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PhosChol is the Gold Standard in pharmaceutical grade PPC (polyenylphosphatidylcholine). It is the only 100 percent purified source of PPC and delivers the highest concentration of 1,2 DLPC. DLPC is the molecule that is both quantitatively and qualitatively responsible for the the superior therapeutic effects of PPC. No other products compare. PhosChol is the holistic and physiological way to optimal health and wellness Doctor Recommended PhosChol is 100 percent pure polyenylphosphatidylcholine (PPC), with up to 52% DLPC. In fact, PhosChol delivers the highest available concentrated source of dilinoleoylphosphatidylcholine (DLPC). No other product can compare. We encourage you to take the time to learn about PhosChol and discover why PhosChol may be just what your body needs. We recommend speaking with your doctor about the many health benefits of PhosChol and to determine if PhosChol is right for you. If you are seeking a safe and proven alternative than PhosChol may be what you are looking for. Your doctor may not know about PhosChol and how it may be able to help you. When speaking with your doctor about PhosChol, we recommend providing them with a copy of the PhosChol brochure. You can download a copy of the PhosChol brochure or request a brochure be sent to you. Most doctors who learn about PhosChol, usually prescribe it to their patients! Over 100 million daily doses have been sold worldwide, with no known side effects, contraindications, or interactions. PhosChol is trusted even with long-term use. PhosChol is a 100 percent pure source of polyenylphosphatidylcholine (PPC) and an oral therapy for use as a membrane therapeutic. With its special ingredient 1,2-dilinoleoylphosphatidylcholine (up to 52%), PPC is theoretically of importance in all disorders in which damaged membrane structures, reduced phospholipid levels and/or decreased membrane fluidity are present. This hypothesis is supported by experimental and clinical investigations on various membrane-associated disorders and illnesses. Pharmacological investigations, a broad range of clinical trials, and other available data on PPC and its different modes of action, demonstrate that PPC acts primarily through its influence on membranes. As cell membrane changes and damages occur in many disorders, PPC�s therapeutic approach in man is a physiological and holistic one. The Gold Standard -PhosChol is the first and only 100% pure source of Polyenylphosphatidylcholine (PPC). -PhosChol delivers 900mg of purified PPC per softgel capsule, and 3 grams of purified PPC per measured teaspoon of liquid concentrate. -PhosChol delivers more than seven times the PPC content of any other store brand. -PhosChol contains up to 52% DLPC. -PhosChol may enhance cell membrane related physiological processes. -PhosChol is bio-available (greater than 90% absorption), and contains no other phosphatides that compete for absorption. -PhosChol is safe and clinically proven effective. -PhosChol is trusted and recommended by doctors. In numerous studies, purified polyenylphosphatidylcholine (PPC) has been shown to: -Help sustain healthy cardiovascular levels -Support hepatocyte protection -Help maintain membrane fluidity -Aid in Gastric Mucosal Protection (from NSAIDs damage) -Provide neuronutrient support -Boost the immune system and protect against opportunistic infections -Improve Physical Performance PhosChol: A Membrane Therapeutic for Liver Disturbances According to the intensity of exposure to noxae, malnutrition or viruses, liver damage may manifest itself as: -acute and chronic hepatitus -fatty liver -liver cirrhosis -others PPC is a superior protectant against liver damage. Irrespective of the origin, damage to liver cell membranes and to their organelles is generally present in hepatopathies. Metabolic functions of the liver cell and the activity of enzymes bound to membranes are inhibited, thus causing the clinical picture of liver disorders. References: Zierenberg, O. and Grundy, S.M., J. Lipid. Res., 23:1136 (1982). Dargel R. et al., Z. Gastroenteral. 29 (Suppl. 2):18 (1991). Lekim, D. and Betzing, H., Arzneimit Forsch, 2: 1772 (1976). Indovina, J. et al., Epatologica, 27:261 (1981). Navder K. P. and Lieber C. S., Biochem. Biophys. Res. Commun. 291:1109 (2002). M�ting, D. et al., Verh. Dtsch. Ges. innere Med., 78:1389 (1972). Kuntz, H. D. it al., Med. Welt., 29:452 (1978). Chanussot, F. and Benaoel, L., Life Sciences 73:381 (2003). Saratikov A.S. and Vengerovskii A.I., Biull. Eksp. Biol. Med. 127:392 (1999). Alliet, J. et al., L�Quest Medical, 29:85 (1976). Holecek, M. et al., in: Liver and Drugs 1994 edt. by J. Holoman and J. Glasa. Progress in Hepato-Pharmacol. 1:202 (1995). What is PhosChol?PhosChol® is the first and only, all natural, soy-derived 100 percent pure source of polyenylphosphatidylcholine (PPC). PhosChol® is an oral therapy for use as a membrane therapeutic. With its special ingredient 1,2-dilinoleoylphosphatidylcholine (up to 52%) it is theoretically of importance in all areas in which damaged membrane structures, reduced phospholipid levels and/or decreased membrane fluidity are present. This is a hypothesis, which is supported by experimental and clinical investigations on various membrane-associated disorders and illnesses.What is a Phospholipid?PhosChol™ is comprised of pure polyenylphosphatidylcholine, a phospholipid commonly found in soybean lecithin. Chemically speaking, phospholipids are the active component in lecithin. Compared to a typical fat or triglyceride (“Tri”meaning three fatty acids attached) phospholipids normally contain two fatty acids and in place of the third fatty acid they have a phosphorous containing head group. A phospholipid is unique because its fatty acid tails like oil and its head group likes water. When a phospholipid comes in contact with water, it spontaneously forms what is commonly referred to as a bilayer structure. The bilayer functions as the “skin” or “membrane” of living cells and organelles.Another crucial component of a phospholipid is the type of fatty acids attached to it. A phospholipid such as soy-derived polyenylphosphatidylcholine is rich in linoleic and linolenic acid, and polyunsaturated fatty acids that provide “fluidity” to the cell membrane. Maintaining membrane fluidity is crucial, as the membrane is central to the majority of cellular activities.What is PhosChol most used for? Pharmacological investigations, a