The Energy Blueprint (8)

WHAT'S IN ENERGENESIS?   Energenesis is like a 5-star MEAL for your Mitochondria (LOADED with rare nutrients, energy boosters and powerful antioxidants, because your body needs a variety – each one works differently!) AND… we have gone to amazing lengths to source the highest quality ingredients, with unparalleled potency, purity, biological availability, and effectiveness…   If you want to see a breakdown of the exact ingredients and amounts, you can look in the right column of the image below…   It’s a potent cocktail of the most powerful mitochondrial regenerating ingredients designed to literally CHARGE your cells back up, so you can have the energy you had when you were young – ALL DAY ENERGY.   If you’ve been struggling with fatigue or low energy levels, it’s time to stop dragging yourself through the day with caffeine and stimulants…   It’s time to start building REAL ENERGY.   You can certainly use the information here to go out and buy all these compounds as separate supplements, but I strongly encourage you to simply get Energenesis. It’s obviously far more convenient to get everything in one formula rather than fiddling with 20 different bottles and 25 pills each day. Also, you don’t have to worry about dosing everything correctly.   And, on top of that, I’ve tried to make it a complete no brainer for you by making it way cheaper for you to order it this way (as opposed to buying 20+ different supplements).   Energenesis is simply the most powerful formula ever developed for that purpose.UNLIKE PREVIOUS GENERATION “ENERGY SUPPLEMENTS,” IT CONTAINS NO STIMULANTS, NO CAFFEINE, AND NO SUGAR. THIS ISN’T ABOUT GIVING YOU A FAKE ENERGY BOOST, WHILE ACTUALLY MAKING YOUR ENERGY LEVELS WORSE OVER TIME. Energenesis builds REAL ENERGY! This is not a supplement designed to fill to people’s desire for quick fixes and instant gratification through stimulants and temporary boosts of fake energy. Energenesis is for people looking for REAL ANSWERS, who want to address ROOT CAUSES, and want to build real energy at the cellular level. As a result, the energy your mitochondria produce naturally decreases over time, reducing your health and longevity — and ultimately, causing fatigue. On top of that, stressors in our life — from psychological stress, to environmental toxins (like heavy metals and air pollutants), to a poor diet, to poor gut health, to chronic inflammation — all cause mitochondrial damage, dysfunction and shut down (they shift out of energy mode into a cell protection response). Research is now showing that these three things — the loss of mitochondria, the damage/dysfunction of mitochondria, and the shut down of mitochondria — are the primary factors that drive low energy levels. In other words, if you’ve got low energy levels, it likely simply means that your mitochondria have become weak, damaged, dysfunctional, and switched off over time.   ENERGENESIS INGREDIENTSWhat's Inside The Most Powerful Energy Supplement Ever CreatedMITOCHONDRIAL MEMBRANE SUPPORT COMPLEX   NT FACTOR PHOSPHOLIPIDS   NTFactor® is a digestion-resistant phospholipid complex that supplies the materials necessary to repair and regenerate damaged cell membranes directly to mitochondria, a treatment called lipid replacement therapy [1].    By supplying the bioactive phospholipids that mitochondria require to naturally replace damaged membrane components, NTFactor® is able to regenerate dysfunctional mitochondria, increase energy production, and enhance the energy levels of those using it.   Numerous studies have shown that NTFactor® reduces fatigue by 24–43 percent among those with chronic fatigue syndrome or conditions associated with fatigue, like general aging, obesity, lyme disease, and Gulf War Illness [2]. In older adults, NTFactor® restored mitochondrial function to a level matching healthy 29 year-olds [3].   ASTAXANTHIN   Astaxanthin is one of the most powerful membrane-specific antioxidants in existence. Not only is it 30–85 percent more potent than vitamin E and carotenoids like β-carotene, lycopene, and lutein [4], but it has a unique polar structure that allows it to cross through, protect, and stabilize the entire mitochondrial membrane [5].   Due to astaxanthin’s consistent and powerful ability to prevent oxidative damage and dysfunction to mitochondria [6–8], some researchers have even determined it to be “mitochondria-targeted antioxidant” [9].   Interventions have shown that astaxanthin supplementation increases muscular strength and power output in fatigued adults [10], enhances muscular endurance and recovery in recreational athletes [11,12], and reduces muscle damage and oxidative stress in elite soccer players [13].   MITOCHONDRIAL ENERGY PRODUCTION COFACTOR COMPLEX   ACETYL-L-CARNITINE   Acetyl-L-Carnitine (ALCAR) is a special form of carnitine that achieves two goals: (1) it supplies the carnitine your mitochondria need to produce energy, and (2) it provides an acetyl moiety that your mitochondria use to remain youthful and healthy.   The carnitine shuttle system is essential for bringing fatty acids into mitochondria to be used for energy production, and carnitine deficits (even mild ones) have been documented in those with chronic fatigue [14]. Moreover, over 20 percent of mitochondrial proteins rely on acetyl moieties to properly function, including those involved in antioxidant defenses and energy production [15,16].   For these reasons, some researchers have proposed that ALCAR should be considered a “mitochondrial rejuvenator” [17]. In chronically fatigued older adults, ALCAR supplementation led to profound benefits to their wellbeing — a 24 percent increase in physical function and close to a whopping 50 percent reduction in mental fatigue, physical fatigue, and overall fatigue severity [18].   CREATINE   Creatine is a molecule necessary for rapid and explosive energy production when energy needs cannot be immediately met by our mitochondria. Supplementation works by increasing the amount of available creatine within our muscles.   