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The Essential Builder and Healer Benefits: Speeds Up Recovery Easy to Mix With Food Repairs Soft Tissue Product Description: 1 bag of Upgraded Collagen Protein (1 lb) Upgraded Collagen is the gold standard for achieving the fastest possible healthy tissue repair, muscle matrix, bone renewal and recovery after exercise! It can boost mental clarity, reduce inflammation, upgrade your skin, and it mixes easily with other foods and shakes thanks to its neutral taste. Benefits of Upgraded Collagen: Fast Tissue Repair - Upgraded Collagen provides the particular proteins that ensure cohesion, elasticity and regeneration of skin, cartilage and bone. Greater Flexibility and Mobility - Upgraded Collagen makes the main building blocks of connective tissue more bioavailable and better absorbed into joints for greater flexibility and mobility. Stronger Bones and Joints - Upgraded Collagen supports strong, heavier, denser bones and is an excellent source of proline and glycine, two building blocks of cartilage that are essential for refueling after exercise and sports. Revitalized Skin - Upgraded Collagen promotes skin hydration, reduces the number of fine lines, prevents deeper wrinkles, and maintains the suppleness of your skin from the inside-out. Weight Loss - Upgraded Collagen (97% pure protein) helps with weight loss by delivering quick satiation of hunger. Build Muscle - Upgraded Collagen supports muscle building by facilitating the synthesis of creatine in the body. Reduce Aging - Upgraded Collagen replaces the necessary proteins that diminish and breakdown from aging. Deeper Sleep - Upgraded Collagen taken at bedtime deepens sleep, provides arginine to stimulate growth hormone release, and provides nutrients necessary to perform tissue repair while sleeping. Brain Function - Upgraded Collagen provides glycine, a neurotransmitter involved in motor and sensory pathways as well as ATP synthesis. Upgraded Collagen is High Quality and Pure Our Upgraded Collagen is sourced from the purest pasture-raised cows. These cattle are untouched by drugs or hormones and are not just "grass-fed" (which can mean grass-fed, but grain finished, or only fed grass sometimes) but actually spend their entire lives in the pasture. Unlike gelatin, which is damaged by heat processing, Upgraded Collagen is enzymatically processed several times to leave its peptides intact, resulting in a neutral tasting, highly available protein that doesn’t clump up or have a strong taste like gelatin. It is far easier to use and contains more collagen than bone broth. Upgraded Collagen does not contain any dairy, egg, sugar, corn, yeast, wheat, soy, gluten, artificial flavors, or preservatives. Our collagen source has been used safely for many years, and is certified by the FDA as GRAS (generally recognized as safe). Upgraded Collagen supplies essential proteins that our bodies use to build and repair our bones, joint surfaces, skin, teeth, eyes, arteries, intervertebral disks, and much more. Collagen is one of the most important nutrients needed to maintain a strong body, keep you in healing mode, and counter-act the degenerative effects of aging. Unfortunately, in this day and age, the average person has hardly any collagen in their diet! Collagen traditionally made its way into our diets through bone-broths, slow-cooked organ meats, kidney pie, baked beef heart, whole crustaceans, and whole fish soups and stews. But now, few people prepare foods with this source of meats, so we developed Upgraded Collagen to give ourselves the simplest and best source of these essential nutrients. Upgraded Collagen is a dietary supplement that can be added to any liquid drink, or paleo meal you already make, without needing to cook time-consuming broths, stews, soups, and organ meats. Recommended Usage: use 1 tbls in 1/2 a cup or more of water or in your favorite beverage. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. We've used the following sources to research and refine our Upgraded Collagen Proteins: Mathews CK, Van Holde KE, Ahern KG. Biochemistry 3rd edition. San Francisco, Addison Wesly Longmnan, Inc., 2000. http://www.ncbi.nlm.nih.gov/pubmed/22204879 http://www.ncbi.nlm.nih.gov/pubmed Veldhorst, M. A breakfast with a-lactalbumin protein. Clinical Nutrition. 2009;28: 147. Gotthoffer NR. Gelatin in Nutrition and Medicine. Grayslake, Illinois, Grayslake Gelatin Company, 1945. http://www.ncbi.nlm.nih.gov/pubmed/16330011

IMPORTANT: Drink only from glass (never put Divinia into plastic containers, or plastic water bottles) DIVINIA is the only bottled water proven Exclusion Zone, deuterium depleted, & highly energetic (naturally bioavailable oxygen and hydrogen) by independent research conducted at 7 American universities! Packaged in 16 oz recyclable glass bottles, DIVINIA's benefits make it a necessity to have at the gym, office, school, or even in the car. Take clean, pure, hydrating, cellular water with you no matter where you go. This order is for 24 bottles. Each bottle is made of 35% recycled glass. Measured at <1.00 ppm for contaminants. NOTE: NOT LABELED FOR RESALEIMPORTANT: Drink only from glass (never put Divinia into plastic containers, or plastic water bottles) All of the benefits found in DIVINIA are uniquely combined to make one special bottle of water, however, many people wonder how DIVINIA compares to specific kinds of water like deuterium depleted water, hydrogen water, or water with polarized gas. As a company founded by a scientist, DIVINIA places emphasis on pursuing greater research and understanding of our water. Below we address common questions in comparing DIVINIA to other leading products, while highlighting our independent research that substantiates our product. What is the parts per million of your deuterium? Why don't you have a lower deuterium level? Isn't it better to drink water at 50 or 75 ppm deuterium depletion to see a difference? We are asked numerous times a week on the deuterium levels of DIVINIA. By any and all scientific standards, DIVINIA is deuterium depleted at around 125 - 130 ppm. This matches the same levels of Hunza water, which has been researched for decades by doctors because of the longevity and health of the Hunza people who drink it.  