broad range of clinical trials, and other available data on PPC and its different modes of action, demonstrate that PPC acts primarily through its influence on membranes. As cell membrane changes and damages occur in many disorders, PPC’s therapeutic approach in man is a physiological and holistic one.Purified PPC aids the body in many ways. It is important to remember that PPC is an essential nutrient comprising approximately (65%) of every cell membrane in your body.PhosChol is often recommended to: (among other uses) Help manage and sustain healthy lipid levels Provide neuronutrient support Help to maintain and improve membrane fluidity Support hepatocyte protection, function and regeneration Aid in Gastric Mucosa Protection – “Leaky Gut Syndrome” brought on by the use of NSAIDs, Non Steroidal Anti Inflammatory Drugs like Ibuprofen and Naproxen Boost immune system strength Purified PPC is commonly used for:Acute and chronic hepatitis; cirrhosis; intoxications; fatty degeneration of the liver of any origin; cholestasis; prophylaxis of gallstone formation; radiation syndrome; pre-and postoperative care, especially in liver/gallbladder surgery; dyslipoproteinemia (hypercholesterolemia, hypertriglyceridemia and hypoalphalipoproteinemia); atherosclerosis; coronary, cerebral, and peripheral circulatory disturbances; angina pectoris; condition following myocardial infarction, and apoplexy; hypertension due to sclerosis; vascular diseases, especially in diabetes mellitus; nephritic syndrome; pre-operative treatment for the prevention of thrombo-embolism.Is PhosChol safe and are there any potential side effects?From the toxicological investigations, from safety pharmacology, and from the general pharmacodynamic effects of PPC (the active substance in PhosChol) it is evident that this extract is safe and non-toxic.In over fifty years of use, and in thousands of animal and clinical studies, PPC has been proven safe and reliable.Over 30 million daily doses of PhosChol have been sold worldwide, and according to a rough estimation a total of 350 million daily doses of PPC (used in a similar European product) were sold in Germany between 1954 and 2000 and approximately 600 million daily doses globally.No manifestations of intoxication or overdosing have been reported. There are neither contraindications nor precautions to be observed in the administration of the preparation.What if I am taking other medications?PhosChol is generally well tolerated and can be taken with other medications. If you are prescribed a medication while taking PhosChol or wish to take PhosChol while on another medication, it is always best, and we strongly recommend that you notify your physician.You can request a brochure to show to your Physician or you can have your physician or primary care giver contact us for any of their informational needs. We will be happy to assist them.Doctors who learn about PhosChol usually recommend it.How much PPC is one dose of PhosChol?PhosChol has a PPC content of 900mg (~1 gram) per softgel capsule, and 3000mg (~3 grams) per teaspoon in the liquid concentrate.Recommended Dosage and AdministrationThe recommended daily dose is 2-3 capsule – once daily, or 2/3 to a 1 full tsp. of liquid concentrate – once daily. To be swallowed whole during meals with a little liquid if required. (PhosChol may be taken on an empty stomach, no irritability has been reported)Is PhosChol safe during Pregnancy?PhosChol is often recommended during pregnancy and post pregnancy. As a nutritional supplement PhosChol is an aid to good health and guards against low blood choline levels. PhosChol provides a preferred source of highly bio-available choline.Because choline is so important in membrane development and repair, it is transported across the placenta from the mother to the fetus by a 1:14 ratio. Similarly, the choline concentration in mother's milk is over 100 times the level in the maternal bloodstream. Thus, the requirement for choline appears to be especially high in women during pregnancy and lactation. Because of the heightened requirement for choline, it is likely that both pregnant and lactating mothers, who are not taking choline supplements, have lower serum choline concentrations than non-pregnant women.Given the role of choline in memory and cognitive function and the diversion of choline from the mother to the fetus, it is speculated that the periodic lapses in memory and mental acuity often experienced by pregnant and lactating mothers may be related to lowered choline levels.Are There any Similar Products like PhosChol Available in the Market?There are no similar products available in North America. PhosChol is the only 100% pure source of PPC available in North America. And, only PhosChol delivers up to 52% dilinoleoylphosphatidylcholine (DLPC). No other product can compare. A product similar to PhosChol has been used in Europe as a pharmaceutical (approved by the Bfarm) for over 50 years. During this time, millions of Europeans and Asians have enjoyed the healthy membrane therapeutic benefits of purified PPC. Discover why so many people have added all natural, 100% pure PhosChol to their daily supplement program.I’ve heard choline in small and in large doses can cause fishy body order – can this happen with PhosChol?PhosChol is an all natural, soy-derived 100% pure source of polyenylphosphatidylcholine (PPC). PhosChol provides the body with a preferred source of bio-available choline and will not cause fish body odor, even at extremely high doses.Other products are either phospholipid complexes or choline salts. The complexes contain only about a third of the PPC in PhosChol. And, the other phospholipids they contain compete with PPC for absorption.Choline salts are processed differently by the body than PPC reducing the actual amount of pure choline available and often resulting in objectionable fishy body odor.PhosChol is a natural alternative to synthetic choline salts and can fulfill the dietary reference or adequate intake (AI) for Choline. And, no energy consuming Polyenylphosphatidylcholine synthesis from choline is necessary.Is PhosChol A Drug?PhosChol® is not a drug. PhosChol is an all natural soy-derived dietary supplement. The United States Food and Drug Administration does not permit Nutrasal to make any claim “to…diagnose, mitigate, treat, cure, or prevent a specific disease or class of diseases,” and no such claim is being made.Is PhosChol GMO Free?The short answer is yes.

