WAM Essentials (Dr Wong) (18)

The word “systemic” means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ. But let’s take first things first, what is an enzyme? An enzyme is a biocatalyst - something that makes something else work or work faster. Chemical reactions are generally slow things, enzymes speed them up. Without enzymes the chemical reactions that make up our life would be too slow for life as we know it. (As slow as sap running down a tree in winter). For life to manifest as we know it, enzymes are essential to speed up the reactions. We have roughly some 3000 enzymes in our bodies and that results in over 7000 enzymic reactions. Most of these enzymes are derived or created from what we think of as the protein digesting enzymes. But while digestion is an important part of what enzymes do, it's almost the absolute last function. First and foremost these body wide proteolytic (protein eating) enzymes have the following actions: Natural Anti-Inflammatory: Inflammation is a reaction by the immune system to an irritation. Let’s say you have an injured right knee. The immune system, sensing the irritation the knee is undergoing, creates a protein chain called a Circulating Immune Complex (CIC for short), tagged specifically for that right knee. (The Nobel Prize in biology was won in 1999 by a scientist who discovered this tagging mechanism). This CIC floats down to the right knee and causes pain, redness and swelling; the classic earmarks for inflammation. This at first is a beneficial reaction because it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating; itself creating an irritation that the body makes CIC’s to in response!   At this point, most people turn to their medicine chest and take a couple of Non Steroidal Anti-Inflammatory drugs (NSAIDs) like Aspirin, Ibuprofen, Celebrex, Vioxx, etc. And the problem with that is: NSAID's work by keeping the body from making all CIC's!!! This ignores the fact that some CIC’s are vital to life, like those that maintain the lining of the intestines and those that keep the kidneys functioning! Not to mention the fact that the NSAID’s, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs. (4,5). This is where systemic enzyme use is so important.   Systemic Enzymes are the first line of defense against inflammation. (1,2,3). Systemic enzymes are perfectly safe and free of dangerous side effects and they have no LD-50, or toxic dose. (6). Best of all systemic enzymes can tell the difference between the good CIC’s and the bad ones because hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC’s. So instead of preventing the creation of all CIC’s, systemic enzymes just “eat” the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also. Anti-Fibrosis:  Systemic Enzymes eat scar tissue and fibrosis. (7). Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain: As we age, which starts at 27, we have a diminishing of the bodies’ output of enzymes. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 27. At that point the body knows that if it keeps up that rate of consumption we’ll run out of enzymes and be dead by the time we reach our 40’s. (Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually don’t make it past their 20’s before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue). So, our body in it's wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon; as a result, the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (meaning scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars. If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be “eaten away” from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 40 years! Blood Cleansing:  The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its "first pass", or the first time it goes through but given the sluggish and near toxic or toxic states of everyone's liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks! (8). When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by: Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots. (8).  Breaking dead material down small enough that it can immediately pass into the bowel. (8). Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection. (9). And here we come to the only warning we have to give concerning the use of systemic enzymes - don't use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin and Heparin, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much. Immune System Modulating:  Enzymes are adaptogenic seeking to restore a steady state to the body. (9). When the immune system is running low we become susceptible to infectious disease, when it’s cranked up too high then the system creates antibodies that attack it's own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue. Virus and Bacteria Fighting:  Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. (10,11). Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, (again the enzyme lock and key mechanism). Serrapeptase has the strongest protein eating effect of any commercially available enzyme and can be of help in combating viruses. Systemic Enzymes also have been found to have mild anti-bacterial properties. A bacteria is a foreign protein (exogenous). Proteolytic enzymes eat exogenous proteins in the body. One note: many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf (MD & PhD x7) at Columbia University in the 40’s through the 70’s has not made it to the awareness of most doctors. There are currently over 200 peer reviewed research articles dealing with the absorption, utilization and therapeutic action of orally administered systemic enzymes. A search through Pub Med using the key words: serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Systemic enzymes now have a 4 decade plus history of widespread medical use in central Europe and Japan. Original Formula New & Improved Formula References: 1) Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent in emergency surgery. Arztl. Praxis 24 (1972), 2307. 2) Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. 3) Kee W., H. Tan S, L., Lee V. Salmon Y. M.: The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore Med J. 1989:30(l):48-54. 4) Celebrex article Wall Street Journal 19 April 1999. 5) No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997. 6) Enzymes ñ A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published 1993 Eco Med. 7) Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982. 8) Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. 9) Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991. 10) Jager H.: Hydrolytic Enzymes in the therapy of HIV disease. Zeitschr. Allgemeinmed., 19 (1990), 160. 11) Bartsch W.: The treatment of herpes zoster using proteolytic enzymes. Der Informierte Arzt. 2 (1974), 424-429. Why Zymessence®: Because You Asked and We Listened! The New Formula is Even Stronger! You asked for a systemic enzyme that did not need to be taken by the handful (not the recommended dose on the label but how many you actually have to take to get good effects, usually: 10 - 60 capsules/tablets a day). With Zymessence®, you only need to take 2 to 3 capsules a day! You asked for a systemic enzyme that was affordable. With Zymessence®, a 60 day supply will only cost $89.95 at the full suggested retail price!   What Makes Zymessence® Better: It's All in the Mix! Zymessence™ is part of an emerging "new breed" of products in the field of Systemic Enzyme Therapy. It combines the best of both the "Old School" and the "New School" science of proteolytic enzymes to form a super effective and affordable blend. The "Old School" Systemic Enzymes, blended animal pancreatin (usually a 4X, 6X, 8X or 10X dilution) with fruit enzymes and then added Trypsin and Chymotrypsin extracts (also from Pancreatin) to create a wide-ranging and effective action. The drawback is Trypsin and Chymotrypsin are extremely expensive so not a lot is put into each tablet or capsule! The upside to using animal based pancreatin is research and clinical experience show that these enzyme blends last 24 to 36 hours in the body. The "New School" Systemic Enzymes, blend fruit, vegetable and fermented fungal based enzymes (such as fermented Serrapeptase), to increase the action of their product. As Serrapeptase is substantially stronger than Trypsin or Chymotrypsin, it does in fact increase the effectiveness of these enzyme blends several fold. The drawback is that clinical experience and research both show that these enzyme products only have 4 to 6 hours of action before they leave the body. The upside is Serrapeptase, though stronger, is far less expensive than Chymotrypsin and Trypsin so more can be put into each tablet or capsule! Zymessence® takes a page from the "Old School": The Zymessence® blend uses undiluted, full strength animal (porcine) based Pancreatin (with its naturally occurring Trypsin and Chymotrypsin) for its longer lasting effects. Zymessence® takes a page from the "New School": Then Zymessence® combines the usual fruit enzymes with Serrapeptidase (Serrapeptase) to greatly increase its effectiveness while keeping costs low! And More... Zymessence® uses "enteric matrix technology": Common enteric coatings just on the outside of a tablet or capsule are meant to protect the contents against destruction by stomach acid. Most enzymes are very sensitive to acids and are easily destroyed. But mere enteric coatings on the outside can be scratched or pitted just by the tablets/capsules knocking around inside their bottle! This allows stomach acid to enter the product and deactivate it before it has a chance to do any good. The "Enteric Matrix Technology" used in the production of Zymessence® means the entire caplet is protected inside and out by an enteric film that runs through every micro-granule within it, thus ensuring greater protection of the enzymes and increased absorption for you!   Zymessence®, the first and only systemic enzyme blend actually developed by Dr. William Wong, ND, PhD Dear Dr. Wong: I am on my 2nd bottle of Zymessence and LOVE it. I have MS and Fibromyalgia therefore cannot live without Zymessence for imflammation and immune support! AND, as a bonus it has helped my allergic reactions that I've developed to peanuts and some grains-stopped skin from itching, etc. Rita B. Customer Testimonial