Scientifically speaking, deuterium-depleted water (DDW) has a lower concentration of deuterium than occurs naturally (less than 145 ppm); the depletion in DIVINIA is independently verified by an American university. We did not set out to "create" a deuterium depleted water, but rather the depletion is a natural product of our purification; the deuterium depletion in DIVINIA is not artificially driven down or forced. Most other waters are around 155 ppm and, though, and though 15% decrease may not seem like much, the Griffiths Theory suggests the adverse biological effect of deuterium goes by the square of the concentration. Additionally, more doctors and naturopaths are telling their patients about DIVINIA because the concentration is not too aggressive or drastic. DIVINIA's deuterium depletion matches that of spring or glacial water,making it ideal for everyday hydration! Though useful in urgent cases, doctors and experts say drinking extremely low levels of deuterium depleted water is meant for medicinal purposes;very low deuterium depletion is not meant for everyday drinking, as it may have deleterious effects over extended periods of time. Furthermore, doctors and salesmen who sell low deuterium levels actually suggest you dilute their water to bring it up to the 130 ppm level, which is the same exact level DIVINIA and Hunza water in the first place! Does DIVINIA Water have extra hydrogen? Do you put hydrogen gas in your water? The thought of hydrogen water to have particular healing or therapeutic properties comes from the understanding that hydrogen is the smallest and most prolific molecule in the universe. Hydrogen can aid in gut health, reduce inflammation, improve skin quality, etc. by acting as an antioxidant molecule. This is done when hydrogen interacts with the oxygen free in radicals, helping to restrain them by combining with the oxygen to make water. Because hydrogen is so small, it's believed that it easily enters the mitochondria to fight free radicals that may cause oxidative stress. So, why don't we infuse DIVINIA with hydrogen? Well, there's 2 good reasons. First reason is that there is no need to. In 2007, overwhelming research conducted by Dr. Rustum Roy (founder of the Materials Research Laboratory at Penn State University) demonstrated a significantly higher energy bond between the hydrogen and oxygen molecules of DIVINIA Water compared to deionized water. The higher energy between the molecules means the hydrogen and oxygen molecules in DIVINIA break apart easier, making the hydrogen and oxygen more bioavailable with less energy to separate and use them biologically. Secondly, hydrogen gas is very small. When pumped into water and packaged, the hydrogen gas can easily escape and leave the water behind at normal hydrogen levels. Furthermore, hydrogen water companies are relying on aluminum cans and aluminum-lined hydropacks to keep the hydrogen gas in tact. Consistent exposure to aluminum can potentially lead to bone disease, nervous system problems, brain disease and disorders, respiratory problems, impaired iron absorption, and many other diseases and ailments. If you are still considering the purchase of the leading hydrogen water brands, please check the label! Some of the most popular brands use water from Japan, and given the nuclear spill in Fukushima this makes us a little nervous.  How does your water compare to water infused with polarized gas? Other waters claim to be Exclusion Zone water... is yours the same? DIVINIA began as purification technology company back in 2002, when we developed our patented, proprietary technology. With almost 20 years of research to this date, we have developed a brand of water unlike any other. By exposing a unique niche in the bottled water market, it is no surprise that there are companies that will attempt to re-create or imitate our purification system and water. This is not only confusing for customers seeking the best product available, it is also misleading as some might categorize their water as "EZ water" without the scientific research to back it up. Since 2011, DIVINIA Water is scientifically categorized as Exclusion Zone (EZ) water by independent research done by Dr. Gerald Pollack and his team at Pollack Laboratory with University of Washington. The results of the study showed a clear and significant peak of 270nm of energy in DIVINIA Water, the same peak associated with Exclusion Zone water per the discovery of Dr. Pollack himself. EZ water is understood to be the kind of water found in fruits, plants, and living organisms; it's the very same water that is also understood to deliver energy to the mitochondria, keeping cells healthy and free of toxins. Many water companies claim to bottle EZ water, but do so without the explicit scientific research and study to support it. However, they look to mimic our patented purification technology/patent-pending water by subjecting purified water to polarized gas. This process is not the same as DIVINIA Water's.  Much like the discussion of hydrogen gas above, exposing water to gas may not inherently change or alter the water being exposed. DIVINIA is directly purified and subjected to magnetic waves within a resonant chamber proven to fundamentally organize/energize the water molecule permanently, per years of research done by Dr. Rustum Roy and Dr. Gerald Pollack.

Facial Cleansers are the first step towards truly healthy skin by effectively purging dirt, make-up and environmental pollution. The Alitura Pearl Cleanser is a universal daily facial cleanser for all skin types. Gentle and soothing, the Pearl Cleanser was designed to calm irritation and remove excess dirt and oil while leaving your skin soft as silk, fresh and radiant. Alitura Naturals Pearl Cleanser - 100ml This creamy cleanser uses an ancient Chinese beauty secret of Pearl Powder, a micro-exfoliator that is packed with calcium and magnesium to immediately brighten and leave your skin smoother. Carefully sourced, innovative ingredients such as Marine Collagen, Wildcrafted Tremella Mushroom (nature’s highest source of hyaluronic acid) Organic Panax Ginseng, Colloidal Silver and Organic Green Coffee to stimulate and “wake up” tired skin cells. The final addition is a subtle aroma of Organic Australian Sandalwood, Wildcrafted Palo Santo, Organic Ylang Ylang and Wildcrafted Violet that evokes emotion and leaves you excited for more. Cleanse, renew and protect your face with the power and brilliance of Nature’s best. Perfect for the high-performance lifestyle, this creamy blend of Freshwater Pearl Powder and Wild Tremella Mushroom combined with pure plant botanicals and essential oils gently wipe off dirt and oil to leave your skin clear, luminous, and radiant. This rich, exquisite facial cleanser will transform your skin and help mitigate redness and irritation by removing excess dirt and oil without harsh surfactants that dry out the skin. Carefully formulated by using natural cleansing properties for deep renewal and delicate enough to maintain the balance of the skin. Concentrated, potent yet gentle, a little goes a long way to achieve a complete cleanse. For a wholesome, revitalizing and refreshing experience, let our Pearl Cleanser gift your face with the grace of plant medicine Pearl Cleanser Ingredients: Water/Aqua, Kaolin Clay, Geranium Flower Water*, Rose Flower Water*, Olive Oil*, Sodium Olivoyl Glutamate, Leuconostoc/Radish Root Ferment Filtrate, Lactobacillus (and) Cocos Nucifera (Coconut) Fruit Extract, Pearl Powder, Vegetable Glycerin*, Guar Gum* Wildcrafted Tremella Mushroom, Betaine, Wild Thyme*, Horsetail*, Marshmallow Root*, Burdock Root*, Gotu Kola*, Eyebright*, Giant Sea Kelp Extract*, Panax Ginseng Root*, Wild Yam Root*, Green Coffee Seed*, Laminaria Japonica Extract (Marine Collagen), Rosehips Seed Oil,* Schizandra Fruit*, Tocopherol, Colloidal Silver, Aloe Vera*, Essential Oils (Wildcrafted Violet, Sweet Orange Peel* Wildcrafted Ecuadorian Palo Santo, Frankincense* Pomegranate Seed*, Australian Sandalwood*, Blue Chamomile*,Ylang Ylang Flower*, Immortelle Flower*) *Organic Ingredient Disclaimer: Statements contained herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat and cure, or prevent disease.

