Arthur Andrew Medical Serretia 180caps (250,000 SPU's) (Arthur Andrew Medical) (serrapeptase supplement)
Rating:   (4) 5 out of 5 stars
£88.00
Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*
HCP Formulas Fibrenza Systemic Enzymes 500mg (240caps)
Rating:   (7) 4.9 out of 5 stars
£92.99
Fibrin Defense Detoxification Cardiovascular Support AcidDefenz Time Release Capsule Enzymes are required for all living functions, including eating, breathing, and sleeping. The body produces its own enzymes to support these functions. As we age, the bodies’ ability to produce sufficient levels of enzymes to maintain optimal health significantly decreases. Insufficient levels of enzymes may lead to excess fibrin buildup, impurities in the cardiovascular system, fatigue, and other symptoms of chronic illness. Fibrenza is a powerful advanced blend of 14 powerful systemic enzymes that are specifically formulated to supplement the bodies’ ability to dissolve fibrin, cleanse the blood, and detoxify the body. Fibrenza has been formulated to provide maximum body-wide benefit. This means only the highest quality pharmaceutical grade enzymes are utilized. Fibrenza utilizes AcidDefenz capsule technology that allows the enzymes to withstand harsh stomach acids, providing maximum systemic benefit. Suggested Use: Adults take 2 capsules twice daily on an empty stomach (at least 45 minutes before or 60 minutes after meals) with water or as recommended by your healthcare provider.     Ingredients:   SUPPLEMENT FACTSServing size: 2 CapsulesServings per Container: 120   AmountPer Serving % Daily Value Proprietary Enzyme Blend 1000 mg *    Protease    Superoxide Dismutase (SOD)    Nattokinase NSK-SD    Pancreatin 8X    Trypsin    Peptidase    Acid Stable Protease    Amylase    Seaprose S    Papain    Lipase    Chymotrypsin * Daily Value Not Established Percent Daily Values are based on a 2,000 calorie diet. Other Ingredients: Cellulose (Vegetable Capsules), Rice Bran, Rice Extract Does NOT contain: phthalates, maltodextrin, dairy, wheat, yeast, gluten, fish, magnesium stearate, talc, artificial colors or flavors. Non-GMO Warning: As with any dietary supplement, consult your healthcare provider before using this product, especially if you are pregnant, nursing, or are taking medication.
Arthur Andrew Medical Serretia 90caps (250,000 SPU's) (Arthur Andrew Medical) (serrapeptase supplement)
Rating:   (1) 5 out of 5 stars
£48.00
Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*
AST Enzymes AST Enzymes Serracor-NK 300caps
Rating:   (4) 4.8 out of 5 stars
£110.99
Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.
AST Enzymes AST Enzymes Serrapeptase 120 caps (80,000 SU)
Rating:   (5) 5 out of 5 stars
£39.99
Peptizyme-SP Enteric Coated Serrapeptase The Problem with Pain Systemic enzymes are a key to a healthy lifestyle. Processed food, exposure to environmental toxins and occasional illness cause the body to use up these enzymes, forcing it to work even harder to synthesize these enzymes and use them in the many complex reactions that take place every moment in our bodies.  Many people reach for NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen and naproxen to address pain and inflammation.  They are effective but come with serious side effects such as gastric bleeding, joint/cartilage damage, disrupted metabolism, increased blood sugar, loss of bone and emotional disorders, among others. In July 1998, The American Journal of Medicine stated the following about NSAID-related gastrointestinal and metabolic complications: “Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) complications and at least 16,500 NSAID-related deaths occur each year among arthritis patients alone. The figures of all NSAID users would be overwhelming, yet the scope of this problem is generally under-appreciated.” An all-natural systemic enzyme, serrapeptase is a biocatalyst which stimulates and modulates the body’s own intrinsic capacity to recover from injury—with hardly any side effects. Peptizyme-SP for Healthy Fibrin Metabolism Peptizyme-SP®(serrapeptase) is a powerful systemic enzyme that supports the body's response to inflammation and the respiratory and sinus systems. Providing 80,000 SU (serrapeptase units) of activity per capsule, Peptizyme-SP is unrivaled among products of its kind. Serrapeptase – also known by serrapeptidase, serratiopeptidase and serratia peptidase - is a powerful proteolytic enzyme derived from a species of bacteria originally found in the intestine of silkworms. The bacterium, Serratia mercesans, produces the enzyme serrapeptase to enable the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Don’t worry – no worms were harmed in the making of Peptizyme-SP. Serratia is now grown in cultures to produce serrapeptase by fermentation. Peptizyme SP supports our body's systems with the bio-energetic charge of enzymes to help them operate optimally, and address issues such as inflammation, excessive mucus in the respiratory and sinus systems and fibrin build-up. Serrapeptase has the unique ability to digest non-living tissue that is a by-product of the healing response without harming living tissue. Fibrin is a tough protein arranged in long fibrous chains.  