Comprehensive Cardiovascular FormulaExceptionally effective, ACC Cardio Extra Strength contains a unique blend of proven cardio-protective ingredients, including L-arginine, CoQ10 (Ubiquinone), Red Yeast Rice, Lycopene, Garlic, Magnesium, Vitamin D3, Vitamin K2 and Cinnamon extract promoting healthy heart muscle, blood pressure, circulation and more. The First L-arginine Intra-oral SpraySay goodbye to messy powders, ACC Cardio is the first cardiovascular formula that features L-arginine and more in a simple to take great tasting spray. Instantly absorbed L-arginine increases nitric oxide levels and has been scientifically proven to help maintain healthy blood pressure, optimize cholesterol levels, blood flow and arterial function Supports Healthy Blood PressureACC Cardio supports enhanced blood flow, blood vessel protection, healthy blood pressure and enhanced large artery elasticity, with highly beneficial vascular effects.* Supports Healthy CholesterolProvides all the benefits of Garlic without the smell or after taste. Garlic has been used extensively throughout history for its many health promoting benefits, including cardiovascular health. There are over 641 study references validating the efficacy of Garlic for enhancing immunity and cardiovascular health by supporting healthy cholesterol levels, blood pressure and more. Clinically Proven ResultsA clinically validated cardiovascular health formula with over 2,000 reference studies citing the ingredients included, many of which are determined essential to maintaining a healthy heart and cardiovascular system. Results are fast acting and safe.* Essential Daily SupportMagnesium is vital to cardiovascular health and is included. A lack of Magnesium has been shown to raise blood pressure, reduce glucose tolerance and cause neural excitation. Dietary deficiency of Magnesium plays an important role in different types of cardiovascular disorders such as ischemic heart disease, congestive heart failure, sudden cardiac death, atheroscelerosis, a number of cardiac arrhythmias and ventricular complications. Anti-inflammatory SupportACC Cardio contains many ingredients with proven anti-inflammatory, antimicrobial, antioxidant, cholesterol-lowering, and immune boosting properties. Advanced Cellular TechnologyACC Cardio delivers the power of each ingredient in the most effective manner possible; achieving maximum results without stomach discomfort or side effects. With Advanced Cellular Technology, ACC Cardio Extra Strength Intra-oral spray is immediately absorbed, simple to take, and has a pleasant taste with a hint of natural mint. Just spray, swish, and swallow. Standard Dose Take 6 sprays by mouth, twice daily. Higher Dose Take 12 sprays by mouth, twice daily. Optimal Use Spray, swish and swallow. You may take other Results RNA formulas immediately. Do not eat or drink for 2 minutes following. Take as recommended by your physician. SERVING SIZE Serving size: 12 SpraysServings Per Container: Approx. 60AMOUNT PER SERVINGProprietary Blend Tincture ~18000 mcg* Ingredients CoQ10 (Ubiquinone), Red Yeast Rice (Monascus purpureus), Lycopene, L-Arginine, Garlic, Magnesium, Vitamin D3 (as Cholacalciferol), Vitamin K2, Cinnamon extract (Cinnamomum cassia), Peppermint Leaf (Mentha x piperita) and Natural Trace Minerals. Other Ingredients: Ultra-Pure Deionized Water * % Daily value not established For Best Results: Take ACC Cardio Extra Strength with ACS 200 and ACZ Nano Extra Strength to achieve optimal cardiovascular support and total body detoxification. RESEARCH AND SUMMARY COMMENTSACC CARDIO EXTRA STRENGTH COENZYME Q10 (UBIQUINONE) 1. Overview of the use of CoQ10 in cardiovascular disease. The clinical experience in cardiology with CoQ10 includes studies on congestive heart failure, ischemic heart disease, hypertensive heart disease, diastolic dysfunction of the left ventricle, and reperfusion injury as it relates to coronary artery bypass graft surgery. Supplemental CoQ10 alters the natural history of cardiovascular illnesses and has the potential for prevention of cardiovascular disease through the inhibition of LDL cholesterol oxidation and by the maintenance of optimal cellular and mitochondrial function throughout the ravages of time and internal and external stresses.Takeaway: • Supplementation with CoQ10 (Ubiquinone) has deep history with regard to cardiovascular disease. Its primary benefits relate to inhibition of LDL cholesterol oxidation and by the maintenance of optimal cellular and mitochondrial function. 2. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Coenzyme Q10 (ubiquinone) is a mitochondrial coenzyme which is essential for the production of ATP. Being at the core of cellular energy processes it assumes importance in cells with high energy requirements like the cardiac cells which are extremely sensitive to CoQ10 deficiency produced by cardiac diseases. CoQ10 has thus a potential role for prevention and treatment of heart ailments by improving cellular bioenergetics. In addition it has an antioxidant, a free radical scavenging and a vasodilator effect which may be helpful in these conditions. It inhibits LDL oxidation and thus the progression of atherosclerosis.Takeaway: • Verification of CoQ10’s importance to heart health, with additional insights, which speak to its benefits as an antioxidant, free radical scavenger and CoQ10’s vasodilating effect, all of which contribute to the inhibition of LDL oxidation and progression of atherosclerosis. RED YEAST RICE (MONASCUS PUREPUREUS) 3. The effect of red yeast rice (Monascus purpureus) in dyslipidemia and other disorders. Red Yeast Rice (RYR) is a traditional Chinese food that is fermented and obtained after red yeast (Monascus purpureus) is grown on rice. RYR contains Monacolin K (Lovastatin) and other active ingredients that are thought to play a role in the management of cholesterol levels. Recently, many clinical trials have focused on the uses of RYR, including for dyslipidemia, coronary heart