Dopamine Brain Food™ is designed to promote the production of dopamine, a neurotransmitter essential to the central nervous system. Research suggests that the compounds in Dopamine Brain Food™ can improve attention and learning, as well as movement and balance. The benefits include: ● Increased mental alertness● Increased drive to accomplish tasks● Support for athletic performance This natural formula contains all the necessary precursors and cofactors for optimal dopamine metabolism. What is “brain food”? Neurochemistry, the chemical patterns and processes that cause your brain to function as it does, is highly complex. It varies significantly between individuals, and is heavily influenced by a large range of factors. Your diet, exercise habits, sun exposure, social group and genetics all have a role to play in your brain’s chemical behaviour. Most of us do not get enough of everything we need every day to keep our brain function 100% optimized. That’s why supplementing with brain food can give you such an edge. Brain food are natural nutrients that act as fuel for specific neurotransmitters in the brain. They can be taken daily to boost various states of optimal performance. By addressing any deficiencies or imbalances in the delicate neurological system, you can increase your ability to concentrate, regulate your energy, and balance your mood. The importance of Dopamine Dopamine is a neurotransmitter that is associated with motivation, short-term memory, creativity and personality. It is metabolized into epinephrine and norepinephrine, which increase alertness and attention. Abnormal dopamine levels can cause a wide range of diseases. Low levels are associated with Alzheimers, Parkinsons and depression. Getting your dopamine levels balanced and in an optimal range can have a profound influence on your health and quality of life. When your dopamine is being produced at the optimal pace, you will feel alert and engaged. Your mood will be stable and well balanced. You’ll feel calm and steady, while being able to think creatively and with total clarity. Complete Neurotransmitter Support The best way to optimize dopamine levels is to ensure that the necessary precursors and cofactors are available. These precursors and cofactors pave the way for your brain to produce and then use dopamine at an optimal rate. Dopamine Brain Food™ provides these essential compounds. It contains amino acid precursors (L-Phenylalanine & L-Tyrosine), dopamine metabolism cofactors and antioxidants (Vitamin B­6, Vitamin C, & Selenium), as well as specific nutrients to optimize the SAM cycle (Folate, Vitamin B­12, & Trimethylglycine). For Mental Alertness SUGGESTED USE: Take a serving of 2 or 3 capsules in the morning, or as directed by a healthcare practitioner. Do not take more than 3 capsules per day. Dopamine Brain Fuel works synergistically with CILTEP by ensuring that the increase in intracellular cAMP is supported for an extended period of time, leading to even more pronounced motivation and focus. U.S.A manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients. L-Phenylalanine As a precursor to dopamine, this essential amino acid is directly converted into phenylethylamine, an important neurotransmitter and neuromodulator. It is converted into L­tyrosine in the body by phenylalanine hydroxylase. It’s present in many foods such as eggs, meat and dairy. L-Tyrosine A non-essential amino acids found in many foods including meats and dairy that is converted by tyrosine hydroxylase into L-DOPA, the direct precursor to dopamine. Vitamin B­6 (Pyridoxal-5-phosphate) An essential vitamin that is also a necessary cofactor that is used by the enzyme DOPA decarboxylase to convert L-DOPA into dopamine. Vitamin C(Quali-C®) A familiar essential vitamin and antioxidant found in high amounts in fruits. It is a co­factor that helps dopamine β­hydroxylase convert dopamine into noradrenaline. Vitamin C speeds up this conversion process and plays an important neuroprotective role. Folate (Quatrefolic® L-Methylfolate), Vitamin B­12 (Methylcobalamin), & Trimethylglycine(TMG) These nutrients help turn homocysteine into SAM-E by acting as cofactors and substrates for the SAM cycle. Creating optimal amounts of SAM-E is important, as it is a precursor to the body’s natural production of many beneficial endogenous substances such as creatine. It also provides the methylation fuel that turns noradrenaline in to adrenaline. Selenium An essential vitamin and antioxidant that protects cells and helps keep the brain’s levels of dopamine producing enzymes at optimal levels. Quali-C® is a registered trademark of DSM. Quatrefolic® is a registered trademark of Merck KGaA, Darmstadt, Germany. Dopamine Metabolism, by Abelard Lindsay Dopamine is a neurotransmitter that is, among other things, associated with motivation, short-term memory, creativity and personality [1][2][3]. It is metabolized into epinephrine and norepinephrine to increase alertness and attention [4]. It must be properly balanced and metabolized for optimal benefit. Too much dopamine can result in manic states [5] and too little can cause depression and lack of motivation [6]. Dopamine metabolism can be metaphorically compared to a factory process where raw materials such as L-Phenylalanine and L-Tyrosine, which are amino acids present in foods, are transformed by various workers (enzymes) who use various materials (cofactors) in each transformation step. The intermediate products of this metabolism are used to transmit signals through the body and the brain [7]. Unlike a regular factory, the intermediate products are the useful aspects of production and are used primarily in signaling. At the beginning of dopamine metabolism, the dietary amino acid L-Phenylalanine is converted into L-Tyrosine by phenylalanine hydroxylase, and L-Tyrosine into L-Dopa by tyrosine hydroxylase. Studies suggest that tyrosine hydroxylase is upregulated by phosphorylated CREB, which is activated during cAMP/PKA driven long-term potentiation [8]. This is one of the theorized mechanisms of action of CILTEP. Tyrosine hydroxylase activity is the rate limiting step in this metabolic process [12]. Further down the metabolic chain from L-Tyrosine is L-Dopa, which is also available as a drug and in the supplement mucuna pruriens [13]. L-Dopa’s synthesis into dopamine is supported by the active form of vitamin B6, known as pyridoxal phosphate, commonly abbreviated as p5p , and the enzyme dopadecarboxylase [14]. Some intermediate products of dopamine metabolism act as an agonist at the TAAR1 receptor [15]. This receptor is