The word “systemic” means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ. But let’s take first things first, what is an enzyme? An enzyme is a biocatalyst - something that makes something else work or work faster. Chemical reactions are generally slow things, enzymes speed them up. Without enzymes the chemical reactions that make up our life would be too slow for life as we know it. (As slow as sap running down a tree in winter). For life to manifest as we know it, enzymes are essential to speed up the reactions. We have roughly some 3000 enzymes in our bodies and that results in over 7000 enzymic reactions. Most of these enzymes are derived or created from what we think of as the protein digesting enzymes. But while digestion is an important part of what enzymes do, it's almost the absolute last function. First and foremost these body wide proteolytic (protein eating) enzymes have the following actions: Natural Anti-Inflammatory: Inflammation is a reaction by the immune system to an irritation. Let’s say you have an injured right knee. The immune system, sensing the irritation the knee is undergoing, creates a protein chain called a Circulating Immune Complex (CIC for short), tagged specifically for that right knee. (The Nobel Prize in biology was won in 1999 by a scientist who discovered this tagging mechanism). This CIC floats down to the right knee and causes pain, redness and swelling; the classic earmarks for inflammation. This at first is a beneficial reaction because it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating; itself creating an irritation that the body makes CIC’s to in response!   At this point, most people turn to their medicine chest and take a couple of Non Steroidal Anti-Inflammatory drugs (NSAIDs) like Aspirin, Ibuprofen, Celebrex, Vioxx, etc. And the problem with that is: NSAID's work by keeping the body from making all CIC's!!! This ignores the fact that some CIC’s are vital to life, like those that maintain the lining of the intestines and those that keep the kidneys functioning! Not to mention the fact that the NSAID’s, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs. (4,5). This is where systemic enzyme use is so important.   Systemic Enzymes are the first line of defense against inflammation. (1,2,3). Systemic enzymes are perfectly safe and free of dangerous side effects and they have no LD-50, or toxic dose. (6). Best of all systemic enzymes can tell the difference between the good CIC’s and the bad ones because hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC’s. So instead of preventing the creation of all CIC’s, systemic enzymes just “eat” the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also. Anti-Fibrosis:  Systemic Enzymes eat scar tissue and fibrosis. (7). Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain: As we age, which starts at 27, we have a diminishing of the bodies’ output of enzymes. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 27. At that point the body knows that if it keeps up that rate of consumption we’ll run out of enzymes and be dead by the time we reach our 40’s. (Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually don’t make it past their 20’s before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue). So, our body in it's wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon; as a result, the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (meaning scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars. If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be “eaten away” from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 40 years! Blood Cleansing:  The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its "first pass", or the first time it goes through but given the sluggish and near toxic or toxic states of everyone's liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks! (8). When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by: Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots. (8).  Breaking dead material down small enough that it can immediately pass into the bowel. (8). Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection. (9). And here we come to the only warning we have to give concerning the use of systemic enzymes - don't use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin and Heparin, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much. Immune System Modulating:  Enzymes are adaptogenic seeking to restore a steady state to the body. (9). When the immune system is running low we become susceptible to infectious disease, when it’s cranked up too high then the system creates antibodies that attack it's own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue. Virus and Bacteria Fighting:  Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. (10,11). Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, (again the enzyme lock and key mechanism). Serrapeptase has the strongest protein eating effect of any commercially available enzyme and can be of help in combating viruses. Systemic Enzymes also have been found to have mild anti-bacterial properties. A bacteria is a foreign protein (exogenous). Proteolytic enzymes eat exogenous proteins in the body. One note: many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf (MD & PhD x7) at Columbia University in the 40’s through the 70’s has not made it to the awareness of most doctors. There are currently over 200 peer reviewed research articles dealing with the absorption, utilization and therapeutic action of orally administered systemic enzymes. A search through Pub Med using the key words: serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Systemic enzymes now have a 4 decade plus history of widespread medical use in central Europe and Japan. Original Formula New & Improved Formula References: 1) Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent in emergency surgery. Arztl. Praxis 24 (1972), 2307. 2) Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. 3) Kee W., H. Tan S, L., Lee V. Salmon Y. M.: The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore Med J. 1989:30(l):48-54. 4) Celebrex article Wall Street Journal 19 April 1999. 5) No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997. 6) Enzymes ñ A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published 1993 Eco Med. 7) Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982. 8) Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. 9) Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991. 10) Jager H.: Hydrolytic Enzymes in the therapy of HIV disease. Zeitschr. Allgemeinmed., 19 (1990), 160. 11) Bartsch W.: The treatment of herpes zoster using proteolytic enzymes. Der Informierte Arzt. 2 (1974), 424-429. Why Zymessence®: Because You Asked and We Listened! The New Formula is Even Stronger! You asked for a systemic enzyme that did not need to be taken by the handful (not the recommended dose on the label but how many you actually have to take to get good effects, usually: 10 - 60 capsules/tablets a day). With Zymessence®, you only need to take 2 to 3 capsules a day! You asked for a systemic enzyme that was affordable. With Zymessence®, a 60 day supply will only cost $89.95 at the full suggested retail price!   What Makes Zymessence® Better: It's All in the Mix! Zymessence™ is part of an emerging "new breed" of products in the field of Systemic Enzyme Therapy. It combines the best of both the "Old School" and the "New School" science of proteolytic enzymes to form a super effective and affordable blend. The "Old School" Systemic Enzymes, blended animal pancreatin (usually a 4X, 6X, 8X or 10X dilution) with fruit enzymes and then added Trypsin and Chymotrypsin extracts (also from Pancreatin) to create a wide-ranging and effective action. The drawback is Trypsin and Chymotrypsin are extremely expensive so not a lot is put into each tablet or capsule! The upside to using animal based pancreatin is research and clinical experience show that these enzyme blends last 24 to 36 hours in the body. The "New School" Systemic Enzymes, blend fruit, vegetable and fermented fungal based enzymes (such as fermented Serrapeptase), to increase the action of their product. As Serrapeptase is substantially stronger than Trypsin or Chymotrypsin, it does in fact increase the effectiveness of these enzyme blends several fold. The drawback is that clinical experience and research both show that these enzyme products only have 4 to 6 hours of action before they leave the body. The upside is Serrapeptase, though stronger, is far less expensive than Chymotrypsin and Trypsin so more can be put into each tablet or capsule! Zymessence® takes a page from the "Old School": The Zymessence® blend uses undiluted, full strength animal (porcine) based Pancreatin (with its naturally occurring Trypsin and Chymotrypsin) for its longer lasting effects. Zymessence® takes a page from the "New School": Then Zymessence® combines the usual fruit enzymes with Serrapeptidase (Serrapeptase) to greatly increase its effectiveness while keeping costs low! And More... Zymessence® uses "enteric matrix technology": Common enteric coatings just on the outside of a tablet or capsule are meant to protect the contents against destruction by stomach acid. Most enzymes are very sensitive to acids and are easily destroyed. But mere enteric coatings on the outside can be scratched or pitted just by the tablets/capsules knocking around inside their bottle! This allows stomach acid to enter the product and deactivate it before it has a chance to do any good. The "Enteric Matrix Technology" used in the production of Zymessence® means the entire caplet is protected inside and out by an enteric film that runs through every micro-granule within it, thus ensuring greater protection of the enzymes and increased absorption for you!   Zymessence®, the first and only systemic enzyme blend actually developed by Dr. William Wong, ND, PhD Dear Dr. Wong: I am on my 2nd bottle of Zymessence and LOVE it. I have MS and Fibromyalgia therefore cannot live without Zymessence for imflammation and immune support! AND, as a bonus it has helped my allergic reactions that I've developed to peanuts and some grains-stopped skin from itching, etc. Rita B. Customer Testimonial

