Sovereign Labs Curcumin LD 500mg 60 caps

Inflammation - the silent killer Inflammation is a natural response to stress, injury, or illness as part of the body’s normal recovery process.  However problems arise if you’re constantly in an inflammatory state.  Inflammation is the #1 performance robber.  It can negatively affect your joints, brain function, and gut health on a daily basis. Unfortunately, in today’s world it’s impossible to completely protect yourself from inflammation.  Things like exposure to wireless internet signals, too much artificial light, not getting enough sleep, and consuming too much sugar or processed foods are all causes of inflammation. And the negative side effects of inflammation are cumulative.  It may go un-noticed until you experience things like minor joint pain or occasional brain fog, but then it can develop into serious health problems.  In fact, chronic inflammation is the common link among the leading causes of death in developed nations.  It’s the root factor for 7 of the top 10 causes of death, including heart disease, cancer, diabetes, and Alzheimer’s. (1) Reducing inflammation is essential for performing at your highest level every day and living a long, healthy life.   Curcumin - fight inflammation and live optimal The root of the turmeric plant has been used has been used for centuries in Chinese and Ayurvedic medicine to treat various inflammatory conditions.  The natural phenol of turmeric responsible for its powerful anti-inflammatory properties is called Curcumin. Curcumin is capable of interacting with a number of different molecular targets involved in inflammation.  It modulates the inflammatory response by down-regulating the activity of enzymes such as lipoxygenase, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) - the target of the pharmaceutical drug Celebrex®.  It also inhibits the production of inflammatory cytokines including tumor necrosis factor-alpha (TNF-a), interleukin (IL) -1, -2, -6, -8, and -12, monocyte chemoattractant protein (MCP), and migration inhibitory protein.  This multi-pronged attack on inflammation is the key to its effectiveness.  Numerous studies over recent decades have substantiated the exciting mental and physical performance boosting benefits of curcumin.  It’s has been shown to: Reduce inflammation and lower disease risk (2,3) Increase BDNF (Brain-Derived Neurotrophic Factor) (4,5) Increase insulin sensitivity (6) Reduce symptoms of depression and increase mood (5,7) Speed recovery (8) Protect against neural degradation (9) Increase testosterone and boost muscle growth (10,11) However, curcumin powder has very low bioavailability…. The downside for curcumin - and the reason it hasn’t (yet) become a health superstar - is that it has very low oral bioavailability, resulting from poor solubility in the aqueous phase of the digestive fluids, limited intestinal uptake, rapid metabolism, and urinary excretion. (12) Our goal with Natural Stacks Curcumin was to change that. The science is too convincing and the benefits are too life-changing to simply throw curcumin away due to “low bioavailability”. Creating a superior curcumin supplement Unlike regular curcumin powder, we start with a standardized 95% curcumin extract - purified and concentrated from raw turmeric root.  We use the patented NovaSOL solubilisation technology to suspend the curcumin extract in microscopic spheres called micelles which transform the dense and opaque extract into a body-ready liquid form.  The liquid micelles are completely stable at gastric pH and are so microscopically small that the curcumin is readily absorbed and passed directly into the bloodstream. A human clinical trial showed that NovaSOL Curcumin is 185X MORE BIOAVAILABLE than regular curcumin powder and 10X MORE BIOAVAILABLE than a fully standardized (95%) curcumin extract.  It was also shown to be long lasting, remaining in blood plasma for up to 24 hours. (13) To take it a step further, we combined the liquid curcumin micelles with organic coconut oil for superior bioavailability. Anti-Inflammatory SUGGESTED USE: Take 1 serving per day, or as directed by a healthcare practitioner. U.S.A manufactured in a cGMP facility.  Natural Stacks proudly uses only the highest quality ingredients. NovaSOL® Curcumin Each serving contains 1,000 mg of NovaSOL curcumin, shown to be 10x more bioavailable than a fully standardized (95%) curcumin extract.  