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Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.

Dark organic chocolate with a generously good crunch of toasted hazelnut. These cocoa beans proudly come from the UNOCACE Fortaleza cooperatives in Ecuador. As with all our cocoa, it is from organic Fairtrade-certified cooperatives committed to improving their members' livelihoods. We then partner with our Swiss chocolate maker, who offsets all CO2 from our production by planting timber trees in the growing areas for additional farmer income. The native birds of South America gracing our recyclable packaging remind us of this thriving ecosystem behind every chocolate bar.Birds: Pied-crested Tit-tyrant & Golden-backed Mountain Tanager Ingredients Ecuador cocoa beans*, raw cane sugar*, cocoa butter*, toasted hazelnuts*, Madagascar vanilla beans*.CONTAINS HAZELNUTS. MAY CONTAIN MILK, ALMONDS AND SOY.Cocoa solids 60% minimum.*Certified organic and certified FairtradeCertified as Vegan through The International Vegan Society. Certified Gluten Free by Coeliac Society, New Zealand.

  Complete Canine Multi-minerals are the perfect multi-mineral for your dog.  They not only give your dog the full-spectrum of minerals your dog needs throughout their entire life, they also provide the transportation for those minerals into the cells. How to Use Complete Canine Multi-mineralsThis product is best delivered by putting it on your dog’s food daily. Use the table below to determine the daily amount to put on your Dog’s food:Please note that precise amounts are not essential or provided. The trace minerals in our products are both, super bioavailable, so your dog will get what their system needs, based on their level of activity, age, health and need.  Any excess will naturally and easily be flushed from their system. 

Product Details Rebuilds both yin and yang aspects of jing essence Restores foundational energy and vitality Anti-stress formula that supports kidneys and adrenals Promotes pre-workout endurance and post workout recovery Supports injury recovery Helps build bone density, strengthens joints, cartilage and connective tissue Helps to restore libido and fertility in men and women Builds healthy blood Modulates immune function Supplement Facts:Ingredients: 
Pure Himalayan Shilajit, Deer Antler Velvet, Prepared He Shou Wu, Prepared Rehmannia, Astragalus Root, Eucommia Bark, Epimedium Leaf.Net Weight: 55gServing Size: One gram (half a teaspoon)Serving Per Container: 55Jīng 精 is the Chinese word for "essence". Along with qi (animating wind) and shén (spirit), it is considered one of the Three Treasures of Traditional Chinese Medicine. Jīng or Essence can be summarised in two parts: the Yin, being congenital or prenatal, and the Yang, being postnatal or acquired. Prenatal Jing is acquired at birth from the parents: the father's sperm and the mother's ovum. This is a similar concept to DNA. Postnatal Jing is acquired after birth through food, water, oxygen, as well as environmental and social conditions—very much like the concept of epigenetics. Jing essence can be exhausted through stress, sickness, injury, childbirth, excessive sexual activity and the natural processes of ageing. Lost Jing results in decreased vitality, lowered immunity, loss of strength and endurance, a sunken mental state and rapid ageing. However, there are a number of methods that can be applied in order to restore our spent vitality, one of which is the unique classification of powerful Jing tonics according to traditional eastern medicine.Nyishar Jing Redux is a perfectly balanced formula that restores both the yin and yang aspects of our deepest vitality - our innate reservoir of Jing. This formula offers excellent support when recovering from stress and exhaustion and facilitates physical healing of the joints and connective tissue. Traditionally this formula was used when deep revitalisation was needed, and when both men and women were attempting to increase and rebuild reproductive fertility.The original Jing Redux formula has now expanded to include Himalayan Shilajit and Deer Antler Velvet. This further enhances the Jing restoring properties of this medicine as well as exponentially increasing its potency. This is by far the strongest and most effective incarnation of Jing Redux yet. Every ingredient undergoes a multi-step extraction process in order to ensure maximum bioavailability and efficacy.There are a total of seven medicinal herbs that synergistically collaborate to create Jing Redux. Here is a breakdown of the formula and how it works:Himalayan ShilajitThis is the primary, chief herbal extract in this formula. Shilajit has been a revered herbal substance in Ayurvedic, Tibetan, Unani-Tibb and traditional Chinese medicine for centuries. Ayurveda has always referred to this substance as 'the destroyer of weakness' and the 'conqueror of mountains' in reference to its unrivalled fortification of body and mind, restoring them to their maximum state of strength and vitality.Shilajit contains over 80 different bioavailable ionic trace minerals, dibenzo-alpha-pyrones, as well as humic and fulvic acids. Fulvic acid is understood to regulate blood pressure/sugar/lipids, as well as improve digestion, immune function, increase muscle strength and stamina, while also influencing the healthy production of steroid hormones.Shilajit is also known to improve the efficiency of intra-cellular metabolism and has been used for many centuries as an amplifying medicine, due to its ability to elevate the potency and utility of all other medicines it is taken with. This 'potentiating' quality is driven by a number of compounds including dibenzo-alpha-pyrones - metabolites that proliferate throughout Shilajit. From the perspective of Chinese medicine, Shilajit is a superior grade jing herb that is deeply restorative but also encourages the healthy circulation of our subtle energies (qi) and has a stabilising and clarifying effect on the mind and emotions (shen).According to a collective anthology of scientific research on the health benefits of Shilajit (Carlos Carrasco-Gallardo et al, 2021), preclinical and clinical studies have determined shilajit to be a potential medicine for inflammation, pain relief, diabetes, treatment of gastric ulcers, infectious diseases and modulating immune function.However, the current emphasis of western scientific medicine is to explore the neuro-protective properties of Shilajit and its role in the treatment of cognitive disorders and dementia. In 2011 the Journal of Alzheimer's Disease reported on a study that was conducted by A Cornejo et al, which found that the fulvic acid in Shilajit can inhibit the formation of tau fibrils and amyloid plaque that is synonymous with the progression of dementia. It is also currently being studied as an anxiolytic medicine. At the Institute of Medical Sciences in Varanasi, AK Jaiswal et al conducted an in vivo trial where Shilajit was shown to dramatically reduce anxiety and improve memory in test subjects.Traditionally, Shilajit was recommended when the pathology had a hidden or deep-rooted nature, because it can amplify the therapeutic effects of an entourage of medicines that it is taken with. In Tibetan medicine this type of substance is known as a 'medicine horse', because it is like a powerful horse that the medicine rides quickly and efficiently to the site of the body that needs to be healed. Interestingly, this theory was explored in 2021 from Mohd Aamir Mirza et al. The study focused on the