Systemic Enzymes (15)

The word “systemic” means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ. But let’s take first things first, what is an enzyme? An enzyme is a biocatalyst - something that makes something else work or work faster. Chemical reactions are generally slow things, enzymes speed them up. Without enzymes the chemical reactions that make up our life would be too slow for life as we know it. (As slow as sap running down a tree in winter). For life to manifest as we know it, enzymes are essential to speed up the reactions. We have roughly some 3000 enzymes in our bodies and that results in over 7000 enzymic reactions. Most of these enzymes are derived or created from what we think of as the protein digesting enzymes. But while digestion is an important part of what enzymes do, it's almost the absolute last function. First and foremost these body wide proteolytic (protein eating) enzymes have the following actions: Natural Anti-Inflammatory: Inflammation is a reaction by the immune system to an irritation. Let’s say you have an injured right knee. The immune system, sensing the irritation the knee is undergoing, creates a protein chain called a Circulating Immune Complex (CIC for short), tagged specifically for that right knee. (The Nobel Prize in biology was won in 1999 by a scientist who discovered this tagging mechanism). This CIC floats down to the right knee and causes pain, redness and swelling; the classic earmarks for inflammation. This at first is a beneficial reaction because it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating; itself creating an irritation that the body makes CIC’s to in response!   At this point, most people turn to their medicine chest and take a couple of Non Steroidal Anti-Inflammatory drugs (NSAIDs) like Aspirin, Ibuprofen, Celebrex, Vioxx, etc. And the problem with that is: NSAID's work by keeping the body from making all CIC's!!! This ignores the fact that some CIC’s are vital to life, like those that maintain the lining of the intestines and those that keep the kidneys functioning! Not to mention the fact that the NSAID’s, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs. (4,5). This is where systemic enzyme use is so important.   Systemic Enzymes are the first line of defense against inflammation. (1,2,3). Systemic enzymes are perfectly safe and free of dangerous side effects and they have no LD-50, or toxic dose. (6). Best of all systemic enzymes can tell the difference between the good CIC’s and the bad ones because hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC’s. So instead of preventing the creation of all CIC’s, systemic enzymes just “eat” the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also. Anti-Fibrosis:  Systemic Enzymes eat scar tissue and fibrosis. (7). Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain: As we age, which starts at 27, we have a diminishing of the bodies’ output of enzymes. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 27. At that point the body knows that if it keeps up that rate of consumption we’ll run out of enzymes and be dead by the time we reach our 40’s. (Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually don’t make it past their 20’s before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue). So, our body in it's wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon; as a result, the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (meaning scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars. If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be “eaten away” from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 40 years! Blood Cleansing:  The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its "first pass", or the first time it goes through but given the sluggish and near toxic or toxic states of everyone's liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks! (8). When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by: Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots. (8).  Breaking dead material down small enough that it can immediately pass into the bowel. (8). Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection. (9). And here we come to the only warning we have to give concerning the use of systemic enzymes - don't use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin and Heparin, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much. Immune System Modulating:  Enzymes are adaptogenic seeking to restore a steady state to the body. (9). When the immune system is running low we become susceptible to infectious disease, when it’s cranked up too high then the system creates antibodies that attack it's own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue. Virus and Bacteria Fighting:  Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. (10,11). Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, (again the enzyme lock and key mechanism). Serrapeptase has the strongest protein eating effect of any commercially available enzyme and can be of help in combating viruses. Systemic Enzymes also have been found to have mild anti-bacterial properties. A bacteria is a foreign protein (exogenous). Proteolytic enzymes eat exogenous proteins in the body. One note: many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf (MD & PhD x7) at Columbia University in the 40’s through the 70’s has not made it to the awareness of most doctors. There are currently over 200 peer reviewed research articles dealing with the absorption, utilization and therapeutic action of orally administered systemic enzymes. A search through Pub Med using the key words: serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Systemic enzymes now have a 4 decade plus history of widespread medical use in central Europe and Japan. Original Formula New & Improved Formula References: 1) Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent in emergency surgery. Arztl. Praxis 24 (1972), 2307. 2) Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. 3) Kee W., H. Tan S, L., Lee V. Salmon Y. M.: The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore Med J. 1989:30(l):48-54. 4) Celebrex article Wall Street Journal 19 April 1999. 5) No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997. 6) Enzymes ñ A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published 1993 Eco Med. 7) Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982. 8) Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. 9) Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991. 10) Jager H.: Hydrolytic Enzymes in the therapy of HIV disease. Zeitschr. Allgemeinmed., 19 (1990), 160. 11) Bartsch W.: The treatment of herpes zoster using proteolytic enzymes. Der Informierte Arzt. 2 (1974), 424-429. Why Zymessence®: Because You Asked and We Listened! The New Formula is Even Stronger! You asked for a systemic enzyme that did not need to be taken by the handful (not the recommended dose on the label but how many you actually have to take to get good effects, usually: 10 - 60 capsules/tablets a day). With Zymessence®, you only need to take 2 to 3 capsules a day! You asked for a systemic enzyme that was affordable. With Zymessence®, a 60 day supply will only cost $89.95 at the full suggested retail price!   What Makes Zymessence® Better: It's All in the Mix! Zymessence™ is part of an emerging "new breed" of products in the field of Systemic Enzyme Therapy. It combines the best of both the "Old School" and the "New School" science of proteolytic enzymes to form a super effective and affordable blend. The "Old School" Systemic Enzymes, blended animal pancreatin (usually a 4X, 6X, 8X or 10X dilution) with fruit enzymes and then added Trypsin and Chymotrypsin extracts (also from Pancreatin) to create a wide-ranging and effective action. The drawback is Trypsin and Chymotrypsin are extremely expensive so not a lot is put into each tablet or capsule! The upside to using animal based pancreatin is research and clinical experience show that these enzyme blends last 24 to 36 hours in the body. The "New School" Systemic Enzymes, blend fruit, vegetable and fermented fungal based enzymes (such as fermented Serrapeptase), to increase the action of their product. As Serrapeptase is substantially stronger than Trypsin or Chymotrypsin, it does in fact increase the effectiveness of these enzyme blends several fold. The drawback is that clinical experience and research both show that these enzyme products only have 4 to 6 hours of action before they leave the body. The upside is Serrapeptase, though stronger, is far less expensive than Chymotrypsin and Trypsin so more can be put into each tablet or capsule! Zymessence® takes a page from the "Old School": The Zymessence® blend uses undiluted, full strength animal (porcine) based Pancreatin (with its naturally occurring Trypsin and Chymotrypsin) for its longer lasting effects. Zymessence® takes a page from the "New School": Then Zymessence® combines the usual fruit enzymes with Serrapeptidase (Serrapeptase) to greatly increase its effectiveness while keeping costs low! And More... Zymessence® uses "enteric matrix technology": Common enteric coatings just on the outside of a tablet or capsule are meant to protect the contents against destruction by stomach acid. Most enzymes are very sensitive to acids and are easily destroyed. But mere enteric coatings on the outside can be scratched or pitted just by the tablets/capsules knocking around inside their bottle! This allows stomach acid to enter the product and deactivate it before it has a chance to do any good. The "Enteric Matrix Technology" used in the production of Zymessence® means the entire caplet is protected inside and out by an enteric film that runs through every micro-granule within it, thus ensuring greater protection of the enzymes and increased absorption for you!   Zymessence®, the first and only systemic enzyme blend actually developed by Dr. William Wong, ND, PhD Dear Dr. Wong: I am on my 2nd bottle of Zymessence and LOVE it. I have MS and Fibromyalgia therefore cannot live without Zymessence for imflammation and immune support! AND, as a bonus it has helped my allergic reactions that I've developed to peanuts and some grains-stopped skin from itching, etc. Rita B. Customer Testimonial