disease, diabetes, osteoporosis, cancer, non-alcoholic fatty liver disease, fatigue, and memory. The primary objective of this review is to evaluate the effectiveness of RYR on the management of dyslipidemia. Studies reviewed show that RYR significantly lowered LDL cholesterol and total cholesterol. Effects on triglycerides and HDL cholesterol were also observed in some studies. Compared with statins, RYR was shown to have an equal efficacy to statins when combined with or without other dietary supplements. RYR also appeared to be superior to placebo in preventing nonfatal myocardial infarction, total coronary heart disease events, and total deaths.Takeaway: • Red Yeast Rice has a long history with regard to its use for CVD. The specific focus and strongest evidence points to its use for the management of dyslipidemia.Lycopene 4. Lycopene Deficiency in Ageing and Cardiovascular Disease. The recent body of evidence suggests that plasma concentration of lycopene is not only a function of intestinal absorption rate but also lycopene breakdown via enzymatic and oxidative pathways in blood and tissues. Oxidative stress and the accumulation of reactive oxygen species and nitric oxide may represent a major cause of lycopene depletion in ageing, cardiovascular disease, and type 2 diabetes mellitus. It has been shown recently that low carotenoid levels, and especially decreased serum lycopene levels, are strongly predictive of all-cause mortality and poor outcomes of cardiovascular disease. Hence, it is very unlikely that nutritional intervention alone could be instrumental in the correction of lycopene and carotenoid deficiency. Therefore, new nutraceutical formulations of carotenoids with enhanced bioavailability are urgently needed.Takeaway: • Given the relationship between serum lycopene levels and cardiovascular disease outcomes, it is important to introduce supplemental Lycopene given that levels typically decline with aging. 5. Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. The management of overweight subjects by interventions aimed at reducing inflammation is highly desirable. To date, observational studies have identified a link between increased dietary antioxidant intake and reduced cardiovascular morbidity. However, direct trial evidence regarding the ability of antioxidants to influence inflammation is lacking. Therefore, this study examined lycopene’s ability to lower systemic and high-density lipoprotein (HDL)-associated inflammation in moderately overweight middle-aged subjects. These results demonstrate that in moderately overweight, middle-aged subjects, increasing lycopene intake leads to changes to HDL(2&3), which we suggest enhanced their antiatherogenic properties.Takeaway: • Lycopene has heart-protective properties given its ability to inhibit atherogenesis (oxidation of LDL). L-ARGININE 6. l-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting PlasmaArginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors. We sought to determine the effects of a low dose of a sustained-release (SR) l-arginine supplement on postprandial endothelial function in healthy overweight adults with cardio metabolic risk factors and to investigate whether this effect may vary by baseline arginine status. In a randomized, double-blind, 2-period crossover, placebo-controlled trial (4-wk treatment, 4-wk washout), we compared the effects of 1.5 g SR-l-arginine 3 times/d (4.5 g/d) with placebo in 33 healthy overweight adults [body mass index (BMI, in kg/m2): 25 to >30] with the hypertriglyceridemic waist (HTW) phenotype [plasma triglycerides > 150 mg/dL; waist circumference > 94 cm (men) or > 80 cm (women)]. Supplementation with low-dose SR-arginine alleviates postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low.Takeaway: • L-Arginine’s benefit here – in this study, low dose arginine offsets postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low GARLIC 7. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. Hypertension affects 30% of adults worldwide. Garlic supplements have shown promise in the treatment of uncontrolled hypertension, and the mechanism of action is biologically plausible. Our trial is the first to assess the effect of aged garlic extract on central blood pressure and arterial stiffness, regarded as important risk factors for cardiovascular morbidity.A total of 88 general practice patients and community members with uncontrolled hypertension completed a double-blind randomized placebo-controlled trial of 12 weeks investigating the effect of daily intake of aged garlic extract (1.2 g containing 1.2 mg S-allylcysteine) or placebo on blood pressure, and secondary outcome measures of central-hemodynamics and other cardiovascular markers, including cholesterol, homocysteine, platelet function, and inflammatory markers. Mean blood pressure was significantly reduced by 5.0±2.1 mmHg (P=0.016) systolic, and in responders by 11.5±1.9 mmHg systolic and 6.3±1.1 mmHg diastolic compared to placebo (P<0.001). Central hemodynamic-measures tended to improve in the garlic group more than in the placebo group, including central blood pressure, central pulse pressure, mean arterial pressure, augmentation pressure, pulse-wave velocity, and arterial stiffness. Our trial suggests that aged garlic extract is effective in reducing peripheral and central blood pressure in a large proportion of patients with uncontrolled hypertension, and has the potential to improve arterial stiffness, inflammation, and other cardiovascular markers in patients with elevated levels. Aged garlic extract was highly tolerable with a high safety profile as a stand-alone or adjunctive antihypertensive treatment.Takeaway: • Garlic’s primary contribution is as a safe and effective means of addressing hypertension. This study also revealed potential, other benefits – improved arterial stiffness, inflammation, and other cardiovascular markers in patients with elevated levels. MAGNESIUM 8. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies We performed a systematic review and meta-analysis to investigate prospective associations of circulating and dietary magnesium with incidence of CVD, IHD, and fatal IHD. Circulating magnesium was significantly associated with a lower risk of CVD, with trends toward a lower risk of IHD and fatal IHD. Dietary magnesium was associated with a significantly lower risk of IHD and showed a nonlinear association with fatal IHD. Note: It is estimated that 70%-80% of consumers are not meeting their recommended intakes of magnesium.Takeaway: • Given the established relationship between magnesium and CVD, and the data suggesting a nationwide deficiency, magnesium supplementation is recommended for those at risk as well as healthy subjects. VITAMIN D3 9. LOW VITAMIN D STATUS: A CONTRIBUTING FACTOR IN THE PATHOGENESIS OF CONGESTIVE HEART FAILURE? This study was designed to evaluate the association between vitamin D status and congestive heart failure (CHF). Both groups of CHF patients had markedly increased serum levels of NT-proANP (p < 0.001), increased serum phosphorus levels (p < 0.001), and reduced circulating levels of both 25-hydroxyvitamin D (p < 0.001) and calcitriol (p < 0.001). The low vitamin D status can explain alterations in mineral metabolism as well as myocardial dysfunction in the CHF patients, and it may therefore be a contributing factor in the pathogenesis of CHF. Takeaway: • This study raises the question and provides evidence that reduced levels of vitamin D may be related to CHF. VITAMIN K2 10. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. In contrast, vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls. Vitamin K, particularly as vitamin K2, is nearly nonexistent in junk food, with little being consumed even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could be a means of lowering calcium-associated health risks. Takeaway: • Increased intake of vitamin K2 could be a viable means of reducing calcium – associated health risks, specifically CVD. CINNAMON EXTRACT (CINAMOMUM CASIA) 11. Cinnamon and its Components Suppress Vascular Smooth Muscle Cell Proliferation by Up-Regulating Cyclin-Dependent Kinase Inhibitors. Cinnamomum cassia bark has been used in traditional herbal medicine to treat a variety of cardiovascular diseases. However, the anti-proliferative effect of cinnamon extract on vascular smooth muscle cells (VSMCs) and the corresponding restenosis has not been explored. Hence, after examining the effect of cinnamon extract on VSMC proliferation, we investigated the possible involvement of signal transduction pathways associated with early signal and cell cycle analysis, including regulatory proteins. Cinnamon extract inhibited platelet-derived growth factor (PDGF)-BB-induced VSMC proliferation and suppressed the PDGF-stimulated early signal transduction. In addition, cinnamon extract arrested the cell cycle and inhibited positive regulatory proteins. Correspondingly, the protein levels of p21 and p27 not only were increased in the presence of cinnamon extract, also the expression of proliferating cell nuclear antigen (PCNA) was inhibited by cinnamon extract. Besides, among the components of cinnamon extract, cinnamic acid (CA), eugenol (EG) and cinnamyl alcohol significantly inhibited the VSMC proliferation. Overall, the present study demonstrates that cinnamon extract inhibited the PDGF-BB-induced proliferation of VSMCs through a G0/G1 arrest, which down-regulated the expression of cell cycle positive regulatory proteins by up-regulating p21 and p27 expression.Takeaway:The ability of Cinnamon extract to inhibit proliferation of VSMCs is a key factor in preventing atherosclerosis. Citation links:1. https://www.ncbi.nlm.nih.gov/pubmed/104160412. https://www.ncbi.nlm.nih.gov/pubmed/196382843. https://www.ncbi.nlm.nih.gov/pubmed/231313804. https://www.ncbi.nlm.nih.gov/pubmed/268810235. https://www.ncbi.nlm.nih.gov/pubmed/228195556. https://www.ncbi.nlm.nih.gov/pubmed/272818007. https://www.ncbi.nlm.nih.gov/pubmed/268698118. http://ajcn.nutrition.org/content/98/1/160.full#ref-19. https://www.ncbi.nlm.nih.gov/pubmed/12570952?dopt=Abstract10. https://www.ncbi.nlm.nih.gov/pubmed/2677012911. https://www.ncbi.nlm.nih.gov/pubmed/26119954

Soothing and EffectiveACS Silver-Glutathione Gel provides significant relief from eczema, sunburn, burns, cuts, scrapes, rashes and more for enhanced healing and discernable relief. Zero Side EffectsOther topical creams and ointments can actually damage the skin. ACS Silver-Glutathione Gel Extra Strength provides effective healing and topical relief without harmful chemicals or side effects. The First and OnlyCan be applied to both face and body. Contains Advanced Cellular Silver, Advanced Cellular Glutathione in a topical gel. Superior Silver Superior GlutathionePowered by the same patented technology as ACS 200 Extra Strength and ACG Glutathione Extra Strength. Independent StudiesView complete studies here Practitioner EndorsedACS 200 Extra Strength is prescribed by doctors in over 15 countries. Recommended Topical Applications 1 Abrasions2 Acne3 Age spots4 Anal irritation5 Athletes foot6 Bed bug bites7 Bee stings8 Blisters9 Body odor10 Broken skin11 Bruises12 Bug bites13 Burns14 Candidiasis15 Cat scratches16 Cellulitis17 Chaffing18 Cracked lips19 Cracked skin20 Cuts21 Dandruff22 Decubitus Ulcers (pressure ulcers)23 Diaper rash24 Dog bites25 Dry cracked heels26 Dry skin27 Eczema28 Edema29 Foot odor30 Fungal nail infection31 Genital irritation32 Gym burn33 Hemorrhoids34 Hives35 Infected wounds36 Jock itch37 lascerations38 Mosquito bites39 MRSA skin infection40 Nasal boils or zits41 Nasal skin irritation42 Nipple irritation43 Peeling skin44 Pierce hole redness / irritation45 Poison Ivy irritation46 Post dermal scrub 47 Post laser treatment48 Post plastic surgery49 Post tattoo50 Post-intercourse irritation51 Post-shaving irritation52 Post-sliver removal irritation53 Post-surgery skin infections54 Post-surgery skin sutures / stitches55 Post-surgery wounds56 Pre-surgery skin treatment57 Redness58 