primarily targeted by ADHD drugs [16]. It causes increases in cAMP levels in the cell [17]. Unlike forskolin, the aforementioned ADHD drugs cause efflux of stored dopamine into the synaptic cleft via modulation of the dopamine transporter protein known as DAT [18][19]. This efflux leads to increases in dopamine in the synaptic cleft, producing fast increases in arousal. From reading through a lot of anecdotal experiences and research, that it appears to be undesirable to rapidly raise neurotransmitter levels in the synaptic cleft above a given baseline, as it can lead to excessive arousal and unbalanced cognitive effects. It’s better to help the “factory” produce optimally by supplying cofactors and optimally helping and directing each intermediate reaction and postsynaptic metabolic pathways. Another place that products from dopamine metabolism operate is in the dopamine receptors themselves. The D1, D2, D3, D4, and D5 receptors all respond to dopamine in the brain and have various cognitive related effects. D2 receptors modulate prolactin, [20] which some studies suggest is linked to the male sexual refractory time [21]. Direct agonists for these receptors are usually in the class of dopamine agonist drugs that are sometimes prescribed for Parkinson’s symptoms [22][23][24]. D1 and D2 are involved in novelty detection [25] and sexual desire [26]. While D1 and D5 are involved in memory formation [27], D2 and D3 are associated with addiction [28] and compulsions [29]. D4 is involved with cognitive performance [30]. The various mood, addiction, compulsion and sexual influencing effects of dopamine agonists in the brain and various accounts of socially undesirable behavior under the administration of direct dopamine agonists [31] (usually in Parkinsons treatment) leads me to avoid the direct stimulation of these pathways. It appears that it is better to provide cofactors to aid and assist in metabolism along dopaminergic pathways than to directly activate receptors with agonists. However, direct agonists certainly have their uses. Dopamine is converted into norepinephrine with vitamin C (ascorbic acid) as a cofactor via the enzyme dopamine b-hydroxylase. That is further converted to epinephrine via phenylethanolamine n-methyltransferase with SAMe as a cofactor. You can read more about SAMe in an earlier essay “The SAM Cycle And The Brain”. Dopamine can also be converted to the TAAR1 agonist 3Methoxytyramine via the enzyme COMT [32]. COMT inhibition is an interesting area of exploration in cognitive enhancement. There is a gene polymorphism, the val158met polymorphism, that influences the rate at which dopamine is processed into further metabolic intermediates via the COMT enzyme. The quick processing polymorphism is called val/val and the more slowly processing polymorphism is called met/met. In one study, participants with the val/val gene had lower scores on a memory test known as dual n­back [33]. Another study suggests that those with the met158 allele have better cognitive performance. To quote the study “The low activity met158 allele has been associated with improved working memory, executive functioning, and attentional control, but also with a higher risk of anxietyrelated behaviors” [34]. It is interesting to note that Luteolin is a substrate for COMT [35], so variations in the COMT allele might account for different anecdotal effects of Luteolin from artichoke extract. How we metabolize dopamine is a core contributor to mood and cognitive function.

Perfect Press® Black Cumin (Nigella Sativa) Oil has a long history of use as a natural health and beauty remedy. Black Cumin contains essential fatty acids, phytosterols and volatile compounds that are beneficial for total body health.Every bottle contains the oil of thousands of Perfectly Pressed organic seeds. Our unique pressing process ensures that there is no damage to the nutritional properties. The finished product is stored in UV-protective Miron glass bottles to maintain quality over time. Zero damage equals zero rancidity. This superfat helps your body in over 67 different ways. Cleopatra used this superfat for beauty. Queen Nefertiti applied this superfat to her hair and nails to add shine and strength. Hippocrates (the “Father of Modern Medicine”) prescribed this superfat for digestive and weight problems. It has been used by practitioners of Ayurveda and Traditional Chinese Medicine for ages to support the body in dozens of different ways. With over 3,300 years of successful use and more than 741 studies Black Cumin oil is the most therapeutic fatty acid ever discovered. IMPROVED DIGESTION The Internet Journal of Pharmacology states that this ‘mystery’ seed oil can help to reduce abdominal fat, maintain healthy blood pressure balance, support healthy cholesterol levels and promote blood sugar stability. As little as 2.5 ml per day has been shown to dramatically affect waist-to-hip ratios, HDL cholesterol, triglyceride levels, fasting blood glucose levels and blood pressure. Youthful Skin & Hair Black cumin oil or “black seed oil”—the name some give this superfat—happens to be one of the most studied oils in existence. It has some medical experts calling it the “fountain of youth” because it has the ability to support the body in so many profound ways. Our Perfect Press method produces the purest, most nutritionally potent black cumin oil in the world today. There are absolutely no pollutants, toxins, heavy metals or microbes in any of our oils

Living Libations Organic Hemp Wash Cloth Organic Hemp Face Cloths have been available in our Beauty Kits by popular request they are available individually for using with our Seabuckthorn Best Skin Ever for cleansing. Review(s) Great for cleansing and exfoliating I have several of these Face Cloths for exfoliating/cleansing my face with the Best Skin Ever. I can't imagine using anything else - the perfect compliment of soft for cleansing with a little edge for exfoliation - effective - Gets the job done. My daughter and I are huge fans. Love these! Wonderful cloth. Great for a light exfoliation and environmentally friendly! I can't wait to order more. Feels great These cloths are great for cleansing your face. They have just the right absorbency, but not so much that they suck up too much of your precious Best Skin Ever. Plus, they have the perfect amount of texture to give your skin an awesome exfoliation! I bought the multi pack so that I could alternate each day. After use, I leave the cloth on a towel rack (or outside) to dry out then I throw in the hamper to be washed. Love them for the body too!  