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Vitalzym Extra Strength Systemic Enzymes Vitalzym Extra Strength soft gels are the world’s leading all-natural, vegetarian systemic enzyme supplement. Vitalzym features an unmatched proprietary blend that includes Serrapeptase, Bromelain, Papain, Rutin, Amylase, Protease, Lipase and Amla Extract. These softgel capsules are available in 60, 180 and 360 count bottles. Vitalzym is the only systemic enzyme on the market today boasting the revolutionary enteric-coated, liquid-gel delivery system. Unlike many of the competitors’ tablet- or powder-based products, Vitalzym’s enteric-coated, liquid-gel system ensures that 100 percent of the enzymes survive the harsh acidic environment of the stomach and reach the small intestine, where they become available for absorption into the bloodstream and then are dispersed throughout the entire body.† What does this mean for you? Bottom line, you’ll be enjoying a smaller, easy-to-swallow capsule, taking less capsules per each dose and less doses per day to receive maximum systemic support. Thanks to Vitalzyms advanced delivery system, superior potency, unrivaled absorption rates and reliable consistency, you won’t need to wait three months to see results. You should feel a difference within weeks, or even days! Features of Vitalzym Extra Strength Vitalzym Extra Strength has been formulated with a technologically advanced delivery system that allows forreduced dosage and vastly increased effectiveness as compared to Original Vitalzym Twice as strong as Original Vitalzym Less cost per dose Enteric coated for ideal release of active ingredients Liquid filled for optimal absorption Half the dose of original Vitalzym Smaller and more convenient packaging, with flip-top lid 100% non-GMO Vegetarian Completely recyclable packagin Systemic Enzymes Help You Feel Better, Look Better, and Live Longer Enzymes are said to be the “sparks of life.” They are considered keys that can unlock the door to a healthier you because they not only help improve digestion and nutrient absorption; they are also responsible for millions of bodily functions. Vitalzym contains potent proteolytic enzymes designed to support health. It is an extremely effective systemic enzyme blend with a high Serrapeptase content. Vitalzym works synergistically to provide total system support. According to Dr. Peter Streichhan, a world-renowned enzyme researcher from Germany, "enzyme mixtures have a wider range of therapeutic advantages than do individual enzymes." 1 Vitalzym is specially engineered to help support: Healthy inflammation response Healthy blood sugar levels Healthy immune systems Healthy joint function And so much more Enzyme authority Dr. Anthony Cichoke says, "Every day, researchers throughout the world are discovering new enzymes and new therapeutic uses for them...Researchers are even studying enzyme replacement therapy devising new treatment methods for diseases that they have historically been unable to treat. This includes many diseases that result from inborn errors of metabolism, such as the inability of the body to make a particular enzyme."

Original Vitalzym is a hybrid formula that combines systemic and digestive delivery to provide total system support. It contains protease, serrapeptase, papain, bromelain, amylase, lipase, rutin and amla. Vitalzym systemic proteolytic enzyme therapy assists the body in fighting: Autoimmune conditions Fibromyalgia symptoms Uterine Fibroid Tumors  Pain and Inflammation Fibrosis of the organs Scar tissue Toxins and impurities in the blood Viruses Our bodies have a variety of functional units, such as a digestive system, an immune system, a cardiovascular system, and a circulatory system, just to name a few.  Each system requires energy in order to perform optimally.  It just so happens that enzymes provide this much needed energy for the successful completion of each biological function. The Purpose of Enzymes Enzymes are said to be the “sparks of life.” They are considered keys that can unlock the door to a healthier you because they not only help improve digestion and nutrient absorption; they are also responsible for millions of bodily functions. What exactly are enzymes?  They are proteins that are responsible for every chemical reaction that goes on in your body; governing all functions related to your tissues, muscles, bones, organs, and cells.  Every second of our lives, over 3,000 different enzymes are constantly renewing and changing, often at unbelievable speeds.    The Purpose of Enzymes Enzymes are said to be the “sparks of life.” They are considered keys that can unlock the door to a healthier you because they not only help improve digestion and nutrient absorption; they are also responsible for millions of bodily functions.  What exactly are enzymes?  They are proteins that are responsible for every chemical reaction that goes on in your body; governing all functions related to your tissues, muscles, bones, organs, and cells.  Every second of our lives, over 3,000 different enzymes are constantly renewing and changing, often at unbelievable speeds.  Enzymes are responsible for everyday bodily processes, such as: Metabolism Digestion Breathing Movement Liver function Immune regulation Viscosity of blood Cellular detoxification Energy production Stamina Ability to utilize vitamins and minerals Enzymes have been studied since the early 1900s.  Even though there is over a century's worth of information regarding their use, we still have much to learn about them.  Although, one thing is for certain; life as we know it, would not exist without them. Over the last decade, science has uncovered numerous roles for enzymes than ever thought possible, as they literally initiate millions of reactions within your body.  In fact, many health care professionals are now advocating the use of enzymes for various conditions and post-operative healing. When referring to enzymatic supplements, it's important to distinguish between those used for digestionand those used systemically. Digestive enzymes are taken orally with food in order to help break down fats, carbohydrates, and proteins for improved digestive function and nutrient absorption. Original Vitalzym can assist with digestion, but are not primarily a digestive enzyme. Systemic enzymes, such as those in original Vitalzym, are taken orally in between meals on an empty stomach. This way they can be absorbed by the intestines into the bloodstream where the body can utilize them for countless bodily processes.    Vitalzym Systemic Enzyme Therapy As we age, our body's natural production of enzymes begins to slow down.  Some health care professionals believe that our natural production of enzymes starts to decrease after the age of 27.  It is not too long after this that many of us begin to notice symptoms of low enzyme production, which can include:  Slow wound healing Increased scarring Poor digestion Fibrosis conditions Internal inflammation Dr. Anthony Cichoke, enzyme authority, states in his book, Enzymes and Enzyme Therapy, that "Our body's ability to function, to repair when injured, and to ward off disease is directly related to the strength and numbers of our enzymes.” 1 Supplemental enzymes like those in Original Vitalzym, New Vitalzym andVitalzym Cardio along with proper diet and exercise can help to maintain your normal enzyme levels and balance your body's own repair mechanisms. They can also help reduce the incidence of inflammatory and fibrosis conditions.   References 1. Cichoke Enzymes and Enzyme Therapy, (Keats Publishing, Chicago, IL, 2000) 2.  Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. 3.  Kunze R., Ransberger K., et at: Humoral immunomodulatory capacity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991.    