This not only increases muscular performance, but also helps stimulate mitochondrial energy production when faced with signals to do so (like being physically active) [24], enhance mitochondrial biogenesis and integrity [25], and protect mitochondria from oxidative damage [26,27].   Accordingly, creatine is one of the most extensively researched supplements for improving exercise performance, muscle strength, and power output in people of all ages [28–32].   COENZYME Q10   Coenzyme Q10 (CoQ10) is an essential component of mitochondrial energy production, serving as both an antioxidant and an energy-transferring molecule. As such, deficits in CoQ10 will not only lead to a cessation of energy production, but also an increase in oxidative damage.   Individuals with chronic fatigue regularly show deficiencies in CoQ10 concentrations throughout the body [33], as do those with conditions in which fatigue is a common symptom, like fibromyalgia [34–36], those who have survived heart attacks or heart failure [37,38], and multiple sclerosis [39,40].   Supplementation with CoQ10 improves fatigue, autonomic nervous system activity (the part of the nervous system involved in rest and recovery), and biochemical parameters of mitochondrial energy production in those with chronic fatigue [41–44], and reduces general fatigue and oxidative stress in healthy adults [45,46].   ALPHA-LIPOIC ACID (IDEALLY R-ALA)   Alpha-lipoic acid (ALA) is a mitochondrial molecule involved in energy metabolism and the antioxidant system. It is not only essential for mitochondria to create cellular energy, but also serves to function as an antioxidant, replenish other antioxidants, and stimulate the production of antioxidant enzymes like glutathione [47].   Accordingly, ALA has been heavily investigated as a mitochondrial rejunivator, able to help reverse age-related declines in mitochondrial energy production [48], particularly within the brian [49,50].    By improving mitochondrial function and protecting against oxidative stress, ALA has been shown to benefit metabolic health [51,52], as well as facilitate weight loss among those who are overweight [53–55].   ALA exists as either an S or R isomer, with unspecified ALA being a 50-50 ‘racemic’ solution of both. Most studies use the racemic solution, but only R-ALA has biological activity in the body and is more bioavailable [56], which is why we use it in Energenesis.   NAD+ REGENERATION COMPLEX   TAURINE   Taurine is an omnipresent amino acid within the body, essential for the development and function of our cardiovascular, muscular, nervous, and ocular systems [57]. It’s also essential for mitochondrial energy production and protein synthesis [58,59]   The highest amounts of taurine are in tissues with huge energy requirements and a lot of mitochondria, such as the retina, nerves, kidney, heart, and skeletal muscle [60]. If mitochondria don’t have enough taurine, energy production decreases and oxidative stress increases [61].   Insufficient taurine has been implicated in numerous chronic disease states [62,63], and several clinical trials have shown that supplementing with taurine reduces oxidative stress and inflammation in those with metabolic dysfunction [64–66].   Additionally, a meta-analysis reported that taurine supplementation improved endurance exercise performance, particularly power output and the amount of time that people could run before exhaustion [67].   MAGNESIUM   Magnesium is required for over 300 enzymes to function properly — muscle contractions, blood vessel regulation, insulin signaling, the synthesis of DNA and proteins, and nerve transmission all require magnesium [68].   One of the enzymes that relies on magnesium is ATP synthase, which is responsible for generating cellular energy (ATP) within mitochondria. Without magnesium, your mitochondria simply can’t function efficiently [69,70].   Energenesis provides two forms of magnesium, citrate and malate, which are both cofactors for mitochondrial energy production themselves.   B3 VARIANTS (NMN, NR, NIACIN & NIACINAMIDE)   Niacin is an essential component of energy-carrying molecules within the mitochondria, all of which are derivatives of nicotinamide adenine dinucleotide (NAD+). NAD+ is important for energy production, mitochondrial function, and cellular repair processes.   The primary route of NAD+ synthesis is through something called the salvage pathway, in which niacinamide serves as the starting molecule. We can also make NAD+ from nicotinic acid using an alternative pathway, which is why we’ve included both forms in Energenesis to ensure that NAD+ generation is not being impeded by a simple vitamin insufficiency.   MITOCHONDRIAL ENERGY PRODUCTION COFACTOR COMPLEX   POMEGRANATE   Pomegranate is a rich source of ellagitannins, potent antioxidant molecules that can be further metabolized into other antioxidant derivatives like ellagic acid and urolithins [71,72]. These substances have been heavily investigated for their mitochondrial and cardiovascular benefits.   Pomegranate ellagitannins and their derivatives have been shown to enhance mitochondrial function [73] and increase rates of mitophagy (mitochondria + autophagy) [74,75], which is a quality control pathway that preserves mitochondrial health by targeting damaged mitochondria for autophagic degradation, making anything that facilitates mitophagy absolutely vital for optimal health and disease prevention.   In recreational endurance athletes, supplementing with pomegranate extract for just two weeks increased the total time the athletes could cycle before complete exhaustion by 14 percent and increased the amount of time they could rely on their mitochondria to supply most of their energy by 10 percent [76].   Moreover, pomegranate supplementation has been shown to reduce blood lipid oxidation and the accumulation of plaque in arteries [77], particularly in people who have higher levels of oxidative stress [78,79].   GREEN TEA CATECHINS   Green tea (Camellia Sinensis) catechins are four phytochemical molecules, the most potent one being epigallocatechin-3-gallate (EGCG). It has been implicated in benefiting almost every organ system in the body in doses you can obtain easily from simply drinking green tea [87–89].   