Heart Health

We don’t compromise: Gluten free, 100% natural, organic, non-GMO, made in the USA.Product Details: Cardio Miracle recommended dosage of one scoop, twice daily.Superior bioavailabilityOver 700 natural products that can be isolated from the 50+ ingredients derived whole-food bioavailable nutrients delivered in each and every serving.Made for everyoneYoung, old, and in between, we all need more nutrients and nitric oxide in our bodies.Backed by scienceIn vitro and in silico studies by world-leading scientists and PhDs. ConvenientOne scoop twice a day - it’s that easy!AffordableLess than you'd pay for a cup of coffee.Boosts EnergyNitric oxide regulates and directs muscle function and performance by stimulating vasodilation. This increases blood flow to working muscles, leading to increased oxygen transport, delivery of nutrients to skeletal muscle, and reduction in blood pressure. Bottom line… your energy increases and your physical performance improves.Helps RecoveryNitric Oxide stimulates blood vessel flexibility, thereby improving blood viscosity and flow, blood supply, and oxygen levels. This process promotes muscle Fiber repair and improves lactic acid and clearance, leading to quicker recovery.Supports immunityNitric oxide is recognised as one of the most active and versatile molecules in the immune system. It is powerful toxic defence molecule against infectious organisms. It regulates the functions, growth, and death of many immune and inflammatory cell types (including T lymphocytes, macrophages, mast cells, antigen-presenting cells, NK cells and neutrophils). Hence, it controls autoimmune processes and chronic inflammatory and degenerative diseases.Improves Mental ClarityNitric Oxide is known to relax blood vessels and to increase blood supply to the brain, thus inducing neuronal activity. Nitric Oxide plays a vital role in both the learning process and memory. It modulates the release of neurotransmitters acting as a cellular communicator in brain plasticity and development   Testimonials Here’s what some of our friends are saying:I am now going on my 7th - 8th canister of Cardio Miracle (2 scoops a day). I am happier and more energetic than I have ever been. NO depression, NO anxiety, NONE! My energy level is quite honestly ridiculous and I am 59 years old. You care only for us, the best products to help us! My life has changed immeasurably with God and Cardio Miracle on my side. - Jaynie B, GA   I am a new user of Cardio Miracle. I notice that my mood and my energy is a lot better since day one. - Randy T, MD   John Hewlett is amazing and got me interested in trying Cardio Miracle. For me personally, I noticed I have more energy and oxygen. When I heard about Cardio Miracle I thought to myself, "but I'm not getting nitric oxide in my system." My dad is on it too and says he feels better, and he has all kinds of health problems. I am definitely hooked on this product, I have to admit. Please don't ever stop making Cardio Miracle! - Ronald P.I am lucky to be alive. I had to close my business as a result of my heart issues and have tried many pricey supplements over the years. I think there is something about Cardio Miracle being a drink, rather than hard pills, because it works well for me. I noticed a difference in my energy level and my breathing within a couple weeks of taking Cardio Miracle. - Dee P   I've been taking Cardio Miracle twice a day for almost one month. After 3 days, my ankles stopped swelling at night. After a couple of weeks, my sciatica disappeared. I've also lost 6 lbs and no longer crave sweets. Recommending this to my family and friends! - Lisa H, TX   Thanks for sharing Cardio Miracle with us. We take it every day. We're so thankful for the benefits and reassurance of Cardio Miracle, especially after Scott's heart attack in 2018. - Scott and Janece L,

BENEFITSMaintaining calcium and phosphorus levels for healthy bones and feet*Providing a good source of Vitamin D3 for those with limited sun exposure*Boosting one’s immune, brain and nervous systems*Improving one’s mood and feel-good barometer*Many people are known to have a deficiency of Vitamin D, known as the “sunshine” vitamin. Due to indoor lifestyles and limited D3 food sources available, an extra source of Vitamin D can be found through supplements. Vitamin D3 (from cholecalciferol) is an effective source for supplementing the body’s natural Vitamin D production. Also, Vitamin K2 is great for promoting healthy, flexible arteries and overall heart health, as well as bone health.VITAMIN D3 LIQUID SUPPLEMENTS WITH K2 IS IDEAL FOR: Maintaining calcium and phosphorus levels for healthy bones and feet Providing a good source of Vitamin D3 for those with limited sun exposure Boosting one's immune, brain and nervous systems Improving one’s mood and feel-good barometer Helping to improve cognitive function for all age groups Fast-Acting, Effective Vitamin D3 & K2 Drops MORE ABOUT OUR DAILY DROPS No PreservativesNo Artificial SweetenersGluten-Free100% Money Back GuaranteeThird-Party TestedGMP CertifiedINGREDIENTS: Vitamin D3 (from cholecalciferol) Vitamin K2 (as the MK-7 (MenaQ7®)) MCT oil (medium chain triglycerides)

