AST Enzymes (15)

A full-spectrum blend of probiotics, prebiotics and enzymes designed to maintain intestinal microflora balance, promote colon health, and serve as a Candida yeast cleanse* Floracor-GI:• Candida yeast cleanse*• intestinal and colon cleanse*• microflora recolonization*• stimulates immune system*• supports gastrointestinal health*• sustains intestinal flora*• nutrient support for bloating*• provides relief from constipation* Floracor-GI® is a revolutionary blend of probiotics, prebiotics and enzymes especially formulated to help maintain a proper balance of intestinal microflora, inhibit pathogenic bacteria and prevent the overgrowth of yeast organisms, mainly Candida.* Candida albicans is usually a harmless yeast present in the body. However, stress, in the form of modern lifestyles, hormonal imbalances, excessive sugar consumption, environmental pollutants, and pharmaceutical drugs, including antibiotics and oral contraceptives, can wreak havoc on the proper balance of microorganisms in the gastro-intestinal tract. Candida, being an opportunistic organism, will flourish under these adverse conditions. And when Candida is anchored to the intestinal tract, intestinal leakage and immune disorders may result.Candida removal is the logical first step toward effective intestinal cleansing. The protease enzyme Serrapeptase and enzymes like Cellulase and Chitosanase attack the outer cell wall of Candida yeast, weakening its hold on the intestinal mucosa and reducing their viability. Floracor-GI distinguishes itself from other intestinal cleansing formulas in the following ways: • Chitosanase is a unique and powerful enzyme that helps to break down chitin, an important part of the structure of the Candida cell wall. Cellulase enhances this activity by breaking down the cellulose component of the cell wall. • SEBiotic® is a special spore-forming probiotic that is incredibly stable in the dormant state. Using our Enhanced Probiotic Delivery System™(EPDS), this probiotic can exist in a dehydrated state indefinitely. EPDS™ delivers larger amounts of living bacteria into the intestinal tract, where they colonize and flourish. Once in the intestinal tract, these bacteria exit their spores, attach themselves to the intestinal mucosa, and begin to germinate, producing new colonies of friendly bacteria. • The Fructooligosaccharides (FOS), nutrient-dense alfalfa, and papaya powder in its fortified Prebiotic blend enhance the growth and stability of probiotics in the gut. • The high-activity proteases, including Peptizyme-SP brand serrapeptase, in Floracor-GI hydrolyze putrefying food matter trapped between the intestinal villi. This results in a better intestinal environment, improved absorption, motility and better overall colon health. Floracor-GI is a thorough and effective intestinal cleansing containing the following ingredients: ALFALFA POWDER promotes colon health and is a rich source of vitamins and minerals, and protein. It works well with prebiotics in promoting overall digestive health. AMLA, or Indian gooseberry (Emblica officinalis), is a natural and efficacious antioxidant. It is one of the richest sources of absorbable vitamin C available. PAPAYA JUICE POWDER from green papaya is dehydrated at a controlled temperature to ensure its maximum nutritional value. It is 100% natural and nothing is added as a drying aid or preservative. It retains the natural proteolytic, active enzyme, papain. Papain has been used for centuries as an effective digestive aid. LACTOBACILLUS ACIDOPHILUS is a probiotic that produces lactic acid that inhibits the growth of pathogenic bacteria and yeasts. LACTOBACILLUS CASEI is another probiotic that produces lactic acid and has a wide pH and temperature range and complements the growth of L. acidophilus in the production of the enzyme amylase. LACTOBACILLUS BULGARICUS, a probiotic widely known to increase longevity. It cooperates with L. acidophilus in creating a protective colonization in the intestinal tract. LACTOBACILLUS PLANTARUM is a probiotic that works with L. acidophilus in inhibiting pathogens. It also produces L-lysine, a beneficial amino acid. LACTOBACILLUS BREVIS is a species of lactic acid bacteria. It is very prevalent in fermented foods such as sauerkraut and pickles and has been found to improve the immune system health. LACTOBACILLUS CAUCASIUM is a species of lactic acid bacteria used for its health-promoting properties. LACTOBACILLUS HELVETICUS is a lactic-acid producing rod shaped bacterium of the genus Lactobacillus. It is most commonly used in the production of cheese. Some research has indicated that powdered milk fermented with L. Helveticus helped reduce blood pressure. BIFIDOBACTERIUM BIFIDUM, a probiotic well-documented for its adverse effect on pathogenic or disease causing bacteria. Bifidobacteria aid in digestion, and are often used as probiotics (good bacteria) for their immune stimulating properties. SEBiotic (Bacillus coagulans or Lactobacillus Sporogenes) is a spore forming lactogenic probiotic with the trade name SEBiotic. As with other probiotics, it demonstrates significant immune strengthening properties. As a spore forming probiotic and through our Enhanced Probiotic Delivery System (EPDS), more SEBiotic is delivered to the gut where the bacteria begin to germinate, and eventually colonize. SACCHAROMYCES BOULARDII is a probiotic that helps maintain and restore the balance of microflora in the large and small intestine. FRUTOOLIGOSACCHARIDES (FOS) are short-chain sugars that stimulate the growth of probiotics in the digestive system. FULVIC ACID makes minerals bioactive and available to the cells of the body including probiotics. They stimulate metabolism, enhance respiration, increase metabolism of proteins, the activity of multiple enzymes, enhances the permeability of cell membranes and promotes cell division. * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any diseases. All material on this website is for informational purposes only. Nothing contained on this website is intended to be used as a medical diagnosis or treatment. It should not be used in place of the advice of your physician or qualified healthcare provider

Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.