Zinc is an essential mineral, necessary for sustaining all life. It is estimated that 3,000 of the hundreds of thousands of proteins in the human body contain zinc..... Zinc ions are now considered neurotransmitters. Cells in the salivary gland, prostate, immune system and intestine are other types of tissues that highly need zinc. The below information is from MineralsInc.com. Read the full text with references at: MineralsInc.com Role of Zinc in Human Nutrition Zinc is involved in well over one hundred metabolic process and body functions, Normal growth and development Maintaining healthy skin and bones Essential in various metabolic processes Healing and immune functions Physiologically, zinc is vital for growth and developments, sexual maturation and reproduction, dark vision adaptation, olfactory and gustatory activity, insulin storage and release and for a variety of host immune defenses, among other things. Zinc deficiency can result in growth retardation, immune dysfunction, increased incidence of infections, hypogonadism, oligospermia, anorexia, diarrhea, weight loss, delayed wound healing, neural tube defects of the fetus, increased risk for abortion, alopecia, mental lethargy and skin changes. Zinc may have immunomodulatory activity. It may also have antioxidant activity. Zinc has putative antiviral, fertility- enhancing and retinoprotective activities. Effects of Zinc Deficiency Even borderline zinc deficiency or disturbances in zinc metabolism can have profound adverse health effects. Those at greatest risk of such deficiencies and disturbances include infants, children, the elderly and pregnant women. Due to conditions that can limit the bioavailability of zinc, even when there is adequate zinc intake, zinc deficiency may affect still larger population. Among diseases and conditions associated with zinc deficiency are alcoholism, malabsorption syndromes, acrodermatitis enteropathica, anorexia nervosa, thermal burns and total parenteral nutrition without zinc supplementation. Zinc Supplementation as Zinc Citrate Supplemental zinc may be helpful in some of the foregoing, in some conditions of immune impairment, in some complications of pregnancy, in the prevention of some cases of fetal neural tube defects, diarrhea, oligospermia, delayed wound healing and some cognitive disorders. It may also help against some inflammatory disorders. Zinc is essential for proper formation and maturation of spermatozoa. There is some evidence that zinc can promote and accelerate wound healing in some circumstances. Zinc is also very important to the newborn when breast milk may be its only source of Zinc. Zinc Citrate represents a totally reacted and nutritionally functional Chelate of Zinc and the naturally occurring citrate in the human body. Zinc citrate caters to the need of "optimal mineral nutrition" with respect to zinc by delivering it in a more bio-available, energy rich, tolerant and safe form. Additional information: Adapted from Wikipedia. Read the full text with references at: Wikipedia.com "Zinc deficiency results from inadequate intake of zinc, or inadequate absorption of zinc into the body. Signs of zinc deficiency include hair loss, skin lesions, diarrhea, prostate swelling, delayed wound healing (epithelial tissue won't heal as well or as fast as it should in a zinc deficient state), wasting of body tissues and white spots on the nails. Eyesight, taste, smell and memory are also connected with zinc. A deficiency in zinc can cause malfunctions of these organs and functions. Congenital abnormalities causing zinc deficiency may lead to a disease called Acrodermatitis enteropathica (Caution: the linked-to website has some rather graphic pictures of infants afflicted with acrodermatitis enteropathica). Obtaining a sufficient zinc intake during pregnancy and in young children is a very real problem, especially among those who cannot afford a good and varied diet. Brain development is stunted by zinc insufficiency in the womb and in youth. It is widely recognized that lack of zinc can contribute to acne. When asked his opinion, here's what Dr. Wong had to say about Zinc Citrate: "This warrants repeating: 'Zinc is the most essential mineral for sexual function' and Zinc Citrate is the best absorbed zinc! Why? Because most zinc supplements are very, very poorly absorbed. The oxides are mostly excreted. Those Zincs that are chelated to amino acids need to further bond to a lipid (fat) to be transported across the intestinal wall. Zincs that are chelated to sugars (gluconates) don’t get in well either. But, anything bonded to anything in the Vit. C family such as citric acid, Vit. C, ascorbates, etc. are taken in instantly and almost completely! That is why, despite all the sales hype to the contrary, calcium citrate, magnesium citrate and zinc citrate are the best absorbed minerals of their kind."