humic acids in Shilajit and how they can dramatically increase the absorption and utility of pharmaceutical drugs. In the study, the solubility of the anti-epileptic drug carbamazepine was increased by an enormous 1742%. The sustained release of the drug into the blood improved by 78% and its absorption increased by 3.5 times.Deer Antler VelvetDeer Antler Velvet is another natural healing product utilised for more than two thousand years in traditional Asian medical systems. It is regarded in TCM as one of the absolute finest medicines for restoring our depleted essence and for regenerating the body and mind. About two months after the antlers begin to grow, they are still very pliable, filled with blood and an assortment of growth factors, and the outer surface is soft and velvety.Antlers are a very special phenomenon in nature, in that they are a complex organ which completely regenerates every single year. While the antlers are still young (before they harden) they can completely renew any loss through damage or injury. When harvested, only the last few inches are collected, and it is the outermost tips of these segments that are the most therapeutically useful, because this is where the highest concentration of transforming growth factors, ecto-saponins, collagen and androgenic growth hormones are found. When harvested ethically and conscientiously, the tips of the budding new antlers regenerate rapidly (2cm per day) and have zero negative impact on their structure and function during the rutting season later in the year.Traditionally Deer Antler Velvet extract was utilised as a profound restorative medicine. TCM understands this medicine to restore both the yin and especially the yang aspects of Jing and act as a heart tonic that fortifies and regulates blood circulation, as well as the circulation of subtle energies throughout the meridians of the body and mind. Correspondingly, this promotes a radiance that is also expressed through a more healthy emotional balance and stable perception of the mind. Deer Antler Velvet has also been used with great success in treating fertility and libido in both men and women.Since the early 1930's, almost 300 different research papers have been published within scientific literature, expounding the benefits of this unique medicine and investigating the compounds that may be responsible. Deer Antler Velvet tips contain a high concentration of type II collagen, which has proven itself very useful in the treatment of both osteoarthritis and rheumatoid arthritis. According to a 1993 research paper by Trentham et al entitled 'Effects of oral administration of type II collagen on rheumatoid arthritis', Deer Antler Velvet can promote healthy collagen synthesis and optimal maintenance of joint cartilage. Also, type II collagen can help to inhibit pro-inflammatory cytokines and hence decrease inflammation in the affected joints, a phenomenon that was investigated in detail by Kalden and Sieper et al in their 1998 report 'Oral collagen in the treatment of rheumatoid arthritis'. The bioavailable glucosamine, chondroitin, prostaglandins, pantocrin and hyaluronic acid in Deer Antler Velvet can also further support arthritic joint care from their anti-inflammatory and analgesic properties, as reported in the Canadian Journal of Animal Science in 1997 in an article named 'Glycosaminoglycans from growing antlers of Cervus sp.' by Sim and Sun-woo et al. The Medical Hypothesis Journal also reported similar findings in 'Hyaluronic acid and high-dose glucosamine in the treatment of oste-arthritis' by McCarthy et al in 1998.In vivo research has also proven high quality Deer Antler Velvet to be an immune amphoteric - a medicine that acts as an adaptogen to the immune system, either stimulating or pacifying the activity of immune cells according to the needs of the biological environment. This offers a broad spectrum of potential benefits in the treatment of numerous immunological diseases, as determined by a spate of scientific research throughout the 90's (conducted by Suttie et al in 1996 and Church et al in 1999) which focused specifically on Deer Antler Velvet and how it modulates immune function. This in vivo research focused primarily on its beneficial effects on viral infections, tumour growth and chemotherapy.The anti-stress and exhaustion properties of Deer Antler Velvet are one of the most timely benefits for modern humans. It has been prescribed for centuries in cases of exhaustion and severe depletion, and more recent scientific findings have been confirming these benefits from a biochemical perspective. In a human trial that was conducted at the turn of this century, Fisher et al observed the physical training regimen of an entire police squadron in Edmonton, Alberta, and how the test subjects were influenced by the consumption of this medicine. 80% of participants exhibited significant cardiovascular benefits - the more efficient regulation of blood pressure and serum cholesterol caused the parasympathetic nervous system to activate more quickly after exercise, which improved circulation and lowered stress.In the 1980's, Fulder et al explained that the unique glycosides in Deer Antler Velvet had a direct influence on the hypothalamus and pituitary glands in the brain. These glands are the master regulators of our stress response and control the function of the adrenal glands. This is understood (in part) to be the reason why this medicine is such a potent adaptogen.Deer Antler Velvet contains numerous growth hormone precursors which can help with repair and regeneration of muscle tissue, cartilage and bone, as well as metabolising excess body fat and raising energy levels. This assortment of hormonal precursors include amino acids like valine, leucine and isoleucine alongside associated minerals and trace minerals such as magnesium and zinc. This is partly why Deer Antler Velvet is so anabolic and able to stimulate such rapid growth and repair of the antlers during springtime. In the aforementioned study on the Edmonton police force, Fisher et al discovered that oral supplementation increased blood plasma testosterone levels by up to six times the base level.In a Russian study as far back as 1974, Yudin and Dubryakov et al observed that the pantocrin in Deer Antler Velvet enabled a threefold increase in dynamic output and post-workout recovery in track athletes when compared to the control group that didn't receive the medicine. Overall, this adaptogenic result was understood to be caused by not only pantocrin, but the complex interdependence between many compounds.Both Shilajit and Deer Antler Velvet are the new driving forces that direct the medicinal attributes of the Jing Redux formula for obvious reason, however let's take a look at the original herbs that create this restorative product:Prepared He Shou WuThe primary essence replenishing tonic of Chinese herbal medicine - prepared He Shou Wu restores the yin quality of our jing vitality. This herb received a detailed entry in the Chinese medicine classic 'The Great Compendium of Herbs' by Li Shizhen in 1596, where it was stated that daily use for one year would completely restore youthful vitality. It is an organ tonic to both the kidneys and liver and helps to enrich the blood. Throughout history this medicine has been known to reverse grey hair, restore bone density and healthy joint mobility, and has been utilised throughout Asia for many centuries as a powerful anti-ageing tonic. Prepared He Shou Wu is also central to the majority of