Rosacea59 Rug burn60 Runner thigh chaffing61 Sagging skin under eyes62 Scalp irritation63 Scarring64 Scrapes65 Scratches66 Shingles sores67 Skin allergies68 Skin transplant69 Skin ulcers70 Spider bites71 Sports irritated hands or feet72 Stinging nettle irritation73 Stretch marks74 Sunburn75 Sunspots76 Toe fungus77 Underarm itch78 Vaginal irritation79 Warts80 Wind chapping81 Wounds82 Wrinkles   Richard G.FYI, ACS200 is amazing. Best silver product bar none. I’ve been using it for years both internally and external. Last year I treated one of our cats who had a nasty abscess from one of our other cats and when it opened she licked the entire area so much before I was able to put a cone around her head that she wound up with a massive open wound as big as my hand that covered 3/4 of her chest, and under her front leg. There was literally no skin, just exposed muscle. Gruesome injury. Vet couldn’t do much for her. I thought for sure that we’d have to put her down Started her on another brand of silver gel that I could get a hold of right away then ordered the ACS200 gel. That’s what made the difference and when it really healed up fast. Took over 2 months but she healed up 100%. 2 very long months of her not being able to go outside but she made it through. Vet said the fur wouldn’t grow back but I remembered the story about the little dog with the skin disease. Wished I’d kept a picture record of the healing but I only have 1 before shot but people who helped me treat her were astounded. thanks Results RNA you saved Kimba’s life!!* Xavier KeoughI’ve been using this for roughly 8 months and it has changed my life after suffering for 5 years and nearly dying. I never thought it would be as effective as antibiotics but it has been and then some…and without all the dangerous side effects. I’m grateful and pray it continues to work.* Jorge L. MorenoWe have had great response to many different types of illnesses/infections using the ACS200 products!* Kathy FlaneryMy daughter used it for new stretch marks and it’s effects were remarkable.* Rita Bradley Taylor PettitIt really works. I will stay on a maintainable dose for the rest of my life. Thank you to all of the brilliant scientist who invented this pure form of silver. * Moji Lavi-KhorramianI am so thankful and beyond happy to have used this prouducts and can honestly say that has changed my life Thank you thank you thank you How lucky and blessed I feel to have found this . It’s worth every penny I rather not eat but use this no matter how little or limited I am financially. Thank you * Nicole PigeaultThe BEST Silver Spray… I always have some in my house 

PURE ENERGY EXTRA STRENGTH Caffeine Free Energy Formula Recommended by Leading Practitioners Worldwide Whether your day requires energies of physical or mental activity, Pure Energy Extra Strength provides powerful nutrients to see you through. Most energy products provide only a temporary lift that you pay for later as your energy levels crash. Pure Energy Extra Strength is a different kind of energy formula. Containing no stimulants of any kind, this unique spray provides focused nutrients that support enhanced Serotonin and Melatonin production. Having increased amounts of these important neurotransmitters in your body is significant. Simply stated, you will have more energy during the day, while enjoying a deeper and more rejuvenating sleep at night. Lacking 16 hour a day energy? Take Pure Energy Extra Strength and awaken every morning feeling refreshed, with energy to outlast the day.  Pure Energy Extra Strength results are fast acting and safe. Pure Energy Extra Strength is not a stimulant and is non-addicting. Significant benefit can be felt within the first few days of product use. Continual use provides increased and continual benefit. Pure Energy Extra Strength has no side effects. Results RNA Intra-oral sprays provide a new age in nutritional supplementation. Enjoy instant absorption and profound efficacy. No more swallowing capsules or pills. Just spray, swish and swallow. Simple and refreshing, Pure Energy Extra Strength has a mild, pleasant taste with a hint of natural mint. Serotonin Facts: Serotonin is a monoamine neurotransmitter. It is found extensively in the gastrointestinal tract of animals, and about 80 to 90 percent of the human body’s total serotonin is located in the enterochromaffin cells in the gut, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic neurons in the central nervous system (CNS) where it has various functions, including the regulation of mood, appetite, sleep, muscle contraction, and some cognitive functions including memory and learning. Melatonin Facts: Melatonin is a naturally occurring hormone found in animals and in some other living organisms. Circulating levels vary in a daily cycle, and melatonin is important in the regulation of the circadian rhythms of several biological functions. Many biological effects of melatonin are produced through activation of melatonin receptors, while others are due to its role as a pervasive and powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA. Standard Dose Take 6 sprays by mouth, twice daily. Higher Dose Take 12 sprays by mouth, twice daily. Optimal Use Spray, swish and swallow. You may take other Results RNA formulas immediately. Do not eat or drink for 2 minutes following. SERVING SIZE Serving size: 6 SpraysServings Per Container: Approx. 60AMOUNT PER SERVINGProprietary Blend Tincture <800 mcg* Ingredients Formula derived using a proprietary selective nutrient extraction process with Peppermint Leaf (Mentha x piperita), Kelp (Laminaria species), Gotu Kola Herb (Centella asiatica), Ashwagandha Root (Withania somnifera), Dandelion Leaf (Taraxacum officinale), Licorice Root (Glycyrrhiza glabra).Other Ingredients: Ultra-Pure Deionized Water Offered in 2 oz Intra-oral Spray * % Daily value not established   For Best Results: Take Pure Energy with ACS 200 and ACZ Nano Extra Strength to achieve optimal energy levels and total body detoxification.