Serracor-NK Professional-Strength Systemic Enzyme Blend Understanding Fibrin Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a “patch” or small clot to prevent further damage.   Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events. According to Scripps Research Institute, “It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues.” The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.* Serracor-NK for Circulatory & Inflammation Support Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.**  We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab). SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.* Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). Enteric coated Serrapeptase and Nattokinase: Why is it important? Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*   The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines.  If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab). How do Fibrinolytic Units (FU's) relate to enteric coating? Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach.  Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach).  In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.  Enzyme Stabilization with BPPS® The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes. The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's. It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes. Serracor-NK Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.* Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Serracor-NK vs Neprinol   Serracor NK vs Neprinol** Brand Enteric coated Serrapeptase and Nattokinase Enzyme Stabilizer BPPS® Enzyme Manufacturing Source Price Neprinol(2004-2008) Yes Yes India $144.99 Neprinol  (Current) No Unknown Japan * $144.99 Serracor-NK Yes Yes India $124.99   * http://aznow.biz/health-care/justin-marsh-japanese-enzymes-cure-people   AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK. Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula. SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part of the original formula of Neprinol until 2008. During the duration of this contract: SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol. SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers. A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards. Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the manufacturer, requesting the original SEBkinase formula. The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices. Specialty Enzymes and Biotechnologies is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today. Please feel free to call us with questions. Serracor-NK SEBkinase Formula Remains Unchanged Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name. Enteric Coated Serrapeptase and Nattokinase All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness, serrapeptase and nattokinase are best when enterically coated. When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB (enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy. Make an Informed Choice There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)* Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Acid Armor®(extra-thick cellulose layer)** Contains Phthalates NO YES YES NO Considered Enteric Coating YES YES YES NO Studies supporting Efficacy as Enteric Coating YES YES YES NO Gastro-resistance YES YES YES UNKNOWN FDA GRAS YES YES YES YES Time in Use   >50 years   >70 years   ~40 years   ~1 year     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Nattokinase Research:  Fibrinoyltic Activity In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1   A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke.  It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure.  Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4 A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity.  The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time.  The results indicate natto generates an increased ability to dissolve blood clots.  As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity.  The tests showed no significant change.5 The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event.  For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted.  The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7 Nattokinase Benefits & Blood Clots Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system.  These clots can cause blockage of blood flow.  If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies.  In the heart, this can result in myocardial infarction (heart attack).  In the brain, it can result in strokes or mini-strokes.  Deep vein thrombosis can result in pulmonary emboli.  All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity.  The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8 The process of forming a clot is complex and involves several enzymes.  However, the body mainly produces one central enzyme for dissolving a clot, plasmin.  It happens that the properties of nattokinase are very similar to plasmin.  Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways.  It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase.  An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats.  A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9 A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses.  The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals.  After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group.  The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10 Serrapeptase Benefits and Respiratory Health When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health. Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11 Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12 The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13 Enzyme Activity: Enzymes & Herbs How it Works NATTOKINASE Derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity.* A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme “nattokinase,” meaning “enzyme in natto.” SERRAPEPTASE Derived from a species of bacteria originally found in the intestine of silkworms; the bacteria, Serratia mercesans, produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase’s formidable anti-inflammatory, proteolytic (protein dissolving), mucolytic (mucus dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.* Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive as well its anti-inflammatory properties. A good substitute for animal-derived enzymes pepsin and trypsin for both digestive and systemic support due to its activity across a wide pH range* Papain Obtained from the latex of the fruit of the Papaya tree (Carica papaya); used for centuries as an effective digestive aid. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells* Proteases Hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body. Rutin Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation* Amla Also known as Indian gooseberry (Emblica officinalis); it is a natural, efficacious antioxidant and is one of the richest sources of absorbable vitamin C. COENZYME Q10 An essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys and heart; a vital part of energy production and overall cell health* MAGNESIUM An essential mineral used as a co-factor by over 350 enzymes in the body; critical part of cardiovascular and nerve physiology. Magnesium helps relax arteries and assists in proper nerve impulse function*     References 1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of NattokinasesActa Haematol1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime HiratanicaDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;bDepartment of Biochemistry, Oklahoma State University, Okla., USA;cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan 2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours.Health Sciences Institute, March 2002. 3. Effect of Natto Diet on Blood Pressure.JTTAS, 1995. Maruyama M, Sumi H.. 4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583–1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5, 5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan 6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132 7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006Tai MW , Sweet BV 8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ 9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3 10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al. 11. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Respirology. 2003 Sep;8(3):316-20. Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Japan. 12. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. Department of Otorhinolaryngology, Mie University School of Medicine, Japan. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. 13. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88. Institute of Clinical Otorhinolaryngology, University of Naples, Italy. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Serracor-NK on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serracor-NK with food will compromise their absorption, as well as their effectiveness.   Does Serracor-NK have an enteric coating? Yes, the serrapeptase and nattokinase in Serracor-NK are enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority.To learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab.   How long should I take Serracor-NK before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Does Serracor-NK have any side effects? The use of Serracor-NK has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Serracor-NK with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Serracor-NK and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Serracor-NK with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 150 or 300 Amount Per Serving:                          %DV Serracor-NK® Blend                       500 mg          *  SEBkinase® Blend:                   15,000 FU    NattoSEB® (Enteric coated    Nattokinase), Peptizyme SP® EN    (Enteric coated Serrapeptase)   Enzyme & Cofactor Blend:    Bromelain, Papain, Lipase,    Proteases, Rutin, Amla,    Coenzymes Q10    & Magnesium *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules three times a day. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Dosage can be increased or reduced as needed to achieve desired benefits. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are taking anticoagulants, like warfarin type drugs, do not take this without consulting your physician. If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. This Product does not contain soy.