fertility formulas in Chinese medicine - it can increase sperm count and improve vitality of the ova. It is also widely used as a postpartum recovery agent for women, due to its deeply restorative yin jing properties.This herb can significantly increase one of the body's master antioxidant enzymes known as superoxide dismutase (SOD), which contributes to its longevity effects. This herb should be cooked in a black bean stew in order to activate its potential as a tonic adaptogen. The unprepared herb is a totally different type of medicine - more of a laxative than a restorative. In order to receive the yin jing properties, the tuber must first be three to four years old and needs to be 'prepared' prior to consumption. This will yield the premium quality, deeply regenerative medicine for rebuilding our lost essence and vitality.Prepared He Shou Wu has a heavy and moist energy as a medicine which makes it very grounding and stabilising, but it should be combined with other medicines that exhibit more of a lighter, warm and dry energy in order to balance these polarities and ensure the medicine is the most effective.Prepared Rehmannia One of the quintessential 'yin jing' herbs of Chinese medicine, prepared rehmannia is one of the most restorative herbs to the kidneys, adrenals and to our reproductive fertility, and as such can be combined with Prepared He Shou Wu for optimal replenishment of our vital essence. Not unlike He Shou Wu, it is excellent for nourishing the blood and is a tonic for the liver and heart. The process of macerating and 'preparing' this herb in a tonic wine causes its revitalising properties to become exponentially more powerful. Chinese medicine has always prescribed this herb for rebuilding the body and mind after stress or trauma of some kind, after energy reserves have been depleted and for mitigating the symptoms of ageing. It can replenish marrow and increase bone density, and as the physical reserves of the body are restored, it can serve as a stable foundation for the mind to settle and function with greater efficiency.This has in fact been the focus of modern pharmacological studies - prepared rehmannia has been observed to repair structural abnormalities in the cerebral cortex. In 2018, Haixia Yuan et al found that catalpol (a unique glycoside found in rehmannia) can increase brain-derived-neurotrophic-factor (BDNF), which is a protein that promotes the survival of neurons within the brain. This in vivo trial showed that impulsive, hyperactive and destructive behaviour decreased and brain cell survival increased when test subjects were given an extract of prepared rehmannia.Astragalus RootAstragalus has over 2000 years of documented use throughout Asian medical systems. It is not categorised as a Jing herb itself, however it is one of the premier Qi tonics that supports the animation and healthy circulation of our deepest vitality reserves. Astragalus is a tonic to the spleen and the lungs and nourishes our 'wei qi', which is considered to be a subtle protective forcefield that circulates on the surface of the body. This helps to remove obstruction within the subtle channels of the body and ensure the efficient circulation of all fluids and subtle winds, as well as fortify the first line of defence of the immune system. This is very important because through stress, exhaustion, depletion and ageing, our 'wei qi' and also our 'upright qi' can become weaker, contributing to poor posture, organ prolapse and poor circulation. As a qi tonic, Astragalus can help to rectify such issues during the process of restoring our depleted jing essence.Astragalus has long been used as a respiratory tonic as it is understood to strengthen the lung qi and fortify lung capacity while preventing and treating many pathologies of the lungs. Modern medicine has arrived at similar conclusions, albeit from a different standpoint. A 2013 stduy from Chuan Zou et al found that consistent use of high quality Astragalus could reduce bronchial inflammation and bolster the immune response when dealing with allergies and treating infections of the upper respiratory tract. Astragalus facilitated deeper breathing, a decrease in fatigue and eventually allowed patients to eliminate dependency on the drug prednisone.With its warm, light and yang nature, Astragalus combines perfectly with the heavy, colder and more restorative properties of both Prepared He Shou Wu and Rehmannia. It can stimulate the processes of digestion and improve the nutrient extraction from the food we consume, helping to further strengthen the blood and alongside the circulating wei qi on the surface membrane of the body, it can help to transform the skin to a more radiant complexion.Astragalus has been employed as a highly effective immune system adaptogen for millennia, which is an area of interest that modern scientific medicine has been investigating for many decades now. More than 200 different compounds have been identified in Astragalus, with its range of polysaccharides, flavonoids and saponins among the most studied. The Peking University Health Science Centre in Beijing found that the polysaccharides, flavonoids and triterpenoid saponins in Astragalus could work synergistically to promote greater adaptivity amongst immune cells. Extracts were found to restore balance in the activity of pro-inflammatory cytokines which enhanced the immune response to infection, as well as improving the function of lymphocytes within the body.Interestingly, a unique chemical called TA-65 has been isolated from Astragalus which has been studied for its broad anti-ageing properties. The root of these benefits is considered to be the fact that TA-65 can increase the length of telomeres. Telomeres are structural proteins found at each end of a chromosome. Every time a cell divides, the telomeres shorten, until eventually they completely run out and the cell dies. This process underlies all disease and ultimately, death. However, TA-65 activates an enzyme called telomerase which is in fact responsible for cleaving new sections of DNA which then get added to existing telomeres. This prevents the cell from dying and enables it to live in a functional state for longer. There have been many investigations into TA-65 and its ability to regenerate telomeres, including a comprehensive investigation of Astragalus in 2017 by Ping Liu et al for the National Science Foundation in China.Eucommia BarkMedicinal Eucommia comes from bark that is annually removed from the only species of rubber tree to proliferate within a temperate climate. Sandwiched within the core of the bark is a type of latex - very pliable and elastic - which is where the concentration of medicine can be found. According to Chinese medicine, Eucommia possesses the ability to restore both the yin and yang aspects of the Jing essence, although its energy is predominantly yang. It offers tonic benefits to the kidneys and liver, and is traditionally used to restore spent vitality, to speed up the healing process and to increase reproductive vitality in both men and women. The elasticity at the core of Eucommia is understood to rebuild the physical structure of the body - to promote bone density and the elasticity of cartilage and other connective tissues. This is why Eucommia was routinely prescribed for centuries when treating many kinds of stress, because it could help to reverse the destructive physical toll that stress can inflict upon the body. This also made it central to many herbal formulas for treating arthritis and for