Hydrogen (3)

Molecular Hydrogen is the smallest molecule that exists, and serves as a powerful antioxidant within the body, crossing cellular barriers and entering the mitochondria and cell nucleus. Hydrogen immediately provides balance in the body by neutralizing free radical damage and oxidative stress. By achieving this deep at the cellular level, the body maintains homeostasis and decreases the chance of premature aging. Benefits: Hydrogen is the most powerful antioxidant and the only molecule that can neutralize the most harmful free radical (hydroxyl) Stopping oxidative stress in its tracks while protecting cell integrity.The smallest antioxidant that can easily penetrate the cell and travel throughout the body.Antioxidants act as stabilizers in your body, countering the effects of free radical damage.Hydrogen activates NFR2 which is a protein within the cell that encourages healthy DNA transcription. Ingredients: Elemental Magnesium, Malic Acid, Dextrose, Tartaric Acid, Adipic Acid.

One Molecule. Hundreds Of Benefits. Over 2000 Scientific Studies.It’s not too good to be true—Molecular Hydrogen is the energy-boosting, brain-enhancing, performance-improving, pro-longevity antioxidant, anti-inflammatory, and anti-wrinkle supplement only researchers have heard of.Say Hello To HydrogenThe molecular answer to modern disease. You know the numbers… Every 33 seconds, someone in the United States dies from cardiovascular disease [1]. Every 52 seconds, someone dies from cancer [2].Statistically, one out of every three of your friends has metabolic syndrome and a higher risk of heart disease, diabetes, and stroke [3].The solution?One of the smallest compounds on Earth.Over 2000 studies prove molecular hydrogen’s powerful ability to support the underlying causes of modern disease.Benefit From... Sharper brain function [4] Sustained energy [5] Balanced body composition [6] Better Skin [7] Boosted metabolism [8] Improved immune function [9] Faster recovery [10] Powerful anti-aging [11] Potent mitochondrial protection [12] The vitality to do what you love Most Antioxidants Have A Dark Side...Generally, antioxidants do a lot of good. Research shows they fight aging, support our immune system, and help us avoid heart disease and cancer (13).But they also have a dark side.Why?Your body does best with balance. The right amount of stress—even oxidative stress—is a crucial trigger for powerful endogenous antioxidants like superoxide dismutase, catalase, and glutathione peroxidase.Most supplemental antioxidants disturb this delicate balance.But Molecular Hydrogen isn't most antioxidants.It acts as a master antioxidant by stimulating your body’s own internal defense system—your best source of optimized energy, performance, and recovery [14,15].Molecular Hydrogen Promotes Health In Three Primary Ways: Unique antioxidant action: Directly and indirectly protects cells, proteins, and DNA from oxidative damage while elegantly influencing intracellular communication Powerful anti-inflammatory: Reduces innate immune activation and promotes balance of pro- and anti-inflammatory cytokines at the genetic level (16, 17) Dynamic apoptotic regulation: Adaptively balances programmed cell death and degradation—protects normal cells and may inhibit proliferation of malignant cells (18)     Blood Sugar Balance And Beauty With zero side effectsSustained Energy Molecular hydrogen positively impacts mitochondrial function and supports both acute and chronic fatigue [19] Hydrogen’s ability to easily cross biological membranes, such as the double membrane surrounding mitochondria, allows easy entrance and quick action for those experiencing the increase in reactive oxygen and nitrogen species often associated with fatigue from disease states, stress, or high-intensity exercise [20]. In both animal and human studies, hydrogen has been shown to improve energy thanks to its antioxidant, anti-inflammatory, and even gene-level effects. It works within the mitochondria to quell hydroxyl radicals and block specific inflammatory pathways, such as the NLRP3 inflammasome. Weight Loss & Improved Body Composition Multiple studies have shown that supplemental hydrogen leads not only to weight loss but also improved body composition (fat-to-muscle ratio) [21,22]. In a study of middle-aged, overweight women, four weeks of hydrogen supplementation led to decreases in body fat percentage, serum triglycerides, and fasting serum insulin, likely due to hydrogen’s influence on obesity-associated mitochondrial dysfunction and inflammation. The participants also experienced an increase in the endogenous antioxidant CoQ10 along with an improved lactate-to-pyruvate ratio, indicating positive mitochondrial outcomes [23]. Immune Balance Investigations into the effects of hydrogen on autoimmune disease show a delay in the progression of experimental autoimmune encephalomyelitis, an experimental form of multiple sclerosis. Disease severity, central nervous system infiltration, and demyelination were reduced when hydrogen was administered after the onset of the disease [24]. Supplemental