RASH CARE EXTRA STRENGTH Rash Itchy Skin Relief Recommended by Leading Practitioners Worldwide Rash Care Extra Strength provides significant relief. Most rash products are topical applications, treating the rash as the root problem, instead of the rash as the symptom of the problem. Toxicity must be treated from the inside out, not the outside in. Cleanse the body of toxins from the inside, and provide significant relief to the skin on the outside. Combine Rash Care Extra Strength with ACS 200 Extra Strength and ACZ Nano Extra Strength for a comprehensive detoxification and rash elimination protocol.  Rash Care Extra Strength results are fast acting and safe. Usually significant benefit can be felt within the first few weeks of product use. Continual use provides increased and continual benefit. Rash Care Extra Strength is a natural, herb-derived formula and has no side effects. Results RNA Intra-oral sprays provide a new age in nutritional supplementation. Enjoy instant absorption and profound efficacy. No more swallowing capsules or pills. Just spray, swish and swallow. Simple and refreshing, Rash Care Extra Strength has a mild, pleasant taste with a hint of natural mint. Rash Facts by Lyn Hanshew, M.D. What are Common Skin Rashes? Common rashes are often called dermatitis, meaning inflammation of the skin; they involve changes in the color or texture of the skin including skin redness or inflammation. Common rashes are also known as skin lesions, Rubor and Erythema. The Most Common Rashes and their Causes: Contact Rashes – are common rashes often caused by dyes and chemicals in clothing, rubber, latex and elastic, cosmetics, soaps, detergents and plants like Poison Oak, Poison Ivy and Poison Sumac. Dandruff or Seborrheic Dermatitus – are common rashes associated with age, stress, fatigue, weather extremes, oily skin, infrequent shampooing and alcohol-based lotions. Other common rashes include Eczema (often associated with allergies or asthma), Psoriasis, Impetigo, Shingles and rashes caused by a host of childhood diseases like chickenpox, measles and scarlet fever. Medications can cause rashes as well as insect bites and stings. Standard Dose Take 6 sprays by mouth, twice daily. Higher Dose Take 12 sprays by mouth, twice daily. Optimal Use Spray, swish and swallow. You may take other Results RNA formulas immediately. Do not eat or drink for 2 minutes following. SERVING SIZE Serving size: 6 SpraysServings Per Container: Approx. 60AMOUNT PER SERVINGProprietary Blend Tincture <800 mcg* Ingredients Formula derived using a proprietary selective nutrient extraction process with Peppermint Leaf (Mentha x piperita), Greater Burdock (Arctuim minus), Green Tea Leaf (Camellia sinesis), Peach Leaf (Prunus Persica), Ginkgo Leaf (Ginkgo biloba), Soapwort Herb (Saponaria officinalis).Other Ingredients: Ultra-Pure Deionized Water Offered in 2 oz Intra-oral Spray * % Daily value not established For Best Results: Take Rash Care with ACS 200 and ACZ Nano Extra Strength to achieve optimal skin health and total body detoxification.

Soothing While HealingLubrisine Eye Drops are a the first and only eye drop formula to soothe by healing. Lubrisine eye drops nourish the eyes with beneficial ingredients, unlike the chemicals contained in other eye drops. Naturally EffectiveItchy, burning, watery, red and puffy eyes… Sound familiar? Lubrisine eye drops work in just minutes to soothe and lubricate dry, itchy and irritated eyes. Tired eyes come alive again with only a drop or two in each eye. Allergy Eye ReliefLubrisine eye drops provide brilliant allergy season relief as well as focused nutrients directed towards improving the overall health of the eyes. Morning to NightUse Lubrisine eye drops first thing in the morning to awaken the eyes. Use them just before bed to lubricate the eyes while you sleep. Use a few drops throughout the day and avoid the need to rub. Lubrisine Eye Drops Relieve:  Burning Watery Red Dry Itchy Gritty Irritated Tired Eyes “All of my adult life, I have had to use mast cell stabilizing drops in my eyes, steroid drops, antihistamine drops, lubricants, or a combination of all of these during summer allergy season. Yet, neither over-the-counter, nor Rx anti-allergy drugs felt as good nor performed as well in accomplishing allergic eye itch relief as did Lubrisine.” Dr. James Livengood, Optometrist  Read Dr. Livengood’s complete report here Sherry Anne JoppI will never be without the eye drops…gave my eye’s a life again!!* Casandra JaykusI also love the nasal spray and eye drops. I have seen 4 eye doctors and none helped with my eye situation from this illness. Has been a nightmare till I started the eye drops. Has majorly helped the dry eyes (and floaters, redness and sticking and poking sensations, awful pain gone). Vision getting better as well. Just my eye symptoms were enough to drive a person over the edge.