Vitalzym Extra Strength Systemic Enzymes   Vitalzym Extra Strength soft gels are the world’s leading all-natural, vegetarian systemic enzyme supplement. Vitalzym features an unmatched proprietary blend that includes Serrapeptase, Bromelain, Papain, Rutin, Amylase, Protease, Lipase and Amla Extract. These softgel capsules are available in 60, 180 and 360 count bottles.   Vitalzym is the only systemic enzyme on the market today boasting the revolutionary enteric-coated, liquid-gel delivery system. Unlike many of the competitors’ tablet- or powder-based products, Vitalzym’s enteric-coated, liquid-gel system ensures that 100 percent of the enzymes survive the harsh acidic environment of the stomach and reach the small intestine, where they become available for absorption into the bloodstream and then are dispersed throughout the entire body.†   What does this mean for you? Bottom line, you’ll be enjoying a smaller, easy-to-swallow capsule, taking less capsules per each dose and less doses per day to receive maximum systemic support. Thanks to Vitalzyms advanced delivery system, superior potency, unrivaled absorption rates and reliable consistency, you won’t need to wait three months to see results. You should feel a difference within weeks, or even days!   Features of Vitalzym Extra Strength   Vitalzym Extra Strength has been formulated with a technologically advanced delivery system that allows forreduced dosage and vastly increased effectiveness as compared to Original Vitalzym   Twice as strong as Original Vitalzym Less cost per dose Enteric coated for ideal release of active ingredients Liquid filled for optimal absorption Half the dose of original Vitalzym Smaller and more convenient packaging, with flip-top lid 100% non-GMO Vegetarian Completely recyclable packagin   Systemic Enzymes Help You Feel Better, Look Better, and Live Longer   Enzymes are said to be the “sparks of life.” They are considered keys that can unlock the door to a healthier you because they not only help improve digestion and nutrient absorption; they are also responsible for millions of bodily functions.   Vitalzym contains potent proteolytic enzymes designed to support health. It is an extremely effective systemic enzyme blend with a high Serrapeptase content. Vitalzym works synergistically to provide total system support. According to Dr. Peter Streichhan, a world-renowned enzyme researcher from Germany, "enzyme mixtures have a wider range of therapeutic advantages than do individual enzymes." 1   Vitalzym is specially engineered to help support:   Healthy inflammation response Healthy blood sugar levels Healthy immune systems Healthy joint function And so much more   Enzyme authority Dr. Anthony Cichoke says, "Every day, researchers throughout the world are discovering new enzymes and new therapeutic uses for them...Researchers are even studying enzyme replacement therapy devising new treatment methods for diseases that they have historically been unable to treat. This includes many diseases that result from inborn errors of metabolism, such as the inability of the body to make a particular enzyme."  

The word “systemic” means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ. But let’s take first things first, what is an enzyme? An enzyme is a biocatalyst - something that makes something else work or work faster. Chemical reactions are generally slow things, enzymes speed them up. Without enzymes the chemical reactions that make up our life would be too slow for life as we know it. (As slow as sap running down a tree in winter). For life to manifest as we know it, enzymes are essential to speed up the reactions. We have roughly some 3000 enzymes in our bodies and that results in over 7000 enzymic reactions. Most of these enzymes are derived or created from what we think of as the protein digesting enzymes. But while digestion is an important part of what enzymes do, it's almost the absolute last function. First and foremost these body wide proteolytic (protein eating) enzymes have the following actions: Natural Anti-Inflammatory: Inflammation is a reaction by the immune system to an irritation. Let’s say you have an injured right knee. The immune system, sensing the irritation the knee is undergoing, creates a protein chain called a Circulating Immune Complex (CIC for short), tagged specifically for that right knee. (The Nobel Prize in biology was won in 1999 by a scientist who discovered this tagging mechanism). This CIC floats down to the right knee and causes pain, redness and swelling; the classic earmarks for inflammation. This at first is a beneficial reaction because it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating; itself creating an irritation that the body makes CIC’s to in response!   At this point, most people turn to their medicine chest and take a couple of Non Steroidal Anti-Inflammatory drugs (NSAIDs) like Aspirin, Ibuprofen, Celebrex, Vioxx, etc. And the problem with that is: NSAID's work by keeping the body from making all CIC's!!! This ignores the fact that some CIC’s are vital to life, like those that maintain the lining of the intestines and those that keep the kidneys functioning! Not to mention the fact that the NSAID’s, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs. (4,5). This is where systemic enzyme use is so important.   Systemic Enzymes are the first line of defense against inflammation. (1,2,3). Systemic enzymes are perfectly safe and free of dangerous side effects and they have no LD-50, or toxic dose. (6). Best of all systemic enzymes can tell the difference between the good CIC’s and the bad ones because hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC’s. So instead of preventing the creation of all CIC’s, systemic enzymes just “eat” the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also. Anti-Fibrosis:  Systemic Enzymes eat scar tissue and fibrosis. (7). Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain: As we age, which starts at 27, we have a diminishing of the bodies’ output of enzymes. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 27. At that point the body knows that if it keeps up that rate of consumption we’ll run out of enzymes and be dead by the time we reach our 40’s. (Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually don’t make it past their 20’s before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue). So, our body in it's wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon; as a result, the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (meaning scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars. If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be “eaten away” from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 40 years! Blood Cleansing:  The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its "first pass", or the first time it goes through but given the sluggish and near toxic or toxic states of everyone's liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks! (8). When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by: Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots. (8).  Breaking dead material down small enough that it can immediately pass into the bowel. (8). Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection. (9). And here we come to the only warning we have to give concerning the use of systemic enzymes - don't use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin and Heparin, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much. Immune System Modulating:  Enzymes are adaptogenic seeking to restore a steady state to the body. (9). When the immune system is running low we become susceptible to infectious disease, when it’s cranked up too high then the system creates antibodies that attack it's own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue. Virus and Bacteria Fighting:  Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. (10,11). Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, (again the enzyme lock and key mechanism). Serrapeptase has the strongest protein eating effect of any commercially available enzyme and can be of help in combating viruses. Systemic Enzymes also have been found to have mild anti-bacterial properties. A bacteria is a foreign protein (exogenous). Proteolytic enzymes eat exogenous proteins in the body. One note: many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf (MD & PhD x7) at Columbia University in the 40’s through the 70’s has not made it to the awareness of most doctors. There are currently over 200 peer reviewed research articles dealing with the absorption, utilization and therapeutic action of orally administered systemic enzymes. A search through Pub Med using the key words: serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Systemic enzymes now have a 4 decade plus history of widespread medical use in central Europe and Japan. Original Formula New & Improved Formula References: 1) Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent in emergency surgery. Arztl. Praxis 24 (1972), 2307. 2) Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. 3) Kee W., H. Tan S, L., Lee V. Salmon Y. M.: The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore Med J. 1989:30(l):48-54. 4) Celebrex article Wall Street Journal 19 April 1999. 5) No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997. 6) Enzymes ñ A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published 1993 Eco Med. 7) Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982. 8) Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. 9) Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991. 10) Jager H.: Hydrolytic Enzymes in the therapy of HIV disease. Zeitschr. Allgemeinmed., 19 (1990), 160. 11) Bartsch W.: The treatment of herpes zoster using proteolytic enzymes. Der Informierte Arzt. 2 (1974), 424-429. Why Zymessence®: Because You Asked and We Listened! The New Formula is Even Stronger! You asked for a systemic enzyme that did not need to be taken by the handful (not the recommended dose on the label but how many you actually have to take to get good effects, usually: 10 - 60 capsules/tablets a day). With Zymessence®, you only need to take 2 to 3 capsules a day! You asked for a systemic enzyme that was affordable. With Zymessence®, a 60 day supply will only cost $89.95 at the full suggested retail price!   What Makes Zymessence® Better: It's All in the Mix! Zymessence™ is part of an emerging "new breed" of products in the field of Systemic Enzyme Therapy. It combines the best of both the "Old School" and the "New School" science of proteolytic enzymes to form a super effective and affordable blend. The "Old School" Systemic Enzymes, blended animal pancreatin (usually a 4X, 6X, 8X or 10X dilution) with fruit enzymes and then added Trypsin and Chymotrypsin extracts (also from Pancreatin) to create a wide-ranging and effective action. The drawback is Trypsin and Chymotrypsin are extremely expensive so not a lot is put into each tablet or capsule! The upside to using animal based pancreatin is research and clinical experience show that these enzyme blends last 24 to 36 hours in the body. The "New School" Systemic Enzymes, blend fruit, vegetable and fermented fungal based enzymes (such as fermented Serrapeptase), to increase the action of their product. As Serrapeptase is substantially stronger than Trypsin or Chymotrypsin, it does in fact increase the effectiveness of these enzyme blends several fold. The drawback is that clinical experience and research both show that these enzyme products only have 4 to 6 hours of action before they leave the body. The upside is Serrapeptase, though stronger, is far less expensive than Chymotrypsin and Trypsin so more can be put into each tablet or capsule! Zymessence® takes a page from the "Old School": The Zymessence® blend uses undiluted, full strength animal (porcine) based Pancreatin (with its naturally occurring Trypsin and Chymotrypsin) for its longer lasting effects. Zymessence® takes a page from the "New School": Then Zymessence® combines the usual fruit enzymes with Serrapeptidase (Serrapeptase) to greatly increase its effectiveness while keeping costs low! And More... Zymessence® uses "enteric matrix technology": Common enteric coatings just on the outside of a tablet or capsule are meant to protect the contents against destruction by stomach acid. Most enzymes are very sensitive to acids and are easily destroyed. But mere enteric coatings on the outside can be scratched or pitted just by the tablets/capsules knocking around inside their bottle! This allows stomach acid to enter the product and deactivate it before it has a chance to do any good. The "Enteric Matrix Technology" used in the production of Zymessence® means the entire caplet is protected inside and out by an enteric film that runs through every micro-granule within it, thus ensuring greater protection of the enzymes and increased absorption for you!   Zymessence®, the first and only systemic enzyme blend actually developed by Dr. William Wong, ND, PhD Dear Dr. Wong: I am on my 2nd bottle of Zymessence and LOVE it. I have MS and Fibromyalgia therefore cannot live without Zymessence for imflammation and immune support! AND, as a bonus it has helped my allergic reactions that I've developed to peanuts and some grains-stopped skin from itching, etc. Rita B. Customer Testimonial

Fibrin Defense Detoxification Cardiovascular Support AcidDefenz Time Release Capsule Enzymes are required for all living functions, including eating, breathing, and sleeping. The body produces its own enzymes to support these functions. As we age, the bodies’ ability to produce sufficient levels of enzymes to maintain optimal health significantly decreases. Insufficient levels of enzymes may lead to excess fibrin buildup, impurities in the cardiovascular system, fatigue, and other symptoms of chronic illness. Fibrenza is a powerful advanced blend of 14 powerful systemic enzymes that are specifically formulated to supplement the bodies’ ability to dissolve fibrin, cleanse the blood, and detoxify the body. Fibrenza has been formulated to provide maximum body-wide benefit. This means only the highest quality pharmaceutical grade enzymes are utilized. Fibrenza utilizes AcidDefenz capsule technology that allows the enzymes to withstand harsh stomach acids, providing maximum systemic benefit. Suggested Use: Adults take 2 capsules twice daily on an empty stomach (at least 45 minutes before or 60 minutes after meals) with water or as recommended by your healthcare provider.     Ingredients:   SUPPLEMENT FACTSServing size: 2 CapsulesServings per Container: 120   AmountPer Serving % Daily Value Proprietary Enzyme Blend 1000 mg *    Protease    Superoxide Dismutase (SOD)    Nattokinase NSK-SD    Pancreatin 8X    Trypsin    Peptidase    Acid Stable Protease    Amylase    Seaprose S    Papain    Lipase    Chymotrypsin * Daily Value Not Established Percent Daily Values are based on a 2,000 calorie diet. Other Ingredients: Cellulose (Vegetable Capsules), Rice Bran, Rice Extract Does NOT contain: phthalates, maltodextrin, dairy, wheat, yeast, gluten, fish, magnesium stearate, talc, artificial colors or flavors. Non-GMO Warning: As with any dietary supplement, consult your healthcare provider before using this product, especially if you are pregnant, nursing, or are taking medication.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Fibrin Defense Detoxification Cardiovascular Support AcidDefenz Time Release Capsule Enzymes are required for all living functions, including eating, breathing, and sleeping. The body produces its own enzymes to support these functions. As we age, the bodies’ ability to produce sufficient levels of enzymes to maintain optimal health significantly decreases. Insufficient levels of enzymes may lead to excess fibrin buildup, impurities in the cardiovascular system, fatigue, and other symptoms of chronic illness. Fibrenza is a powerful advanced blend of 14 powerful systemic enzymes that are specifically formulated to supplement the bodies’ ability to dissolve fibrin, cleanse the blood, and detoxify the body. Fibrenza has been formulated to provide maximum body-wide benefit. This means only the highest quality pharmaceutical grade enzymes are utilized. Fibrenza utilizes AcidDefenz capsule technology that allows the enzymes to withstand harsh stomach acids, providing maximum systemic benefit. Suggested Use: Adults take 2 capsules twice daily on an empty stomach (at least 45 minutes before or 60 minutes after meals) with water or as recommended by your healthcare provider.   Ingredients:   SUPPLEMENT FACTSServing size: 2 CapsulesServings per Container: 30   AmountPer Serving % Daily Value Proprietary Enzyme Blend 1000 mg *    Protease    Superoxide Dismutase (SOD)    Nattokinase NSK-SD    Pancreatin 8X    Trypsin    Peptidase    Acid Stable Protease    Amylase    Seaprose S    Papain    Lipase    Chymotrypsin * Daily Value Not Established Percent Daily Values are based on a 2,000 calorie diet. Other Ingredients: Cellulose (Vegetable Capsules), Rice Bran, Rice Extract Does NOT contain: phthalates, maltodextrin, dairy, wheat, yeast, gluten, fish, magnesium stearate, talc, artificial colors or flavors. Non-GMO Warning: As with any dietary supplement, consult your healthcare provider before using this product, especially if you are pregnant, nursing, or are taking medication.