Peptizyme-SP Enteric Coated Serrapeptase The Problem with Pain Systemic enzymes are a key to a healthy lifestyle. Processed food, exposure to environmental toxins and occasional illness cause the body to use up these enzymes, forcing it to work even harder to synthesize these enzymes and use them in the many complex reactions that take place every moment in our bodies.  Many people reach for NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen and naproxen to address pain and inflammation.  They are effective but come with serious side effects such as gastric bleeding, joint/cartilage damage, disrupted metabolism, increased blood sugar, loss of bone and emotional disorders, among others. In July 1998, The American Journal of Medicine stated the following about NSAID-related gastrointestinal and metabolic complications: “Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) complications and at least 16,500 NSAID-related deaths occur each year among arthritis patients alone. The figures of all NSAID users would be overwhelming, yet the scope of this problem is generally under-appreciated.” An all-natural systemic enzyme, serrapeptase is a biocatalyst which stimulates and modulates the body’s own intrinsic capacity to recover from injury—with hardly any side effects. Peptizyme-SP for Healthy Fibrin Metabolism Peptizyme-SP®(serrapeptase) is a powerful systemic enzyme that supports the body's response to inflammation and the respiratory and sinus systems. Providing 80,000 SU (serrapeptase units) of activity per capsule, Peptizyme-SP is unrivaled among products of its kind. Serrapeptase – also known by serrapeptidase, serratiopeptidase and serratia peptidase - is a powerful proteolytic enzyme derived from a species of bacteria originally found in the intestine of silkworms. The bacterium, Serratia mercesans, produces the enzyme serrapeptase to enable the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Don’t worry – no worms were harmed in the making of Peptizyme-SP. Serratia is now grown in cultures to produce serrapeptase by fermentation. Peptizyme SP supports our body's systems with the bio-energetic charge of enzymes to help them operate optimally, and address issues such as inflammation, excessive mucus in the respiratory and sinus systems and fibrin build-up. Serrapeptase has the unique ability to digest non-living tissue that is a by-product of the healing response without harming living tissue. Fibrin is a tough protein arranged in long fibrous chains.  It is formed from fibrinogen, a soluble protein produced by the liver and found in blood plasma.  Fibrin tends to form circulating complexes that create barriers against the absorption of healing nutrients in and around areas of inflammation.  Numerous research and clinical studies have demonstrated serrapeptase has anti-inflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. This unique activity of Peptizyme SP’s enteric-coated serrapeptase supports normal fibrin metabolism, blood viscosity and blood flow. Serrapeptase supports healthy inflammatory response by reducing metabolic inflammation, usually an asymptomatic inflammatory process in response to stress, improper nutrition and other environmental issues. In addition, there is evidence of inhibition of C-reactive protein, a marker of inflammation that has been linked to cardiovascular health.* How do SU’s relate to IU’s? Enzyme activity is often measured through a FCC (Food Chemicals Codex) or USP (United States Pharmacopeia) assays and is denoted by IU, or international unit. Some enzymes don’t have a standard FCC or USP assay, such as serrapeptase. However, Japanese Pharmacopeia (JP) has established an activity assay specific for serrapeptase, which measures activity in SU, or serrapeptase unit. You may see IU or SU used interchangeably on different serrapeptase products. While we do not know what sort of assays other companies use to test their enzymes, you can still compare the activity level on a one-to-one basis. So 80,000 IU is 80,000 SU, but SU is specific to serrapeptase. Unlike other supplements, the weight (mg) of an enzyme supplement carries no significance. It is not the amount but the potency, or activity, of the enzyme that really matters. Guaranteeing the ingredients are available to the body is more important than how much of the ingredient is listed on a supplement label. Peptizyme SP Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule two times a day. After three days, increase your Peptizyme dosage to 2 capsules two times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules two times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules two times a day. Peptizyme-SP can be used along with other systemic enzyme blends such as Exclzyme or Serracor-NK to enhance fibrinolytic activity, as well as increase positive effects on inflammation and reduce mucus viscosity in the respiratory system.* Peptizyme-SP vs. Serrétia** Brand Methacrylic Acid Copolymer (MAAC) Acid Armor®**(extra-thickcellulose layer) Considered Enteric Coating? Enzyme Stabilizer BPPS® Price per bottle Serrétia(formerly Serracel) -- Yes No Unknown $99.99 for180 capsules Peptizyme-SP Yes -- Yes Yes $39.98 for120 capsules     Enteric-Coated Serrapeptase Peptizyme-SP® brand serrapeptase is enteric coated to survive the acidic conditions of the stomach without being degraded. This allows for optimum absorption in the small intestine and greater systemic activity. The pH resistant enteric coating disintegrates after it enters the alkaline environment of the intestine. Most serrapeptase brands on the market are not enteric coated, which means this low-pH sensitive enzyme can lose activity, and thus effectiveness, when entering the stomach. The enteric coating in Peptizyme SP allows the enzymes to survive the acidic conditions of the stomach, which increases absorption in the small intestine, systemic activity and efficacy.   ** Serrétia™ and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes. Research Serrapeptase has been thoroughly researched for its numerous and diverse effects on inflammation, pain, infection and healing. Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1 A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing inflammation in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2 A prospective study was conducted on the effect of serrapeptase on post-operative swelling and pain of the ankle. In the serrapeptase group, the swelling decreased by 50% on the third post-operative day, while in the control groups (no treatment and treatment with ice) no reduction in swelling occurred. A decrease in pain correlated for the most part with the reduction in swelling. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of ice.3 The efficacy of serrapeptase was evaluated in a multicenter, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation.4 Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.5 An unusual clinical trial evaluated the effectiveness of serratiopeptidase in the eradication of a periprosthetic infection (an infection at the site of an implanted orthopedic device) in an in vivo animal model. Infections of slime-forming bacteria are especially difficult at these sites. Rats were inoculated with Staphylococcus epidermidis at the prosthetic site. After two weeks, infection persisted in 63.2% of animals in the no-treatment group; 37.5% of animals in an antibiotic-only group; and only 5.6% of animals in the serratiopeptidase-and-antibiotic group. The authors conclude that serratiopeptidase was effective at eradicating infection in this experimental animal model and may enhance antibiotic efficacy in the treatment of staphylococcal infections.6   References1.   Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000 Nov;48(11):1130.2.   Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb;30(1):48-54.3.   Gerngross H, Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study(German). Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2. Esch PM,4.   Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.J Int Med Res. 1990; 18(5):379-88.5.   Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep;8(3):316-20.6.   Mecikoglu M, Saygi B, Yildirim Y, Karadag-Saygi E, Ramadan SS, Esemenli T.The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection. J Bone Joint Surg Am. 2006 Jun;88(6):1208-14. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.    What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Peptizyme-SP on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Peptizyme-SP with food will compromise their absorption, as well as their effectiveness.   