It is formed from fibrinogen, a soluble protein produced by the liver and found in blood plasma.  Fibrin tends to form circulating complexes that create barriers against the absorption of healing nutrients in and around areas of inflammation.  Numerous research and clinical studies have demonstrated serrapeptase has anti-inflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. This unique activity of Peptizyme SP’s enteric-coated serrapeptase supports normal fibrin metabolism, blood viscosity and blood flow. Serrapeptase supports healthy inflammatory response by reducing metabolic inflammation, usually an asymptomatic inflammatory process in response to stress, improper nutrition and other environmental issues. In addition, there is evidence of inhibition of C-reactive protein, a marker of inflammation that has been linked to cardiovascular health.* How do SU’s relate to IU’s? Enzyme activity is often measured through a FCC (Food Chemicals Codex) or USP (United States Pharmacopeia) assays and is denoted by IU, or international unit. Some enzymes don’t have a standard FCC or USP assay, such as serrapeptase. However, Japanese Pharmacopeia (JP) has established an activity assay specific for serrapeptase, which measures activity in SU, or serrapeptase unit. You may see IU or SU used interchangeably on different serrapeptase products. While we do not know what sort of assays other companies use to test their enzymes, you can still compare the activity level on a one-to-one basis. So 80,000 IU is 80,000 SU, but SU is specific to serrapeptase. Unlike other supplements, the weight (mg) of an enzyme supplement carries no significance. It is not the amount but the potency, or activity, of the enzyme that really matters. Guaranteeing the ingredients are available to the body is more important than how much of the ingredient is listed on a supplement label. Peptizyme SP Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule two times a day. After three days, increase your Peptizyme dosage to 2 capsules two times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules two times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules two times a day. Peptizyme-SP can be used along with other systemic enzyme blends such as Exclzyme or Serracor-NK to enhance fibrinolytic activity, as well as increase positive effects on inflammation and reduce mucus viscosity in the respiratory system.* Peptizyme-SP vs. Serrétia** Brand Methacrylic Acid Copolymer (MAAC) Acid Armor®**(extra-thickcellulose layer) Considered Enteric Coating? Enzyme Stabilizer BPPS® Price per bottle Serrétia(formerly Serracel) -- Yes No Unknown $99.99 for180 capsules Peptizyme-SP Yes -- Yes Yes $39.98 for120 capsules     Enteric-Coated Serrapeptase Peptizyme-SP® brand serrapeptase is enteric coated to survive the acidic conditions of the stomach without being degraded. This allows for optimum absorption in the small intestine and greater systemic activity. The pH resistant enteric coating disintegrates after it enters the alkaline environment of the intestine. Most serrapeptase brands on the market are not enteric coated, which means this low-pH sensitive enzyme can lose activity, and thus effectiveness, when entering the stomach. The enteric coating in Peptizyme SP allows the enzymes to survive the acidic conditions of the stomach, which increases absorption in the small intestine, systemic activity and efficacy.   ** Serrétia™ and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Serrapeptase has been thoroughly researched for its numerous and diverse effects on inflammation, pain, infection and healing. Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1 A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing inflammation in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2 A prospective study was conducted on the effect of serrapeptase on post-operative swelling and pain of the ankle. In the serrapeptase group, the swelling decreased by 50% on the third post-operative day, while in the control groups (no treatment and treatment with ice) no reduction in swelling occurred. A decrease in pain correlated for the most part with the reduction in swelling. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of ice.3 The efficacy of serrapeptase was evaluated in a multicenter, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation.4 Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.5 An unusual clinical trial evaluated the effectiveness of serratiopeptidase in the eradication of a periprosthetic infection (an infection at the site of an implanted orthopedic device) in an in vivo animal model. Infections of slime-forming bacteria are especially difficult at these sites. Rats were inoculated with Staphylococcus epidermidis at the prosthetic site. After two weeks, infection persisted in 63.2% of animals in the no-treatment group; 37.5% of animals in an antibiotic-only group; and only 5.6% of animals in the serratiopeptidase-and-antibiotic group. The authors conclude that serratiopeptidase was effective at eradicating infection in this experimental animal model and may enhance antibiotic efficacy in the treatment of staphylococcal infections.6   References1.   Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000 Nov;48(11):1130.2.   Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb;30(1):48-54.3.   Gerngross H, Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study(German). Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2. Esch PM,4.   Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.J Int Med Res. 1990; 18(5):379-88.5.   Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep;8(3):316-20.6.   Mecikoglu M, Saygi B, Yildirim Y, Karadag-Saygi E, Ramadan SS, Esemenli T.The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection. J Bone Joint Surg Am. 2006 Jun;88(6):1208-14. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Peptizyme-SP on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Peptizyme-SP with food will compromise their absorption, as well as their effectiveness.   Does Peptizyme-SP have an enteric coating? Yes, the serrapeptase in Peptizyme-SP is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please see our “Compare” tab.   How long should I take Peptizyme-SP before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After one week of proven tolerance, the dose can be increased to a therapeutic dose of 2 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 6 to 9 capsules per day, while others only need 2 to 3. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Are there any side effects involved with Peptizyme-SP? The use of Peptizyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Peptizyme-SP with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products Peptizyme-SP and Serracor-NK often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Peptizyme-SP with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Peptizyme-SP  – Enteric Coated Serrapeptase ~ 80,000 SU’s of Activity Per Capsule ~ Peptizyme-SP® is a potent and purified strain of Serrapeptase, also called Serratiopeptidase.  Supplement Facts Serving Size: 1 CapsuleServings Per Container: 60 Amount Per Serving:                           % DV Peptizyme-SP®                         500 mg *Enteric Coated Serrapeptase     80,000 SU’s *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules twice a day on an empty stomach. Take capsules at least 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.
AST Enzymes AST Enzymes Serracor-NK 150caps
Rating:   (3) 4.7 out of 5 stars
£65.99
Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.
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HCP Formulas Fibrenza Systemic Enzymes 500mg (60caps)
Rating:   (2) 4.5 out of 5 stars
£33.99
Fibrin Defense Detoxification Cardiovascular Support AcidDefenz Time Release Capsule Enzymes are required for all living functions, including eating, breathing, and sleeping. The body produces its own enzymes to support these functions. As we age, the bodies’ ability to produce sufficient levels of enzymes to maintain optimal health significantly decreases. Insufficient levels of enzymes may lead to excess fibrin buildup, impurities in the cardiovascular system, fatigue, and other symptoms of chronic illness. Fibrenza is a powerful advanced blend of 14 powerful systemic enzymes that are specifically formulated to supplement the bodies’ ability to dissolve fibrin, cleanse the blood, and detoxify the body. Fibrenza has been formulated to provide maximum body-wide benefit. This means only the highest quality pharmaceutical grade enzymes are utilized. Fibrenza utilizes AcidDefenz capsule technology that allows the enzymes to withstand harsh stomach acids, providing maximum systemic benefit. Suggested Use: Adults take 2 capsules twice daily on an empty stomach (at least 45 minutes before or 60 minutes after meals) with water or as recommended by your healthcare provider.   Ingredients:   SUPPLEMENT FACTSServing size: 2 CapsulesServings per Container: 30   AmountPer Serving % Daily Value Proprietary Enzyme Blend 1000 mg *    Protease    Superoxide Dismutase (SOD)    Nattokinase NSK-SD    Pancreatin 8X    Trypsin    Peptidase    Acid Stable Protease    Amylase    Seaprose S    Papain    Lipase    Chymotrypsin * Daily Value Not Established Percent Daily Values are based on a 2,000 calorie diet. Other Ingredients: Cellulose (Vegetable Capsules), Rice Bran, Rice Extract Does NOT contain: phthalates, maltodextrin, dairy, wheat, yeast, gluten, fish, magnesium stearate, talc, artificial colors or flavors. Non-GMO Warning: As with any dietary supplement, consult your healthcare provider before using this product, especially if you are pregnant, nursing, or are taking medication.