Dr. Wong's Newly Formulated Magnesium Product is Now In-Stock and Available for Immediate Shipping!  Magnesium is an essential mineral nutrient for life. It is present in every cell type in every organism and is vital to the well being of all organisms.* Adult human bodies contain about 24 grams of magnesium, with 60% in the skeleton, 39% intracellular (20% in skeletal muscle), and 1% extracellular. ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active.* Over 300 enzymes require magnesium ions in order to function*. Magnesium in one of its various forms (ie: gluconate, malate, orotate, magnesia, citrate etc) can be found in common laxatives, antacids (i.e., milk of magnesia), and can be used in a number of situations where stabilization of abnormal nerve excitation and blood vessel spasm is required.* The average adult human daily nutritional requirement is set to 300-400 mg per day of elemental magnesium. Inadequate magnesium intake frequently causes muscle spasms, and has been associated with cardiovascular disease, diabetes, high blood pressure, anxiety disorders, migraines, osteoporosis and cerebral infarction[1]*. Human magnesium deficiency (including conditions which show few overt symptoms) is relatively common, with only 32% of the United States meeting the RDA-DRI,[2] and has been implicated in the development of a number of human illnesses such as asthma, osteoporosis, and ADHD.[3]* Due to its basic struction/function, magnesium may effect muscle relaxation through direct action on the cell membrane.* With the addition of magnesium, more channels may be blocked and the nerve may have less activity which could help support the body in reducing the itching/crawling sensations commonly noticed during periods of rest or sleep.* According to a randomised, double-blind study, done in 2003, scientists found Magnesium citrate to be more bioavailable than oxide or amino-acid chelate (glycinate) forms[4].*  We have blended our own “chelated” magnesium using just enough Vit. C (345 mg) to assure good absorption of the mineral, while providing the full load of elemental mineral stated on the label: 510 mg of magnesium.    We chose to use the more expensive Vit. C instead of the cheaper citric acid as the chelating agent because Vit. C has health benefits to your body that citric acid does not have. Now to answer the question:  Why did we use Magnesium Oxide in our product?  What folks don't understand that Dr. Wong has taught in his shows is that the elemental magnesium in all chelated mag products is magnesium oxide!    All chelated minerals are a blend of the mineral source and the chelating agent.   The chelating agent is always cheaper than the mineral source so they put in a lot of that and little mineral. The industry standard would look like this: 85% citric acid and only 15% magnesium oxide (for magnesium citrate as an example) References:1. Larsson SC, Virtanen MJ, Mars M, et al (March 2008). "Magnesium, calcium, potassium, and sodium intakes and risk of stroke in male smokers". Arch. Intern. Med. 168 (5): 459–65. doi:10.1001/archinte.168.5.459. PMID 18332289.2. "Lack Energy? Maybe It's Your Magnesium Level". United States Department of Agriculture. Retrieved on 2008-09-18. Last paragraph3. University of Maryland Medical Center. Magnesium 4. Walker AF, Marakis G, Christie S, Byng M (September 2003). "Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study". Magnes Res 16 (3): 183–91. PMID 14596323. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.    

  Karuna Natural Progesterone Cream is a hypoallergenic formula free from all synthetic fragrances, emulsifiers, emollients, fillers, alcohol, and preservatives. Benefits of Karuna Progesterone Pure: Progesterone Pure is a pure, hypoallergenic formula free from all synthetic fragrances, emulsifiers, emollients, fillers, alcohol and preservatives. Karuna Progesterone Pure is free of alcohol, parabens and urea. Each 2 oz. tube is standardized, quality-controlled and safety-sealed to prevent oxidation and bacterial contamination. Each 2 oz. tube contains natural progesterone derived from wild yam (25 mg per ¼ tsp.), which applies easily and absorbs rapidly into the skin, leaving no sticky or oily residue. Each box is accompanied by complete usage instructions and other valuable information.   Supplement Facts: 48 servings (1/4 tsp) with 30 mg of progesterone per serving. Ingredients per 2 oz tube: Purified Water‚ Jojoba Oil‚ Whole Leaf Aloe Vera Extract‚ Shea Butter‚ Cetyl Alcohol (coconut oil derived) ‚ Micronized USP Progesterone (wild yam derived) 1440 mg‚ Stearic Acid (palm kernel derived thickener)‚ Monosodium Salt‚ Disodium Edetate (plant derived preservative)‚ Grapefruit Seed Extract‚ Potassium Sorbate‚ Vitamin E‚ Xanthan Gum (seaweed derived thickener)  

The forgotten nutrient for heart health, blood flow and sexual function!*    A ton of invalid studies using sub-clinical doses of Vitamin E have said this vitamin is of no use for the heart.   And at the levels of dosing they were using the studies were correct, the studies were concocted to make the Vitamin E fail.     First point:  All of the valid studies on Vitamin E and heart health and sexual function, especially those done at the Univ. of Southern Illinois by Dr. Thomas Cureton  in the 1960’s and ’70’s were done with D Alpha Tocopherol.   It was found back then that the other tocopherols and tocotrinols were mere window dressing, the strongest active component of all of the E’s is the D Alpha.     Secondly:  doses needed to be 400 IU and above to have a physiologic function!   Next: the nutritional industry, seeing their profits from Vit. E drop after the vitamin was made from fermentation instead of being cold pressed from wheat germ oil or soy oil, decided to drop their emphasis on Vitamin E and transfer the heart health claims to the much more profitable CoQ10, and the super profitable Ubiquinol.    There was a way to bring back profitability to Vitamin E:  Again skewed studies seemed to show that the only way Vitamin E worked was to mix in the very expensive tocotrinols and mixed tocopherols!   Lastly: Vitamin E when isolated either from cold pressing and extraction or from fermentation needs to be stabilized in oil or freeze dried into a powder or it looses its effectiveness and has a very low shelf life.    All but 1 company we know of mixes the Vitamin E with soy oil, known for its high estrogen content!    So the product is estrogenic. Our Dry E - 500 IU also has the selenium that is the partner for Vitamin E in performing its actions, especially in maintaining healthy/normal prostate health.*  Dr. Kurt Donsback taught back in the 1980’s that ALL prostate swelling, regardless of what it turned into later, started from a Vitamin E and Zinc deficiency!*     Dr. Wongs Essentials® Dry E - 500 IU, has no estrogens!    Each capsule is at the physiologic activation level of dosing and has no widow dressing, just the known-to-be- active D Alpha Tocopherol form of the vitamin.  Daily dose should be one or two capsules taken daily.  