EGCG is neuroprotective [90,91], cardioprotective [92,93], anti-obesity [94–96], anti-carcinogenic [97,98], and anti-diabetic [99], all due primarily to its ability to stimulate mitochondrial biogenesis, enhance energy production, and protect mitochondria from oxidative stress [100,101].   Supplementation of EGCG plus resveratrol (another ingredient of Energenesis) has been shown to significantly increase mitochondrial function and the use of fatty acids for energy production [102], and several meta-analyses have concluded that EGCG reduces body weight and body fat [103–106], particularly abdominal fat [107].    GYNOSTEMMA   Gynostemma is a climbing vine native to SouthEast Asia and related to Panax Ginseng, containing many of the same bioactive molecules. Unlike ginseng, however, gynostemma also possesses an array of gypenosides that have been shown to upregulate several signaling molecule likes sirtuins and AMPK which facilitate mitochondrial function and biogenesis [108–110].   Clinical trials have shown that supplementation with gynostemma improves metabolic health through these mechanisms. A study of overweight men and women reported that supplementing with 450 mg of gynostemma daily for 12 weeks reduced total abdominal fat by 6%, visceral fat by 10%, and subcutaneous fat by 4% compared to a placebo [111].   Drinking 6 grams of gynostemma in the form of a tea lowered fasting glucose and insulin resistance each by 30% compared to a placebo after 12 weeks in adults with type 2 diabetes [112], and supplementing with 80 mL of gynostemma extract may improve liver health alongside dieting more than dieting alone in adults with fatty liver disease [113].   ASHWAGANDHA (SHODEN EXTRACT)   Ashwagandha (Withania somnifera) is a nightshade revered in Ayurvedic medicine for its physical- and mental-enhancing effects [114]. Today, it’s considered an adaptogen for similar reasons, able to increase a person’s resilience to stress and help reduce anxiety [115,116].   These effects are largely due to its constituent withanolide structures, which have several important neuroprotective effects within the brain, such as scavenging free radicals, reducing neuroinflammation, and promoting neurotransmitter signaling [117]. They also improve mitochondrial function and energy production [118].   In Energenesis, we use the most potent form of ashwagandha, a 35% withanolide concentrate called the Shoden extract. Just 240 mg of Shoden ashwagandha reduces stress and anxiety by 30% in mildly stressed adults [119], while a mere 60 mg can boost DHEA-S and testosterone by 15–18% in middle-aged men [120].   In another large randomized placebo-controlled trial of 150 men and women, supplementing 120 mg has been documented to improve physical and psychological quality of life by 8% and enhance sleep quality by 40% compared to placebo, including dramatically improving the time it took to fall asleep, total sleep time, and nightly awakenings [121].   Other studies have shown ashwagandha supplementation to reduce perceived stress, anxiety, and depression in mildly stressed healthy adults [122,123], adults battling chronic mental stress [124], and adults with an anxiety disorder [125].   PANAX GINSENG   Panax ginseng has been used medicinally for thousands of years in China, Korea, and Japan to alleviate physical and mental fatigue. While there are several types of ginseng on the market, panax ginseng is considered the “true” ginseng.   At a fundamental level, panax ginseng works to protect mitochondria from oxidative damage and improve energy production under conditions of oxidative stress [126,127]. A systematic review and meta-analysis of five studies in chronic fatigue patients found significant benefits of ginseng supplementation for reducing fatigue severity [128], with reductions of 20 percent after one month not being uncommon [129,130].   PQQ (PYRROLOQUINOLINE QUINONE)   Pyrroloquinoline Quinone (PQQ) is a potent stimulator of pathways involved in mitochondrial biogenesis and antioxidant defenses [131,132]. In particular, it stimulates pathways shared by exercise training and is believed to potentiate and enhance activity-induced benefits on mitochondria [133].   Supplementation has been shown to reduce fatigue and increase vigor by 20 percent in adults complaining of poor sleep and energy levels, as well as improve mood, sleep quality, and overall quality of life [134]. In another study of healthy adults, PQQ reduced inflammation and improved markers of mitochondrial respiration [135].   References

Imagine a probiotic bacteria that doesn’t just improve your gut but skyrockets energy, shrinks fat, boosts muscle, and heals your gut at the same time! Introducing TWK10 EnergyBiotic The only probiotic strain scientifically proven to help you lose fat, lessen fatigue, increase energy, enhance muscle, and amplify exercise performance. It’s not just a probiotic…it’s an EnergyBiotic! TWK10 EnergyBiotic powers your performance Whether you’re an athlete or just athletic… Competing in or completing your first 5K… Getting stage ready or gently strengthening your muscles… We searched the scientific literature and found the most effective, advanced compound available to promote gut health and your unique performance goals. TWK10 EnergyBiotic is the only probiotic backed by human studies to… Increase energy and exercise performance by up to 42%! [1] Balance body composition Lower body fat Enhance grip strength [2] Optimize muscle growth and strength Boost balance and walking speed Decrease abdominal fat Minimize inflammation [3] Fight fatigue at the cellular level Promote a healthy gut environment Did you know low muscle strength is linked to a 134% increased risk of death from any cause? [4] Aging doesn’t have to be a slow decline. Disability, dysfunction, and premature death are not mandatory. TWK10 EnergyBiotic is backed by multiple studies to strengthen your muscles, your mind, and burn fat at the same time. “...TWK10 significantly elevated…exercise performance…and improved the fatigue-associated features correlated with better physiological adaptation. The change in body composition shifted in the healthy direction for TWK10 administration groups...which showed that body fat significantly decreased and muscle mass significantly increased.” – “Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans,” Huang et al., 2019, Nutrients TWK10 has postbiotic power, too Postbiotics are one of the newest fields of gut microbiota study. But…what are they?  