injury recovery.Contemporary investigations into Eucommia have revealed that it contains a spectrum of different therapeutic compounds including phenols, lignans, terpenoids, sterols and polysaccharides. A 2016 study led by Tarique Hussein et al explained that Eucommia exhibited cardiovascular benefits and helped to regulate blood pressure, was a very useful antioxidant and anti-inflammatory medicine with immunological properties including antiviral and antibacterial actions. It also showed legitimate potential in the inhibition of neuro-degenerative conditions that lead to dementia by reversing the formation of amyloid plaques, and also demonstrated a protective influence over liver cells.Scientific enquiry of Eucommia has also verified its use as a physcial healing catalyst for bones and connective tissue - glycosides found in the extracts of this species significantly increased bone mineral density and femur strength for in vivo test subjects. A 2007 study from Victor Y C Ong et al published in the Complementary and Alternative Medicine Journal stated that Eucommia extract induced the release of growth hormone responsible for bone remodelling.Epimedium LeafEpimedium is a powerful Jing tonic that is predominantly yang in nature. It has been used for centuries as a reproductive herb for men and women as it is very energising and can stimulate the libido, and is used in female fertility formulas and also when treating erectile dysfunction. Epimedium is typically included in smaller quantities within larger formulas that contain other yin tonics to counterbalance its 'outpouring energy'. Framed within this kind of herbal context, Epimedium is an incredible medicine for replenishing vitality, and indeed, using that vitality. It is also a tonic to the liver and kidneys, as well as being an excellent qi tonic that can help to animate our vitality once restored. It has a warm and drying nature, so again, is best formulated alongside other medicines with cooler, softer and smoother characteristics.More recently Epimedium has been scrutinised in both laboratory and clinical settings in order to determine what the benefits are as well as their mode of action. Firstly, it has proven itself as an anti-fatigue herb that can promote greater bone density, while also helping with arthritic nerve pain and inflammation, as well as a cardiovascular adaptogen that is used in the treatment of hypertension. Icariin - a unique glycoside that has been isolated from this species - is believed to be a major component in these cardiovascular benefits. An in vivo study in 2010 performed by Alan W. Shindel et al also indicated that icariin was effective at stimulating nerves within the genital regions and as a treatment for erectile dysfunction.Nyishar products and the claims made about them on or through this site have not been evaluated by the MHRA or United States Food and Drug Administration and are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your doctor/physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or as a substitute for medication or other treatment prescribed by your doctor/physician or health care provider.

Would you like… Better Bone Health Immune System Support Improved Mood Improved Heart Health Anti-Inflammatory Support Support Losing Weight If so, you may want to give our Vitamin D3 5000iu + Vitamin K2 1000iu MK-7 a try!Our Vitamin D3 with K2 can also potentially give you a whole host of additional benefits such as: Increase Muscle Strength & Repair Increased Longevity Improved Brain Function and Memory Improved Dental Health Brain Protection Promote Proper Blood Clotting UV Protection Reduced Chance of High Blood Sugar Levels What is Vitamin D3?Vitamin D is a fat soluble vitamin that our body requires in order to absorb calcium in the gut, as well as regulating calcium and phosphorus for bone mineralization [1].Vitamin D is also incredibly important in the regulation of mood, prevention of cardiovascular problems and improving heart health, lowering pro-inflammatory and increasing anti-inflammatory components of the immune system, supporting weight loss, supporting bone health and more.There are two main types of vitamin D - D2 and D3. D2 can be found naturally in some plants, whereas D3 is naturally formed in animals when their skin is exposed to sunlight. The difference being that D3 is roughly 87% more potent at increasing blood vitamin D levels and maintaining concentrations. D3 also provides 2-3 times more storage of vitamin D in the body’s cells than D2.For example, a study on older women found that a single dose of vitamin D3 was almost twice more effective than vitamin D2 at increasing calcifediol levels [2].Vitamin D3 is indeed synthesized in your skin too when directly exposed to the sun's UV rays [3], specifically the ultraviolet B rays that are responsible for sunburn. When the UVB rays interact with a protein in your skin called 7-DHC (7-Dehydrocholesterol), it is converted into the active form of vitamin D (D3) that is then absorbed into your body [4].While the sun is an extremely important source, most people do not get enough sun on their bare skin throughout the year, so you should also acquire vitamin D3 from foods, such as fatty fish (such as mackerel, sardines, salmon and tuna), cod liver oil, egg yolks, but this is also often difficult, which is why many people prefer to supplement Vitamin D3 [5].What causes Vitamin D deficiency?A variety of factors can lead to vitamin D deficiency - the main being simply not getting enough sunlight. Here are some of the reasons you may not be getting enough vitamin D: Not exposing enough of your body for long enough (15 minutes in the sun wearing nothing but underwear will provide enough vitamin D for the day) Sitting in the shade - it’s important to understand that your exposed skin needs to be in direct sunlight Using sunscreen which blocks the UVB rays needed to synthesize vitamin D Living in areas where the sun is blocked, like cities with tall buildings Living in countries where there isn’t much sun, or working night shifts so you don’t see much sun   Winter in most countries (when the sun isn’t as strong/doesn’t appear often) Having darker skin (the darker your skin, the less able you are to absorb vitamin D due to the higher melanin content) If you’re deficient in vitamin D, a variety of problems can occur such as: Rickets (children) or Osteomalacia (adults) - distortion and softening of the bones [6] Low mood [7] Increased risk of cardiovascular problems [8] Increase risk of bone fractures and breaks from falls [9] Tiredness, pains and aches Can you test your levels of Vitamin D?If you suspect you have low vitamin D levels, or simply want to find out what your levels are - your doctor can perform a simple blood test. You can also order this test for yourself privately in most locations, we recommend this as it’s very important to have the optimals levels of Vitamin D3, not too little, not too much.If you are found to be deficient, your doctor may also want to perform x-rays to check the strength of your bones.What is Vitamin K2?Vitamin K is another fat soluble vitamin that is essential for the metabolism of calcium, blood clotting, heart health, bone health and many other functions in our bodies [10].The two types of vitamin K are K1 and K2. K1 is a plant form and can be found in some green vegetables, whereas K2 can be found in fermented and animal foods. Vitamin K2’s long side chain allows it to remain in the blood and circulate for longer, making K2 the