Dr. Wong's Essentials® TMG-DMG Plus is a blend of Trimethylglycine (TMG), Dimethylglycine, Yohimbe Bark Extract and Serrapeptidase to help the body make Nitric Oxide; increase vaginal lubrication and clitoral engorgement; and increase the making of strong, large and motile sperm.   Dimethylglycine (DMG) and Trimethylglycine (TMG): Amino acids.   Mostly used as an immune modulator to boost immunity, to sharpen thinking and increase attention span and as a methyl donor to the Kreb’s Cycle increasing the production of ATP.   In this product these two amino acids are used for what they biosynthesize in the body, which is Nitric Oxide, the blood gas that dilates blood vessels all over the body.     The difference in the steps needed to make NO between the DMG and TMG allows for the DMG to produce a faster creation of NO while the TMG takes a step longer and starts later and that prolongs the NO making effects of the product.     Yohimbe, is a known vasodilator which also when taken in high doses of the raw powder or in a concentrate will also increase dopamine production and thus have its well known effect of increasing libido with out increasing testosterone level (2). The pharmecutical extract of Yohimbe Yohimbine HCl was the first product approved by FDA for use as an Aphrodisiac.   A novel use of Yominbine HCl is to treat PTSD and Social Anxiety Disorder(1).   Serrapeptidase Proteolytic enzymes greatly increase absorption of anything taken with it, vitamins, minerals, herbs, medications, etc. In Europe and Asia, even antibiotics are mixed with proteolytic enzymes (pancreatin or serrapeptidase) to enhance absorption and utilization. With that thought in mind, many of our supplements have been blended with serrapeptidase to enhance absorption. When the Nitric Oxide increasing effect of the DMG and TMG is combined with the blood vessel dilating effect of the Yohimbe extract, the synergy of the individual ingredients in dilating blood vessels all over the body is enhanced greatly,       Research: Research on DMG and TMG forthcoming in a book. Research On Yohimbe:   https://www.ncbi.nlm.nih.gov/pubmed/29448886   https://www.ncbi.nlm.nih.gov/pubmed/24237691   https://www.ncbi.nlm.nih.gov/pubmed/23939512

"In Germany one of the most frequently prescribed treatments for heart conditions is the herb Hawthorne (Crataegus orycantholdes). Germany, like many European countries, has a government agency called the Kommission E which produces official monographs guiding the safe prescription, usage and manufacture of herbal medicines. Amongst current monographs is one on hawthorne which states that it is useful for heart insufficiency (classes 1 and 2) by strengthening heart contractions, lowering blood pressure and lowering pulse rate, as well as improving physical work capacity and anaerobic capacity (the ability to continue functioning in low oxygen conditions).* The berry from hawthorn is widely employed for arrhythmia (irregular heartbeats, palpitations), high blood pressure and hardening of the arteries.* Clinical and laboratory research findings abound that hawthorne may be beneficial in treating heart conditions, including arrhythmia, angina, atherosclerosis, high blood pressure and elevated cholesterol levels.* Clinical trials have also found benefits in the elderly with no heart conditions but simply deteriorating heart function with age (Hoffmann 1995).* Hawthorne is reported to be beneficial for heart complaints during menopause, anxiety and nervous disorders (Hobbs & Foster 1990).* There is limited preliminary research showing that hawthorne relieves muscle tension and promotes relaxation and sleep (Djumlija 1994) (Chang & But 1986).* These are factors that may be beneficial in heart conditions." The above text is an excerpt from: ZHealthInfo.com. Click to read the full text with references: www.zhealthinfo.com Hawthorne berry is a great nutritional supplement to regulate and strengthen heart beat*. However, Hawthorne berry works best as a full strength extract of just the berries as the leaves and stems are not physiologically active parts of the plants.*   To enhance absorption and utilization, Dr. Wong has added the enzyme Serrapeptidase to our Hawthorne Berry Extract supplement.* Heart patients should combine the use of Hawthorne with magnesium to achieve best results.* Arginine and TMG (TriMethylGlycine) can also be used to help dialiate blood vessels and further improve results.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  

Dr. Wong's Essentials Digest Fuerte™ provides a blend of strong digestive enzymes including cellulase to more fully extract the nutrients from food and ease your digest process. No other digestive enzyme product is as potent or complete in its action as Digest-Fuerte. This blend contains enzymes that are actually fully active, ready to digest proteins, carbohydrates and especially fats.   A great help to those with gall bladder problems who have difficulty digesting fats.    We were the first digestive product to offer cellulase, the enzyme needed to break down the cell walls of plants so the nutrients inside the plant can be available to digestion.   Humans have not made cellulase in 4 million years!   Essential for vegetarians!   One capsule should be able to help you digest a thanksgiving or Christmas feast!  The ginger, cinnamon and cayenne cause the body to secrete added digestive juices also improving digestion.   And finally the aloe vera extract and peppermint help to soothe and protect the digestive tract.    Especially helpful with folks who are fighting GI inflammations and irritations!     Those are to help prevent the digestion and passage of food from increasing bowel irritation and inflammation!   Peppermint Leaf Powder Peppermint has a long history of use in aromatherapy and folk medicine for ailments such as vomiting, abdominal pain, indigestion and bloating. In Germany, the Commisson E monographs show peppermint leaf as being used to treat irritable bowel syndrome (IBS), in addition to other health concerns. Cellulase Cellulase is an enzyme that breaks down cellulose (major component of plant cell walls). Since humans do not produce cellulase, we can only partially break down cellulose through fermentation by the flora in the intestines which greatly reduces the nutrients we can utilize. As a result, in order to properly digest leafy greens, sprouts and herbs, we need to supplement Cellulase in our diet. Pancreatin Amylase: Breaks down starches into sugars to be utilized by the body as energy.Lipase: Breaks down fatsProtease: An enzyme that begins the process of breaking down proteins for energy. Papain Papain breaks down proteins (meat fibres). Pepsin Pepsin breaks down proteins (meat fibres). It is one of the three primary protein-degrading enzymes in the digestive system. Allowing them to be more easily absorbed in the intestines.

The term "stress" was coined in the 1930's and refers to the body's inability to respond appropriately to perceived emotional or physical threats. Signs of "stress" can include exhaustion, irritability/moodiness, muscular tension, inability to concentrate, agitation, sense of loneliness/depression, headaches, elevated heart rate, and more.* At some point in their lives, most individuals will experience at least 1 "stressful event". Unfortunately, most people will have several. And then others will experience some stressful event almost daily whether it be from their job, their personal life or that of a friend or loved one. These "events" can lead folks to feeling overwhelmed, depressed, angry or withdrawn to name a few. It can also lead to a weakening of the immune system which can contribute to an increased risk of catching colds or the flu. While most anti-stress nutritional supplements advertised on the market contain a complex of b vitamins to help boost the bodies depletion of those much needed nutrients during times of stress, they don't really do much to help the body cope with the actual stress. This is where Equanimity™ comes in. Equanimity™ is not your typical anti-stress supplement; it does not contain any b vitamins! Equanimity™ is an old herbal formula that was given to Dr. Wong by an aged grand master herbalist over 30 years ago. This formula, has the ability to help calm down the user without causing sedation; in layman's words it will calm you down without knocking you out or making you dopey. Quite the opposite. Equanimity™ sharpens thinking while acting to lower stress levels*; it takes the teeth out of what's gnawing at you and also helps you put your stress into perspective.* But don't confuse anti-stress with anti-depressant. Even though these terms have been used interchangeable in both natural health circles and medical circles, they are not the same. Equanimity™ is not an anti-depressant supplement, which are meant to elevate mood. Equanimity™ is for stress and is composed of herbs known since ancient times to help cope with stress. To be physiologically effective each of these herbs needs to be taken by the teaspoon full. In comparison, mere capsules with raw herbs will not do as the average capsule is only 1/5 of a teaspoon. Using a German pharmacological extraction process, each caplet of Equanimity contains more than a teaspoon of each herb and is more potent than a large mug full of herbal tea. Each caplet of Equanimity contains 265 mg of these extracted herbs: Valerian Root has been used as a medicinal herb since at least the times of ancient Greece and Rome. It's historical use has been as a sedative.* Chamomile Flowers is a traditional medicinal herb. It was revered a sacred herb by the ancient Saxons and was valued by the Egyptians. It's traditional uses are many and varied but include sedative and calmative.* Skull Cap is used in herbal medicine as a mild sedative and sleep promoter.* Hops Flowers are used in herbal medicine similar to way valerian is used; for anxiety, restlessness and insomnia.* Please note: Hops are toxic to dogs and thus this product should not be given to them.* Pancreatin is used in this formula to help increase absorption and utilization of the herbs.*