Does Peptizyme-SP have an enteric coating? Yes, the serrapeptase in Peptizyme-SP is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please see our “Compare” tab.   How long should I take Peptizyme-SP before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After one week of proven tolerance, the dose can be increased to a therapeutic dose of 2 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 6 to 9 capsules per day, while others only need 2 to 3. There are several factors that may affect results and required dosage, including: Height Weight Age Severity of symptoms Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Are there any side effects involved with Peptizyme-SP? The use of Peptizyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Peptizyme-SP with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products Peptizyme-SP and Serracor-NK often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Peptizyme-SP with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.   Peptizyme-SP  – Enteric Coated Serrapeptase ~ 80,000 SU’s of Activity Per Capsule ~ Peptizyme-SP® is a potent and purified strain of Serrapeptase, also called Serratiopeptidase.  Supplement Facts Serving Size: 1 CapsuleServings Per Container: 60 Amount Per Serving:                           % DV Peptizyme-SP®                         500 mg *Enteric Coated Serrapeptase     80,000 SU’s *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule) Directions: Take 1 to 2 capsules twice a day on an empty stomach. Take capsules at least 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Product InfoDigest-GI Extra Strength Complete DigestionGood Health Begins With Proper DigestionSpecialized cells in the pancreas, stomach and salivary glands produce digestive enzymes. These enzymes, along with those found in live foods, facilitate the breakdown or digestion of food, which is how the body absorbs nutrients, and eventually produces energy.When we eat a meal, producing digestive enzymes is a high priority for the body, requiring energy and adding stress to the pancreas. Sometimes the body’s production of enzymes doesn’t meet its needs, for a variety of reasons:Age, stress, lifestyle choicesNon-digestible, complex sugars often found in legumes, cruciferous vegetables, and cereal grainsConsuming more protein than the body can digestLactose, casein, or gluten intolerancesTaking a digestive enzyme formula can support normal digestion, nutrient absorption, and overall health.Digest-GI Extra Strength – Powerful Digestive SupportDigest-GI Extra Strength is recommended for those who need the maximum level of digestion assistance. It is a potent, all-encompassing blend of digestive enzymes formulated to support the digestion of gluten, dairy, legumes, cruciferous vegetables, cereal grains, proteins, and other foods. Digest-GI Extra Strength includes amylase, invertase, cellulase, alpha galactosidase, lactase, lipase, and a complete array of protease enzymes including DPP IV, all of which are designed to promote the digestion of carbohydrates, dairy, fats, and proteins, while supporting nutrient absorption. *Digest-GI Extra Strength contains all-natural digestive enzymes designed to be effective across a wide pH range throughout the entire digestive tract.Digest-GI Extra Strength DosageTake 1 or more capsules with each meal, or as directed by your healthcare professional.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. FAQWhat is digestive enzyme therapy?Digestive enzyme therapy is the use of plant or animal-based dietary supplements to aid in digestion and promote balanced metabolism.* They enzymes in this blend are 100% vegetarian/vegan. The body produces digestive enzymes. Factors ranging from age to stress to lifestyle choices affect enzyme production.What is a digestive proteolytic enzyme?Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. The body requires 20 different amino acids, 8 of which are referred to as essential amino acids because they cannot be synthesized by the human body. These essential amino acids must be obtained from the food we eat. Without sufficient proteolytic enzymes, the body is unable to break down and absorb these necessary nutrients. How long should I take Digest-GI Extra Strength before feeling results?Take Digest-GI 5-10 minutes prior to eating. Take 1 to 2 capsules per meal. Variable that affect dosage include:Content of mealSize of mealNutritional statusDepending on these variables, along with one’s individual response to digestive enzyme therapy, the dose can be as high as 2-3capsules per meal. It is advisable to experiment with dosage, considering there is no upper limit or adverse effects in exceeding your supplement needs.What if I miss a dose?Digestive enzymes aid in digestion of food. It is recommended you take digestive enzymes prior to a meal, but if you miss a dose, we recommend you take them directly after your meal.Why is it important to take Digest-GI with food?Since Digest-GI Extra Strength aids in overall digestion, it is contraindicated to use the enzyme without eating. Although it is not harmful to take Digest-GI on an empty stomach, it is simply a waste of money.  If you take digestive enzymes too soon before a meal, you risk the enzyme becoming inactive. The food and enzyme must be in the stomach together for proper results.Are there any side effects involved with Digest-GI?Side effects with Digest-GI are rare. Mild cramping, bloating or gas may occur. Starting off at a low dose can minimize any possible side effects. Side effects should clear with regular use, after a tolerance is established.Can I take Digest-GI with other systemic or digestive enzymes?Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they should not be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes, and thus should be taken as directed for best results.Can I open the capsule and pour it onto my food instead of swallowing the capsule?If you find that you have trouble swallowing the capsules, pouring its contents onto food is definitely an option. You may also open the capsule into a glass of water, being sure to drink the entire glass. If you choose to take the enzymes this way, it is best to consume the entire content as soon as possible to ensure you are receiving the full benefits within your body (rather than on your plate).

Exclzyme The Original Full-Strength Formula Everybody Needs a Healthy Body Elimination of potentially toxic substances from the body is a crucial part in the metabolic processes for optimal health. A variety of health issues can develop if toxins within the body impair enzyme function or availability or without a proper store of enzymes. For instance, the immune system can be overwhelmed with bacteria, fungi, toxins and even food particles that don’t get completely digested in the gastro-intestinal tract. In many instances, proteins created by these distresses found within the body, which the body detects as foreign, can initiate an immune response. Recognized as antigens, the immune system produces antibodies to start the process of the proteins’ degradation and removal. After coupling with one another, these antigens and antibodies form circulating immune complexes (CICs), which induce attack and destruction by the immune system’s macrophages (white blood cells specifically designed to destroy CICs). This process is known as inflammation – the body’s natural healing mechanism In cases where inflammation is prolonged or when CICs are predominant within the body’s tissues and organs, the body may not have enough enzyme potential to begin the next process of renewal and recovery. Moreover, research has demonstrated that a lack of proteolytic enzymes may not cause an adequate response to a large accumulation of CIC’s in the body. Exclzyme® for Total Body Support To address this problem, Exclzyme has been formulated with an ample supply of various proteases to facilitate the body’s immune defenses and breakdown free-roaming CICs that can keep the body in a constant state of inflammation. Enteric-coated serrapeptase highlights this powerful mix of proteolytic enzymes with its scientifically proven fibrinolytic power (to learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab). Exclzyme also contains papain and bromelain, enzymes known for their potent systemic properties. In addition to these systemic and digestive proteases, lipase and amylase also offer their own enzyme activity to bolster the body with extra catalytic energy, especially for the complete digestion of fats, sugar and protein complexes. And for extra synergy, Exclzyme is rounded with anti-oxidant support in the form of rutin and amla, herbs well known for their unique bioflavanoid content, especially useful for tissue rejuvenation and recovery.