Along with probiotics, postbiotics are gut-balancing compounds that create robust benefits for your digestive system, immune function, and, in the case of TWK10 EnergyBiotic, your performance. [8] Research in healthy adults found that the postbiotic function of TWK10 led to... A 33% increase in endurance [3] Significant decreases in inflammation Positive changes in body composition Increased short-chain fatty acids* Known for their anti-obesity, anti-diabetes, liver protective, neuroprotective, immune balancing, anti-inflammatory, and cardiovascular protective qualities [9] Beneficial shifts in the gut microbiome Plus, animal studies using TWK10 have shown... Lower body weight by up to 7.5% [10] As much as a 4.81-fold improvement in exercise performance! Up to 26.6% decrease in total cholesterol and lower triglycerides 1.72-fold increase in mitochondria-rich muscle fibers Strengthened bone quality Healthier vitamin D levels [11] Improved learning and memory abilities Improved learning and memory abilities Increased liver and kidney function [12] This might sound like a minor detail…but specificity matters. L. plantarum TWK10 versus unspecified L. plantarum is the difference between a probiotic that works, backed by dozens of scientific studies… …compared to one with questionable results. [13] Consider this analogy: A Chihuahua and a Doberman are both canines but aren’t the same breed or “strain” of canine. They are obviously very different in their behavior and efficacy in accomplishing certain objectives, e.g., being a lap dog versus a guard dog. Comparing L. plantarum to L. plantarum TWK10 is like comparing a Chihuahua to a Doberman. Only L. plantarum TWK10 can help you accomplish your goals to lose fat, build muscle, increase endurance, and enhance energy. Huang W-C, Lee M-C, Lee C-C, Ng K-S, Hsu Y-J, Tsai T-Y, et al. Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans. Nutrients [Internet]. 2019;11. Available from: http://dx.doi.org/10.3390/nu11112836 Lee M-C, Tu Y-T, Lee C-C, Tsai S-C, Hsu H-Y, Tsai T-Y, et al. Lactobacillus plantarum TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial. Microorganisms [Internet]. 2021;9. Available from: http://dx.doi.org/10.3390/microorganisms9071466 Lee C-C, Liao Y-C, Lee M-C, Cheng Y-C, Chiou S-Y, Lin J-S, et al. Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans. Microorganisms [Internet]. 2022;10. Available from: http://dx.doi.org/10.3390/microorganisms10112181 Li R, Xia J, Zhang XI, Gathirua-Mwangi WG, Guo J, Li Y, et al. Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults. Med Sci Sports Exerc. 2018;50:458–67. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50:889–96. Landi F, Calvani R, Cesari M, Tosato M, Martone AM, Bernabei R, et al. Sarcopenia as the Biological Substrate of Physical Frailty. Clin Geriatr Med. 2015;31:367–74. Kojima G. Frailty as a Predictor of Nursing Home Placement Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. J Geriatr Phys Ther. 2018;41:42–8. Vinderola G, Sanders ME, Salminen S. The Concept of Postbiotics. Foods [Internet]. 2022;11. Available from: http://dx.doi.org/10.3390/foods11081077 Xiong R-G, Zhou D-D, Wu S-X, Huang S-Y, Saimaiti A, Yang Z-J, et al. Health Benefits and Side Effects of Short-Chain Fatty Acids. Foods [Internet]. 2022;11. Available from: http://dx.doi.org/10.3390/foods11182863 Chen Y-M, Wei L, Chiu Y-S, Hsu Y-J, Tsai T-Y, Wang M-F, et al. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice. Nutrients. 2016;8:205. Lee C-C, Liao Y-C, Lee M-C, Lin K-J, Hsu H-Y, Chiou S-Y, et al. Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice. Front Nutr. 2021;8:708096. Chen Y-M, Liao C-C, Huang Y-C, Chen M-Y, Huang C-C, Chen W-C, et al. Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice. Food Sci Nutr. 2020;8:3525–34. McFarland LV, Evans CT, Goldstein EJC. Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Front Med. 2018;5:124.

One Molecule. Hundreds Of Benefits. Over 2000 Scientific Studies.It’s not too good to be true—Molecular Hydrogen is the energy-boosting, brain-enhancing, performance-improving, pro-longevity antioxidant, anti-inflammatory, and anti-wrinkle supplement only researchers have heard of.Say Hello To HydrogenThe molecular answer to modern disease. You know the numbers… Every 33 seconds, someone in the United States dies from cardiovascular disease [1]. Every 52 seconds, someone dies from cancer [2].Statistically, one out of every three of your friends has metabolic syndrome and a higher risk of heart disease, diabetes, and stroke [3].The solution?One of the smallest compounds on Earth.Over 2000 studies prove molecular hydrogen’s powerful ability to support the underlying causes of modern disease.Benefit From... Sharper brain function [4] Sustained energy [5] Balanced body composition [6] Better Skin [7] Boosted metabolism [8] Improved immune function [9] Faster recovery [10] Powerful anti-aging [11] Potent mitochondrial protection [12] The vitality to do what you love Most Antioxidants Have A Dark Side...Generally, antioxidants do a lot of good. Research shows they fight aging, support our immune system, and help us avoid heart disease and cancer (13).But they also have a dark side.Why?Your body does best with balance. The right amount of stress—even oxidative stress—is a crucial trigger for powerful endogenous antioxidants like superoxide dismutase, catalase, and glutathione peroxidase.Most supplemental antioxidants disturb this delicate balance.But Molecular Hydrogen isn't most antioxidants.It acts as a master antioxidant by stimulating your body’s own internal defense system—your best source of optimized energy, performance, and recovery [14,15].Molecular Hydrogen Promotes