Devigest Advanced Digestive Support is more powerful and concentrated than its earlier predecessors. Just one capsule with meals can ease the digestion of even the most troublesome of foods. Now more powerful and concentrated, Devigest can support reduced food irritations and sensitivities as well as reduce occasional abdominal gas and bloating. Devigest now contains a highly potent Peptidase with 500 units of DPP-IV activity per serving. Peptidase breaks down gluten and casein, two digestive irritants. Many formulas today have begun to utilize this amazing enzyme, but rarely is it incorporated in a broad spectrum blend, which leaves many formulas incomplete. Devigest is a complete and broad spectrum formula, making the need for supplementing other digestive enzyme products obsolete. Devigest also includes Alpha Galactosidase which is the active ingredient in the ever-popular product Beano®. Our bodies lack the enzymes that are responsible for breaking down certain carbohydrates in the small intestine. This causes improperly digested food to enter the large intestine where bacteria then begin to break it down, creating large amounts of gas which can lead to flatulence, abdominal bloating and digestive discomfort. Unlike many other gas medicines, Alpha Galactosidase can help prevent gas before it starts by breaking down the complex carbohydrates found in gassy foods into simpler, more easily digestible sugars. A similar phenomenon occurs with those that experience digestive distress when comsuming dairy foods. Lactose intolerance is the inability to break down lactose, which is milk sugar found in most dairy products. Lactose intolerance is the result of lacking the essential enzyme Lactase. Devigest now contains 444% more lactase than its predecessor per serving allowing those with lactose intolerance to enjoy dairy foods without the digestive distress. Proper digestion is a prerequisite for optimal health. Unless digestive physiology is in order, no other self-regulating or self-healing systems are able to perform in normal states. Devigest ADS serves not only in the aiding of the digestive process as a whole, but also therapeutic applications. Too often insufficient digestive enzyme production is overlooked as the culprit of indigestion and other digestive compliactions. Gas, bloating, incomplete digestion, and abdominal discomfort can play a part in the everyday life of many individuals. Properly digested foods add nutrients to our bodies, provide energy, and provide support to the countless other processes that are vital for proper human function. Supplementing with a high-quality digestive enzyme like Devigest ADS may be the answer to many of these concerns. Suggested Use Directions: Take 1 to 2 capsules between meals. Warning: Do not take Devigest without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Devigest safe? No serious or adverse side effects have been reported from taking digestive enzymes such as Devigest. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. When is the best time to take Devigest? For best results, take the product immediately prior to eating, or with your first bite. Devigest can also be taken after meals to alleviate digestive complications such as gas, bloating and indigestion. Can I take Devigest with other supplements? Devigest can be used safely with other dietary supplements. How long does it take for Devigest to work? The effects of digestive enzymes can be felt fairly quickly when taken after meals for indigestion, bloating or heartburn. When taking the product with meals containing foods that typically cause indigestion, the product should help alleviate the onset of these symptoms by assisting the body's digestive process. Supplement Facts Bromelain A proteolytic enzyme derived from pineapple. Bromelain attacks the long chain polypeptides of proteins ingested, breaking them down into shorter chain peptides, which are then able to be broken down further by other enzymes. Protease A proteolytic enzyme that is capable of digesting nearly every type of protein; protease is responsible for digesting the bulk of ingested proteins and is one of the three enzymes found in our body’s natural pancreatic juices. Devigest contains a blend of proteases to broaden the pH range of the product. Dipeptidyl Peptidase A proteolytic enzyme responsible for completing the digestion of peptides to basic amino acids. Dipeptidyl Peptidase is primarily responsible for the breakdown of gluten which is found in food items made from grains such as wheat or rye. Alpha Galactosidase The primary enzyme used in popular gas-relief products such as Beano®, alpha galactosidase is an enzyme responsible for breaking down complex sugars into simple sugars. This allows for certain foods such as cruciferous vegetables and legumes to be more easily digested, reducing intestinal gas. Amylase An enzyme which partially breaks starch down into maltose; amylase is naturally excreted from the pancreas and saliva. Lipase Triggers the breakdown of fat into fatty acids. Lipase is the third enzyme that is found in our body’s natural pancreatic juices along with protease and amylase. Glucoamylase Converts starch into sugar like amylase, but is most active in a highly acidic pH. The inclusion of this component allows for many sugars to be broken down prior to exiting the stomach. Lactase The enzyme responsible for the hydrolysis of the milk sugar lactose into glucose and galactose. Cellulase An enzyme that digests cellulose, or plant fiber. Most animals (including humans) do not produce cellulase naturally and are therefore unable to use most of the energy contained in plant material. Xylanase An enzyme with the ability to digest artificial food dyes and preservatives, and is usually lacking in other digestive formulas. Papain Derived from the papaya, papain hydrolyzes protein peptides into basic amino acids. Potassium and Calcium Bicarbonates Nutrients in the gastrointestinal tract are absorbed most efficiently when the environment is alkaline (pH over 7). Bicarbonates help to alkalize the digestive tract, allowing for optimal absorption of nutrients and can also ease the symptoms of indigestion when taken after meals. Hemicellulase Breaks down hemicellulose, a type of polysaccharide that is more complex than simple sugar and present along with cellulose in all plant cell walls. Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Calcium Carbonate 60 mg † Potassium Bicarbonate 50 mg † Devigest™ Proprietary Blend:Peptidase DPP-IV, Amylase, Glucoamylase, AlphaGalactosidase, Lactase, Bromelain, Acid Stable Protease, Cellulase, Xylanase, Lipase, Hemicellulase, Papain, B. subtilis 638 mg † Devigest™ Protease Blend:(pH Stable Proteases derived from A. oryzae and B. licheniformis) 52 mg † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Capsules) Devigest™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing. Frequently Asked Questions What is Devigest? Devigest ADS was formulated to replace Devacor, the first digestive enzyme blend introduced by Arthur Andrew Medical. Devigest is a broad spectrum digestive enzyme blend that will help restore the body’s digestive enzymes, supporting balanced digestion and complete food assimilation. Devigest includes a much more potent blend of enzymes for breaking down gluten and dairy products. Additionally, our own pancreatic enzymes require an alkaline pH for maximum activity. Sodium and potassium bicarbonates, which are normal components of pancreatic juices, have been added to ensure that a sufficiently alkaline medium is present. How is Devigest Different From its Predecessors? Devigest includes a highly potent Peptidase with 500 units of DPP-IV activity per serving. It also now contains Alpha Galactosidase (the active ingredient in the product Beano®) as well as higher potency enzymes such as Lactase, Acid-Stable Protease, and Glucoamylase. Devigest was formulated to be more effective and provide even more relief for those with sensitivities to gluten, casein, dairy, and much more. Those with a diet high in gassy foods such as legumes and cruciferous vegetables will highly benefit from the addition of Alpha Galactosidase. What are “Digestive Enzymes”? Enzymes are proteins that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and key. Devigest contains several enzymes or “keys” that can “unlock” (or breakdown) many of the typical types of food common in our diets. The enzymes in Devigest ADS are specific to the digestion of fats, carbohydrates, and proteins. Additional enzymes have been added to help digest dairy products as well as gluten and other food additives. How Do I Know if I Need Digestive Enzymes? A healthy body produces enzymes in sufficient quantities to ensure proper digestion of most foods. However, some people do not produce sufficient quantities of these enzymes, and often get the common symptoms of indigestion such as gas, bloating, heartburn, abdominal discomfort and constipation. These symptoms are common indicators that one may benefit from supplementation of a digestive enzyme. However, virtually everyone, even those who are asymptomatic, could benefit from the use of digestive enzymes. Why Devigest? Devigest ADS is the best choice for supporting optimal digestion. Unless digestive physiology is in order, no other self-regulating or self-healing systems are able to perform in optimal states, including immune function. Gas, bloating and abdominal discomfort can play a part in the everyday life of many individuals. Supplementing with a high-quality digestive enzyme may be the answer to many of these problems. How Does Devigest Work? Devigest ADS is an enzyme blend that allows for more complete digestion of fats, carbohydrates and proteins. Unlike Devigest, many digestive enzyme blends are incomplete as they lack the ability to break down common digestive irritants such as lactose and gluten. Devigest also includes an alkalization formula for optimal enzymatic activity. Is Devigest Safe? No serious or adverse side effects have been reported from taking digestive enzymes such as Devigest. Clinical studies have shown that even extremely large doses of these enzymes are not toxic.

Super Jing Super potent Jing restoration and maintenance Deer Placenta, Cordyceps, Dendrobium stems, Eucommia bark and 8 other superb tonic herbs Helps restore lost Jing Supports healthy stress response Made with top quality herbs Supports Taoist yoga practice Quick acting Jing tonification Product DescriptionSuper Jing is a powerful primal essence formulation suitable for those who require maximum restoration of Jing. Super Jing tonifies Kidney essence (Yin and Yang), builds blood and tonifies Qi. This formula contains most of the major Jing tonic herbs. It also contains powerful yet gentle Qi tonics that enhance vitality. Super Jing Formulation is thus a blend of Yin and Yang tonics designed to build the entire system up from the roots. It is suitable for those who seek maximum restoration of Jing.*Ingredients: Cordyceps mycelium powder, Deer Placenta powder, Dendrobium stem, Chinese Asparagus root, Raw Rehmannia root, Astragalus root, Eucommia bark, Prepared Rehmannia root, Cornus fruit, Codonopsis root, Ophiopogon tuber, Phellodendron bark.Traditional FunctionTonifies Kidney essence (Yin and Yang), builds blood, tonifies Qi.* Neutral in temperature formula that enters the interior primarily through Kidney and Liver channels.Who can use it?It is suitable for adults who seek maximum restoration of JingSpecifications100 Capsules, 500mg eachOther IngredientsPullulan polysaccharide, Rice powder, Bamboo extract powder, Rice Extract Blend.DosageTake 3 capsules, 2 times per day or as directed by a healthcare professional.

Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*

Heaven Mountain® Goji Berries, the only Goji berries that are snack-grade delicious™ Heaven Mountain® Goji Berries are plump, juicy, naturally sweet, and absolutely delicious. Unlike other Gojis on the market, Heaven Mountain® Goji Berries are sweeter, fleshier and have less seeds. They have a much higher moisture level which contributes to their texture as plump and juicy. Most Gojis on the market are rock hard. This is not without a reason. All the Gojis sold in the US come from China, whether they are labeled as Himalayan, Tibetan, or Wild. That translates to a very long transit time from the growing regions to the hands of the consumers. Typically, the berries reach the consumers at least 4-6 months after they are harvested. To stay shelf stable, most Goji farmers dry their Goji until the berries are very bone dry and very hard. After years of research and development, Dragon Herbs has developed a special handling process and a custom designed packaging that allows the berries’ natural moisture level to be retained while satisfying the shelf stability required in commercial trade nowadays. In a test conducted by an independent lab, Heaven Mountain® Goji Berries are shown to be twice as juicy as a competitor’s.  What makes Heaven Mountain® Goji Berries so special? Simply put, Heaven Mountain. Heaven Mountain is a remote mountain range in the northern region of Xin Jiang Province, China. In a more sophisticated way, the concept of Di Dao used in the world of herbalism can best describe the relationship between the geographical and geological features of the region and the phyto chemical profile of Heaven Mountain® Goji Berries.  The “Di Tao” of Herbs There’s a great concept in China known as Di Tao. The literal translation of Di Tao is “Earth Tao,” or “the Way of the Earth.” The Chinese dictionary definition of Di Tao is “from the place noted for the product ~ genuine, authentic, not from an inferior or counterfeit source.” According to the regulations of the Chinese Pharmacopeia, all herbal products manufactured and sold in China must utilize herbs that are Di Tao - that is, the herbs must come from a source that is considered legitimate and genuine. All plants are the product of their growing environment and conditions. Different regions have their distinctive make-up of water, soil, sunshine, climate, and biological distribution. The varying methodologies adopted by different regions in their cultivation, collection, and final preparation of the herbs further differentiate the herbs from different sources. The Di Tao source of an herb is gradually established through the historical use of the herbs. By documenting how herbs from different origins differ in their pharmacological effects on the human body, the regions or sources that produce the most desired results have slowly come to be recognized as the authentic genuine source, Di Tao, both by common knowledge among the practicing herbalists as well as by government supported official recognition in the materia medica. Heaven Mountain® Goji Berries is one such example. The water, the soil, the sunshine and the weather have the precise qualities necessary for producing the best, richest, tastiest, most potent Goji berries on Earth. As a result, they have an extraordinary and balanced phyto-nutrient profile.  