Andeanessence Maxx™ is a nutritional supplement consisting of a full strength extract of highland maca (with all of its component sterols and nutrients in tact and in the extract) blended with a potent ashwaganda root extract plus a touch of serrapeptidase to enhance the absorption of and utilization of the blend.*The Maca plant was first discovered by "modern science" in 1843 by Gerhard Walpers, who originally designated it to the species Lepidium Meyenii, the Latin name recognized by the USDA and FDA. After further study in the 1960's, most botanists determined the most appropriate name for the maca plant to be L. peruvianum and thus it has become known under this species in our more recent times.\Maca is a hearty plant related to the turnip and radish that is cultivated high in the Andean Mountains at elevations from 13,000-15,000 feet. Maca plants grow in terribly harsh cold with poor agricultural soils. As such, nearly all maca cultivation in Peru is carried out organically, as there are few pests naturally occurring at such high altitudes, and maca itself is seldom attacked.In Peru, Maca has been an important traditional food and medicinal plant for about 2000 years. Historically, it has been used for trade and during the Spanish colonization as a form of currency. Maca is regarded as a highly nutritious, energy-imbuing food, that may enhance strength and endurance while supporting healthy feelings of love and desire.* Maca can be found in several forms: Maca Flour (dried, finely ground powder), gelatinized maca, "standardized" extracts (of part of maca's active ingredients) and whole root extracts (containing all of maca's active ingredients).In an effort to reduce the amount of Maca needed to be consumed and relying on the historical data that traditionally the Peruvians have always cooked maca, we have stopped selling the Maca Flour and developed Andeanessence™ now called Andeanessence Maxx™.   Like Andeanessence™, Andeanessence Maxx™ is a concentrated, full-strength, whole maca root extract thus maintaining the synergy of the entire root and all of its nutritive value.*Ashwaganda is an herb widely used, especially by Aurvedic medicine, since acient times for a wide range of energy, health and pro-immunity effects.*The mixing of the ashwaganda extract into the Andeanessence not only provides a new range of positive physiological actions usually found in strong ashwaganda extracts but also it enhances and speeds the physiological actions of the maca creating "feelable" differences in energy, performance and potency within days instead of weeks.* "Hey Dr. Wong,  All I have to say is wow, the Andeanessence™ is the real deal! I took one about 20 minutes before my workout and I have to say I felt like superman the rest of the day. Usually I do chin ups with a 25lb plate in my backpack, this is my second week on that weight and it has been pretty tough. After taking the Andeanessence, I did my usual 25 pounds and it was easy... I could get off 15 chins for the first set (usually can only do 6 or 7). There was no other change in my diet, routine, etc. so I'm pretty amazed. Thanks for making a real kick ass product!" Mike S.

Kidneys are something few think about until the two small organs force themselves into our consciousness by having something afflict them.  Maintaining kidney health should be a mainstay of our natural health practices as detoxing the liver or keeping the bowels flowing and colonized with good bacteria.  But unfortunately few give the kidneys little thought.     There are kidney “dextoing” products on the market but those are either misnamed kidney support products or outright rip offs as the kidneys don’t store anything, even toxins.  The liver and the body fat are the organs of toxin storage.     The kidneys need to be free flowing, free or low on scar tissue build up and free or low on kidney stone build up.    The kidneys want to be kept at just the right level of hydration.  Too little water and the filtering fingers of the insides of the kidneys, the Glomeruli, dry up and scar over with fibrosis.   Too much water and the kidneys distend which also cause scaring.    Too high a protein intake will cause the excess protein not used by the body to be eliminated through the kidneys and that causes two things; an increased ammonia load that becomes caustic and scar tissue formation.  Also the excess protein combines with calcium and sugar to form kidney stones.    Let’s touch on the ammonia issue.   Urine is ammonia based; anyone who’s been around livestock has smelled the stench of ammonia in cow and horse urine.  It’s no different for humans.   Problem is that ammonia is 9.7 pH, highly alkaline.  Now before you tell me that its good for the body to be alkaline let’s point out the physiological fact that while most of the body want’s to be alkaline at 7+ph because it’s supposed to be seawater inside of us from our tears to our blood to our internal body fluid, the stomach and the kidneys are supposed to be acidic.   They are the only two organs in the body that were designed to be acidic and suffer from not being so.     This is where we get to the first of the positive effects of the Crandiazyme.    Of all the cranberry based supplements Crandiazyme has the strongest cranberry content as the 36 to 1 concentration of cranberries far and away out strips the strength found in weaker cranberry extracts or just straight cranberry powder.   Also, the best functioning cranberry product we’ve found so far contained only 5 mg of actual cranberry extract.    While the Crandiazyme formula is a trade secret it does contain several hundred milligrams of the 36 to 1 cranberry extract per capsule.    Cranberry prevents bacteria from attaching to the renal system in several ways: ·      It changes the fimbriae, the tiny arms bad bacteria use to cling onto a surface, so that they don’t work. (1,2). ·      Further, other chemical properties of cranberries keep the bacteria that don’t have fimbriae from attaching on to surfaces of the urinary tract.   (3).   Next we get to the problems of kidney stones, inflammation and scar tissue.   Natural medicine has been working to dissolve renal calculi with magnesium for decades and that works to a point.  (4).   Magnesium bonds, (chelates), onto the calcium of the stone and flushes the calcium out a bit at a time reducing the size stones over time.    The speed of the reduction is governed by the amount of magnesium taken and the amount of fluid passing through the kidney.    While magnesium is not part of Crandiazyme due to restrictions in the amount of magnesium needed to have the chelating effect and the size of the Crandiazyme capsule, use of a separate strong magnesium supplement will work for this effect.   Systemic enzymes have also been used to both reduce kidney inflammation with out the kidney damage that the anti inflammatory NSAID drugs do cause.   The protein lysing enzymes will also lyse away at the fibrosis / scar tissue that grows impeding the function of the glomeruli in filtering.   Serrapeptase, the superior fibrosis lysing enzyme, is part of the Crandiazyme formula.   (5,6).   So between the magnesium and the proteolytic enzymes what’s left to do?    Kidney deposits and formations have what are called sugar notes and these crystalized sugar formations can also be dealt with using a specific sugar lysing enzyme.  (7).   The study shows that the proteolytic (protein cleaving enzymes), worked better at lysing away those deposits to quote the study:    ‘The combination of dextranase plus protease attenuated all components of glomerular injury as judged by clinical and pathologic parameters”.  (7).   While the dextranase used in the study is super expensive, we put an affordable variant of that enzyme in the Crandiazyme.    Crandiazyme was designed to be used alone as a bladder and kidney health support supplement for its very strong cranberry content, and designed to be used in conjunction with our Zymessence and Magscorbate in addressing more serious renal issues.   Used either way taking the Crandiazyme is a significant step in improving ones kidney health.      References: 1)   http://en.wikipedia.org/wiki/Cranberry_juice 2)   http://www.sciencedaily.com/releases/2008/07/080721152005.htm 3)   http://www.ncbi.nlm.nih.gov/pubmed/20646356 4)   http://en.wikipedia.org/wiki/Kidney_stone 5)   http://www.enzymescience.com/Nephrology%20and%20Urology/Glomerulonephritis.htm 6)   http://www.enzymescience.com/Nephrology%20and%20Urology/Renal%20Fibrosis.htm 7)   http://www.enzymescience.com/Nephrology%20and%20Urology/Glomerular%20Immune%20Deposits.htm