best form of vitamin K. Where K1 might stay in the blood for several hours, K2 can remain in circulation for days [11].It’s vital that you take vitamin K2 when taking larger doses of vitamin D, but more on this later.Why you should always take Vitamin K2 alongside D3…It’s absolutely essential to take vitamin K2 alongside vitamin D3 for a couple of reasons. The main reason is that it's much safer to take higher doses of D3 with K2, because too much D3 by itself will pull calcium out of your bones, leading to lower bone density. Excessive vitamin D3, without K2, may also lead to calcium being deposited in your arteries, causing hardening of the arteries (vascular calcification).Vitamin K2 works to put calcium back into your bones [12], as well as helping to keep your arteries clear. A balanced formula with both allows you to reap the anti-inflammatory, immune supporting and other benefits of vitamin D3, while minimizing bone calcium loss and the potential for cardiovascular problems.Why Try Feel Younger® Vitamin D3 5000iu + Vitamin K2 1000iu MK7?Our vitamin D3 5000iu + vitamin K2 1000iu MK7 capsules are antibiotic free, gluten free, sugar free, hormone free, lactose free and contain no nasty binders.We use a type of K2 called MK-7 which is a step up from the normal K2 you’ll find in many other K2 supplements. MK-7 has higher efficacy due to its higher bioavailability and longer half-life than other versions of vitamin K2 [13].We’ve also included Bioperine (a patented black pepper extract) in our vitamin D3 with K2 formula because of its ability to increase nutrient absorption [14].Bioperine in itself also possess potential health benefits, such as boosting brain function by decreasing inflammation [15], improving memory and protecting the myelin sheath [16], anti-inflammatory and antioxidant effects on UV (ultraviolet) induced skin damage [17] and preventing high blood sugar levels [18].This means when you take our vitamin D3 with K2 capsules, you know that you’re getting the highest quality, best forms of vitamin D and vitamin K that are the most bioavailable (available for your body to use) and last the longest in your body (longer half-life) and are going to be absorbed exponentially better than other D3 with K2 products due to our Bioperine content.How do you take it?Take one capsule a day, preferably with some kind of dietary fat to help better absorb the vitamins.Any cautions?Although vitamin D is tolerable in high doses, (10,000 iu & upwards) it’s important to bear your sun time in mind.If you’ve spent hours in strong sunshine, supplementation may not be beneficial (in rare cases, excessive vitamin D can cause nausea, vomiting, dehydration, confusion and abdominal pain).Vitamin K is generally considered to be well tolerated and safe but in rare cases, people may experience minor digestive effects. Scientific References https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#h2 https://www.ncbi.nlm.nih.gov/pubmed/18492750 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/ https://academic.oup.com/jcem/article/96/3/E447/2597204 https://www.ncbi.nlm.nih.gov/books/NBK56061/#ch3.s2 https://publications.aap.org/pediatrics/article/122/5/1142/71470/Prevention-of-Rickets-and-Vitamin-D-Deficiency-in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970300/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726624/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427016/ https://pubmed.ncbi.nlm.nih.gov/21155624/ https://www.ncbi.nlm.nih.gov/pubmed/17158229 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230802/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/ https://pubmed.ncbi.nlm.nih.gov/26648012/ https://pubmed.ncbi.nlm.nih.gov/32335165/ https://pubmed.ncbi.nlm.nih.gov/33091445/ https://pubmed.ncbi.nlm.nih.gov/29683271/

Molecular Hydrogen is the smallest molecule that exists, and serves as a powerful antioxidant within the body, crossing cellular barriers and entering the mitochondria and cell nucleus. Hydrogen immediately provides balance in the body by neutralizing free radical damage and oxidative stress. By achieving this deep at the cellular level, the body maintains homeostasis and decreases the chance of premature aging. Benefits: Hydrogen is the most powerful antioxidant and the only molecule that can neutralize the most harmful free radical (hydroxyl) Stopping oxidative stress in its tracks while protecting cell integrity.The smallest antioxidant that can easily penetrate the cell and travel throughout the body.Antioxidants act as stabilizers in your body, countering the effects of free radical damage.Hydrogen activates NFR2 which is a protein within the cell that encourages healthy DNA transcription. Ingredients: Elemental Magnesium, Malic Acid, Dextrose, Tartaric Acid, Adipic Acid.

Oysters are the ocean's answer to a multivitamin. They are an amazing source of vitamin B12, as well as key minerals such as copper and selenium. However, they are most known for being the number one food source of zinc, which is vital for immune function, metabolism, wound healing, taste, smell and hormonal health. See below for a deeper dive into the beneficial nutrients within oysters. We sustainably harvest our Celtic Oysters from clear, unpolluted waters and gently freeze dry them to maintain their fragile nutrients. We then encapsulate them for your convenience and to remove the taste. Each jar contains 120 300mg capsules (30 - 60 day supply). OCEAN'S MULTIVITAMIN Oysters are a rich source of B12 and minerals such as copper, zinc and selenium. ZINC Oysters are the top food source of zinc, which is vital for immune function, metabolism, wound healing, taste, smell and hormonal health. EPA & DHA These essential fatty acids improve the Omega-3 to Omega-6 ratio within the body, reducing inflammation. DHA also plays a key role in brain health and memory. SUSTAINABLY HARVESTED Sustainably harvested from clear, unpolluted waters and gently freeze dried to maintain their fragile nutrients. Celtic Oysters Oysters are one of the top foods in the world when it comes to nutrient density. They’re packed with bioavailable vitamins, minerals, amino acids and essential fatty acids. Being the number one food source of zinc and also high in healthy cholesterol, they are amazing for both male and female hormonal health. In men these nutrients help in the production of free testosterone, whereas in women zinc aids in the creation of FSH which leads to ovulation and progesterone production. Vitamin B12 plays a key role in methylation and is the nutrient of energy. Copper is required for red blood cell creation, which transports oxygen around the body. Selenium is vital for immunity and thyroid function. The list of the benefits of these nutrients is long so we’ve just covered some of the key ones here. Interestingly copper, selenium and zinc work in tandem to prevent sagging skin. This is just one example of why it’s so important to get your nutrients from whole food sources. When consumed in this way, they come in a format and ratio your body understands, topping up your levels to enable you to function optimally, without upsetting the delicate nutrient ratios within your body. Ingredients: Celtic Oysters* (Vegetarian Capsule). *Allergens in bold HOW TO USE Consume 4 capsules per day (1200mg). See our infographic above to work out the best serving size for you. WHEN TO USE Take 4 capsules per day, ideally in the morning to flood your body with micronutrients for the day ahead. Each jar contains 120 capsules and each capsule is 300mg.