Vitalzym Cardio (formerly VitalzymSEB) was introduced in 2005, after much success of the original Vitalzym, which has become one of the leading systemic enzyme formulations available. Vitalzym Cardio is formulated with your cardiovascular wellbeing in mind. The SEBkinase blend contains "heart healthy" enzymes that may cleanse the blood of excess fibrin and reduce vascular inflammation.*Countless sufferers of chronic conditions such as arthritis, fibromyalgia, systemic inflammation, fibroids, and many more have found relief with the regular use of Vitalzym. A common benefit of Vitalzym has been its ability its ability to cleanse the blood. World Nutrition and Specialty Enzymes have taken the cardiovascular support of Vitalzym and harnessed it with nattokinase and other "heart healthy" nutrients to create an enzyme formulation specifically to support cardiovascular wellness. Vitalzym Cardio also contains powerful antioxidants, such as CoQ10, which has been shown to have significant impact on heart function.*Reduce Fibrin in the BloodThe fibrinolytic enzymes in Vitalzym Cardio have been shown to have the ability to digest excess fibrin (protein buildup) in the blood, which allows for improved blood viscosity. Stacked red blood cells (or Rouleau effect) often reflect poor protein digestion. Symptoms can include fatigue, stress on the heart, and poor circulation. The ingredients in Vitalzym Cardio have been shown, using darkfield microscopy, to significantly reduce the stacking of red blood cells.*C-Reactive ProteinsIncreased vascular inflammation has been recently shown to be a factor in many debilitating issues. C-Reactive Protein levels are used as a marker for vascular inflammation. Then enzymes in Vitalzym Cardio have been shown to reduce the levels of C-Reactive Proteins.*Vitalzym Cardio IngredientsNattokinaseNattokinase is a fibrinolytic enzyme extracted and purified from natto, a fermented soybean food used by the Japanese for thousands of years as a traditional food medicine.Nattokinase was first identified in 1980 by Dr. Hiroyuki Sumi, M.D., Ph.D., who was researching thrombolytic enzymes with the hope of finding a natural agent that could successfully dissolve thrombus associated with cardiac and cerebral infarction (blood clots associated with heart attacks and stroke). After testing more than 200 natural foods as potential thrombolytic agents, Sumi found that natto possessed a substance with a "a potency matched by no other enzyme." Dr. Sumi named the newly discovered enzyme nattikinase.*By dissolving fibrin more completely than any other substance tested by Dr. Sumi, nattokinase may be particularly effective in helping the body fight blood clots. Its thrombolytic activity is enhanced by the enzyme's ability to boost the body's production of both plasmin and other clot-dissolving agents, including endogenous urokinase.*SerrapeptaseSerrapeptase is a proteolytic enzyme that is able to digest dead tissue, blood clots, and cysts. Clinical studies show that serrapeptase induced fibrinolytic, anti-inflammatory, and anti-edemic activity in a number of tissues, and that its anti-inflammatory effects are superior to to other proteolytic enzymes.*Serrapeptase has been used in Europe to treat arterial blockages due to its ability to alleviate arterial inflammation and dissolve blood lots. It has been used to treat arthritis, fibrocystic breast disease, carpal tunnel syndrome, and other fibrinolytic, viral, and inflammatory conditions.*DetoxificationSystemic enzymes will help rid the liver of toxins. Some users will experience a detox reaction to the enzymes, including short-term fatigue, nausea, or headache. Liver detoxification reactions are a beneficial cleansing for the body. Increased water intake can assist in the process; reducing the enzyme dosage will slow the rate of detox. Enzymes also help cleanse metabolic debris and help mainain vital blood quality.* Other Ingredients Maltodextrin, Vegetable Cellulose (Capsule) Suggested Use As a dietary supplement, take 1 capsule three times daily, or more as directed by your healthcare provider. Take capsules at least 30 minutes before a meal, 60 minutes after a meal, or any time in-between meals with water. Warnings If you are pregnant, lactating, taking anti-coagulants, blood thinners, or have a history of thinning blood in your family, do not take this product without direction and supervision from your medical provider. Discontinue use 2 weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. Allergen Info Contains no animal derivatives, artificial flavors, yeast, or gluten. Lactose free and contains no harmful talc. Produced with an enterically coated enzyme.