* Purity and Quality Guaranteed: Lubrisine Eye Drops is produced under strict GMP manufacturing controls in conformance with guidelines for dietary supplements set forth in USP XXVII. For purity and quality, Lubrisine Eye Drops contains no preservatives • no artificial coloring or flavoring. For customer support, please call 1 888 823 3869. Directions: Instill 1 or 2 drops in the affected eye(s) as needed. Warnings: If the solution becomes contaminated do not use. To avoid contamination, do not touch tip of container to any surface. Replace cap after using. Ingredients Vitamin A (from Palmitate and Mixed Carotenoids), Lutein (Natural Lutein Esters), Bilberry (Vaccinium myrtillus) (fruit), Burdock Root (Arctium lappa), Eyebright Herb (Euphrasia officinalis), Blessed Thistle Herb (Cnicus benedicts), Angelica Root (Angelica archangelica), Devil’s Claw Root (Harpagophytum procumbens), Natural Trace Minerals, PEG 400 0.4%, Propylene glycol 0.3% in Ultra-Pure Deionized Water. * % Daily value not established For Best Results: Take Results RNA Lubrisine Eye Drops with ACS 200 Extra Strength and ACZ Nano Extra Strength to achieve enhanced allergy season relief and total body detoxification. RESEARCH AND SUMMARY COMMENTSLUBRISINE EYE DROPS Ingredients: Vitamin A (from Palmitate and Mixed Carotenoids), Lutein (Natural Lutein Esters), Bilberry (Vaccinium myrtillus) (fruit), Burdock Root (Arctium lappa), Eyebright Herb (Euphrasia officinalis), Blessed Thistle Herb (Cnicus benedicts), Angelica Root (Angelica archangelica), Devil’s Claw Root (Harpagophytum procumbens) VITAMIN A (FROM PALMITATE AND MIXED CAROTENOIDS) 1. A comparison of vitamin a and cyclosporine a 0.05% eye drops for treatment of dry eye syndrome. The purpose of the study was to compare the efficacy of vitamin A (retinyl palmitate) and cyclosporine A 0.05% eye drops in treating patients with dry eye disease. A total of 150 patients with defined dry eye disease participated (50 in each treatment group). In 3 identical clinical trials, patients were treated twice daily with cyclosporine A 0.05%, or four times daily with retinyl palmitate 0.05%, or with neither cyclosporine or retinyl palmitate. Adjunctive treatment with preservative-free artificial tears was undertaken four times daily in all 3 groups. Corneal fluorescein staining results, Schirmer tear test (without anesthesia) results, tear film break-up time (BUT), dry eye symptom score, and impression cytologic analysis results were obtained before treatment and at the first, second, and third months after initiation of treatment. Both vitamin A eye drops and topical cyclosporine A 0.05% treatments led to significant improvement in blurred vision, tear film BUT, Schirmer I score results, and impression cytologic findings in patients with dry eye syndrome (P < .05) compared to the control group treated with preservative-free artificial tears alone. Takeaway:• Vitamin A drops are effective for the treatment of dry eye and blurred vision. LUTEIN (NATURAL LUTEIN ESTERS) 2. Lutein acts via multiple antioxidant pathways in the photo-stressed retina. Lutein slows the progression of age-related macular degeneration (AMD), a leading cause of blindness in ageing societies. However, the underlying mechanisms remain elusive. Here, we evaluated lutein’s effects on light-induced AMD-related pathological events. Balb/c mice exposed to light (2000 lux, 3 h) showed tight junction disruption in the retinal pigment epithelium (RPE) at 12 h, as detected by zona occludens-1 immunostaining. Substantial disruption remained 48 h after light exposure in the vehicle-treated group; however, this was ameliorated in the mice treated with intraperitoneal lutein at 12 h, suggesting that lutein promoted tight junction repair. In the photo-stressed RPE and the neighboring choroid tissue, lutein suppressed reactive oxygen species and increased superoxide dismutase (SOD) activity at 24 h, and produced sustained increases in sod1 and sod2 mRNA levels at 48 h.Takeaway:• These findings indicated that lutein promoted tight junction repair and suppressed inflammation in photo-stressed mice, supporting previous findings that lutein is effective in slowing the progression of AMD. BILBERRY (VACCINIUM MYRTILLUS) (FRUIT) 3. Bilberry extract supplementation for preventing eye fatigue in video display terminal workers. The purpose of the study was to examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. Two hundred eighty-one office workers aged 20-40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10-1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group. Takeaway:Bilberry supplementation improved objective and subjective parameters of eye fatigue. EYEBRIGHT HERB (EUPHRASIA OFFICINALIS) 4. Assessment of Eyebright (Euphrasia Officinalis L.) Extract Activity in Relation to Human Corneal Cells Using In Vitro Tests Euphrasia officinalis L. is an herb traditionally used in folk medicine, mainly in the treatment of eye disorders. The present study analyzed the activity of three extracts of E. officinalis L. (ethanol, ethyl acetate and heptane) on cultured human corneal epithelial cells (10.014 pRSV-T). We show that the biological effect depended on both the concentration and the extraction solvent used. Heptane extracts, distinct from those in ethanol and ethyl acetate, were toxic to 10.014 pRSV-T cells at low concentrations (25 μg/mL) and did not demonstrate free radical scavenging effects. All tested extracts decreased pro-inflammatory cytokine expression (IL-1β, IL-6 and TNF-α) and also anti-inflammatory IL-10 expression by human corneal cells when the extracts were added to the cell culture medium for 24 h.Takeaway:E. officinalis L. shows promise as a supplementary therapy for eye inflammation (conjunctivitis) and irritated eyes. Citation links:1. https://www.ncbi.nlm.nih.gov/pubmed/188483182. https://www.ncbi.nlm.nih.gov/pubmed/274440563. https://www.ncbi.nlm.nih.gov/pubmed/259234854. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115993/