Purple Reishi with Spores: Immune system support- Anti-inflammatory- Supports healthy bones, joints & connective tissue- Can help with injury recovery- Cardiovascular tonic- Promotes healthy liver function- Helps to stabilise emotions and calm the mind- Regenerative & restorative Nyishar Purple Reishi Extract is concentrated at a 1:2 ratio, meaning that one part mushroom has been macerated in two parts liquid solvent, creating a maximum potency extract. Firstly, the fruiting body of Ganoderma sinense undergoes hydro-ethanolic dual-extraction, where both procedures are performed separately. The fruiting body is an incredibly rich source of fungal polysaccharides and beta-glucans, with a relatively low overall volume of triterpenes. This why the second process is a pure ethanol extraction of sporoderm-broken spores from Red Reishi (Ganoderma lucidum), as the spores of this renowned species possess a very high percentage of bio-active triterpenes. In total three extracts are produced; hot water and ethanol extractions both fruiting body as well as the ethanol extraction of the sporoderm-broken spores. The hot water extraction is conducted within a pressurised environment to ensure that the water-soluble fraction of the medicine is collected without denaturing from the heat. Each of these extracts are then triple-filtered and combined to produce a complete medicine, offering a wide range pf therapeutic benefits.. Prior to extraction, the Purple Reishi fruiting body is cultivated in a protected mountain reserve in the south east of China, following traditional Di Tao practices. This is a centuries-old method that grows wild-simulated fungi in the same region that true wild specimens can be found. They are grown on the same wood from the same forest, immersed in exactly the same soil with the same micro-organisms, the weather is the same and the same water irrigates the cultivated mushrooms as well as the wild. Read more about Di Tao cultivation HERE. For a detailed exploration into the benefits of Purple Reishi, its historic use in traditional Chinese medicine and many of the scientific studies that have been published, read our full article on the subject HERE, or watch the video above. Nyishar products and the claims made about them on or through this site have not been evaluated by the MHRA or United States Food and Drug Administration and are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your doctor/physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or as a substitute for medication or other treatment prescribed by your doctor/physician or health care provider. Supplement Facts: Ingredients: Di Tao cultivated Ganoderma sinense fruiting body (1:2), Di Tao cultivated Ganoderma lucidum sporoderm-broken spores, rectified ethanol, spring water (from volcanic soil). Volume: 30ml Concentration: 1:2 Serving Size: 2/3 of a dropper (2 squirts) Serving Per Container: 30 Directions: Squirt the tincture into the mouth underneath the tongue and hold it in the mouth for at least 2 minutes before swallowing.

The forgotten nutrient for heart health, blood flow and sexual function!*    A ton of invalid studies using sub-clinical doses of Vitamin E have said this vitamin is of no use for the heart.   And at the levels of dosing they were using the studies were correct, the studies were concocted to make the Vitamin E fail.     First point:  All of the valid studies on Vitamin E and heart health and sexual function, especially those done at the Univ. of Southern Illinois by Dr. Thomas Cureton  in the 1960’s and ’70’s were done with D Alpha Tocopherol.   It was found back then that the other tocopherols and tocotrinols were mere window dressing, the strongest active component of all of the E’s is the D Alpha.     Secondly:  doses needed to be 400 IU and above to have a physiologic function!   Next: the nutritional industry, seeing their profits from Vit. E drop after the vitamin was made from fermentation instead of being cold pressed from wheat germ oil or soy oil, decided to drop their emphasis on Vitamin E and transfer the heart health claims to the much more profitable CoQ10, and the super profitable Ubiquinol.    There was a way to bring back profitability to Vitamin E:  Again skewed studies seemed to show that the only way Vitamin E worked was to mix in the very expensive tocotrinols and mixed tocopherols!   Lastly: Vitamin E when isolated either from cold pressing and extraction or from fermentation needs to be stabilized in oil or freeze dried into a powder or it looses its effectiveness and has a very low shelf life.    All but 1 company we know of mixes the Vitamin E with soy oil, known for its high estrogen content!    So the product is estrogenic. Our Dry E - 500 IU also has the selenium that is the partner for Vitamin E in performing its actions, especially in maintaining healthy/normal prostate health.*  Dr. Kurt Donsback taught back in the 1980’s that ALL prostate swelling, regardless of what it turned into later, started from a Vitamin E and Zinc deficiency!*     Dr. Wongs Essentials® Dry E - 500 IU, has no estrogens!    Each capsule is at the physiologic activation level of dosing and has no widow dressing, just the known-to-be- active D Alpha Tocopherol form of the vitamin.  Daily dose should be one or two capsules taken daily.  