Arthur Andrew Medical Serretia 60caps (250,000 SPU's) (Arthur Andrew Medical) (serrapeptase supplement)
£42.00
Serretia is an incredibly potent pure serrapeptase product. Serretia is rated at 250,000 SPU's per dose. Did you know Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? Serretia is an excellent choice for promoting healthy sinus activity during cold and flu season. Serretia is also the perfect addition to ice to support a normal inflammatory response after sports injuries and invasive procedures. This amazing enzyme is an excellent complement to Neprinol, boosting its ability to reduce occasional discomfort and aiding in normal recovery times.* Originally discovered in the intestine of silkworms, the proteolytic enzyme Serrapeptase is harnessed by Arthur Andrew Medical through the isolation of the microorganism, Serratia E-15. Serrapeptase’s inherent ability to digest dead tissue enables the enzyme to successfully aid in supporting normal scar tissue, normal blood clotting, and allows for more fluid and natural blood flow throughout the body.* Serrétia has a variety of different benefits that may help with the following: Sport injuries* Promote healthy sinus activity* Promote free joint mobility* Muscle tears and pulls* Surgical recovery* Normal fluid retention such as swelling* Potent fibrinolytic activity* Promotes recovery after physical stress* Boosts energy levels* Promotes lean body mass* Suggested Use Directions: Take 2 capsules with 8 oz of water on an empty stomach or as directed by your healthcare practitioner. Maintenance: 2 capsules 1 time per day. Immune Building: 2 capsules 2 times per day. Long Term Immune Support: 2 capsules 3 times per day. Short Term Immune Support: 3 Capsules 3 times per day. Serrétia is an excellent complementary product to any Neprinol or Syntol regimen.* Warning: Do not take Serretia without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.* Is Serrétia safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Serretia.* Supplement Facts Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Serrapeptase 250,000 SPU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Acid Armor™ Capsules) Serretia™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Serrapeptase may thin the blood. Consult your physician if you are currently taking anticoagulants Frequently Asked Questions What is Serretia? Serretia is comprised of 99.99% pure Serratiopeptidase, more commonly known as Serrapeptase. Serrapeptase is a proteolytic enzyme originally discovered in the intestine of silkworms, and is produced by Arthur Andrew Medical through the isolation of the microorganism Serratia E-15. In Japan, Serrapeptase is commonly prescribed as a drug, but here in the US we can experience serrapeptase and all of its wonderful benefits without a prescription.* How Does Serretia Work? Taken on an empty stomach, Serrapeptase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Serrapeptase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to support normal recovery times and support healthy circulation.* Why Should I Take Serretia? Serrapeptase has a variety of benefits, and has been found to successfully aid in the breakdown of scar tissue, cysts, blood clots, and plaque. Serrétia may help to improve recovery after sports injuries or surgery, muscle tears and pulls, sinus activity, joint mobility and fluid retention. Like other proteolytic enzymes, Serrapeptase serves as a healthy choice without the risking detrimental effects on various organs, including the liver and kidneys.* Can I Take Too Much Serrapeptase? Although Serretia contains highly potent Serrapeptase, it can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Serrapeptase. However, it is important to follow dosaging instructions unless otherwise directed by your healthcare provider.* Is Serretia Enteric Coated? Instead of using any type of enteric-coated serrapeptase, the serrapeptase supplement Serrétia uses a different technology known as Acid Armor. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps). Acid Armor capsules have a better-designed way of fitting the two sides of the capsules together, which limits leaking. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.* When is the best time to take Serretia? For best results, take the product at least one hour prior to eating and/or two hours after a meal.* Can I take Serrétia with other supplements? Serretia can be used safely with other dietary supplements. In fact, it is recommended that it be taken in conjunction with Neprinol or Syntol for additional proteolytic and fibrinolytic support.* How long does it take for Serretia to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Serrapeptase has been shown to support normal scar tissue formation, normal blood clotting and allows for more fluid and natural blood flow throughout the body. These effects are typically noticed within a very short time frame, though the other benefits of taking Serrétia on a regular basis are boundless and will progress with time.*