hydrogen’s antioxidant and anti-inflammatory actions, specifically its ability to scavenge hydroxyl radicals, make it a promising therapy for those with rheumatoid arthritis (RA). After 4 weeks of drinking hydrogen-enriched water, patients with RA had lower levels of oxidative marker 8-OHdG and decreased disease activity. Those with early RA achieved disease remission (25,26). Cognitive Performance A small study of hydrogen supplementation’s effect on cognitive function in older women found that those who received hydrogen scored significantly better on tests of mental function, including improvements in word recall and word recognition. The authors report that the average cognitive enhancement was significant enough for the group to progress from mild dementia at baseline to normal cognition at follow-up [27]. A second joint study examined memory-impaired animals and humans with mild cognitive decline. In mice, hydrogen water reduced oxidative stress, suppressed memory impairment and neurodegeneration, and even extended lifespan. After one year of hydrogen water, human participants with the APOE4 genotype, a known risk factor for Alzheimer’s disease, scored significantly better on the Alzheimer’s Disease Assessment Scale, while the control group received slightly worse scores [28]. The Healing Power Of Hydrogen In Every Glass Metabolic Protection A randomized, double-blinded, placebo-controlled study of 30 men and 30 women with metabolic syndrome found that 24 weeks of hydrogen water consumption led to: 18.5 mg/dL reduction in total cholesterol 47 mg/dL reduction in triglycerides 18.4 mg/dL reduction in fasting glucose 12% reduction in HbA1c Reduction of inflammatory markers TNF-a, IL-6, and CRP Additionally, the antioxidant vitamins E and C significantly increased in the group drinking hydrogen water. These effects are likely due to hydrogen’s antioxidant capabilities but may also be related to its positive influence on the electron transport chain, the series of biochemical steps leading to ATP production [29]. Skin Health Hydrogen-rich water may be both internally and externally beneficial for the skin! One small Japanese study found that direct application of hydrogen water to the skin significantly decreased wrinkles, skin blotchiness, and modulated oiliness, meaning it reduced oiliness in participants with excessively oily skin and increased it in participants with dry skin. The authors speculate that the potent antioxidant action of hydrogen water was responsible for mitigating reactive oxygen species damage that leads to skin aging [30]. Hydrogen also shows promise for those healing from skin damage due to radiation. In a recent animal study, radiation-induced skin wounds healed more quickly in the group sprayed with hydrogen water, likely due to lowered levels of malondialdehyde, a marker of oxidative stress, and IL-6, an inflammatory marker. Further, the wounds treated with hydrogen water had increased superoxide dismutase activity, an endogenous antioxidant enzyme [31]. Exercise Performance & Recovery The influence of supplemental hydrogen on athletic performance reveals that even short-term supplementation may have positive benefits on endurance, fatigue, respiratory rate, heart rate, blood lactate levels, and perceived effort [32, 33, 34]. Additionally, hydrogen encourages recovery from soft tissue injuries [35]. Hydrogen’s unique role as a supporter of endogenous antioxidant production makes it particularly valuable to active people who want to achieve optimal health and improved performance. Research shows it balances exercise-induced oxidative stress and may even act as an alkalinizing agent capable of combating fatigue during high-intensity exercise [36]. How Did We Create Drinkable Hydrogen? The answer is a simple (and very safe) chemical reaction—the form of magnesium used in Molecular Hydrogen reacts with water to produce hydrogen gas. For maximum benefit, begin drinking immediately after your tablet dissolves. It won’t be a struggle—Molecular Hydrogen is flavored with 100% natural raspberry powder. Molecular Hydrogen: Supporting Metabolism For Over 2 Billion Years (You read that right.) According to the Hydrogen Hypothesis, hydrogen is the link between evolution and the development of our primary energy producers—mitochondria [37]. Billions of years ago, we evolved with a need for hydrogen. That requirement was fulfilled by the microscopic ancestors of present-day mitochondria. How does evolution affect you today? Research shows that molecular hydrogen has a profound positive impact on metabolism and mitochondrial health. Supplemental Hydrogen Supports Mitochondrial Functions, Including: Balanced cholesterol [38] Metabolic stability [39, 40] Optimal body composition Liver capacity [41,42] Cardiovascular fitness [43] Healthy blood pressure [44] References National Center for Chronic Disease Prevention and Health Promotion, Division for Heart Disease and Stroke Prevention. Heart Disease Facts. Last Reviewed: May 15, 2023. Division of Cancer Prevention and Control, Centers for Disease Control and Prevention. An Update on Cancer Deaths in the United States. Page last reviewed: February 28, 2022. Hirode G, Wong RJ. Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016. JAMA. 2020;323(24):2526-2528. Mizuno K, Sasaki AT, Ebisu K, et al. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res. 2018;7(4):247-255. Barancik M, Kura B, LeBaron TW, Bolli R, Buday J, Slezak J. Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems. Antioxidants (Basel). 2020;9(12):1281. LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896. Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B. 2012;106:24-33. LeBaron TW, Singh RB, Fatima G, Kartikey K, Sharma JP, Ostojic SM, Gvozdjakova A, Kura B, Noda M, Mojto V, Niaz MA, Slezak J. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896. Qiu P, Liu Y, Zhang J. Recent Advances in Studies of Molecular Hydrogen against Sepsis. Int J Biol Sci. 2019;15(6):1261-1275. Tarnava A. Supersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report. JoSaM. 2021;3(1). Fu Z, Zhang J, Zhang Y. Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases. Oxid Med Cell Longev. 2022;2022:2249749. Yamamoto H, Ichikawa Y, Hirano SI, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases. Int J Mol Sci. 2021;22(13):7211. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46(2):140-149. Trivic T, Vojnovic M, Drid P, Ostojic S. Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: a pilot study. Current Topics in Nutraceutical Research. 2017;15(1). Sim M, Kim CS, Shon WJ, Lee YK, Choi EY, Shin DM. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. Sci Rep. 2020;10(1):12130. Tian Y, Zhang Y, Wang Y, et al. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Front Physiol. 2021;12:789507. Mohd Noor MNZ, Alauddin AS, Wong YH, et al. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pac J Cancer Prev. 2023;24(1):37-47. Hirano SI, Ichikawa Y, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review. Front Neurol. 2022;13:841310. Zhou K, Liu M, Wang Y, et al. Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis. Front Nutr. 2023;10:1094767. Kamimura N, Nishimaki K, Ohsawa I, Ohta S. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring). 2011;19(7):1396-1403. LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896. Korovljev D, Trivic T, Drid P, Ostojic SM. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci. 2018;187(1):85-89. Zhao M, Liu MD, Pu YY, et al. Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol. 2016;294:6-13. Ishibashi T. Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases. Curr Pharm Des. 2013;19(35):6375-6381. Ishibashi T, Sato B, Rikitake M, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27. Korovljev D, Trivic T, Drid P, Stater V. Short-Term H2 Inhalation Improves Cognitive Function in Older Women: A Pilot Study. International Journal of Gerontology. 2020;14(2):149-150. Nishimaki K, Asada T, Ohsawa I, et al. Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res. 2018;15(5):482-492. LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:889-896. Tanaka Y, Miwa N. Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture. Hydrogen. 2022; 3(2):161-178. Zhou P, Lin B, Wang P, Pan T, Wang S, Chen W, et al. The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats, Journal of Radiation Research. 2019;60(1):17–22. Mikami T, Tano K, Lee H, et al. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Can J Physiol Pharmacol. 2019;97(9):857-862. LeBaron TW, Larson AJ, Ohta S, et al. Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study. J Lifestyle Med. 2019;9(1):36-43. Botek M, Krejci J, Mckune A, Sládečková B, Naumovski N. Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise. Int J Sports Med 2019;40(14):879-885. Ostojic SM, Vukomanovic B, Calleja-Gonzalez J, Hoffman JR. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med. 2014;126(5):187-195. Ostojic SM. Molecular hydrogen in sports medicine: new therapeutic perspectives. Int J Sports Med. 2015;36(4):273-279. Martin W, Müller M. The hydrogen hypothesis for the first eukaryote. Nature. 1998;392(6671):37-41. Todorovic N, Fernández-Landa J, Santibañez A, Kura B, Stajer V, Korovljev D, Ostojic SM. The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis. Pharmaceuticals. 2023; 16(2):142. Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28(3):137-143. Asada R, Tazawa K, Sato S, Miwa N. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. Med Gas Res. 2020;10(3):114-121. Korovljev D, Stajer V, Ostojic J, LeBaron TW, Ostojic SM. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clin Res Hepatol Gastroenterol. 2019;43(6):688-693. Kura B, Szantova M, LeBaron TW, Mojto V, Barancik M, Szeiffova Bacova B, Kalocayova B, Sykora M, Okruhlicova L, Tribulova N, et al. Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial. Antioxidants. 2022; 11(10):1935. Saengsin K, Sittiwangkul R, Chattipakorn SC, Chattipakorn N. Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application. Cell Mol Life Sci. 2023;80(6):174. Sugai K, Tamura T, Sano M, et al. Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. Sci Rep. 2020;10(1):20173.