KIKI Health’s Krill Oil delivers omega-3 EPA and DHA in a naturally phospholipid-bound form, sourced from Antarctic waters and encapsulated in Licaps® for convenient daily use. Each capsule also provides choline, which contributes to normal liver function and lipid metabolism. Product Description KIKI Health’s Krill Oil is sustainably harvested from Antarctic waters and purified using controlled, low-temperature processing methods to maintain quality and remove unwanted impurities. Each capsule contains omega-3 fatty acids EPA and DHA bound to phospholipids, alongside naturally occurring choline and astaxanthin. Choline contributes to normal homocysteine metabolism, normal lipid metabolism and the maintenance of normal liver function. The Licaps® capsule format makes the product easy to swallow and convenient to incorporate into a daily routine. Key Features Sustainably sourced Antarctic krill oil Provides EPA and DHA omega-3 fatty acids in a convenient once-daily format. Contains naturally occurring choline Delivered in Licaps® capsules designed for smooth swallowing and convenient daily use. 30-day supply Ingredients Krill Oil (crustacean) (Euphausia superba)Licaps® Capsule: Piscene (fish) gelatin and water Allergens: See ingredients in bold. Suggested Use Adults: Take 1–2 capsules daily with food. Do not exceed the recommended daily intake. Nutrition Information Serving Size: 1 capsule (590mg)Servings Per Bottle: 30 Nutrient Per Serving Total Omega-3 160mg EPA (Eicosapentaenoic Acid) 89mg DHA (Docosahexaenoic Acid) 41mg Phospholipids 331mg Astaxanthin 50µg Choline 41mg Storage Store in a cool, dry place away from direct sunlight. Refrigeration is not required. Important Information Food supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. Consult a healthcare professional before use if pregnant, breastfeeding, taking medication or under medical supervision. Keep out of reach of children.

Comprehensive Cardiovascular FormulaExceptionally effective, ACC Cardio Extra Strength contains a unique blend of proven cardio-protective ingredients, including L-arginine, CoQ10 (Ubiquinone), Red Yeast Rice, Lycopene, Garlic, Magnesium, Vitamin D3, Vitamin K2 and Cinnamon extract promoting healthy heart muscle, blood pressure, circulation and more. The First L-arginine Intra-oral SpraySay goodbye to messy powders, ACC Cardio is the first cardiovascular formula that features L-arginine and more in a simple to take great tasting spray. Instantly absorbed L-arginine increases nitric oxide levels and has been scientifically proven to help maintain healthy blood pressure, optimize cholesterol levels, blood flow and arterial function Supports Healthy Blood PressureACC Cardio supports enhanced blood flow, blood vessel protection, healthy blood pressure and enhanced large artery elasticity, with highly beneficial vascular effects.* Supports Healthy CholesterolProvides all the benefits of Garlic without the smell or after taste. Garlic has been used extensively throughout history for its many health promoting benefits, including cardiovascular health. There are over 641 study references validating the efficacy of Garlic for enhancing immunity and cardiovascular health by supporting healthy cholesterol levels, blood pressure and more. Clinically Proven ResultsA clinically validated cardiovascular health formula with over 2,000 reference studies citing the ingredients included, many of which are determined essential to maintaining a healthy heart and cardiovascular system. Results are fast acting and safe.* Essential Daily SupportMagnesium is vital to cardiovascular health and is included. A lack of Magnesium has been shown to raise blood pressure, reduce glucose tolerance and cause neural excitation. Dietary deficiency of Magnesium plays an important role in different types of cardiovascular disorders such as ischemic heart disease, congestive heart failure, sudden cardiac death, atheroscelerosis, a number of cardiac arrhythmias and ventricular complications. Anti-inflammatory SupportACC Cardio contains many ingredients with proven anti-inflammatory, antimicrobial, antioxidant, cholesterol-lowering, and immune boosting properties. Advanced Cellular TechnologyACC Cardio delivers the power of each ingredient in the most effective manner possible; achieving maximum results without stomach discomfort or side effects. With Advanced Cellular Technology, ACC Cardio Extra Strength Intra-oral spray is immediately absorbed, simple to take, and has a pleasant taste with a hint of natural mint. Just spray, swish, and swallow. Standard Dose Take 6 sprays by mouth, twice daily. Higher Dose Take 12 sprays by mouth, twice daily. Optimal Use Spray, swish and swallow. You may take other Results RNA formulas immediately. Do not eat or drink for 2 minutes following. Take as recommended by your physician. SERVING SIZE Serving size: 12 SpraysServings Per Container: Approx. 