*The entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). The Original Systemic Enzyme Formula Exclzyme is a proven systemic enzyme therapy for overall health. A powerful blend of serrapeptase, proteases and herbs, Exclzyme supports the body’s response to inflammation, metabolic activity, blood, joints and circulation. The Exclzyme formula has been used for more than a decade by thousands of people as a daily dietary supplement. In fact, you may have been using the original formula for years without knowing it (to learn more about Exclzyme vs. Vitalzym®, please click the "Compare" tab).** AST Enzymes’ family of companies is among the largest manufacturers of enzymes in the world. For decades, we have supplied enzymes to marketing companies who have built their businesses on enzyme supplements our experts formulated and manufactured. The Exclzyme formulation has been commercially available since 1999 and is the most successful non-animal derived systemic enzyme blend on the market today. Exclzyme Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Exclzyme dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Exclzyme with additional serrapeptase can increase proteolytic activity, as well as increase positive effects on inflammation and provide faster recovery and healing from injury.*Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Exclzyme vs Vitalzym   Exclzyme vs Vitalzym Comparison Chart Brand Enteric Coated Serrapeptase Serrapeptase Manufacturing Source Price Original Vitalzym (2000-2009) Yes India $114.00 "Original" Vitalzym (Current) No Japan $114.00 Vitalzym 360 Liquid Capsules (Current) Yes Japan $149.99 Original Exclzyme Yes India $99.95   If your systemic enzyme supplement recently changed, we have the original formula. Some companies claim to continue to carry the original formula. One easy way to check is to see if the bottle says the enzyme serrapeptase is enteric-coated. Studies show serrapeptase, sourced from the bacterium Serratia marcescens and the key ingredient in the original Full-Strength Exclzyme, must be enteric coated so it can pass through the acid environment of the stomach without being damaged. And as for the new formulas on the market claiming to be stronger or more technologically advanced: the proof is in the results. There is an underlying art when it comes to manufacturing enzyme products. Systemic enzyme blends must be formulated expertly and correctly for maximum effectiveness. In fact, alterations to an already successful systemic enzyme product may not provide the same results you’ve come to expect. Many companies, including ours, use proprietary formulas to protect their products from being copied and used by others. But all companies must list all of the ingredients by name, and rank the ingredients according to the percentage amounts in the formula. For instance, in the original Exclzyme formula, enteric-coated serrapeptase is listed on our ingredient list as the second most prevalent ingredient in our formulation. If your “new and improved” systemic formula does not list serrapeptase as the second ingredient and it doesn’t say enteric-coated, you’re probably not getting the most out of your systemic enzyme formula. Serrapeptase has always been the hallmark of the original Exclzyme formula, making it the choice of companies and consumers alike.   ----------------------------------------------------------------------------------------------   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)*   Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Contains Phthalates NO YES YES Considered Enteric Coating YES YES YES Studies supporting Efficacy as Enteric Coating YES YES YES Gastro-resistance YES YES YES FDA GRAS YES YES YES Time in Use   >50 years   >70 years   ~40 years     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Vitalzym® is a registered trademark of World Nutrition Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes.   Research   Inflammation and Fibrin The reality of inflammation is that it affects everyone, men and women alike. However, along with nearly all other tissue and organs, inflammation can affect reproductive tissue and organs particularly. For instance, many women experience painful swelling of the breast as well as uterine fibroids. In men, prostate health is a major concern. Although inflammation in each case may manifest differently in both men and women, inflammation has one thing in common: fibrin. Fibrin is an essential protein that is produced during inflammation. As a blood clotting protein, the body utilizes fibrin to contain blood loss and keep infection at bay after injury. It is the initial step in the body’s attempts at recovery. However, when inflammation has become prolonged, fibrin along with other proteins such as collagen can begin to transform original tissue into a tough fibrous matrix. Differentiated and sometimes sequestered apart from healthy tissue, this fibrous matrix still has the biological markers of inflammation. Nutrients and other building blocks are still needed for healthy and normal tissue. Systemic and proteolytic enzyme research over the years suggests that fibroids in women and swollen prostate glands in men are indications that the body has not been able to get past inflammation. The resulting fibrous tissue usually accumulates toxins that have not been adequately removed by the body. Serrapeptase Research: Anti-inflammatory Activity For nearly 40 years, serrapeptase has been at the heart of systemic enzyme therapy. Systemic enzymes such as serrapeptase have been used for optimal cell, tissue, organ and metabolic function. Likewise, companies, health practitioners and consumers have turned to the original Exclzyme formulation for their systemic enzyme therapy needs. Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1 A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing inflammation in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2 Moving to another part of the body, a study was conducted in men with amicrobial prostato-vesiculitis (APV is a non-infectious inflammation of the prostate). The researchers wanted to determine if treatment with nonsteroidal anti-inflammatory (NSAIDS) drugs, including serrapeptase, could reduce inflammation and swelling of the prostate. The doctors conclude that in APV patients, the treatment with NSAIDS, including serrapeptase is an effective therapy, producing multiple positive effects.3 Exclzyme Benefits and Sports Nutrition Enzymes are energetic catalysts that push essential chemical reactions in the body in the right direction. In its quest for internal balance, the body always turns to enzymes for help. In this way, Exclzyme helps get inflamed tissue over the hump. Exclzyme’s superior proteolytic action assists the body in removing those larger protein molecules from damaged cells and tissues as well as the inflammatory response itself. In helping breakdown these compounds, the impediments for sustaining healthy cell and tissue growth are removed and the processes for rejuvenation and recovery can move forward. These facets of Exclzyme make it ideal for maintaining healthy tissue repair following strenuous physical training and activity. Sport- and exercise-related muscle pain and inflammation brought on by strong physical tension, excessive training, and heavy competition are decreased with “excellent results” due to the specific activity of systemic enzymes on exercise-induced inflammation.4 Taking systemic enzymes prior activity can also provide protective benefits to athletes who are at risk of injury, resulting in significantly reduced duration of injury symptoms and related absences from training and work. Systemic enzyme support also improves recovery from sprains, as well as shortens recovery from sport injuries severe enough to require surgery.5,6 Enzyme Activity  Enteric Coated Serrapeptase Used by silkworms to digest and emerge from their silken cocoons; studied extensively for more than 50 years; an excellent fibrinolytic (fibrin digesting) and powerful anti-inflammatory enzyme* Protease Hydrolyze (break-down) proteins like casein, steak, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its anti-inflammatory properties.  