Water As part of the enormous Gobi Desert that covers southern Mongolia and northern China, Xin Jiang receives little to no rain each year. Every drop of water in the growing fields is derived from the melted snow and glacial runoff from the pristine Heaven Mountain. This water is pure and structured – it is nature’s ultimate irrigation system.    Millions of people throughout Asia consume Goji berries every day for both their unique, satisfying flavor, and for their health benefits. In China’s first herbal encyclopedia, Shen Nong’s Materia Medica, written in the 1st century B.C., Goji was classified as a “superior tonic,” a class of herbs that people should take on an on-going basis to preserve youth and to promote general well being of life. Goji’s superior tonic classification has stood the test of time. Two thousand years later, Goji berries are still being consumed regularly throughout Asian civilizations for those purported reasons. We now know that Goji berries are a “high-ORAC” antioxidant-rich superfruit featuring important phytochemicals such a beta-carotene, zeaxanthin, betaine, polysaccharides (LBPs), trace minerals and vitamins.  Soil The virgin land of the Gobi Desert has little vegetation. It has a very high content of alkaline minerals. The pH level of the soil can be as high as 8.7 (17 times more alkaline than neutral) and the soil salt content can reach 1%. Few plants can survive in this kind of harsh environment. Goji, however, being an extremely adaptable plant, thrives here.  Daylight Duration Xin Jiang province has the longest daylight duration among all provinces in China (Tibet included). It averages 2550 to 3300 hours of sunshine per year. The intensive sun light allows for much more productive photosynthesis in the Goji plants, leading to more flesh, sweeter taste, and naturally, higher content of active ingredients such as Lycium Polysaccharides (LBP).  Precipitous Daily Temperature Fluctuation Another unique weather characteristic of Xin Jiang is the precipitous temperature fluctuation between day and night, usually as much as 36 to 45 °F within a single day. The locals joke that in Xin Jiang, no traveling is necessary in order to experience the four seasons within one day. It is quite common that you start the day with a winter jacket, strip down to a silk shirt at noon, then at night, you can enjoy their famous watermelons, next to a bonfire, that is. It is Heaven Mountain Goji’s superb adaptability that makes it a highly revered adaptogenic, stressfighting tonic herb. The Ministry of Agriculture of the People’s Republic of China has officially certified Heaven Mountain goji berries as Di Tao.   

Schizandra & Lycium Drops, composed out of Schizandra and Goji (Lycium barbarum) tincture has served as the masthead of our tincture product-line for twenty-two years. Every month of every year, it is always our number one selling tincture. There must be something very special about it in order to maintain such dominance among elite herbal connoisseurs for over two decades without ever falling off the throne.According to the great Taoist Master Sung Jin Park, the blend can restore youthfulness, slow down aging, invigorate all twelve meridians, increase vitality, calm the nerves, nourish and cleanse our blood, protect the liver, strengthen the mind, improve sexual functioning for both men and women, improve respiratory functions and beautify the skin.Though this is a long list of potential benefits, Master Park's claims are based on over two thousand years of experience by Asian people with this combination. These claims are all classical benefits believed to be derived from these two remarkable tonic fruits.  What does Goji & Schizandra Drops do? Traditional and Modern Conventional Asian Functions Primary Functions: Promote radiant health on all levels and to protect the body and mind. To nurture Yin. Promote adaptability. To help maintain a happy healthy mood.Secondary Functions: Protect the liver. Nourish the blood. Strengthen the eyes. Help maintain healthy sexual function. Strengthen the mind.Treasures: Jing, Qi, ShenAtmospheric Energy: WarmTaste: Contains all five flavors: Sour, sweet, salty, pungent, slight bitter.Organ Associations: All 12 organ/meridian systems. Name Change We've changed the name from Schizandra & Lycium Drops to Goji & Schizandra Drops. Many people are looking for a quality Goji extract and we felt they could find it easier with the new name using the more popular nomenclature (the name "Goji" had not been coined when we first created the product 22 years ago). The product is still 50% Goji and 50% Schizandra, so in this regard there is no change. We hope all you "old timers" don't take any offense or become confused by this name change. Made with Fingerprint Identical Transfer Technology™ (FITT™) Over the years, we have made Goji & Schizandra Drops (formerly called Schizandra & Lycium Drops) with several different producers, each with slightly different extraction technologies, secrets and skills. For the last few years, we have been thinking about using FITT™ to make our tinctures, which is a green technology that uses a room temperature process to extract herbs so as to preserve all the valuable components in their natural state and proportion. This proprietary extraction technology captures the original phytochemical profile of a botanical (the plant’s fingerprint) and transfers its safely and almost identically into the final extract, preserving the aroma, color and taste of the plant perfectly.  Recently, we were overwhelmingly successful at extracting very high quality Deer Antler as a water-alcohol extract (a tincture) with FITT™. We were so impressed with what we got out of the Deer Antler that we have now switched our production of Goji & Schizandra Drops to FITT™. We’ve been working on it for more than two years and have produced samples with FITT™ a couple of different times to make sure we should make the switch. Each time, our herbalists and local testers raved about the samples and implored us to make the move. The results are amazing! We are surprised that a tincture could be this good! It is potent and it is incredibly delicious, in its own unique way of course (we’re sure you’ll love it). Our in-house herbalists and local clients have practically gone off the deep end for this new FITT™ Goji & Schizandra Drops.  