Estrogens are part of the female hormones that are also found in abundance in the foods we eat as well as our surrounding environment. Today, estrogen is found and marketed mostly in foods such as soy, flax and all seeds, beans, pods and peas.   Excess environmental estrogens in pollution and in foods contribute to various estrogen dominant conditions in women from uterine fibroids, ovarian cysts, fibrocystic breast conditions, endometriosis and infertility.   While dietary and environmental estrogen from soy formula, pesticides and plastics have been shown to be responsible for very early onset of menstruation in young girls.   In men, it is estrogen dominance that creates DHT, which leads to balding and swollen prostates.  Estrogen dominance is responsible for the onset of Andropause (male menopause) in men between the ages of 40 and 55. And environmental estrogens have been shown as a feminizing and sterilizing agent in boys.   In both sexes, estrogen dominance causes fat gain from the waist to the knees, moodiness, crankiness, lack of libido and depression.  Sinest® is a preparation of proven estrogen blocking or aromatase inhibiting agents to either block the action of estrogen in the body or block the making of estradiol and estrone, the two most dangerous and carcinogenic forms of estrogen.*  While many supplements have these ingredients, they are normally not found in a dosage sufficient to have a physiological effect.   According to the head of hormone research at Georgetown University, these herbs only have the anti estrogenic actions when taken in doses above 1 gram (1000 mg) of the raw powdered herbs.   In creating Sinest™, full strength extracts of the component herbs were used and combined so that in a single caplet there is the equivalent of over a teaspoon (5000 mg) of each herb.

Enkindle® is a full strength herbal extract designed to increase sexual desire (libido) and intimacy in both women and men.* It is not an erection enhancing or anti-ED product. Can and should be used by both men and women in combination with Andeanessence™ for libido, hormone-enhancing, and anti-aging benefits.* New & Improved Formula! Catauba Extract...more Catauba is extracted from the bark of some trees (including Erythroxylum vacciniifolium, Trichilia catigua, Juniperus Brasiliensis, ets) native to Brazil.  In traditional Brazilian medicine, it is used as an aphrodisiac, libido stimulant in men & women, and central nervous system stimulant.   Mucuna Pruriens Herb...more Mucuna pruriens is a tropical legume from an annual, climbing shrub with long vines that can reach over 15 m in length. Mucuna pruriens seeds contain high concentrations of levodopa, a direct precursor of the neurotransmitter dopamine.* Which has been the primary reasy it has long been used in traditional Ayurvedic Indian medicine for health conditions including Parkinson's Disease.[1][2] In addition to levodopa, Mucuna also contains serotonin (5-HT), 5-HTP, nicotine, N,N-DMT (DMT), bufotenine, and 5-MeO-DMT. L- Dopa contains natural secretagogues which may support the body's ability to stimulate the natural release of growth hormone. An increase in dopamine levels may also optimize the production of hormones leading to increased sex drive and improved sexual performance for both men and women.* References 1) Manyam BV, Dhanasekaran M, Hare TA. Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters. 2004. Phytother Res 18:97-101. DOI: 10.1002/ptr.1407 PMID 15022157 2) Manyam BV, Dhanasekaran M, Hare TA. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. 2004. Phytother Res 18:706-712. DOI: 10.1002/ptr.1514 PMID 15478206 ***Do not use this supplement if you are or think you may be pregnant. Discontinue use if you become pregnant.*** *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