A good substitute for animal-based enzymes a good substitute for pepsin and trypsin for digestive support* Papain Obtained from the latex of the fruit of the Papaya tree; used for centuries as an effective digestive aid* Amylase Breaks down carbohydrates, or more specifically, starches, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants Lipase Catalyzes the break-down of fats into essential fatty acids needed for healthy tissues and cells* Amla Also known as Indian gooseberry (Emblica officinalis); a natural, efficacious antioxidant, and one of the richest sources of absorbable vitamin C Rutin Bioflavonoid; strengthens and tones arteries and veins; provides antioxidant support against free-radicals and inflammation*     References 1. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000 Nov; 48(11):1130. 2. Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb; 30(1):48-54. 3. Vicari E, La Vignera S, Battiato C, Arancio A. Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings[Article in Italian]. Minerva Urol Nefrol. 2005 Mar; 57(1):53-9. 4. Nouza K. Physical activity and immune system. Systemic enzyme therapy in prevention and treatment. Medicina Sportiva Boh Slov. 1997; 6(2):41–45. 5. Zuschlag JM. Prophylactic administration of Wobenzym to reduce consequences of sports injuries in karate fighters. MUCOS Pharma GmbH & Co, Dept. Clinical Research, Geretsried, Germany. 6. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004 Aug; 38(4):431–435. FAQ         What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.   What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Exclzyme on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme with food will compromise their absorption, as well as their effectiveness.   Does Exclzyme have an enteric coating? Yes, the serrapeptase in Exclzyme is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please click the 'Compare" tab.   How long should I take Exclzyme before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-15 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: ·         Height ·         Weight ·         Age ·         Severity of symptoms ·         Tolerance ·         Time of administration (Better absorbed on an empty stomach) ·         Adherence to regimen ·         Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Are there any side effects involved with Exclzyme? The use of Exclzyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Exclzyme with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Exclzyme with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.     Supplement Facts Serving Size:  1 CapsulesServings Per Container: 450 Amount Per Serving                          %DV Proprietary Enzyme Blend:                      500 mg *   Protease, Peptizyme SP® EN (Enteric   coated Serrapeptase), Papain,   Bromelain, Amylase, Lipase, Rutin   and Amla. *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose, and cellulose. Directions: Take 2 capsules three times a day. In three days, if desired benefit is not achieved, take 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Product InfoIMMUNE SYSTEM SUPPORT Your immune system is essential to fighting off germs. Immune support is especially vital when everyone around you is sick! Our Immunity Boost Bundles can provide great support for your body to keep healthy. ImmunoSEB™ This powerful enzymatic formula was designed to boost our bodies’ natural resistance against harmful organisms which threaten our life systems.  ImmunoSEB™ is one of the strongest immune system support formulas we offer!  It contains: Enteric-Coated Serrapeptase and Peptidase enzymes that help break down proteins into amino acids needed for healthy immune function. Bromelain and Papain enzymes derived from pineapples and papayas long known to support the body’s natural response to inflammation. Lysozyme, amylases, catalase, lactoferrin proteins to provide natural antimicrobial properties, and natural antioxidant benefits.* A Safe and Natural Regimen We believe in safety first!  Other companies merely buy and repackage someone else’s product.  But, as a true manufacturer, we control safety from the beginning. ImmunoSEB™ is free of pesticides, chemicals, preservatives, animal derivatives, soy, wheat, peanuts, tree nuts, fish and shellfish. All enzyme ingredients are kosher-certified, and suitable for vegetarians. ImmunoSEB™ is manufactured in the USA in an FDA-registered facility that follows cGMP guidelines, and are composed of domestic and international ingredients. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of enzymes to support healthy cardiovascular, respiratory, immune systems, among others. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system.  Different systemic enzyme blends offer support to different areas of the body. ImmunoSEB™ is packed with potent proteolytic enzymes at high activities, and antioxidants required for supporting a strong immune system. What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. How long should I take ImmunoSEB™ before feeling results? The length of time to experience the benefits of systemic enzymes varies by individual. Some people notice a difference within days. For others, it’s a week or 10 days. For long-term benefits, it’s important to take systemic enzymes consistently over several months. New systemic enzyme users should start off slow, with one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a 2 capsules, 3 times per day.  onitored, and dosage should be adjusted accordingly.  There are several factors that may affect required dosage, including: Height Weight Age Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up” on one dose. Also remember, systemic enzymes are best absorbed on an empty stomach. Why is it important to take ImmunoSEB™ on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes survive the stomach intact. If enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like ImmunoSEB with food will compromise their absorption, as well as their effectiveness. Are there any side effects involved with ImmunoSEB™? The use of ImmunoSEB™ has not been shown to exhibit detrimental effects, long term or short term. Minor side effects may vary. Gastrointestinal disturbances have been reported by a small percentage of new users, but once the dosage is adjusted, tolerance is maintained. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, particularly if you are on blood-thinning medications, or are pregnant or nursing. Can I take ImmunoSEB™ with other systemic or digestive enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Separate blends or enzymes often work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on supporting the body are more attainable.

Lipase-HP Plus How well do you breakdown the fat that you eat? Fat or lipids are heavily consumed in the average diet. Some of these fats are healthy and some are not quite as beneficial to our health. Regardless of the dietary nutritional value of the types of fat we consume, it is essential to properly break them down for our body to either utilize or remove. Dietary fats can be difficult to properly break down: first, because they are large molecules, and secondly, because they are not water soluble. Factors such as age, stress or lifestyle choices can affect the production of enzymes to support proper digestion, such as lipase (fat-digesting enzyme), and vital fluids such as bile. Lipases are a class of enzymes responsible for the breakdown of fats within the digestive system.  Produced by the liver and stored in the gallbladder, bile salts function in breaking down larger molecule of fats (triglycerides), allowing more surface for lipid to efficiently break down fats. Once properly broken down, they move along the lining of the small intestine for further processing, and are then absorbed. When the digestive system does not produce or secrete adequate amounts of lipase to accommodate dietary fat intake, symptoms like bloating, cramping, flatulence, undesired weight gain, and sometimes steatorrhea (fat in the stool) may occur. Lipases are produced primarily by the pancreas as pancreatic enzymes. If the pancreas isn’t functioning properly, it is likely to cause fat maldigestion and malabsorption, which results poor nutritional absorption. Lipase HP Plus for better Absorption Take a lipase supplement supports people whose pancreas isn’t producing a sufficient amount of lipase in digesting fats. Taking lipase with omega-3, fish oils and other fatty acid supplements supports nutrient absorption. Lipase HP Plus is a highly effective blend of essential enzymes promoting nutrition absorption. Lipase HP Plus’s high concentration of Lipase is used to in combination with amylase and proteases to suppor the breakdown of protein, sugars, and most importantly, fats in our diets. Taking Lipase HP Plus before a meal supports fat digestion and nutrient absorption.