60AMOUNT PER SERVINGProprietary Blend Tincture ~18000 mcg* Ingredients CoQ10 (Ubiquinone), Red Yeast Rice (Monascus purpureus), Lycopene, L-Arginine, Garlic, Magnesium, Vitamin D3 (as Cholacalciferol), Vitamin K2, Cinnamon extract (Cinnamomum cassia), Peppermint Leaf (Mentha x piperita) and Natural Trace Minerals. Other Ingredients: Ultra-Pure Deionized Water * % Daily value not established For Best Results: Take ACC Cardio Extra Strength with ACS 200 and ACZ Nano Extra Strength to achieve optimal cardiovascular support and total body detoxification. RESEARCH AND SUMMARY COMMENTSACC CARDIO EXTRA STRENGTH COENZYME Q10 (UBIQUINONE) 1. Overview of the use of CoQ10 in cardiovascular disease. The clinical experience in cardiology with CoQ10 includes studies on congestive heart failure, ischemic heart disease, hypertensive heart disease, diastolic dysfunction of the left ventricle, and reperfusion injury as it relates to coronary artery bypass graft surgery. Supplemental CoQ10 alters the natural history of cardiovascular illnesses and has the potential for prevention of cardiovascular disease through the inhibition of LDL cholesterol oxidation and by the maintenance of optimal cellular and mitochondrial function throughout the ravages of time and internal and external stresses.Takeaway: • Supplementation with CoQ10 (Ubiquinone) has deep history with regard to cardiovascular disease. Its primary benefits relate to inhibition of LDL cholesterol oxidation and by the maintenance of optimal cellular and mitochondrial function. 2. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Coenzyme Q10 (ubiquinone) is a mitochondrial coenzyme which is essential for the production of ATP. Being at the core of cellular energy processes it assumes importance in cells with high energy requirements like the cardiac cells which are extremely sensitive to CoQ10 deficiency produced by cardiac diseases. CoQ10 has thus a potential role for prevention and treatment of heart ailments by improving cellular bioenergetics. In addition it has an antioxidant, a free radical scavenging and a vasodilator effect which may be helpful in these conditions. It inhibits LDL oxidation and thus the progression of atherosclerosis.Takeaway: • Verification of CoQ10’s importance to heart health, with additional insights, which speak to its benefits as an antioxidant, free radical scavenger and CoQ10’s vasodilating effect, all of which contribute to the inhibition of LDL oxidation and progression of atherosclerosis. RED YEAST RICE (MONASCUS PUREPUREUS) 3. The effect of red yeast rice (Monascus purpureus) in dyslipidemia and other disorders. Red Yeast Rice (RYR) is a traditional Chinese food that is fermented and obtained after red yeast (Monascus purpureus) is grown on rice. RYR contains Monacolin K (Lovastatin) and other active ingredients that are thought to play a role in the management of cholesterol levels. Recently, many clinical trials have focused on the uses of RYR, including for dyslipidemia, coronary heart disease, diabetes, osteoporosis, cancer, non-alcoholic fatty liver disease, fatigue, and memory. The primary objective of this review is to evaluate the effectiveness of RYR on the management of dyslipidemia. Studies reviewed show that RYR significantly lowered LDL cholesterol and total cholesterol. Effects on triglycerides and HDL cholesterol were also observed in some studies. Compared with statins, RYR was shown to have an equal efficacy to statins when combined with or without other dietary supplements. RYR also appeared to be superior to placebo in preventing nonfatal myocardial infarction, total coronary heart disease events, and total deaths.Takeaway: • Red Yeast Rice has a long history with regard to its use for CVD. The specific focus and strongest evidence points to its use for the management of dyslipidemia.Lycopene 4. Lycopene Deficiency in Ageing and Cardiovascular Disease. The recent body of evidence suggests that plasma concentration of lycopene is not only a function of intestinal absorption rate but also lycopene breakdown via enzymatic and oxidative pathways in blood and tissues. Oxidative stress and the accumulation of reactive oxygen species and nitric oxide may represent a major cause of lycopene depletion in ageing, cardiovascular disease, and type 2 diabetes mellitus. It has been shown recently that low carotenoid levels, and especially decreased serum lycopene levels, are strongly predictive of all-cause mortality and poor outcomes of cardiovascular disease. Hence, it is very unlikely that nutritional intervention alone could be instrumental in the correction of lycopene and carotenoid deficiency. Therefore, new nutraceutical formulations of carotenoids with enhanced bioavailability are urgently needed.Takeaway: • Given the relationship between serum lycopene levels and cardiovascular disease outcomes, it is important to introduce supplemental Lycopene given that levels typically decline with aging. 5. Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. The management of overweight subjects by interventions aimed at reducing inflammation is highly desirable. To date, observational studies have identified a link between increased dietary antioxidant intake and reduced cardiovascular morbidity. However, direct trial evidence regarding the ability of antioxidants to influence inflammation is lacking. Therefore, this study examined lycopene’s ability to lower systemic and high-density lipoprotein (HDL)-associated inflammation in moderately overweight middle-aged subjects. These results demonstrate that in moderately overweight, middle-aged subjects, increasing lycopene intake leads to changes to HDL(2&3), which we suggest enhanced their antiatherogenic properties.Takeaway: • Lycopene has heart-protective properties given its ability to inhibit atherogenesis (oxidation of LDL). L-ARGININE 6. l-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting PlasmaArginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors. We sought to determine the effects of a low dose of a sustained-release (SR) l-arginine supplement on postprandial endothelial function in healthy overweight adults with cardio metabolic risk factors and to investigate whether this effect may vary by baseline arginine status. In a randomized, double-blind, 2-period crossover, placebo-controlled trial (4-wk treatment, 4-wk washout), we compared the effects of 1.5 g SR-l-arginine 3 times/d (4.5 g/d) with placebo in 33 healthy overweight adults [body mass index (BMI, in kg/m2): 25 to >30] with the hypertriglyceridemic waist (HTW) phenotype [plasma triglycerides > 150 mg/dL; waist circumference > 94 cm (men) or > 80 cm (women)]. Supplementation with low-dose SR-arginine alleviates postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low.Takeaway: • L-Arginine’s benefit here – in this study, low dose arginine offsets postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low GARLIC 7. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. Hypertension affects 30% of adults worldwide. Garlic supplements have shown promise in the treatment of uncontrolled hypertension, and the mechanism of action is biologically plausible. Our trial is the first to assess the effect of aged garlic extract on central blood pressure and arterial stiffness, regarded as important risk factors for cardiovascular morbidity.A total of 88 general practice patients and community members with uncontrolled hypertension completed a double-blind randomized placebo-controlled trial of 12 weeks investigating the effect of daily intake of aged garlic extract (1.2 g containing 1.2 mg S-allylcysteine) or placebo on blood pressure, and secondary outcome measures of central-hemodynamics and other cardiovascular markers, including cholesterol, homocysteine, platelet function, and inflammatory markers. Mean blood pressure was significantly reduced by 5.0±2.1 mmHg (P=0.016) systolic, and in responders by 11.5±1.9 mmHg systolic and 6.3±1.1 mmHg diastolic compared to placebo (P<0.001). Central hemodynamic-measures tended to improve in the garlic group more than in the placebo group, including central blood pressure, central pulse pressure, mean arterial pressure, augmentation pressure, pulse-wave velocity, and arterial stiffness. Our trial suggests that aged garlic extract is effective in reducing peripheral and central blood pressure in a large proportion of patients with uncontrolled hypertension, and has the potential to improve arterial stiffness, inflammation, and other cardiovascular markers in patients with elevated levels. Aged garlic extract was highly tolerable with a high safety profile as a stand-alone or adjunctive antihypertensive treatment.Takeaway: • Garlic’s primary contribution is as a safe and effective means of addressing hypertension. This study also revealed potential, other benefits – improved arterial stiffness, inflammation, and other cardiovascular markers in patients with elevated levels. MAGNESIUM 8. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies We performed a systematic review and meta-analysis to investigate prospective associations of circulating and dietary magnesium with incidence of CVD, IHD, and fatal IHD. Circulating magnesium was significantly associated with a lower risk of CVD, with trends toward a lower risk of IHD and fatal IHD. Dietary magnesium was associated with a significantly lower risk of IHD and showed a nonlinear association with fatal IHD. Note: It is estimated that 70%-80% of consumers are not meeting their recommended intakes of magnesium.Takeaway: • Given the established relationship between magnesium and CVD, and the data suggesting a nationwide deficiency, magnesium supplementation is recommended for those at risk as well as healthy subjects. VITAMIN D3 9. LOW VITAMIN D STATUS: A CONTRIBUTING FACTOR IN THE PATHOGENESIS OF CONGESTIVE HEART FAILURE? This study was designed to evaluate the association between vitamin D status and congestive heart failure (CHF). Both groups of CHF patients had markedly increased serum levels of NT-proANP (p < 0.001), increased serum phosphorus levels (p < 0.001), and reduced circulating levels of both 25-hydroxyvitamin D (p < 0.001) and calcitriol (p < 0.001). The low vitamin D status can explain alterations in mineral metabolism as well as myocardial dysfunction in the CHF patients, and it may therefore be a contributing factor in the pathogenesis of CHF. Takeaway: • This study raises the question and provides evidence that reduced levels of vitamin D may be related to CHF. VITAMIN K2 10. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. In contrast, vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls. Vitamin K, particularly as vitamin K2, is nearly nonexistent in junk food, with little being consumed even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could be a means of lowering calcium-associated health risks. Takeaway: • Increased intake of vitamin K2 could be a viable means of reducing calcium – associated health risks, specifically CVD. CINNAMON EXTRACT (CINAMOMUM CASIA) 11. Cinnamon and its Components Suppress Vascular Smooth Muscle Cell Proliferation by Up-Regulating Cyclin-Dependent Kinase Inhibitors. Cinnamomum cassia bark has been used in traditional herbal medicine to treat a variety of cardiovascular diseases. However, the anti-proliferative effect of cinnamon extract on vascular smooth muscle cells (VSMCs) and the corresponding restenosis has not been explored. Hence, after examining the effect of cinnamon extract on VSMC proliferation, we investigated the possible involvement of signal transduction pathways associated with early signal and cell cycle analysis, including regulatory proteins. Cinnamon extract inhibited platelet-derived growth factor (PDGF)-BB-induced VSMC proliferation and suppressed the PDGF-stimulated early signal transduction. In addition, cinnamon extract arrested the cell cycle and inhibited positive regulatory proteins. Correspondingly, the protein levels of p21 and p27 not only were increased in the presence of cinnamon extract, also the expression of proliferating cell nuclear antigen (PCNA) was inhibited by cinnamon extract. Besides, among the components of cinnamon extract, cinnamic acid (CA), eugenol (EG) and cinnamyl alcohol significantly inhibited the VSMC proliferation. Overall, the present study demonstrates that cinnamon extract inhibited the PDGF-BB-induced proliferation of VSMCs through a G0/G1 arrest, which down-regulated the expression of cell cycle positive regulatory proteins by up-regulating p21 and p27 expression.Takeaway:The ability of Cinnamon extract to inhibit proliferation of VSMCs is a key factor in preventing atherosclerosis. Citation links:1. https://www.ncbi.nlm.nih.gov/pubmed/104160412. https://www.ncbi.nlm.nih.gov/pubmed/196382843. https://www.ncbi.nlm.nih.gov/pubmed/231313804. https://www.ncbi.nlm.nih.gov/pubmed/268810235. https://www.ncbi.nlm.nih.gov/pubmed/228195556. https://www.ncbi.nlm.nih.gov/pubmed/272818007. https://www.ncbi.nlm.nih.gov/pubmed/268698118. http://ajcn.nutrition.org/content/98/1/160.full#ref-19. https://www.ncbi.nlm.nih.gov/pubmed/12570952?dopt=Abstract10. https://www.ncbi.nlm.nih.gov/pubmed/2677012911. https://www.ncbi.nlm.nih.gov/pubmed/26119954

Nattovena is the world’s first ultra-concentrated 4,000 FU pure nattokinase dietary supplement, in easy-to-swallow micro-caps. Nattovena contains ultra-refined, pharmaceutical grade, acid stable nattokinase. Nattovena's potency is unparalleled in its class. The standard for nattokinase manufacturing is a potency of up to 2,000 FU’s, or fibrinolytic units, of fibrin degrading activity per capsule. Nattovéna has broken the mold by providing 4,000 FU’s of activity, or double the ordinary dose, offering the strongest nattokinase activity per capsule, period. Nattovena is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory health concerns. What is Nattokinase? Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting. Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 4,000 units of fibrin per capsule, thereby optimizing its cardiovascular benefits and promoting normal blood viscosity. How Does Nattokinase Work? Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase supplementation can tip the balance back in favor of fibrin removal using two different mechanisms. Firstly, nattokinase is a fibrinolytic enzyme, which means that it can literally dissolve excessive fibrin produced during the healing process. In fact, studies show that nattokinase is actually four times (4x) more potent than the body’s own plasmin in terms of fibrinolytic activity1. Secondly, nattokinase blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal, since PAI-1 blocks the body’s natural production of plasmin. By impeding PAI-1, nattokinase promotes the creation of more plasmin from plasminogen (its building block), increasing the amount of natural fibrinolytic enzymes created within the body2.   Suggested Use Suggested Use: Take 1 capsule 2 to 3 times daily on an empty stomach. Higher doses may be taken as needed, but it is recommended to not exceed 15 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner. WARNING: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing. Supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your GP or healthcare professional before taking any food supplement, especially if you are pregnant, breastfeeding, taking medication, or have a medical condition.   Frequently Asked Questions What does Nattovena do? Studies have demonstrated that nattokinase improves overall circulation, promotes healthy blood viscosity, promotes healthy clotting factors, keeps blood cells from sticking together, and maintains blood pressure levels already within normal range.* How does it work? Nattovena supports normal clot formation by maintaining normal levels of blood coagulation factors.