Health In Three Primary Ways: Unique antioxidant action: Directly and indirectly protects cells, proteins, and DNA from oxidative damage while elegantly influencing intracellular communication Powerful anti-inflammatory: Reduces innate immune activation and promotes balance of pro- and anti-inflammatory cytokines at the genetic level (16, 17) Dynamic apoptotic regulation: Adaptively balances programmed cell death and degradation—protects normal cells and may inhibit proliferation of malignant cells (18)     Blood Sugar Balance And Beauty With zero side effectsSustained Energy Molecular hydrogen positively impacts mitochondrial function and supports both acute and chronic fatigue [19] Hydrogen’s ability to easily cross biological membranes, such as the double membrane surrounding mitochondria, allows easy entrance and quick action for those experiencing the increase in reactive oxygen and nitrogen species often associated with fatigue from disease states, stress, or high-intensity exercise [20]. In both animal and human studies, hydrogen has been shown to improve energy thanks to its antioxidant, anti-inflammatory, and even gene-level effects. It works within the mitochondria to quell hydroxyl radicals and block specific inflammatory pathways, such as the NLRP3 inflammasome. Weight Loss & Improved Body Composition Multiple studies have shown that supplemental hydrogen leads not only to weight loss but also improved body composition (fat-to-muscle ratio) [21,22]. In a study of middle-aged, overweight women, four weeks of hydrogen supplementation led to decreases in body fat percentage, serum triglycerides, and fasting serum insulin, likely due to hydrogen’s influence on obesity-associated mitochondrial dysfunction and inflammation. The participants also experienced an increase in the endogenous antioxidant CoQ10 along with an improved lactate-to-pyruvate ratio, indicating positive mitochondrial outcomes [23]. Immune Balance Investigations into the effects of hydrogen on autoimmune disease show a delay in the progression of experimental autoimmune encephalomyelitis, an experimental form of multiple sclerosis. Disease severity, central nervous system infiltration, and demyelination were reduced when hydrogen was administered after the onset of the disease [24]. Supplemental hydrogen’s antioxidant and anti-inflammatory actions, specifically its ability to scavenge hydroxyl radicals, make it a promising therapy for those with rheumatoid arthritis (RA). After 4 weeks of drinking hydrogen-enriched water, patients with RA had lower levels of oxidative marker 8-OHdG and decreased disease activity. Those with early RA achieved disease remission (25,26). Cognitive Performance A small study of hydrogen supplementation’s effect on cognitive function in older women found that those who received hydrogen scored significantly better on tests of mental function, including improvements in word recall and word recognition. The authors report that the average cognitive enhancement was significant enough for the group to progress from mild dementia at baseline to normal cognition at follow-up [27]. A second joint study examined memory-impaired animals and humans with mild cognitive decline. In mice, hydrogen water reduced oxidative stress, suppressed memory impairment and neurodegeneration, and even extended lifespan. After one year of hydrogen water, human participants with the APOE4 genotype, a known risk factor for Alzheimer’s disease, scored significantly better on the Alzheimer’s Disease Assessment Scale, while the control group received slightly worse scores [28]. The Healing Power Of Hydrogen In Every Glass Metabolic Protection A randomized, double-blinded, placebo-controlled study of 30 men and 30 women with metabolic syndrome found that 24 weeks of hydrogen water consumption led to: 18.5 mg/dL reduction in total cholesterol 47 mg/dL reduction in triglycerides 18.4 mg/dL reduction in fasting glucose 12% reduction in HbA1c Reduction of inflammatory markers TNF-a, IL-6, and CRP Additionally, the antioxidant vitamins E and C significantly increased in the group drinking hydrogen water. These effects are likely due to hydrogen’s antioxidant capabilities but may also be related to its positive influence on the electron transport chain, the series of biochemical steps leading to ATP production [29]. Skin Health Hydrogen-rich water may be both internally and externally beneficial for the skin! One small Japanese study found that direct application of hydrogen water to the skin significantly decreased wrinkles, skin blotchiness, and modulated oiliness, meaning it reduced oiliness in participants with excessively oily skin and increased it in participants with dry skin. The authors speculate that the potent antioxidant action of hydrogen water was responsible for mitigating reactive oxygen species damage that leads to skin aging [30]. Hydrogen also shows promise for those healing from skin damage due to radiation. In a recent animal study, radiation-induced skin wounds healed more quickly in the group sprayed with hydrogen water, likely due to lowered levels of malondialdehyde, a marker of oxidative stress, and IL-6, an inflammatory marker. Further, the wounds treated with hydrogen water had increased superoxide dismutase activity, an endogenous antioxidant enzyme [31]. Exercise Performance & Recovery The influence of supplemental hydrogen on athletic performance reveals that even short-term supplementation may have positive benefits on endurance, fatigue, respiratory rate, heart rate, blood lactate levels, and perceived effort [32, 33, 34]. Additionally, hydrogen encourages recovery from soft tissue injuries [35]. Hydrogen’s unique role as a supporter of endogenous antioxidant production makes it particularly valuable to active people who want to achieve optimal health and improved performance. Research shows it balances exercise-induced oxidative stress and may even act as an alkalinizing agent capable of combating fatigue during high-intensity exercise [36]. How Did We Create Drinkable Hydrogen? The answer is a simple (and very safe) chemical reaction—the