* Lipase HP Plus also contains ox bile to support lipase digestion. Lipase HP Plus is expertly designed to maximize the benefits of food we eat on a daily basis. Our daily diets consist of starches/carbohydrates, proteins, and fats. Lipase HP Plus is formulated to support the breakdown of what we consume into usable sources of energy and nutrition.* Lipase Plus contains high activity lipase to support the breakdown of fats, and also bile as a support via the emulsification process.* Why choose Lipase HP Plus? 1)      Vegetarian enzymes Studies suggest that non-animal sourced enzymes are superior to those sourced from animals. Vegetarian enzymes, studies show, are more concentrated, so fewer capsules are needed. They are also more stable in varying pH levels of the digestive tract. 2)      Ox Bile After the careful consideration of alternative vegetarian emulsifiers to maximize the efficiency of this product, we concluded that ox bile, though not vegetarian, would be the most effective. The addition of ox bile in a unique quality in Lipase HP Plus because it is useful in the emulsification process of fats.* Lipase would not be as effective without bile. 3)      High Potency Lipases The high levels of lipases in our product are sufficient in supporting fat digestion and promoting nutrient absorption.* 4)      Manufactured in Chino, CA As the manufacturers of Lipase HP Plus, we guarantee the freshest products available as well as the expert knowledge of the ingredients that formulate this powerful product. 5)      Additional enzymes Unless your diet consists of only butter, oil, and animal fat, the addition of enzymes such as proteases and amylases are important to support digestion of sugars and proteins.* 6)      For those who do not have the proper function of the pancreas or gallbladder If those organs are not producing bile or lipases, supplementing with bile and/or lipases supports fat digestion and proper digestive function.* *These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure, or prevent any disease. Supplement Facts Serving Size:  1 CapsuleServings Per Container: 90 Amount Per Serving:                        % DV Lipase I & II:                       6,500 FIP *Proteases:                         40,000 HUT  *Amylases:                          12,000 DU *Bile (bovinie):                         50 mg *Amla:                                       50 mg * *Daily Value (DV) not established Other ingredients:  cellulose (vegetarian capsule) Free Of: Egg, nuts, fish, shellfish, potato, rice, preservatives, artificial color or flavor. DIRECTIONS:Lipase HP Plus can be taken systemically or digestively depending on the intent of usage: Digestively: 1 capsule about five minutes prior to each meal Systemically: 1 capsule five minutes prior to each meal and 3 capsules on an empty stomach Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. What is digestive enzyme therapy? Digestive enzyme therapy is the use of plant or animal-based dietary supplements to support digestion and promote metabolism.* The body is equipped with enzymes support digestion, but due to factors ranging from age to stress to lifestyle choices can affect their production and effectiveness. What is a digestive lipolytic enzyme? Lipolytic enzymes (lipases) break down fast into their building-blocks, which are three fatty acids and glycerol. The body requires proper breakdown of fat for absorption, which is critical for the transport of specific vitamins and minerals. How long should I take Lipase HP Plus before feeling results? Lipase HP Plus should be taken 5-10 minutes prior to eating. The typical, recommended dose is 1 to 2 capsules per meal. Variables that may affect dosage include: Content of meal Size of meal Nutritional status Depending on these variables, along with one’s individual response to digestive enzyme therapy, the dose can be as high as 4-5 capsules per meal. It is advisable to experiment with dosage, considering there is no upper limit or adverse effects in exceeding your supplement needs. What if I miss a dose? Digestive enzymes aid in digestion of food. Although it is recommended to take digestive enzyme prior to a meal, if miss a dose, take them directly after your meal. Are there any side effects involved with Lipase HP Plus? Side effects with Lipase HP Plus are rare. Mild cramping, bloating or gas may occur. Starting off at a low dose can minimize any possible side effects. Side effects should clear with regular use, after a tolerance is established. What does “proprietary blend” mean? Proprietary refers to a patent, or ownership. Applying this concept to our digestive enzyme blend, it means that we alone own the rights to the specific blend of enzymes found in Lipase HP Plus, making our product different from similarly marketed digestive enzyme supplements. Lipase HP Plus encompasses an all-inclusive digestive aid product that assists in the digestion of several nutrients, not just fats. Can I take Lipase HP Plus with other systemic or digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they should not be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes, and thus should be taken as directed for best results. Can I open the capsule and pour it onto my food instead of swallowing the capsule? If you find that you have trouble swallowing the capsules, pouring its contents onto food is definitely an option. You may also open the capsule into a glass of water, being sure to drink the entire glass. If you choose to take the enzymes this way, it is best to consume the entire content as soon as possible to ensure you are receiving the full benefits within your body (rather than on your plate). Is this product suitable for vegetarians? No. After extensive research to provide our customers with a vegetarian-sourced product, we concluded Ox Bile (animal-sourced) was essential to this formula. The enzymes are vegetarian, and capsules are derived from a plant source. What is the purpose of Ox Bile? Bile is produced by the liver and stored in gallbladder. The purpose of bile is to emulsify (breakdown) large fat molecules because lipases are less effect when fats are in their original chemical composition. Bile breaks down the large droplets of fat into smaller, manageable pieces lipases utilize, helping the intestine properly absorb them.

Gluten Relief Optimal Digestion The Problem of Gluten and Casein in Foods Gluten digestion is challenging for many people. A significant portion of the population suffers from gluten intolerance, and some struggle with more severe conditions. Celiac disease is a chronic digestive disorder characterized by an extreme sensitivity and allergic reaction to foods containing gluten, requiring individuals with the disease to follow a strict dieting regimen devoid of gluten-containing products. Disorders such as ADD/ADHD and autism have also been linked to improper digestion of gluten and casein. Some say the cognitive and social behaviors associated with these disorders may be influenced by gluten and casein proteins. Gluten is a starch-protein present in most grains and processed foods. Similarly, casein is a protein found in most dairy products which can be difficult to digest, causing discomfort. Gluten and casein intolerances have been primarily treated through maintaining a Gluten-free and/or casein-free (GFCF) diet. However, trace amounts of these proteins can be found in many foods, making avoidance nearly impossible and allowing problems to persist. Foods with hidden gluten can be a serious problem for unsuspecting and discerning gluten-free dieters. The underlying issue for people suffering from gluten and casein intolerance is their body’s inherent enzymes do not have the capacity to digest the offending substances. Incomplete digestion of these proteins damages the villi of the intestinal tract, causes inflammation and creates digestive discomfort. The villi of the small intestine are the site of most nutrient absorption and any damage to them can result in mal-absorption and nutrient deficiencies. Scientists theorize that humans still have not caught up genetically with the introduction of grains to the diet that began nearly 10,000 years ago. Fortunately, advances in biotechnology are striving to bridge that gap. Gluten Relief for Full-Spectrum Protein Digestion Gluten Relief® is specially formulated to support the digestion of gluten, casein and other offending proteins hidden in today’s modern foods. Gluten Relief contains DPP-IV (dipeptidyl peptidase IV), an enzyme complex which specifically breaks down gluten and casein. Our formula includes five additional proteases, each with a specific and unique digesting activity that complements DPP-IV for complete protein degradation. Amylases, lactase and lipase complete Gluten Relief for overall digestive ease. Undigested proteins can enter the bloodstream through a ‘leaky gut’ or permeable mucus lining of the small intestine. Research indicates that a leaky gut invariably leads to autoimmune issues of many kinds. Gluten Relief by AST Enzymes is designed with full-protease power to help digest proteins which cause trouble in the gastro-intestinal tract and throughout the body. DPP-IV and Gluten Relief’s five additional proteases help to breakdown gluten and undigested proteins. Proteins like gluten and casein are large, complex molecules with thousands of amino acid sequences folded and coiled within the molecule, much like a ball of yarn. Without sufficient and specific enzymes to break them down, amino acid bonds within these large proteins can remain inaccessible to enzymes, ultimately resulting in a protein that is only partially degraded.  