Serving Size: 3 capsulesCapsules Per Box: 180 Active Ingredients:Proprietary Enzyme Blend 324 mg contains: Bromelain Papain Rutin Amylase Protease Lipase Serrapeptase Amla Extract   Other Ingredients: Medium-chain Triglycerides, Starch, Glycerin, Polysaccaride, pH Resistent Enteric Coating, Bees Wax, Glycerin Fatty Acid Ester, Riboflavin, Soy Lecithin and Citric Acid Recommended Dosage:As a dietary supplement, take 3 capsules daily with water. This dosage recommendation is for most users and your healthcare professional may recommend a higher activation amount. Warning: If you are currently taking prescription drugs, consult your healthcare professional prior to use. Serrapeptase, a key ingredient in Vxe, was originally discovered in Japan and is commercially produced there for health applications. It has been used as a substitute for animal-derived enzymes (such as chymotrypsin) because of its stronger effect of decomposing bradykinin. Bradykinin is a protein found in the body that causes an inflammatory response.Serrapeptase must be enteric coated to bypass the stomach acids. Without a protective coating the enzyme will be destroyed by the stomach acids.Bromelain is a plant-derived proteolytic enzyme most noted for its ability to break down proteins. Bromelain has been used therapeutically for over 50 years for its anti-inflammatory properties.Papain is also a plant-derived enzyme used both systemically and in the digestive process to break down proteins.Amylase is an enzyme that breaks down carbohydrates.Lipase is an enzyme that breaks down lipids.Rutin is a flavonoid that is used chiefly for strengthening capullary Blood vessels.Amla, also known as the Indian gooseberry, is a rich source of Vitamin C.Vxe also contains natural additives as part of the blending, stabilization, and enteric coating process. Vxe is all-natural and vegetarian. It does not contain talc or titanium dioxide.100% Non-GMO ingredients. Vitalzym XE is recommended by healthcare professionals worldwide. The unique blend of vegetarian enzymes, flavonoids, and antioxidants has been formulated for 100% absorption in the small intestine. All-Natural Enteric CoatingThe effectiveness of any systemic enzyme is determined by the amount of activity level in the bloodstream after the enzyme has been absorbed from the small intestine. Enzymes that are susceptible to destruction in acidic conditions must be protected for delivery to the small intestine. Systemic enzymes will begin to lose their activity once introduced into the low pH (1.0-3.0) acids of the stomach. The amount of activity loss is dependent upon the individual enzyme and the amount of time it spends in the stomach. Studies have shown that unprotected enzymes can lose up to 100% of their activity in fewer than 30 minutes in pH levels below 3.0. The only reliable method of ensuring that 100% of the enzymes are not destroyed by the stomach acids is to enteric-coat the enzymes. Vxe has been formulated to use an enteric coated gel capsule manufactured under pharmaceutical-grade guidelines.*     Vxe, serrapeptase, enzymesThough revolutionary to nutritional enzyme blends, this enteric coating process is similar to that used in todays most advanced products. The capsule has an all-natural shell barrier that allows it to withstand the extremely low pH levels found in the stomach. Once introduced to the pancreatic juices in the duodenum (upper small intestine), the shell barrier breaks down to release the enzymes it contains. The enzymes are then absorbed into the bloodstream through the lining of the small intestine.* The enteric coated gel capsule has been designed to pass both the USP (United States Pharmacopeia) and JP (Japan Pharmacopeia) disintegration tests for enteric coated capsules. Every batch is tested to ensure it meets the agency guidelines before exportation to the U.S.* Please see this great Enzyme Digestion Comparison chart/slides to better understand the enteric coating on this product: http://www.worldnutrition.info/enzyme-choices. Image: Effect of pH on Enzyme Stability. More Concentrated. More Activity. More Stability Powder enzyme blends are available today that use an enteric coating, but they are typically in tablet form (see fig. 1). The disadvantage of these blends is the amount of heat created with compressing the ingredients into a tablet. Enzymes are susceptible to high temperatures and may begin to degrade during the manufacturing process.Vxe is produced under strictly controlled temperature ranges and because of this our LiquidFilled Gel Capsules allow for an enteric coated enzyme to be developed without activity loss from heat.* There are also enzyme formulations available in vegetable and gelatin capsules that claim to have an enteric coating (see fig. 2). An independent laboratory has put these to the test and has yet to find one that passes the US Pharmacopeia standard for enteric coating.In fact, the best performing vegetable capsule tested lost more than 85% of its enzyme activity after being subjected to stomach conditions. In other words, less than 15% of its concentration was available for absorption to the bloodstream. Click here to see the results.Liquid enzyme blends also provide a more uniform dose consistency, because the mixing of liquids allows for optimal particle distribution. In powder formulations, each particle of a different enzyme is different in size, causing greater friction between particles during mixing. Excipients are introduced to powder formulations to increase the mixability, but liquids still provide far more even distribution of ingredients, allowing for more consistent dosages in each capsule.*Enzymes always retain some amount of moisture when they are produced. Enzymes, as proteins, are more susceptible to denaturation at higher moisture. Enzyme powders typically have lower (5-10%) moisture. However, even with lower moisture, enzyme powders will lose some of their activity over time, resulting in a loss of up to 20% of activity over a 12-month period. Vxe contains enzymes with a higher degree of purity and less moisture that, when combined with Medium-Chain Triglycerides (MCT), then decompressed during the manufacturing process, removes the moisture completely. As a result, loss of enzyme activity over time due to moisture will not occur after Vxe is produced. Vxe is manufactured to have a 5-year shelf life with no loss of activity when properly stored in a cool, dry place.* Best ValueThere are many cheap enzyme products available today. However, when comparing the value of each blend, Vxe continues to prove to be the least expensive option due to its unmatched efficacy. High concentrations of active, stable enzymes delivered to the bloodstream allows for the least amount of waste in an oral systemic enzyme supplement. When comparing the amount of pure enzymes delivered to the bloodstream for systemic effect, Vxe offers the best value of any systemic enzyme supplement available today. References: Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent in emergency surgery. Arztl. Praxis 24 (1972), 2307. Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Kee W., H. Tan S, L., Lee V. Salmon Y. M.: The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore Med J. 1989:30(l):48-54. Celebrex article Wall Street Journal 19 April 1999. No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997. Enzymes A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published 1993 Eco Med. Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982. Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. Kunze R., Ransberger K., et at: Humoral immunomodulatory capacity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991. Jager H.: Hydrolytic Enzymes in the therapy of HIV disease. Zeitschr. Allgemeinmed., 19 (1990), 160. Bartsch W.: The treatment of herpes zoster using proteolytic enzymes. Der Informierte Arzt. 2 (1974), 424-429.

Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.