Shou Wu Formulation   Shou Wu Formulation is a Jing tonic designed to nourish the Kidney Yin, build and maintain Qi, and to enrich and maintain the blood. Shou Wu Formulation can be used as a basic Essence (Jing) tonic by men and women. It is a superb rejuvenation formula. The formula is headed by Polygonum multiflorum (He Shou Wu), one of the most powerful tonic herbs known to mankind. In addition it contains other major tonic herbs. This product supports adaptability, enhances sexual and mental energy, supports the back and knees, supports hair growth, fortifies the senses, builds blood and supports the reproductive tissues and organs in healthy men and women. It is a primal Jing tonic that may be consumed for a lifetime.*    The Herbs in Shou Wu Formulation   He Shou Wu Root   Polygonum multiflorum is one of the most important and widely used Chinese tonic herbs. It shares the position as the primary essence tonic of Chinese herbalism with Goji Berry and Prepared Rehmannia Root. The He Shou Wu plant is traditionally believed to be capable of absorbing huge amounts of Qi from the earth it grows in, and stores this Qi in its root system. He Shou Wu (Polygonummultiflorum) is a tonic to the Kidney and Liver functions. It helps tonify the vital essence and blood. He Shou Wu is a very effective blood tonic. It has been used for this purpose for over two thousand years. Recent research corroborates this ability to build healthy red blood cells in healthy individuals. It supports healthy muscles, tendons and bones. It also helps support healthy aging, helps maintain the youthful condition and color of the hair, helps maintain healthy sperm and ova, and helps support the back and knees of normal, healthy individuals. It is the premier longevity herb of Chinese tonic herbalism.   Prepared Rehmannia Root   Prepared Rehmannia Root is traditionally said to be the “Kidney’s own food.”  It is a fundamental Kidney tonic in Chinese tonic herbalism, and is considered to be a primary longevity herb. It is found in a great many common “anti-aging” formulations. It is considered rejuvenating and life supporting.     Prepared Rehmannia Root is a fundamental Yin Jing tonic, providing Yin Jing directly to the Kidney system. The “Kidney” system in Chinese philosophy encompasses the tissues and functions associated with the skeleton, adrenals, sexual glands and organs, the renal system, and the ability to store Jing. Prepared Rehmannia Root is said to benefit sexual functions in men and women and is included in almost every formula that is designed to strengthen reproductive functions, including fertility in healthy individuals. It forms the Yin base of many men’s potency formulas.    Prepared Rehmannia Root is a major blood tonic in traditional Chinese herbalism. This is of course of special importance to women, who always need to rebuild blood. Prepared Rehmannia Root, when combined with Dang Gui becomes an even more potent blood tonic. Dang Gui is Chinese herbalism's premier blood tonic.    Prepared Rehmannia Root is usually combined with at least one Qi tonic to improve its assimilation and effectiveness. In this formula, Eleuthero (Siberian Ginseng), a major Qi tonic, is used. Eleuthero is a superb adaptogen and is also an excellent blood tonic. It quickly increases vitality as well.   Aged Citrus Peel, Red Jujube Date, Licorice Root are all Qi tonics that have the special purpose of helping to regulate Qi and improve digestion and assimilation of the main herbs in this formula. He Shou Wu and, to an even greater degree, Prepared Rehmannia are very rich, so these three herbs are included to make the He Shou Wu and Prepared Rehmannia easily digestible.*   Traditional Function: Tonifies Yin Jing and Qi   Who can use it? Shou Wu Formulation can be used as a basic Essence tonic by anyone, young or old, male or female. It is a superb antiaging and rejuvenation formula.   Concentration: 10:1   Specifications: 100 Capsules 500 mg each   Ingredients: He Shou Wu (Polygonum multiflorum) root, Dang Gui root, Eleuthero root, Prepared Rehmannia root, Aged Tangerine rind, Red Jujube fruit, Chinese Licorice root.   Other Ingredients: Vegan capsules**, bamboo powder.   Usage:Take 3 capsules, 2 times per day or as directed by a healthcare professional   Remember Ron Teeguarden’s “First Rule of Tonic Herbalism,” summed up in a single word – Compliance. If you don’t take the herbs, they won’t work.”   **Pullulan caps 100% natural, water- soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.

Colostrum LD® Capsules :: Micro-Encapsulated Liposomal Delivery Colostrum - 120caps (480mg each) Colostrum LD® Capsules :: Micro-Encapsulated Liposomal Delivery Colostrum 1 Bottle = 120 capsules Colostrum-LD® is the only substance clinically proven to heal and prevent Leaky Gut Syndrome. Most physicians agree that Leaky Gut Syndrome is a primary cause of chronic disease. The LD Difference: Colostrum-LD® remains biologically active at the cellular level with maximal effectiveness (up to 4X more effective than regular colostrum). Colostrum-LD® is the only colostrum certified to contain a minimum of 25-30% Immunoglobulins, 1.5% Lactoferrin, 1.5% Growth Factors and 4.5-5% PRPs (colostrum’s most powerful bioactive component). NOTE: Colostrum LD Capsules and Colostrum LD Powder are the exact same product and differ only in packaging.  Sovereign Laboratories takes a great product (colostrum) and makes it a superior product (Colostrum-LD®). Our proprietary in-house Liposomal Delivery (LD) system is an applied coating which allows colostrum to readily dissolve in liquids and ensures the colostrum will bypass digestion; will be transported through the bowel wall; will circulate throughout the body; will reach the organs and cells; and remain bioavailable at the cellular level. “Liposomal Delivery makes colostrum (and other nutrients) up to 1,500 % more bioavailable” (Robert R. Milne, MD); this makes Colostrum-LD® the most effective colostrum available. Without LD, colostrum loses most of its effectiveness. The LD Difference means that colostrum products from Sovereign Laboratories do what they say. Sovereign Laboratories stands behind its money back guarantee. Expect Results: Colostrum does not oxidize in storage. Colostrum is not digested (digestion destroys colostrum’s bioactivity). Colostrum components are delivered through the bowel wall into the blood stream to reach all organs and cells wherever needed. Colostrum components transport through the cell wall to assist in RNA and DNA repair; stem cell initiation and differentiation; facilitation of cellular growth and repair; infection prevention; and identification of damaged and diseased cells. COLOSTRUM-LD® has been shown to help: Boost, balance, and maintain unsurpassed immune function Eliminate harmful pathogens and fight infection Prevent and eliminate diarrhea from infectious causes Suppress over-reactivity to environmental pathogens and toxins Protect and heal GI and stomach lining (Leaky Gut Syndrome) Increase Natural Killer (NK) cell activity Increase muscle strength and stamina; speed recovery after exercise or injury; burn fat; and maintain blood glucose homeostasis Provide anti-aging benefits Effective Use Colostrum is a food, not a drug or medicine. It is safe, non-toxic, non-allergenic and has no side effects. Bovine Colostrum is safe, non-toxic and can be consumed in any quantity without side effects or drug interactions. It contains special enzymes that prevent its immune and growth factors from being digested. An article written by Robert Preston, ND, President of the International Institute of Nutritional Research, states, "Bovine colostrum is safe. Colostrum contains an unprecedented combination of nutritional factors with which to fortify the immune system. It is so harmless, it has been prepared by Nature as the first food for infants, intended