form of magnesium used in Molecular Hydrogen reacts with water to produce hydrogen gas. For maximum benefit, begin drinking immediately after your tablet dissolves. It won’t be a struggle—Molecular Hydrogen is flavored with 100% natural raspberry powder. Molecular Hydrogen: Supporting Metabolism For Over 2 Billion Years (You read that right.) According to the Hydrogen Hypothesis, hydrogen is the link between evolution and the development of our primary energy producers—mitochondria [37]. Billions of years ago, we evolved with a need for hydrogen. That requirement was fulfilled by the microscopic ancestors of present-day mitochondria. How does evolution affect you today? Research shows that molecular hydrogen has a profound positive impact on metabolism and mitochondrial health. Supplemental Hydrogen Supports Mitochondrial Functions, Including: Balanced cholesterol [38] Metabolic stability [39, 40] Optimal body composition Liver capacity [41,42] Cardiovascular fitness [43] Healthy blood pressure [44] References National Center for Chronic Disease Prevention and Health Promotion, Division for Heart Disease and Stroke Prevention. Heart Disease Facts. Last Reviewed: May 15, 2023. Division of Cancer Prevention and Control, Centers for Disease Control and Prevention. An Update on Cancer Deaths in the United States. Page last reviewed: February 28, 2022. Hirode G, Wong RJ. Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016. JAMA. 2020;323(24):2526-2528. Mizuno K, Sasaki AT, Ebisu K, et al. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res. 2018;7(4):247-255. Barancik M, Kura B, LeBaron TW, Bolli R, Buday J, Slezak J. Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems. Antioxidants (Basel). 2020;9(12):1281. LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896. Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B. 2012;106:24-33. LeBaron TW, Singh RB, Fatima G, Kartikey K, Sharma JP, Ostojic SM, Gvozdjakova A, Kura B, Noda M, Mojto V, Niaz MA, Slezak J. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896. Qiu P, Liu Y, Zhang J. Recent Advances in Studies of Molecular Hydrogen against Sepsis. Int J Biol Sci. 2019;15(6):1261-1275. Tarnava A. Supersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report. JoSaM. 2021;3(1). Fu Z, Zhang J, Zhang Y. Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases. Oxid Med Cell Longev. 2022;2022:2249749. Yamamoto H, Ichikawa Y, Hirano SI, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases. Int J Mol Sci. 2021;22(13):7211. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46(2):140-149. Trivic T, Vojnovic M, Drid P, Ostojic S. Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: a pilot study. Current Topics in Nutraceutical Research. 2017;15(1). Sim M, Kim CS, Shon WJ, Lee YK, Choi EY, Shin DM. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. Sci Rep. 2020;10(1):12130. Tian Y, Zhang Y, Wang Y, et al. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Front Physiol. 2021;12:789507. Mohd Noor MNZ, Alauddin AS, Wong YH, et al. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pac J Cancer Prev. 2023;24(1):37-47. Hirano SI, Ichikawa Y, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review. Front Neurol. 2022;13:841310. Zhou K, Liu M, Wang Y, et al. Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis. Front Nutr. 2023;10:1094767. Kamimura N, Nishimaki K, Ohsawa I, Ohta S. 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The hidden, evidence-based answer to a longer, healthier life? Optimal Cellular Hydration Hydration is much more important than you realize… it's the unlikely key to a LONGER LIFE Research tells us that hydration equals optimal energy, mood, cognition, and skin health. But one surprising benefit you may not know—hydration equals a longer, more vibrant life. Introducing Cellular Hydration. An advanced cellular-level hydration formula that supports energy, brain health, physical performance, and longevity. The Science-Backed Benefits of Cellular Hydration Cellular hydration isn’t just wellness lingo…it’s backed by science Hydration at the cellular level has been connected with: Increased energy at the cellular level [1] Boosted brain function [2] Better mental health and mood [3] Enhanced heart and vascular health [4, 5] Superior muscle performance [6] Deep nourishment from over 70 naturally-derived trace minerals [7] Accelerated anti-aging [8] Exercise performance enhancement [9] Positive changes to gut health and your good bacteria [10] Improved mitochondrial function [11] And a longer, healthier life! [12] The Longevity-Hydration Link New research shows hydration is a powerful key to “slow down aging and prolong a disease-free life.” What if there was a magic elixir that could lower your risk of chronic disease and dying early… Would you drink it? A drink you could sip on every day that would… Lower your risk of disease Give you more energy Better performance Better mood and brain function And slow down the aging process It turns out that hydration – true, cellular hydration – is a major key to health and longevity.  With Hydrate, you can create cellular hydration and all the benefits it provides in mere seconds. According to New Research… Staying Well-Hydrated Is Closely Linked to Longevity According to a National Institutes of Health study published in 2023, “Adults who stay well-hydrated appear to be healthier, develop fewer chronic conditions, such as heart and lung disease, and live longer than those who may not get sufficient fluids” [12]. The study analyzed data from 11,255 adults over a 30-year period for links between hydration status and health conditions. They found something remarkable: Adults with low hydration status had a whopping 64% higher risk of developing heart failure, stroke, atrial fibrillation, peripheral artery disease, chronic lung disease, diabetes, dementia and other diseases.  They found that those with poor hydration status had poorer lung function, more inflammation, and poorer metabolic and cardiovascular health. They even found that hydration status was an indicator of aging faster biologically than chronologically! “The results suggest that proper hydration may slow down aging and prolong a disease-free life.”  – Natalia Dmitrieva, Ph.D., a study author and researcher in the Laboratory of Cardiovascular Regenerative Medicine at the National Heart, Lung, and Blood Institute, part of NIH Poor Hydration is Rampant Optimal hydration isn’t just for athletes sweating a lot or after the sauna. The research is clear: Hydration leads to a long life & healthy aging and is important for EVERYONE. As we age, our ability to sense thirst decreases. Paired with changes in our body’s water and sodium balance, adults tend to become dehydrated.   Electrolytes aren’t just for athletes. They’re for people who want a long, healthy life Large-scale research shows that roughly 1 in 3 older adults is dehydrated, and a much larger percentage may have more subtle issues of poor hydration that don’t qualify as full-blown “dehydration.” [13] Not only that, younger and younger populations are suffering from the negative effects of dehydration: In the United States, over 50% of children between the ages of 6 to 19 are dehydrated. [14] Hydrate is safe, supportive, and, according to science, needed by people of every age. Cellular Hydration’s Ingredients Support Longevity Better Than Any Other Formula Hydration isn’t simply a matter of drinking more fluids. It’s a cellular process. But most electrolyte formulas don’t perform at the cellular level. Hydrate is much more than electrolytes—it’s cellular hydration with every sip. Potassium A Cellular Hydration Superstar We use 200%-1,000% more potassium than typical electrolyte formulas and sports drinks. Why?  Potassium deficiency is rampant and is a major contributor to poor health and dehydration at the deepest levels. Study after study reveals that Western dietary habits leave us deficient in potassium and over-exposed to sodium, a silent imbalance that can lead to high blood pressure, acidic systemic pH, and cellular dehydration. Hydrate contains four types of potassium—potassium citrate, potassium chloride, potassium bicarbonate, and dipotassium phosphate—formulated to mimic the potassium contained in a whole food diet. Potassium regulates cellular hydration Your cells contain 30 times more potassium than the extracellular space! Deep hydration demands adequate potassium [23]. Balanced potassium & sodium lead to less risk of high blood pressure, heart disease, stroke, and other health risks like kidney stones Potassium supports optimal blood pressure, proper nervous system function, bone density, and reduction of kidney stone formation. In a study of 57 people with kidney stones, 75% of those given potassium citrate experienced disease remission, and reduced stone formation was found in ALL patients [24, 25, 26].  Multiple studies show the benefits of increasing potassium and decreasing salt. People who eat high ratios of salt to potassium increase their risk of death by 46% [27]! Potassium contributes to an alkalized body Our modern foods and lifestyles leave us with an acidic systemic pH. Potassium-rich foods and supplements, like Hydrate, are the solution to keep us easily alkalized and at less risk of negative health outcomes from metabolic acidosis, such as hypertension, type 2 diabetes, and even anxiety. An alkalized body also means improved sports performance [28, 29]! In a market flooded with electrolyte formulas, Cellular Hydration stands out Longevity-supporting and performance-enhancing water you can make in seconds Achieve the perfect pH with bicarbonate and other key alkalizing cofactors like citrate, malate, and potassium Plus, benefit from the performance-enhancing benefits of bicarbonate!  A little-known fact is that body pH regulation is a critically important aspect of health. Unfortunately, our modern foods and lifestyles promote an acidic systemic pH and a higher risk of negative health outcomes, such as hypertension, type 2 diabetes, and even anxiety [28]. But with adequate amounts of nutrients and cofactors, your body can masterfully regulate pH. Bicarbonate, citrate, malate, and potassium are powerful pH cofactors and play unique roles in keeping your body within an ideal alkaline pH…something no other electrolyte formula offers [30, 31, 32]. As an added bonus, an alkalized body also means improved sports performance and greater amount of lean muscle mass, especially in older individuals [29, 33]. Bicarbonate Bicarbonate, found in Hydrate as sodium bicarbonate and potassium bicarbonate, is the chief alkalizing substance your body uses to create an optimal pH. Research tells us that a diet rich in fruits and especially vegetables supplies most of our bicarbonate, but your body also creates its own bicarbonate as part of pH buffering. Unfortunately, our current diet and lifestyle patterns skew us toward acidic states that sometimes need outside assistance from supplemental bicarbonate [34]. Hydrate is the perfect way to introduce the extra bicarbonate you need not only for optimal pH but also for the added bonus of increased physical performance. Multiple studies have found benefits of bicarbonate for males and females and in many different forms of exercise, such as endurance, high-intensity training, and even hands-on activities such as karate or judo [32]. Citrate & Malate Both citrate and malate, found in Hydrate as magnesium malate and potassium citrate, are technically known as anions. Your body transforms these compounds into alkalizing bicarbonate during the process of digestion [35]! Along with Hydrate, you’ll find these anions in fruits and especially vegetables. On top of their ability to create an alkaline environment, they also support your body in maintaining adequate calcium stores and, thus, better bone health and less risk of detrimental fractures [36].   