The unique micelle structure is completely stable at gastric pH allowing for rapid absorption, making it very effective at much lower doses. Organic Coconut Oil Certified organic coconut oil is the perfect addition to curcumin, allowing for maximum absorption. NovaSOL® is a registered trademark of Aquanova AG. Sources: http://www.medicalnewstoday.com/articles/282929.php http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/table/T1/ http://www.sciencedirect.com/science/article/pii/S0006899306027144 http://www.sciencedirect.com/science/article/pii/S0166432812006997 http://www.sciencedirect.com/science/article/pii/S0006291X0901571X http://www.ncbi.nlm.nih.gov/pubmed/23832433 http://www.ncbi.nlm.nih.gov/pubmed/26540017 http://www.ncbi.nlm.nih.gov/pubmed/26552010 http://onlinelibrary.wiley.com/doi/10.1046/j.1524-475X.1998.60211.x/abstract http://www.ncbi.nlm.nih.gov/pubmed/15746179 Sharma, R. A., Steward, W.P., Grescher, A. J., Pharmacokinetics and pharmacodynamics of curcumin. Adv. Exp. Med. Biol. 2007, 595, 453-470. http://novasolcurcumin.com/wp-content/uploads/2014/10/NovaSOL-Curcumin-Clinical-Study.pdf NovaSOL Curcumin 185X MORE BIOAVAILABLE than curcumin powder and 10X MORE BIOAVAILABLE than a fully standardized (95%) curcumin extract. According to scientists conducting independent research, “the liquid micellar formulation of curcumin significantly improved its oral bioavailability” and “Consumers will benefit dramatically from consuming relatively low doses of NovaSOL Curcumin (about 80 to 90 mg per day) as that is the bio-equivalent dose of 12 to 15 grams of curcumin powder.” [1] Anti-Inflammatory / Pain Relief / Tissue Healing High doses of curcumin improved tendon healing, lowered inflammation markers, and led to a faster and more complete recovery [2] “Curcumin is capable of promoting peripheral nerve regeneration in normal conditions.” and “In conclusion, curcumin is capable of promoting nerve regeneration after sciatic nerve crush injury in diabetes mellitus, highlighting its therapeutic values as a neuroprotective agent for peripheral nerve injury repair in diabetes mellitus.” [3] Lowers risk of and treats commons diseases of inflammation “This agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. The process of inflammation has been shown to play a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases” [4] including: Alzheimer’s, Multiple Sclerosis, Parkinson’s, Epilepsy, Cerebral Injury, Diabetes & Metabolic Disorders, Arthritis, HIV/AIDS, Allergies, IBS/Crohn's, Cardiovascular Disease, Cancer, and Depression.[5] Mental Performance Curcumin increases Brain-derived neurotrophic factor (BDNF) - the growth hormone responsible for neurogenesis (formation of new neurons) [6] “Curcumin treatment had positive effects on mitochondrial membrane potential.” [7] “Curcumin better than Prozac at lowering symptoms of depression with none of the alarming and unwanted side effects.” [8] Metabolic Disorders & Diabetes A 2009 Study from Auburn University published in Biochemistry and Biophysical Research Communications showed that “Curcumin is literally 400 times more potent than Metformin (a common diabetes drug) in activating AMPK which improves insulin sensitivity which can help reverse Type 2 Diabetes.” [9] Muscle Growth / Recovery Curcumin exhibits strong anti-catabolic properties - protecting muscle from excessive damage during eccentric training and preventing muscle loss during periods of no weight training. [10] The anti-estrogenic effects of curcumin increase ratio of testosterone:estrogen, promoting increased lean muscle mass [11] Webinar replay Discussing inflammation and the scientifically proven benefits of curcumin (link to webinar replay after Thursday 1/21) Sources: http://novasolcurcumin.com/wp-content/uploads/2014/10/NovaSOL-Curcumin-Clinical-Study.pdf http://www.ncbi.nlm.nih.gov/pubmed/26540017 http://www.ncbi.nlm.nih.gov/pubmed/26552010 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/table/T1/ http://www.sciencedirect.com/science/article/pii/S0166432812006997 http://www.jpreventionalzheimer.com/all-issues.html?article=39   http://www.ncbi.nlm.nih.gov/pubmed/23832433 http://www.sciencedirect.com/science/article/pii/S0006291X0901571X http://onlinelibrary.wiley.com/doi/10.1046/j.1524-475X.1998.60211.x/abstract http://www.ncbi.nlm.nih.gov/pubmed/15746179