fuel” necessary to power the processes of enzymes. Magnesium is a very active coenzyme, and is also essential in proper absorption of calcium. Hormonal Support Blend FibroVera also contains a proprietary blend of hormone modulating compounds that work synergistically to restore hormonal equilibrium. P5P, a vitamin B6 derivative is used by the central nervous system in the synthesis of two important neurotransmitter. Serotonin deficiencies are related to depression, sleep disturbances, and even fatigue. GLA, or gamma-Linolenic acid, is an omega-6 fatty acid that has been shown to support a healthy inflammatory response. Diindolmethane, also known as DIM, is an extract derived from cruciferous vegetables. DIM has been shown to modulate estrogen metabolism. The inclusion of DHEA, Dehydroepiandrosterone, may indirectly increase progesterone synthesis, in turn supporting hormone balance. The female tonic Dong Quai produces a relaxing effect on the muscle of the uterus by decreasing sensitivity to inflammation, making it useful for painful menstruation and tenderness. Liver Cleansing Blend As the primary site of hormone metabolite processing, healthy liver function is essential. Milk Thistle Seed has been studied extensively for its use in supporting healthy liver function. In conjunction with Dandelion Root and Hyssop Flowers, it serves to increase the liver’s ability to bind hormonal metabolites to bile and effectively move them into the intestine for excretion. Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Propretary Blend Fibrovera AHS™ 730 mg † Fibrinolytic Enzyme Blend:Serrapeptase, Protease, Bromelain, Papain, Nattokinase NSK®     Cofactor Blend:Calcium Caprylate, Magnesium Ammoniate     Estromin® Hormonal Support Blend:P5P (Pyridoxal-5-Phosphate), GLA (Gamma- Linolenic Acid), DIM (Diindolylmethane), 5 HTP, DHEA (Dehydroepiandrosterone), Dong Quai Root (Angelica Sinesis)     Liver Cleanse:Milk Thistle Seed, Dandelion Root, Hyssop Flowers     * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Capsules), Maltodextrin Fibrovera™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed.   Frequently Asked Questions Will FibroVera help me when I become menopausal? The FibroVera formula was specifically formulated to help support many of the symptomatic challenges experienced by women in hormonal transitions. It is well to consider that many of the fluctuations preceding the cessation of menses may begin a full decade before. As many know, symptom clusters may persist many months and even years after the event. We believe that women experiencing difficulty associated with menopause will note substantial improvement with the consistent use of FibroVera. Can I take FibroVera if I am trying to conceive? FibroVera does not contain any ingredients that will negatively impact conception. However, if you become pregnant while taking FibroVera, or are nursing presently, discontinue use and ask your health care provider for advice on how to proceed. We are aware of the special concerns of pregnant women and our role in insuring safety. Unless drugs, OTCs, and supplements are specifically tested for their safety and efficacy while pregnant and nursing, they should not be used unless specifically evaluated and approved by your physician. Is FibroVera right for all women? FibroVera was designed with every woman in mind. FibroVera does not directly impact hormones. FibroVera provides the key ingredients that metabolize unwanted (non-beneficial) hormone metabolites while promoting the secretion and balance of good (beneficial) ones. FibroVera's ingredients are all natural components that work to replenish missing factors from diet, restoring the inherent processes in any woman's body. Can I take FibroVera with other supplements? FibroVera may be safely taken with Neprinol and other dietary supplements. Neprinol can increase the fibrinolytic (fibrin lysing) portion of FibroVera. Syntol can replenish beneficial flora in the body, and Devacor may reduce gastrointestinal stress induced by the process of digesting foods low in natural enzymes. If I am anemic, can I safely take FibroVera? Excessive blood loss can occur during menstruation. For many forms of anemia, we recommend your healthcare provider consider a heme-iron preparation, a B12 supplement, and folic acid with additional multi-B support to address this situation. If you believe that you are or may be anemic, please consult with your health care provider. Does FibroVera contain soy? Soy food products have been a dietary staple for many cultures for centuries and have undeniable benefits. However, we felt it was best not to include these components in the formula at this time. What can I expect from FibroVera? FibroVera has been designed to work as a part of a balanced food and supplement regimen to target those symptoms associated with hormonal imbalances complicated by inflammation and fibrous tissue changes. In the short term, usually within a few weeks, women should expect to feel and function better. Within a few months, they should notice a decrease in the effects of such issues as fibrous tissue abnormalities and endometriosis. FibroVera can be safely used without significant side effects or dangerous interactions with prescription drugs. Is FibroVera safe? No serious or adverse side effects have been reported from taking FibroVera. If you are taking blood-thinning medication, you should consult with your physician before taking FibroVera.

Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*

Epitalon® Pineal Bioregulator works to support normal sleep cycles and overall well-being. INGREDIENTS: Purified water; Preservatives: Sodium Benzoate, Potassium Sorbate; Peptide complex (Alanine, Glutamic acid, Aspartic acid, Glycine). DIRECTIONS: Spray 5 times under the tongue twice per day before the meal in the morning and afternoon. The daily amount of Epitalon is 0,5 mg (500 mcg) in 5 sprays (daily dose). In 1 spray it is about 100 mcg of Epitalon. STORAGE CONDITIONS:  Store in a dry place and at temperature from 2 to 25°C. Protect from heat and light. Keep out of reach of children. Composition (mg) per 5 pulverizations (1ml):           % NRV (*)Peptide complex:                            0,500Alanine                                             0,125                                        **n.d.Glutamic acid                                  0,125                                        **n.d.Aspartic acid                                   0,125                                        **n.d.Glycine                                             0,125                                        **n.d. *NRV/: Nutrient Reference Values (Regulation (EU) No 1169/2011)**n.d. not defined Suitable for vegetarians and vegans. ATTENTION: Not recommended for children or adolescents. Do not exceed the recommended daily intake, unless medically indicated. This product should not be used as a substitute for a varied and balanced and healthy lifestyle. This product should not be used in case of hypersensitivity or allergy to any of its constituents. Due to the lack of studies confirming the safety of use during pregnancy and breast feeding, this supplement should not be used in these situations, unless medically indicated. NOTE: Supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking any medications, or under medical supervision, please consult a healthcare professional before use. Do not exceed the stated recommended daily dose. Keep out of reach of children. Store in a cool, dry place.

The oil-free, easily absorbed and fresh-smelling Pernaton Gel contains vital GAG (Glycosaminoglycans) and original Perna extract – the special essential element from the sea for the connective tissues of the skin and body. Rub the gel into the skin and feel the cooling sensation and feelings of wellbeing that result – then experience the warming and intense increase in circulation that follows.The GAG (Glycosaminoglycans) have been scientifically studied. Studies show that the elasticity and firmness of the skin is significantly improved and that the skin feels softer, smoother and silkier.As Pernaton Gel is formulated to aid connective tissue and joint care, it can also benefit sportsmen and sportswomen when used before and after exercise. Available in 125ml tube and 1000ml tub. The 1000ml tub is suitable for those people who use the Gel on a regular basis. The gel can be used straight from the tub or with the high quality, hard wearing pump which is available to buy separately. This dispenses a measured dose and is ideal for professional use.Caution: Not suitable for small children. Avoid contact with the eyes or broken skin. Do not use underneath airtight compresses. Not suitable for people with an allergy to shellfish. For external use only. Safe for Professional Use Pernaton Gel has been tested using HFL’s Sports Nutritional Supplement Screen for banned substances. HFL is a WADA accredited Laboratory for human sports testing and is also UKAS ISO 17025 accredited for Sports Nutritional product screening.   Framja Cycling Marathon June 2006 Slovenia. Pernaton®, one of the sponsors, provided a massage with Pernaton® gel before and after the race.   Varaždin Marathon, Croatia September 2006, the race winnerwho received an after race massage said, “No pain with Pernaton” The oil-free, easily absorbed and fresh-smelling Pernaton Gel contains vital GAG (Glycosaminoglycans) and original Perna extract – the special essential element from the sea for the connective tissues of the skin and body. Rub the gel into the skin and feel the cooling sensation and feelings of wellbeing that result – then experience the warming and intense increase in circulation that follows.The GAG (Glycosaminoglycans) have been scientifically studied. Studies show that the elasticity and firmness of the skin is significantly improved and that the skin feels softer, smoother and silkier.As Pernaton Gel is formulated to aid connective tissue and joint care, it can also benefit sportsmen and sportswomen when used before and after exercise. Available in 125ml tube and 1000ml tub. The 1000ml tub is suitable for those people who use the Gel on a regular basis. The gel can be used straight from the tub or with the high quality, hard wearing pump which is available to buy separately. This dispenses a measured dose and is ideal for professional use.Caution: Not suitable for small children. Avoid contact with the eyes or broken skin. Do not use underneath airtight compresses. Not suitable for people with an allergy to shellfish. For external use only. Safe for Professional Use Pernaton Gel has been tested using HFL’s Sports Nutritional Supplement Screen for banned substances. HFL is a WADA accredited Laboratory for human sports testing and is also UKAS ISO 17025 accredited for Sports Nutritional product screening.   Framja Cycling Marathon June 2006 Slovenia. Pernaton®, one of the sponsors, provided a massage with Pernaton® gel before and after the race.   Varaždin Marathon, Croatia September 2006, the race winnerwho received an after race massage said, “No pain with Pernaton”