Potassium Hydrate’s special mixture of potassium promotes pH balance in multiple ways—the alkalizing ions of potassium citrate, the direct buffering of potassium bicarbonate, and the powerful action of potassium itself. The Longevity Power of Taurine L-taurine is best known as a non-structural amino acid, but it plays crucial roles in optimal hydration due to its function as an osmoprotectant, meaning it guards against the negative effects of dehydration and electrolyte imbalance [37]. Additionally, it’s particularly beneficial to the heart, muscle tissue, and brain and is neuroprotective [38, 39]. But new research reveals that taurine slows or even reverses aging at the cellular, mitochondrial, and genetic levels, likely due to its role in combating oxidative stress, mitochondrial dysfunction, and cell deterioration and protection against telomerase deficiency, DNA damage, and inflammation [40, 41]. It’s even been shown to protect against skin aging (aka, wrinkles!) in animal models [42] As one study succinctly stated, “Taurine supplementation extends healthy lifespan.” The 500 milligrams of taurine in each serving of Hydrate also supports digestive health, specifically the lining of the small intestine, as well as the balance of the gut microbiota and bile acid composition needed for optimal fat digestion [43, 44, 45]. Creatine... Not Just for Athletes You probably think of creatine as a supplement just for athletes—that’s a common and unfortunate misconception! Creatine monohydrate is the most extensively researched compound of all time. It’s a powerful sports supplement—for many athletes, it’s a highly effective performance aid as well as a promoter of lean body mass—but it’s also extremely useful for longevity and hydration. Creatine is a hyper-hydrator that leads to greater fluid volume inside the cell. It may also help with thermoregulation, meaning that, in hot or humid environments, creatine allows the body to adapt to higher temperatures and avoid dehydration and heat illness [46, 47]. Along with this, creatine has been well-researched for its ability to help older adults maintain muscle mass and bone vitality. Studies show anti-inflammatory and anti-aging properties, along with a lower risk of falls with creatine use [48]. Creatine also has special neuroprotective qualities and is particularly supportive of brain and cognitive function. One study called it “more than a supplement for athletes” due to its ability to reduce mental fatigue, protect the brain from neurotoxicity, and even improve some neurological disorders like depression and bipolar disorder [49]. All in all, a master ingredient for hydration, performance, and longevity. Fulvic Acid & Trace Minerals: Naturally-derived microminerals Fulvic acid, a crucial element in humus, the nutrient-rich layer of the earth, is created by microbes breaking down plant matter. This compound combines with minerals to form a complex molecular compound. Termed ‘nature’s miracle molecule,’ fulvic acid activates soil nutrients for plant cell utilization, fostering strong and healthy growth. Fulvic acid has recently risen in popularity as a supplement due to studies showing its usefulness in inflammatory conditions, skin disease, metabolic disorders, immune strengthening, wound healing, and digestive function [50].Fulvic acid broadens the mineral profile you receive in each dose of Hydrate. Evidence also shows that it further enhances the absorption of key minerals into the cell. This ingredient is strictly sourced from a pristine area of Northwest New Mexico and contains a thoroughly tested array of naturally occurring fulvic ionic macro and micro trace minerals and elements. Skip the artificial fluorescent green-colored ”ades” for a hydration formula that PERFORMS Replenishing minerals after a sweaty workout or sauna session keeps you feeling and thinking your best. Any sports drink can provide a little extra sodium, potassium, and magnesium (and a LOT of food coloring, sugar, and added ingredients)… But Hydrate isn't just any sports drink. It offers extra minerals—in the forms and amounts that actually make a difference—along with science-backed, pH-balancing ingredients like taurine for anti-aging and cardio-protection, creatine for hyper-hydration, muscle-mass promotion, and more complete recovery, and potassium, citrate, malate, and sodium bicarbonate, for alkalized performance enhancement. The mineral-rich, alkalizing water you create with Hydrate amplifies performance with…  Supercharged Hydration Research shows that mineral-rich, alkalizing water provides hydration that supports your health and keeps you performing at the highest level. One such study of 38 people found that, over a four week period, ingestion of mineral-rich, high alkaline water led to a more favorable bodywide pH and improved hydration status compared to non-mineralized water [51]. Superior Performance Cellular hydration and alkaline pH mean Hydrate is an essential part of your workout. Studies show that high mineral water leads to increased muscle and cardiovascular function, deters metabolic acidosis, and assists in better metabolic function, i.e., it promotes more efficient metabolism so your exercise is energized and you leave the gym feeling your best [52, 53, 54, 55, 56, 57].   Zacchia M, Abategiovanni ML, Stratigis S, Capasso G. Potassium: From Physiology to Clinical Implications. 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Hydration Status in Older Adults: Current Knowledge and Future Challenges. Nutrients. 2023;15(11):2609. Kenney EL, Long MW, Cradock AL, Gortmaker SL. Prevalence of Inadequate Hydration Among US Children and Disparities by Gender and Race/Ethnicity: National Health and Nutrition Examination Survey, 2009-2012. Am J Public Health. 2015;105(8):e113-e118. Armstrong LE, Ganio MS, Casa DJ, et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012;142(2):382-388. Pross N, Demazières A, Girard N, et al. Influence of progressive fluid restriction on mood and physiological markers of dehydration in women. Br J Nutr. 2013;109(2):313-321. Carlton A, Orr RM. The effects of fluid loss on physical performance: A critical review. Journal of Sport and Health Science. 2015;4(4):357-363. Ganio MS, Armstrong LE, Casa DJ, et al. Mild dehydration impairs cognitive performance and mood of men. Br J Nutr. 2011;106(10):1535-1543. Arca KN, Halker Singh RB. Dehydration and Headache. 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