* It also supports normal clot breakdown by maintaining normal fibrinolytic (clot-dissolving) activity, due to its ability to also increase the production of the body's inherent fibrinolytic enzyme plasmin.* Why is fibrinolytic activity important? Fibrin is a vital protein that forms in response to trauma, injury, or even in cases of autoimmune conditions. The body can not only overproduce fibrin in these instances, but can also produce fibrin when there is no trauma or injury, which can lead to a bevy of unwanted symptoms. Fibrinolytic activity is the body’s natural way of breaking up excessive fibrin and unwanted clots. Is Nattovena safe? Nattokinase is derived from natto, which has been a regular food staple within Asian cuisine for centuries. Although nattokinase has many benefits, studies have shown that it also does not have demonstrative side effects, and the ingredient is considered GRAS (generally recognized as safe) within the US. Does Nattovena have value beyond just heart health? Due to the vast array of unhealthy conditions that excessive fibrin can bring, Nattovena has far greater value than a simple cardiovascular support product. Many aspects of health, from muscle recovery, to immune and joint health are directly related to fibrin and blood viscosity.* Is Nattovena safe to use in combination with prescription blood-thinning drug medication? You should always check with your health care provider prior to taking any new dietary supplements in combination with a prescription. However, Nattovena does not contain any vitamin K, so it is assumed to be compatible with these medications since their mode of action is based on inhibiting vitamin K. Nattovena is not contraindicated with aspirin, natural supplements, or antihypertensive medications although medical supervision when implementing any new supplement regimen is always recommended.   Supplement Facts   Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Nattovena™ 200 mg † Nattokinase 4,000 FU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Keep out of reach of children. Store in a cool, dry place with lid tightly closed.

We don’t compromise: Gluten free, 100% natural, organic, non-GMO, made in the USA.Product Details: Cardio Miracle recommended dosage of one scoop, twice daily.Superior bioavailabilityOver 700 natural products that can be isolated from the 50+ ingredients derived whole-food bioavailable nutrients delivered in each and every serving.Made for everyoneYoung, old, and in between, we all need more nutrients and nitric oxide in our bodies.Backed by scienceIn vitro and in silico studies by world-leading scientists and PhDs. ConvenientOne scoop twice a day - it’s that easy!AffordableLess than you'd pay for a cup of coffee.Boosts EnergyNitric oxide regulates and directs muscle function and performance by stimulating vasodilation. This increases blood flow to working muscles, leading to increased oxygen transport, delivery of nutrients to skeletal muscle, and reduction in blood pressure. Bottom line… your energy increases and your physical performance improves.Helps RecoveryNitric Oxide stimulates blood vessel flexibility, thereby improving blood viscosity and flow, blood supply, and oxygen levels. This process promotes muscle Fiber repair and improves lactic acid and clearance, leading to quicker recovery.Supports immunityNitric oxide is recognised as one of the most active and versatile molecules in the immune system. It is powerful toxic defence molecule against infectious organisms. It regulates the functions, growth, and death of many immune and inflammatory cell types (including T lymphocytes, macrophages, mast cells, antigen-presenting cells, NK cells and neutrophils). Hence, it controls autoimmune processes and chronic inflammatory and degenerative diseases.Improves Mental ClarityNitric Oxide is known to relax blood vessels and to increase blood supply to the brain, thus inducing neuronal activity. Nitric Oxide plays a vital role in both the learning process and memory. It modulates the release of neurotransmitters acting as a cellular communicator in brain plasticity and development Testimonials Here’s what some of our friends are saying:I am now going on my 7th - 8th canister of Cardio Miracle (2 scoops a day). I am happier and more energetic than I have ever been. NO depression, NO anxiety, NONE! My energy level is quite honestly ridiculous and I am 59 years old. You care only for us, the best products to help us! My life has changed immeasurably with God and Cardio Miracle on my side. - Jaynie B, GA   I am a new user of Cardio Miracle. I notice that my mood and my energy is a lot better since day one. - Randy T, MD   John Hewlett is amazing and got me interested in trying Cardio Miracle. For me personally, I noticed I have more energy and oxygen. When I heard about Cardio Miracle I thought to myself, "but I'm not getting nitric oxide in my system." My dad is on it too and says he feels better, and he has all kinds of health problems. I am definitely hooked on this product, I have to admit. Please don't ever stop making Cardio Miracle! - Ronald P.I am lucky to be alive. I had to close my business