as their total diet for the first 24 hours." He further states, "It would be hard to imagine any nutritional substance more natural or beneficial than colostrum. It is safe for internal consumption by children, adults and animals." How much should be taken and how often? You should take enough colostrum to obtain results you desire; this amount varies from person to person. If you are not seeing results with colostrum, you are not taking enough. For healthy adults who want to maintain a healthy immune system and prevent Leaky Gut Syndrome, 2 capsules (or 1 teaspoon powder) twice daily are recommended. For anyone whose has compromised health situation, GI or digestive health issues, auto-immune conditions, inflammatory conditions, cancer, heart disease, is recovering from an injury, wants to get rid of allergies, or detects a cold or flu coming on, 4 capsules (1 tablespoon powder) twice a day are recommended. For athletic use and anti-aging, 10-20 grams daily optimizes growth hormone levels which translates to 2 heaping tablespoons of powder twice a day. The dosage can then be lessened to a maintenance level as long as it continues to produce results. Colostrum has a sixteen hour half-life. It should be taken twice a day on an empty stomach with a full glass of water. Colostrum's benefits are cumulative. The longer and more consistent the use, the greater the benefits. Most people feel better right away, yet about one in five first-time users experience a detox event or "healing crisis," consisting of flu-like symptoms such as fatigue, nausea, diarrhea, headache coughing up phlegm, skin rashes and low-grade fever. These are called Herxheimer reactions and typically last only a couple of days. The body is ridding itself of long-accumulated toxins, locked in the body's tissues and fat deposits that have suppressed the immune system and encouraged disease. This is normal, and not a reason to stop taking colostrum. You should reduce your dosage to a minimum amount (one capsule per day, or 1/2 teaspoon) until the body adjusts, and then increase your dosage as desired to achieve optimal results. Colostrum is not just for adults, and remarkable results have been observed in infants and children. Colostrum's test is in the undeniable health of children who receive colostrum and breast milk from their mothers. These children experience less illness, increased mental acuity and have stronger, more vibrant growth. If infants are not breastfed or not breastfed for at least two years, colostrum supplementation is an option. Because children have a tendency to catch colds and illness from peers in daycare and school, colostrum supplementation in these situations will help immensely. Colostrum powder tastes great and is advisable for children who are unable to swallow colostrum capsules. We can't forget our beloved pets. Veterinary use of bovine colostrum with aging and/or ailing animals (mammals) has proven to be very beneficial. Its ability to halt disease is well documented; aging pets with arthritis or joint problems are particularly responsive to colostrum. And most pets love the taste of colostrum. It’s important for each one of us to take responsibility for our own health. Like the “Sovereign” in our company name, we believe in individuals taking “sovereign” charge of their health and well-being. If you are convinced by claims, testimonials, or even research stating that a product will stop disease, you must make certain that there is also supporting research showing that the product does not destroy body tissue, interact with other drugs or supplements, or create harmful side effects in the process. Colostrum-LD® is the only clinically proven substance which heals and prevents Leaky Gut Syndrome and does not cause harm to the body.   Effectiveness of Colostrum This depends on its quality and how it is processed! Research has shown that colostrum which is water-soluble is more easily assimilated. If you are taking colostrum which is only partially soluble, you will not get the full benefits. Colostrum which has been frozen cannot be made water soluble and it must be specially micronized in order to be soluble. Simply empty a capsule into a glass of water, cover and shake. It should dissolve quickly. Tests on several different brands of colostrum have shown that colostrum processed with excessive heat will lose most of its biological activity. This is especially true of colostrum tablets. The heat generated when tablets are formed is so high that it severely compromises colostrum's efficacy. Colostrum that comes from pasture fed herds, who eat healthy green grass produce better milk and colostrum than cows that are fed processed foods. It is also very important that colostrum is standardized by taking it from large numbers of healthy cows. This insures the maximum possible amount of immune factors. Colostrum that is not standardized should be avoided. Some colostrum is manipulated to boost immunoglobulin levels. Recent research, however, has shown that higher percentages of immunoglobulin actually diminish colostrum's effectiveness in combating infection. Therefore, our conclusion is that the most effective colostrum is that which is gently processed, but otherwise left with the balance of its immune and growth factors as nature intended. Let the Buyer Beware! Not all colostrum is processed in accordance with these strict guidelines. Currently no standards exist for the collection and processing of colostrum. Some colostrum contains inexpensive "filler" products such as whey by-products, which severely reduce its effectiveness. Also, if the colostrum is not collected during the first 24 hours after the birth of the calf, it will be missing many of the important growth factors. To help you assess different brands of colostrum, below is a summary of the standard you should look for in high quality colostrum: It should be full water-soluble. It should come only from certified healthy, grade A diary cows (after the needs of the calf are met). It should be collected only from the first milking after the second birth, to ensure maximum biological activity. It should come only from cows which are pasture-fed, and certified to be hormone, pesticide and antibiotic free. It should be filtered and homogenized to break down the long-chain proteins (immunoglobulins) for better assimilation. It should be mixed with the colostrum from thousands of other cows to standardize and maximize the immune factors. It should be processed to remove excess, unwanted fat, and dried with added heat. This process is significantly more costly and time-consuming than regular high-temperature processing. It should be laboratory tested for E.Coli, salmonella, pesticides, heavy metals, antibiotics, other pathogens, a verification of high platelet count (a sign of active "friendly" intestinal bacteria) and immunoglobulin content. There are only a few producers of bovine colostrum which meet the above standards. Read labels carefully and investigate the company. Another way to find a high-quality colostrum is to contact the Center for Nutritional Research (CNR), www.icnr.org, an independent, non-profit research organization. The CNR can provide, free of charge, a list of manufacturers whose colostrum meets our guidelines. Disclaimer: sovereignlaboratories.com is an independent distributor for Sovereign Laboratories, LLC The statements contained in this site have not been evaluated by the Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. The statements contained herein are for informational purposes only, and are not meant to replace the services or recommendations of a physician or qualified health care practitioner. Those with health problems, or who are pregnant or nursing, are specifically advised that they should consult their physician before taking these or any nutritional supplements.