Exclzyme The Original Full-Strength Formula Everybody Needs a Healthy Body Elimination of potentially toxic substances from the body is a crucial part in the metabolic processes for optimal health. A variety of health issues can develop if toxins within the body impair enzyme function or availability or without a proper store of enzymes. For instance, the immune system can be overwhelmed with bacteria, fungi, toxins and even food particles that don’t get completely digested in the gastro-intestinal tract. In many instances, proteins created by these distresses found within the body, which the body detects as foreign, can initiate an immune response. Recognized as antigens, the immune system produces antibodies to start the process of the proteins’ degradation and removal. After coupling with one another, these antigens and antibodies form circulating immune complexes (CICs), which induce attack and destruction by the immune system’s macrophages (white blood cells specifically designed to destroy CICs). This process is known as inflammation – the body’s natural healing mechanism In cases where inflammation is prolonged or when CICs are predominant within the body’s tissues and organs, the body may not have enough enzyme potential to begin the next process of renewal and recovery. Moreover, research has demonstrated that a lack of proteolytic enzymes may not cause an adequate response to a large accumulation of CIC’s in the body. Exclzyme® for Total Body Support To address this problem, Exclzyme has been formulated with an ample supply of various proteases to facilitate the body’s immune defenses and breakdown free-roaming CICs that can keep the body in a constant state of inflammation. Enteric-coated serrapeptase highlights this powerful mix of proteolytic enzymes with its scientifically proven fibrinolytic power (to learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab). Exclzyme also contains papain and bromelain, enzymes known for their potent systemic properties. In addition to these systemic and digestive proteases, lipase and amylase also offer their own enzyme activity to bolster the body with extra catalytic energy, especially for the complete digestion of fats, sugar and protein complexes. And for extra synergy, Exclzyme is rounded with anti-oxidant support in the form of rutin and amla, herbs well known for their unique bioflavanoid content, especially useful for tissue rejuvenation and recovery.*The entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). The Original Systemic Enzyme Formula Exclzyme is a proven systemic enzyme therapy for overall health. A powerful blend of serrapeptase, proteases and herbs, Exclzyme supports the body’s response to inflammation, metabolic activity, blood, joints and circulation. The Exclzyme formula has been used for more than a decade by thousands of people as a daily dietary supplement. In fact, you may have been using the original formula for years without knowing it (to learn more about Exclzyme vs. Vitalzym®, please click the "Compare" tab).** AST Enzymes’ family of companies is among the largest manufacturers of enzymes in the world. For decades, we have supplied enzymes to marketing companies who have built their businesses on enzyme supplements our experts formulated and manufactured. The Exclzyme formulation has been commercially available since 1999 and is the most successful non-animal derived systemic enzyme blend on the market today. Exclzyme Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Exclzyme dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Exclzyme with additional serrapeptase can increase proteolytic activity, as well as increase positive effects on inflammation and provide faster recovery and healing from injury.*Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Exclzyme vs Vitalzym   Exclzyme vs Vitalzym Comparison Chart Brand Enteric Coated Serrapeptase Serrapeptase Manufacturing Source Price Original Vitalzym (2000-2009) Yes India $114.00 "Original" Vitalzym (Current) No Japan $114.00 Vitalzym 360 Liquid Capsules (Current) Yes Japan $149.99 Original Exclzyme Yes India $99.95   If your systemic enzyme supplement recently changed, we have the original formula. Some companies claim to continue to carry the original formula. One easy way to check is to see if the bottle says the enzyme serrapeptase is enteric-coated. Studies show serrapeptase, sourced from the bacterium Serratia marcescens and the key ingredient in the original Full-Strength Exclzyme, must be enteric coated so it can pass through the acid environment of the stomach without being damaged. And as for the new formulas on the market claiming to be stronger or more technologically advanced: the proof is in the results. There is an underlying art when it comes to manufacturing enzyme products. Systemic enzyme blends must be formulated expertly and correctly for maximum effectiveness. In fact, alterations to an already successful systemic enzyme product may not provide the same results you’ve come to expect. Many companies, including ours, use proprietary formulas to protect their products from being copied and used by others. But all companies must list all of the ingredients by name, and rank the ingredients according to the percentage amounts in the formula. For instance, in the original Exclzyme formula, enteric-coated serrapeptase is listed on our ingredient list as the second most prevalent ingredient in our formulation. If your “new and improved” systemic formula does not list serrapeptase as the second ingredient and it doesn’t say enteric-coated, you’re probably not getting the most out of your systemic enzyme formula. Serrapeptase has always been the hallmark of the original Exclzyme formula, making it the choice of companies and consumers alike.   ----------------------------------------------------------------------------------------------   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)*   Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Contains Phthalates NO YES YES Considered Enteric Coating YES YES YES Studies supporting Efficacy as Enteric Coating YES YES YES Gastro-resistance YES YES YES FDA GRAS YES YES YES Time in Use   >50 years   >70 years   ~40 years     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Vitalzym® is a registered trademark of World Nutrition Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes.   Research   Inflammation and Fibrin The reality of inflammation is that it affects everyone, men and women alike. However, along with nearly all other tissue and organs, inflammation can affect reproductive tissue and organs particularly. For instance, many women experience painful swelling of the breast as well as uterine fibroids. In men, prostate health is a major concern. Although inflammation in each case may manifest differently in both men and women, inflammation has one thing in common: fibrin. Fibrin is an essential protein that is produced during inflammation. As a blood clotting protein, the body utilizes fibrin to contain blood loss and keep infection at bay after injury. It is the initial step in the body’s attempts at recovery. However, when inflammation has become prolonged, fibrin along with other proteins such as collagen can begin to transform original tissue into a tough fibrous matrix. Differentiated and sometimes sequestered apart from healthy tissue, this fibrous matrix still has the biological markers of inflammation. Nutrients and other building blocks are still needed for healthy and normal tissue. Systemic and proteolytic enzyme research over the years suggests that fibroids in women and swollen prostate glands in men are indications that the body has not been able to get past inflammation. The resulting fibrous tissue usually accumulates toxins that have not been adequately removed by the body. Serrapeptase Research: Anti-inflammatory Activity For nearly 40 years, serrapeptase has been at the heart of systemic enzyme therapy. Systemic enzymes such as serrapeptase have been used for optimal cell, tissue, organ and metabolic function. Likewise, companies, health practitioners and consumers have turned to the original Exclzyme formulation for their systemic enzyme therapy needs. Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1 A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing inflammation in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2 Moving to another part of the body, a study was conducted in men with amicrobial prostato-vesiculitis (APV is a non-infectious inflammation of the prostate). The researchers wanted to determine if treatment with nonsteroidal anti-inflammatory (NSAIDS) drugs, including serrapeptase, could reduce inflammation and swelling of the prostate. The doctors conclude that in APV patients, the treatment with NSAIDS, including serrapeptase is an effective therapy, producing multiple positive effects.3 Exclzyme Benefits and Sports Nutrition Enzymes are energetic catalysts that push essential chemical reactions in the body in the right direction. In its quest for internal balance, the body always turns to enzymes for help. In this way, Exclzyme helps get inflamed tissue over the hump. Exclzyme’s superior proteolytic action assists the body in removing those larger protein molecules from damaged cells and tissues as well as the inflammatory response itself. In helping breakdown these compounds, the impediments for sustaining healthy cell and tissue growth are removed and the processes for rejuvenation and recovery can move forward. These facets of Exclzyme make it ideal for maintaining healthy tissue repair following strenuous physical training and activity. Sport- and exercise-related muscle pain and inflammation brought on by strong physical tension, excessive training, and heavy competition are decreased with “excellent results” due to the specific activity of systemic enzymes on exercise-induced inflammation.4 Taking systemic enzymes prior activity can also provide protective benefits to athletes who are at risk of injury, resulting in significantly reduced duration of injury symptoms and related absences from training and work. Systemic enzyme support also improves recovery from sprains, as well as shortens recovery from sport injuries severe enough to require surgery.5,6 Enzyme Activity  Enteric Coated Serrapeptase Used by silkworms to digest and emerge from their silken cocoons; studied extensively for more than 50 years; an excellent fibrinolytic (fibrin digesting) and powerful anti-inflammatory enzyme* Protease Hydrolyze (break-down) proteins like casein, steak, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its anti-inflammatory properties.  A good substitute for animal-based enzymes a good substitute for pepsin and trypsin for digestive support* Papain Obtained from the latex of the fruit of the Papaya tree; used for centuries as an effective digestive aid* Amylase Breaks down carbohydrates, or more specifically, starches, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants Lipase Catalyzes the break-down of fats into essential fatty acids needed for healthy tissues and cells* Amla Also known as Indian gooseberry (Emblica officinalis); a natural, efficacious antioxidant, and one of the richest sources of absorbable vitamin C Rutin Bioflavonoid; strengthens and tones arteries and veins; provides antioxidant support against free-radicals and inflammation*     References 1. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000 Nov; 48(11):1130. 2. Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb; 30(1):48-54. 3. Vicari E, La Vignera S, Battiato C, Arancio A. Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings[Article in Italian]. Minerva Urol Nefrol. 2005 Mar; 57(1):53-9. 4. Nouza K. Physical activity and immune system. Systemic enzyme therapy in prevention and treatment. Medicina Sportiva Boh Slov. 1997; 6(2):41–45. 5. Zuschlag JM. Prophylactic administration of Wobenzym to reduce consequences of sports injuries in karate fighters. MUCOS Pharma GmbH & Co, Dept. Clinical Research, Geretsried, Germany. 6. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004 Aug; 38(4):431–435. FAQ         What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.   What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Exclzyme on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme with food will compromise their absorption, as well as their effectiveness.   Does Exclzyme have an enteric coating? Yes, the serrapeptase in Exclzyme is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please click the 'Compare" tab.   How long should I take Exclzyme before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-15 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: ·         Height ·         Weight ·         Age ·         Severity of symptoms ·         Tolerance ·         Time of administration (Better absorbed on an empty stomach) ·         Adherence to regimen ·         Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Are there any side effects involved with Exclzyme? The use of Exclzyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Exclzyme with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Exclzyme with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.     Supplement Facts Serving Size:  1 CapsulesServings Per Container: 450 Amount Per Serving                          %DV Proprietary Enzyme Blend:                      500 mg *   Protease, Peptizyme SP® EN (Enteric   coated Serrapeptase), Papain,   Bromelain, Amylase, Lipase, Rutin   and Amla. *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose, and cellulose. Directions: Take 2 capsules three times a day. In three days, if desired benefit is not achieved, take 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Vitalzym Cardio (formerly VitalzymSEB) was introduced in 2005, after much success of the original Vitalzym, which has become one of the leading systemic enzyme formulations available. Vitalzym Cardio is formulated with your cardiovascular wellbeing in mind. The SEBkinase blend contains "heart healthy" enzymes that may cleanse the blood of excess fibrin and reduce vascular inflammation.*Countless sufferers of chronic conditions such as arthritis, fibromyalgia, systemic inflammation, fibroids, and many more have found relief with the regular use of Vitalzym. A common benefit of Vitalzym has been its ability its ability to cleanse the blood. World Nutrition and Specialty Enzymes have taken the cardiovascular support of Vitalzym and harnessed it with nattokinase and other "heart healthy" nutrients to create an enzyme formulation specifically to support cardiovascular wellness. Vitalzym Cardio also contains powerful antioxidants, such as CoQ10, which has been shown to have significant impact on heart function.*Reduce Fibrin in the BloodThe fibrinolytic enzymes in Vitalzym Cardio have been shown to have the ability to digest excess fibrin (protein buildup) in the blood, which allows for improved blood viscosity. Stacked red blood cells (or Rouleau effect) often reflect poor protein digestion. Symptoms can include fatigue, stress on the heart, and poor circulation. The ingredients in Vitalzym Cardio have been shown, using darkfield microscopy, to significantly reduce the stacking of red blood cells.*C-Reactive ProteinsIncreased vascular inflammation has been recently shown to be a factor in many debilitating issues. C-Reactive Protein levels are used as a marker for vascular inflammation. Then enzymes in Vitalzym Cardio have been shown to reduce the levels of C-Reactive Proteins.*Vitalzym Cardio IngredientsNattokinaseNattokinase is a fibrinolytic enzyme extracted and purified from natto, a fermented soybean food used by the Japanese for thousands of years as a traditional food medicine.Nattokinase was first identified in 1980 by Dr. Hiroyuki Sumi, M.D., Ph.D., who was researching thrombolytic enzymes with the hope of finding a natural agent that could successfully dissolve thrombus associated with cardiac and cerebral infarction (blood clots associated with heart attacks and stroke). After testing more than 200 natural foods as potential thrombolytic agents, Sumi found that natto possessed a substance with a "a potency matched by no other enzyme." Dr. Sumi named the newly discovered enzyme nattikinase.*By dissolving fibrin more completely than any other substance tested by Dr. Sumi, nattokinase may be particularly effective in helping the body fight blood clots. Its thrombolytic activity is enhanced by the enzyme's ability to boost the body's production of both plasmin and other clot-dissolving agents, including endogenous urokinase.*SerrapeptaseSerrapeptase is a proteolytic enzyme that is able to digest dead tissue, blood clots, and cysts. Clinical studies show that serrapeptase induced fibrinolytic, anti-inflammatory, and anti-edemic activity in a number of tissues, and that its anti-inflammatory effects are superior to to other proteolytic enzymes.*Serrapeptase has been used in Europe to treat arterial blockages due to its ability to alleviate arterial inflammation and dissolve blood lots. It has been used to treat arthritis, fibrocystic breast disease, carpal tunnel syndrome, and other fibrinolytic, viral, and inflammatory conditions.*DetoxificationSystemic enzymes will help rid the liver of toxins. Some users will experience a detox reaction to the enzymes, including short-term fatigue, nausea, or headache. Liver detoxification reactions are a beneficial cleansing for the body. Increased water intake can assist in the process; reducing the enzyme dosage will slow the rate of detox. Enzymes also help cleanse metabolic debris and help mainain vital blood quality.* Other Ingredients Maltodextrin, Vegetable Cellulose (Capsule) Suggested Use As a dietary supplement, take 1 capsule three times daily, or more as directed by your healthcare provider. Take capsules at least 30 minutes before a meal, 60 minutes after a meal, or any time in-between meals with water. Warnings If you are pregnant, lactating, taking anti-coagulants, blood thinners, or have a history of thinning blood in your family, do not take this product without direction and supervision from your medical provider. Discontinue use 2 weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. Allergen Info Contains no animal derivatives, artificial flavors, yeast, or gluten. Lactose free and contains no harmful talc. Produced with an enterically coated enzyme.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Product InfoIMMUNE SYSTEM SUPPORT Your immune system is essential to fighting off germs. Immune support is especially vital when everyone around you is sick! Our Immunity Boost Bundles can provide great support for your body to keep healthy. ImmunoSEB™ This powerful enzymatic formula was designed to boost our bodies’ natural resistance against harmful organisms which threaten our life systems.  ImmunoSEB™ is one of the strongest immune system support formulas we offer!  It contains: Enteric-Coated Serrapeptase and Peptidase enzymes that help break down proteins into amino acids needed for healthy immune function. Bromelain and Papain enzymes derived from pineapples and papayas long known to support the body’s natural response to inflammation. Lysozyme, amylases, catalase, lactoferrin proteins to provide natural antimicrobial properties, and natural antioxidant benefits.* A Safe and Natural Regimen We believe in safety first!  Other companies merely buy and repackage someone else’s product.  But, as a true manufacturer, we control safety from the beginning. ImmunoSEB™ is free of pesticides, chemicals, preservatives, animal derivatives, soy, wheat, peanuts, tree nuts, fish and shellfish. All enzyme ingredients are kosher-certified, and suitable for vegetarians. ImmunoSEB™ is manufactured in the USA in an FDA-registered facility that follows cGMP guidelines, and are composed of domestic and international ingredients. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of enzymes to support healthy cardiovascular, respiratory, immune systems, among others. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system.  Different systemic enzyme blends offer support to different areas of the body. ImmunoSEB™ is packed with potent proteolytic enzymes at high activities, and antioxidants required for supporting a strong immune system. What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. How long should I take ImmunoSEB™ before feeling results? The length of time to experience the benefits of systemic enzymes varies by individual. Some people notice a difference within days. For others, it’s a week or 10 days. For long-term benefits, it’s important to take systemic enzymes consistently over several months. New systemic enzyme users should start off slow, with one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a 2 capsules, 3 times per day.  onitored, and dosage should be adjusted accordingly.  There are several factors that may affect required dosage, including: Height Weight Age Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up” on one dose. Also remember, systemic enzymes are best absorbed on an empty stomach. Why is it important to take ImmunoSEB™ on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes survive the stomach intact. If enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like ImmunoSEB with food will compromise their absorption, as well as their effectiveness. Are there any side effects involved with ImmunoSEB™? The use of ImmunoSEB™ has not been shown to exhibit detrimental effects, long term or short term. Minor side effects may vary. Gastrointestinal disturbances have been reported by a small percentage of new users, but once the dosage is adjusted, tolerance is maintained. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, particularly if you are on blood-thinning medications, or are pregnant or nursing. Can I take ImmunoSEB™ with other systemic or digestive enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Separate blends or enzymes often work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on supporting the body are more attainable.