as a result of my heart issues and have tried many pricey supplements over the years. I think there is something about Cardio Miracle being a drink, rather than hard pills, because it works well for me. I noticed a difference in my energy level and my breathing within a couple weeks of taking Cardio Miracle. - Dee P   I've been taking Cardio Miracle twice a day for almost one month. After 3 days, my ankles stopped swelling at night. After a couple of weeks, my sciatica disappeared. I've also lost 6 lbs and no longer crave sweets. Recommending this to my family and friends! - Lisa H, TX   Thanks for sharing Cardio Miracle with us. We take it every day. We're so thankful for the benefits and reassurance of Cardio Miracle, especially after Scott's heart attack in 2018. - Scott and Janece L,

A comprehensive vitamin D3 and vitamin K complex designed to support bone health, calcium balance and normal immune function.Each capsule provides vegan vitamin D3 with a full-spectrum blend of vitamin K forms including K1 and K2 (MK-4, MK-6, MK-7 and MK-9). Product Overview Arthur Andrew Medical KD Ultra® combines vegan vitamin D3 sourced from lichen with a broad-spectrum blend of vitamin K vitamins and the enzyme lipase. Vitamin D and vitamin K are fat-soluble vitamins commonly taken together as part of a balanced nutritional routine. Each capsule provides: Vitamin D3 (62.5 mcg / 2,500 IU) Vitamin K1 (100 mcg) Vitamin K2 complex (MK-4, MK-6, MK-7 and MK-9) Lipase enzyme Vitamin D contributes to normal immune system function, maintenance of normal bones, and normal muscle function. Vitamin K contributes to normal blood clotting and maintenance of normal bones. KD Ultra® is supplied in vegetarian capsules and contains vegan-sourced vitamin D3 from lichen. Sample contains 2 capsules. Key Features • Vegan vitamin D3 from lichen• Full-spectrum vitamin K complex (K1, MK-4, MK-6, MK-7, MK-9)• Includes lipase enzyme (500 FIP)• Vitamin D contributes to normal immune function and bone health• Vitamin K contributes to normal blood clotting and bone maintenance• Vegetarian capsules• 2 capsules per sample Supplement Facts Serving Size: 1 Capsule Amount Per Capsule Vitamin D3 (from Lichen) – 62.5 mcg (2,500 IU)Vitamin K1 (as Phytonadione) – 100 mcg Vitamin K2 Blend – 1,610 mcg total • MK-4 (as menaquinone-4) – 1500 mcg• MK-7 (as trans menaquinone-7) – 110 mcg• MK-6 (trace as menaquinone-6)• MK-9 (trace as menaquinone-9) Lipase – 2.5 mg (500 FIP) Daily value not established for vitamin K2 forms and lipase. Ingredients Vitamin D3 (from Lichen), Vitamin K1, Vitamin K2 (MK-4, MK-6, MK-7, MK-9), Lipase. Other ingredients:Cellulose (vegetarian capsule), Rice Maltodextrin. Suggested Use Take 1 capsule daily, or as directed by a healthcare professional. Storage Store in a cool, dry place with lid tightly closed. Important Information Do not exceed the recommended daily intake. Food supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. If you are pregnant, breastfeeding, taking medication or have a medical condition, consult a healthcare professional before use. Individuals taking anticoagulant medication should consult a healthcare professional before use due to the vitamin K content. Keep out of reach of children. Why Choose KD Ultra® KD Ultra® combines vegan vitamin D3 with a broad-spectrum vitamin K complex in one convenient capsule, making it an easy addition to a daily nutrition routine focused on bone and immune health.

Brings together two trusted botanicals for daily balance and cholesterol support. Key Benefits With Monacolin K from red yeast rice to help maintain normal blood cholesterol levels. Odourless garlic extract for a gentle, easy addition to your daily routine. Thoughtfully formulated for quality and consistency in every capsule. Simple, once-daily support with high-quality ingredients. Start your day with a blend designed for balance. Blueprint’s Red Yeast Rice + Odor-free Garlic pairs red yeast rice - naturally providing Monacolin K, which contributes to the maintenance of normal blood cholesterol levels - with a concentrated, odourless garlic extract. Each capsule delivers carefully measured amounts, making it easy to add to your daily routine. Enjoy the benefits of these time-honoured botanicals in a convenient, gentle formula crafted for everyday wellbeing. Ingredients Red Yeast Rice (Soybeans) Extract, Odorless Garlic 12:1 Extract (from bulb) (Allium sativum), Cellulose (Veggie Capsule), Anti-Caking Agent (Dicalcium Phosphate), Rice Hulls, Starch, Stabiliser (Gum Acacia), Rice Blend Extract. Suggested Use Consume 1 capsule daily. Additional Information Food supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. If you are pregnant, breastfeeding, have a medical condition, or are taking any medications, please consult with a healthcare professional before use. Use products only if the seal is intact. Store in a cool, dry place, out of the reach of young children. Do not exceed the recommended daily intake. We make every effort to ensure that product information on our website is accurate and up to date, but packaging and ingredients may occasionally vary from images shown on site. Please refer to the product label.