It is beyond question that a properly balanced intestinal system has a beneficial, health promoting effect on the body.  As such, it is very important to help maintain a proper balance of good bacteria and yeast in the GI tract. The good bacteria do various super important jobs from simple digestion and the enhancement of food absorption, to turning the colon into the largest organ of immunity in the body.   The intestinal wall, once well colonized with good bacteria, will turn out immunoglobulins by the tens of millions and help the body fight and avoid disease.* When the good bacteria and good yeasts die-off from antibiotic use or long term illness such as Fibromyalgia and Chronic Fatigue, dysbiosis (the condition of having microbial imbalances within the body – specifically referencing the digestive tract here) can occur.* To fight the build up of  the bad bacteria and yeast as well as the alcohol they produce, different natural agents are blended together in Candessence® to cover the spectrum of 1) reducing candida, 2) providing the most survivable probiotic available, 3) ensuring a colonizing medium for the probiotic to flourish in and 4) including a mineral which short circuits candida’s production of alcohol thereby decreasing the instance of brain fog.  This is how Candessence® covers all the bases for returning the GI tract to an optimal state. Cream of Tartar Potassium bitartrate (cream of tartar), also known as potassium hydrogen tartrate, is a byproduct of winemaking. In cooking it is known as cream of tartar. It is obtained when tartaric acid is half neutralized with potassium hydroxide, transforming it into a salt. Grapes are the only significant natural source of tartaric acid, and cream of tartar is obtained from sediment produced in the process of aging wine. It is found on the insides of the wine barrels and sometimes at the bottom of bottles of wine. It crystallizes out as a hard crust in the barrels. During Dr. Tommy Revis' practice he used Cream of Tartar was an integral part of his program to fight candida overgrowth.* And this is why we have included it in Candessence™. The cream of tartar is a must for supporting the body in the removal of the yeast from the intestines and/or any other place it could be hiding!* Lactobacillus Sporogenes Lactobacillus sporogenes is a lactobacillus / bifidus shielded by a spore. This spore "armours" the good bacteria against not only acid but also the other enemies of good bacteria such as heat, light and even antibiotics!* While in acid, the spore holds tight. When in the alkaline environment of the intestine the spore opens and releases the good bacteria. In Asia, savvy pharmaceutical companies are blending their antibiotics with Lactobacillus Sporogenes, to prevent the dysbiosis that happens with antibiotic use.* Smart! This is the only protected and survivable acidophilus.* So survivable it is measured not by how many good bacteria there are per gram but by how well it will re-colonize the intestines!* Good bacteria (pro biotic) products abound in the US market. What makes the Lactobacillus Sporogenes different? Let’s look at the matter of survive-ability. 1) Most probiotic products have tens of millions of live bacteria at the moment they are packaged. Usually 15 to 30 billion per gram (1000 mg). Even though the good bacteria is freeze dried and put into suspended animation there is still a die off which starts while in the bottle. After sitting on the shelf for a while at the makers warehouse, the shippers and then at your local store by the time you buy the product and eat it, the count of good bacteria still alive is about half of what it was when it was made. 2) The great enemy of good bacteria is stomach acid which is usually between 2 and 4 pH. Fairly close to pure hydrochloric acid which has a pH of 1. Acid kills most of the good bacteria. By the time the good bacteria reaches the friendly environment of the intestines, its numbers have been greatly reduced to the point where only thousands continue to exist out of the billions the product started off with. That’s why you have to start off with billions and not mere millions. Will this work, yes we know it will but re-colonization of the gut with good bacteria this way will take quite a long time. The lactobacillus sporogenes is a must for helping to recolonize the intestines with good bacteria.* Chicory Inulin Inulin's are a group of naturally occurring polysaccharides (several simple sugars linked together) produced by many types of plants.[1] They belong to a class of fibers known as fructans. It ranges from completely bland to subtly sweet and can be used to replace sugar, fat, and flour. This is particularly advantageous because inulin contains a third to a quarter of the food energy of sugar or other carbohydrates and a sixth to a ninth of the food energy of fat. Inulin may also increase calcium absorption[2] and possibly magnesium absorption[3], while promoting good intestinal bacteria and suppressing bad intestinal bacteria*. As normal digestion does not break inulin down into monosaccharides, it does not elevate blood sugar levels and may therefore be helpful in the management of blood-sugar related health conditions.* Because Inulin is indigestible by the human enzymes ptyalin and amylase, it passes through much of the digestive system intact. It is only in the colon that bacteria metabolize inulin, with the release of significant quantities of carbon dioxide, hydrogen and/or methane. Inulin is considered a soluble fiber and as such should dissolve in water and when ingested may help lower blood cholesterol and glucose levels.* As Inulin passes through the stomach and duodenum undigested, it is highly available to the gut bacterial flora. This contrasts with proprietary probiotic formulations based on Lactic acid bacteria (LAB) in which the bacteria have to survive very challenging conditions through the gastrointestinal tract before they are able to colonize the gut. Many foods naturally high in inulin or fructo-oligosaccharides, such as chicory have been seen as "stimulants of good health" for centuries.[4]* Inulin is a necessary ingredient in any program designed to build healthy intestinal flora because it gives the good bacteria (acidophilus) a colonizing medium from which to cling to and feed from.* It is also a must in any program to eliminate candida infections (systemic yeast infections) as it helps to force out yeast and bad bacteria while giving the good bacteria a home from which to multiply.* Inulin has several actions: It normalizes bowel moisture which can aid both constipation and diarrhea.* Inulin clings to the bowel wall forming a colonizing medium for good bacteria to cling to and feed from.* This keeps the good bacteria from being passed out of the bowel before having its positive action in digestion and in colonizing the gut with good bacteria.* Inulin may help stabilize blood sugar.* It supprts the body in forcing out bad anaerobic yeast and bacteria.* Has been used to help the body rid itself of H Pylori.* Inulin may increase the body's uptake of calcium and magnesium.* May help decrease iron anemia by improving the body's iron uptake from foods.* References 1 Roberfroid M. "Introducing inulin-type fructans.". Br J Nutr 93 Suppl 1: S13-25. PMID 15877886. 2 Abrams S, Griffin I, Hawthorne K, Liang L, Gunn S, Darlington G, Ellis K (2005). "A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents.". Am J Clin Nutr 82 (2): 471-6. PMID 16087995. 3 Coudray C, Demigné C, Rayssiguier Y (2003). "Effects of dietary fibers on magnesium absorption in animals and humans.". J Nutr 133 (1): 1-4. PMID 12514257. 4 Coussement P (1999). "Inulin and oligofructose: safe intakes and legal status.". J Nutr 129 (7 Suppl): 1412S-7S. PMID 10395609. Text) Molybdenum Citrate Molybdenum is an essential trace mineral in animal and human nutrition. It is found in several tissues of the human body and is required for the activity of some enzymes that are involved in catabolism, including the catabolism of purines and sulfur amino acids.* It is also needed to build strong tooth enamel and it may help prevent dental decay.* Molybdenum may help prevent molybdenum deficiency.* Molybdenum may have putative anti-carcinogenic activity.* As a component of various enzyme systems, molybdenum plays essential roles in the metabolism of carbohydrates, fats, proteins, amino acids that contain sulfur, iron, and genetic material.* Yeast living in you eats the sugars and carbohydrates and urinates out 14% alcohol. This alcohol is responsible for the brain fog and general malaise that candida patients feel. Your basically a walking beer factory. Molybdenum is a mineral which when taken in by the yeast short circuits the alcohol production making it so the yeast urinates out water instead of alcohol.* Thus Molybdenum may help reduce the body's reaction to an overgrowth of yeast including brain fog and bloating.* Molybdenum Citrate is the preferred form of the mineral as it is more highly absorbed and utilized than most any other form of molybdenum.* Where as it would take 500 mcg or more of molybdenum glycinate or gluconate to do the job of stopping alcohol production it only takes 120 mcg of the molybdenum citrate to do the same job. The citrate of any mineral is the best absorbed form of that mineral. The glucinate form are minerals bonded to sugars: sugars slow down mineral absorption. The minerals bonded onto amino acids ignore the fact that proteins need to latch onto a lipid (fat) in order to be transported across the intestinal wall. Anything in the citric acid family, including Vitamin C, gets absorbed instantly with no need to catch a ride onto something else in order to get into the body.*   Note: In reality, there are approximately 163 scoops of Candessence in each "can". At 2 scoops per day, 1 "can" will last approximately 81 days. At 4 scoops per day, 1 "can" will last approximately 40 days. We suggest those who wish to give themselves a quick and hard hitting colon recolonization should use 4 scoops a day for the first "can" and then begin 2 scoops a day until they attain their desired recolonizing. After desired results are had, 1 scoop per day can be used for maintenance.