Exclzyme The Original Full-Strength Formula Everybody Needs a Healthy Body Elimination of potentially toxic substances from the body is a crucial part in the metabolic processes for optimal health. A variety of health issues can develop if toxins within the body impair enzyme function or availability or without a proper store of enzymes. For instance, the immune system can be overwhelmed with bacteria, fungi, toxins and even food particles that don’t get completely digested in the gastro-intestinal tract. In many instances, proteins created by these distresses found within the body, which the body detects as foreign, can initiate an immune response. Recognized as antigens, the immune system produces antibodies to start the process of the proteins’ degradation and removal. After coupling with one another, these antigens and antibodies form circulating immune complexes (CICs), which induce attack and destruction by the immune system’s macrophages (white blood cells specifically designed to destroy CICs). This process is known as inflammation – the body’s natural healing mechanism In cases where inflammation is prolonged or when CICs are predominant within the body’s tissues and organs, the body may not have enough enzyme potential to begin the next process of renewal and recovery. Moreover, research has demonstrated that a lack of proteolytic enzymes may not cause an adequate response to a large accumulation of CIC’s in the body. Exclzyme® for Total Body Support To address this problem, Exclzyme has been formulated with an ample supply of various proteases to facilitate the body’s immune defenses and breakdown free-roaming CICs that can keep the body in a constant state of inflammation. Enteric-coated serrapeptase highlights this powerful mix of proteolytic enzymes with its scientifically proven fibrinolytic power (to learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab). Exclzyme also contains papain and bromelain, enzymes known for their potent systemic properties. In addition to these systemic and digestive proteases, lipase and amylase also offer their own enzyme activity to bolster the body with extra catalytic energy, especially for the complete digestion of fats, sugar and protein complexes. And for extra synergy, Exclzyme is rounded with anti-oxidant support in the form of rutin and amla, herbs well known for their unique bioflavanoid content, especially useful for tissue rejuvenation and recovery.*The entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). The Original Systemic Enzyme Formula Exclzyme is a proven systemic enzyme therapy for overall health. A powerful blend of serrapeptase, proteases and herbs, Exclzyme supports the body’s response to inflammation, metabolic activity, blood, joints and circulation. The Exclzyme formula has been used for more than a decade by thousands of people as a daily dietary supplement. In fact, you may have been using the original formula for years without knowing it (to learn more about Exclzyme vs. Vitalzym®, please click the "Compare" tab).** AST Enzymes’ family of companies is among the largest manufacturers of enzymes in the world. For decades, we have supplied enzymes to marketing companies who have built their businesses on enzyme supplements our experts formulated and manufactured. The Exclzyme formulation has been commercially available since 1999 and is the most successful non-animal derived systemic enzyme blend on the market today. Exclzyme Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Exclzyme dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Exclzyme with additional serrapeptase can increase proteolytic activity, as well as increase positive effects on inflammation and provide faster recovery and healing from injury.*Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Exclzyme vs Vitalzym   Exclzyme vs Vitalzym Comparison Chart Brand Enteric Coated Serrapeptase Serrapeptase Manufacturing Source Price Original Vitalzym (2000-2009) Yes India $114.00 "Original" Vitalzym (Current) No Japan $114.00 Vitalzym 360 Liquid Capsules (Current) Yes Japan $149.99 Original Exclzyme Yes India $99.95   If your systemic enzyme supplement recently changed, we have the original formula. Some companies claim to continue to carry the original formula. One easy way to check is to see if the bottle says the enzyme serrapeptase is enteric-coated. Studies show serrapeptase, sourced from the bacterium Serratia marcescens and the key ingredient in the original Full-Strength Exclzyme, must be enteric coated so it can pass through the acid environment of the stomach without being damaged. And as for the new formulas on the market claiming to be stronger or more technologically advanced: the proof is in the results. There is an underlying art when it comes to manufacturing enzyme products. Systemic enzyme blends must be formulated expertly and correctly for maximum effectiveness. In fact, alterations to an already successful systemic enzyme product may not provide the same results you’ve come to expect. Many companies, including ours, use proprietary formulas to protect their products from being copied and used by others. But all companies must list all of the ingredients by name, and rank the ingredients according to the percentage amounts in the formula. For instance, in the original Exclzyme formula, enteric-coated serrapeptase is listed on our ingredient list as the second most prevalent ingredient in our formulation. If your “new and improved” systemic formula does not list serrapeptase as the second ingredient and it doesn’t say enteric-coated, you’re probably not getting the most out of your systemic enzyme formula. Serrapeptase has always been the hallmark of the original Exclzyme formula, making it the choice of companies and consumers alike.   ----------------------------------------------------------------------------------------------   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)*   Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Contains Phthalates NO YES YES Considered Enteric Coating YES YES YES Studies supporting Efficacy as Enteric Coating YES YES YES Gastro-resistance YES YES YES FDA GRAS YES YES YES Time in Use   >50 years   >70 years   ~40 years     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Vitalzym® is a registered trademark of World Nutrition Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes.   Research   Inflammation and Fibrin The reality of inflammation is that it affects everyone, men and women alike. However, along with nearly all other tissue and organs, inflammation can affect reproductive tissue and organs particularly. For instance, many women experience painful swelling of the breast as well as uterine fibroids. In men, prostate health is a major concern. Although inflammation in each case may manifest differently in both men and women, inflammation has one thing in common: fibrin. Fibrin is an essential protein that is produced during inflammation. As a blood clotting protein, the body utilizes fibrin to contain blood loss and keep infection at bay after injury. It is the initial step in the body’s attempts at recovery. However, when inflammation has become prolonged, fibrin along with other proteins such as collagen can begin to transform original tissue into a tough fibrous matrix. Differentiated and sometimes sequestered apart from healthy tissue, this fibrous matrix still has the biological markers of inflammation. Nutrients and other building blocks are still needed for healthy and normal tissue. Systemic and proteolytic enzyme research over the years suggests that fibroids in women and swollen prostate glands in men are indications that the body has not been able to get past inflammation. The resulting fibrous tissue usually accumulates toxins that have not been adequately removed by the body. Serrapeptase Research: Anti-inflammatory Activity For nearly 40 years, serrapeptase has been at the heart of systemic enzyme therapy. Systemic enzymes such as serrapeptase have been used for optimal cell, tissue, organ and metabolic function. Likewise, companies, health practitioners and consumers have turned to the original Exclzyme formulation for their systemic enzyme therapy needs. Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1 A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing inflammation in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2 Moving to another part of the body, a study was conducted in men with amicrobial prostato-vesiculitis (APV is a non-infectious inflammation of the prostate). The researchers wanted to determine if treatment with nonsteroidal anti-inflammatory (NSAIDS) drugs, including serrapeptase, could reduce inflammation and swelling of the prostate. The doctors conclude that in APV patients, the treatment with NSAIDS, including serrapeptase is an effective therapy, producing multiple positive effects.3 Exclzyme Benefits and Sports Nutrition Enzymes are energetic catalysts that push essential chemical reactions in the body in the right direction. In its quest for internal balance, the body always turns to enzymes for help. In this way, Exclzyme helps get inflamed tissue over the hump. Exclzyme’s superior proteolytic action assists the body in removing those larger protein molecules from damaged cells and tissues as well as the inflammatory response itself. In helping breakdown these compounds, the impediments for sustaining healthy cell and tissue growth are removed and the processes for rejuvenation and recovery can move forward. These facets of Exclzyme make it ideal for maintaining healthy tissue repair following strenuous physical training and activity. Sport- and exercise-related muscle pain and inflammation brought on by strong physical tension, excessive training, and heavy competition are decreased with “excellent results” due to the specific activity of systemic enzymes on exercise-induced inflammation.4 Taking systemic enzymes prior activity can also provide protective benefits to athletes who are at risk of injury, resulting in significantly reduced duration of injury symptoms and related absences from training and work. Systemic enzyme support also improves recovery from sprains, as well as shortens recovery from sport injuries severe enough to require surgery.5,6 Enzyme Activity  Enteric Coated Serrapeptase Used by silkworms to digest and emerge from their silken cocoons; studied extensively for more than 50 years; an excellent fibrinolytic (fibrin digesting) and powerful anti-inflammatory enzyme* Protease Hydrolyze (break-down) proteins like casein, steak, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its anti-inflammatory properties.  A good substitute for animal-based enzymes a good substitute for pepsin and trypsin for digestive support* Papain Obtained from the latex of the fruit of the Papaya tree; used for centuries as an effective digestive aid* Amylase Breaks down carbohydrates, or more specifically, starches, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants Lipase Catalyzes the break-down of fats into essential fatty acids needed for healthy tissues and cells* Amla Also known as Indian gooseberry (Emblica officinalis); a natural, efficacious antioxidant, and one of the richest sources of absorbable vitamin C Rutin Bioflavonoid; strengthens and tones arteries and veins; provides antioxidant support against free-radicals and inflammation*     References 1. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000 Nov; 48(11):1130. 2. Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb; 30(1):48-54. 3. Vicari E, La Vignera S, Battiato C, Arancio A. Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings[Article in Italian]. Minerva Urol Nefrol. 2005 Mar; 57(1):53-9. 4. Nouza K. Physical activity and immune system. Systemic enzyme therapy in prevention and treatment. Medicina Sportiva Boh Slov. 1997; 6(2):41–45. 5. Zuschlag JM. Prophylactic administration of Wobenzym to reduce consequences of sports injuries in karate fighters. MUCOS Pharma GmbH & Co, Dept. Clinical Research, Geretsried, Germany. 6. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004 Aug; 38(4):431–435. FAQ         What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.   What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Exclzyme on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme with food will compromise their absorption, as well as their effectiveness.   Does Exclzyme have an enteric coating? Yes, the serrapeptase in Exclzyme is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please click the 'Compare" tab.   How long should I take Exclzyme before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-15 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: ·         Height ·         Weight ·         Age ·         Severity of symptoms ·         Tolerance ·         Time of administration (Better absorbed on an empty stomach) ·         Adherence to regimen ·         Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Are there any side effects involved with Exclzyme? The use of Exclzyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Exclzyme with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Exclzyme with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.     Supplement Facts Serving Size:  1 CapsulesServings Per Container: 90 Amount Per Serving                          %DV Proprietary Enzyme Blend:                      500 mg *   Protease, Peptizyme SP® EN (Enteric   coated Serrapeptase), Papain,   Bromelain, Amylase, Lipase, Rutin   and Amla. *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose, and cellulose. Directions: Take 2 capsules three times a day. In three days, if desired benefit is not achieved, take 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Product InfoIMMUNE SYSTEM SUPPORT Your immune system is essential to fighting off germs. Immune support is especially vital when everyone around you is sick! Our Immunity Boost Bundles can provide great support for your body to keep healthy. ImmunoSEB™ This powerful enzymatic formula was designed to boost our bodies’ natural resistance against harmful organisms which threaten our life systems.  ImmunoSEB™ is one of the strongest immune system support formulas we offer!  It contains: Enteric-Coated Serrapeptase and Peptidase enzymes that help break down proteins into amino acids needed for healthy immune function. Bromelain and Papain enzymes derived from pineapples and papayas long known to support the body’s natural response to inflammation. Lysozyme, amylases, catalase, lactoferrin proteins to provide natural antimicrobial properties, and natural antioxidant benefits.* A Safe and Natural Regimen We believe in safety first!  Other companies merely buy and repackage someone else’s product.  But, as a true manufacturer, we control safety from the beginning. ImmunoSEB™ is free of pesticides, chemicals, preservatives, animal derivatives, soy, wheat, peanuts, tree nuts, fish and shellfish. All enzyme ingredients are kosher-certified, and suitable for vegetarians. ImmunoSEB™ is manufactured in the USA in an FDA-registered facility that follows cGMP guidelines, and are composed of domestic and international ingredients. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of enzymes to support healthy cardiovascular, respiratory, immune systems, among others. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system.  Different systemic enzyme blends offer support to different areas of the body. ImmunoSEB™ is packed with potent proteolytic enzymes at high activities, and antioxidants required for supporting a strong immune system. What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. How long should I take ImmunoSEB™ before feeling results? The length of time to experience the benefits of systemic enzymes varies by individual. Some people notice a difference within days. For others, it’s a week or 10 days. For long-term benefits, it’s important to take systemic enzymes consistently over several months. New systemic enzyme users should start off slow, with one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a 2 capsules, 3 times per day.  onitored, and dosage should be adjusted accordingly.  There are several factors that may affect required dosage, including: Height Weight Age Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up” on one dose. Also remember, systemic enzymes are best absorbed on an empty stomach. Why is it important to take ImmunoSEB™ on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes survive the stomach intact. If enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like ImmunoSEB with food will compromise their absorption, as well as their effectiveness. Are there any side effects involved with ImmunoSEB™? The use of ImmunoSEB™ has not been shown to exhibit detrimental effects, long term or short term. Minor side effects may vary. Gastrointestinal disturbances have been reported by a small percentage of new users, but once the dosage is adjusted, tolerance is maintained. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, particularly if you are on blood-thinning medications, or are pregnant or nursing. Can I take ImmunoSEB™ with other systemic or digestive enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Separate blends or enzymes often work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on supporting the body are more attainable.