These smaller peptide strands are still long enough to cause problems with digestion: gas, bloating, occasional loose stools, constipation, fatigue, even severe gastro-intestinal inflammation. Improper digestion of carbohydrates is often an issue associated with gluten intolerance. Gluten Relief addresses this issue with the inclusion of two types of amylase, as well as glucoamylase and cellulose for complete sugar and carbohydrate digestion.  Avoiding gluten and casein in food and everyday products can be difficult. Even while maintaining a GFCF lifestyle, many products can be hidden sources of these proteins and cause problems. Gluten Relief can be used in conjunction with a GFCF diet to alleviate the stress caused by hidden gluten and casein, allowing these proteins to be properly broken down and absorbed in their digested state.   Sources of Hidden Gluten You May Not Have Known Blue cheese, bouillon cubes, caramel color or flavoring, commercial chocolate milk and drinks, curry powder, flavored instant tea or coffee, food colorings, gelatin starch, grain alcohol (such as beer, ale, rye, scotch, bourbon or grain vodka), gum base (such as in chewing gum), hydrolyzed vegetable protein, malt, marshmallows, modified food starch, monosodium glutamate, non-dairy creamers, packaged rice mixes, preservatives processed meats (such as sausages, hot dogs, or bologna), pudding, salad dressing, soy sauce, spices and spice mixtures, textured vegetable protein, vegetable starch and white or malt vinegar. Gluten Relief Dosage Take 1 or more capsules with each meal, or as directed by your healthcare professional Compare Compare AST Enzymes’ Digestive Enzyme Blends   DigeSEB®-GI Gluten Relief® Lacto-Relief Protein Digestion          Proteases √   √    Serrapeptase √        DPP-IV   √√      Bromelain √        Papain √     Carbohydrate Digestion          Amylase √ √√ √    Glucoamylase   √      Lactase √ √ √√    Maltase √        Invertase √        Cellulase √ √ √    HemiSEB® √ √ √    Alpha-Galactosidase √ √ √ Fat Digestion          Lipase √ √ √   When choosing a digestive enzyme supplement, it is important to know the specific benefits of the product and how it meets your needs. Each of AST Enzymes’ digestive enzyme blends are specially designed to suit a variety of digestion concerns and issues. DigeSEB®-GI is an all-encompassing digestive enzyme blend. Simply put – it has a little bit of everything. By including a variety of enzymes capable of digesting all food types, DigeSEB-GI is very versatile and can be taken with any meal to aid in the digestive process. Gluten Relief® is specially formulated to assist with the digestion of gluten-rich foods. Products typically characterized by their gluten content such as breads and pasta are also carbohydrate heavy as well. To address this, additional carbohydrate-digesting enzymes are included in Gluten Relief to compliment the powerful DPP-IV activity. Lacto-Relief has the same benefits of a general digestive enzyme blend; however its high concentration of lactase provides an added bonus to those who struggle with proper dairy and milk product digestion. By combining extra lactase with enzymes for all aspects of food digestion, Lacto-Relief acts as a “one-stop shop” for those seeking digestive relief from difficult-to-digest foods. Research The proteolytic enzyme dipeptidyl dipeptidase IV (DPP IV) is contained within the cells that line the villi of the small intestine. Celiac disease research has included the investigation of the role of DPP IV in the digestion of the portion of the protein found in gluten that is recognized as an “offender” by the immune system, also called an epitope. The particular epitopes of concern in gliadin are rich in the amino acid proline. Studies show that endopeptidases, or enzymes that break protein bonds from within the molecule rather than at the ends, that are normally released by the pancreas do not effectively digest the epitopes. This suggests that DPP IV digestion in the small intestine is critical. Research has also found that DPP IV activity in patients with celiac disease is low and that they may not have the capacity to digest the protein after a gluten-rich meal, contributing to the development of the disease.1,2,3 Autism research has included the investigation of the role of DPP IV in the digestion of the epitopes that can trigger an autoimmune response. These epitopes have also demonstrated the ability to pass, or permeate, through the lining of the intestines and travel through the blood to the brain where they interfere with normal cognitive processing.4 At this time, clinical studies relevant to gluten and casein functions in autism are limited to the removal of these factors from the diet rather than DPP IV supplementation to break them down. Proper maintenance of a gluten-free/casein-free diet is difficult, however, because many everyday foods and items are hidden sources. Researchers looked at supplementing with DPP IV, as well as other prolyl (proline-specific) endopeptidases in celiac disease. They found that supplementing with DPP IV can compensate for the slow protein digestion, and that supplementing with additional proteases like prolyl endopeptidase (PEP), in combination with DPP IV, may be useful in reducing or even eliminating the inflammatory response related to gluten.5,6 There is growing evidence that suggests that taking a combination of proteases for gluten digestion is more beneficial than a single enzyme. In one study, activity of X-prolyl dipeptidyl aminopeptidase (X-PDAP), a non-specific DPP enzyme, was measured alone and in combination with another enzyme, non-specific monoanimopeptidase (AP). When AP was combined with subtilisin (a serine-specific endopeptidase), gluten digestion was measured at 47%. Upon adding X-PDAP, activity increased to 64%, suggesting a synergism in breaking down proteins when these enzymes are taken as a complex.7 Another study looked at the possibilities of a combination enzyme therapy in treating celiac disease. Researchers concluded that by combining 2 enzymes with normal digestive activity it should be possible to increase the safe threshold of ingested gluten, reducing the need for a highly restricted diet for celiac patients.8 Enzyme Activity Enzymes How it Works Dipeptidyl Peptidase IV (DPP-IV) DPP-IV is a blend of five powerful proteases that function in a wide pH range, enhancing protein digestion. DPP-IV specifically works on the proline component of gliadin (found in gluten) and casein proteins, and helps regulate the inflammatory response to gluten peptides. Amylase I, II & Glucoamylase Break down carbohydrates, more specifically starch, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants. Cellulase Digests cellulose, a complex polysaccharide found in all plant material, including plant fiber. Hemicellulase and Xylanase,cellulose Break down carbohydrates such as fiber and other plant polysaccharides such as hemicellulose, a major component of plant cell walls. Alpha-Galactosidase Breaks down complex carbohydrates such as raffinose and stachyose commonly contained in legumes, cruciferous vegetables and grains. Lactase Breaks down lactose, the difficult to digest disaccharide found in milk, into simple sugars for easier absorption. Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells.   1.   Kozakova H, Steepankova R, Kolinska J, et al. Brush border enzyme activities in the small intestine after long-term gliadin feeding in animal models of human coeliac disease. Folia Microbiol (Praha). 1998; 43(5):497-500. 2.   Koch S, Anthonsen D, Skovbjerg H, Sjöström H. On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Adv Exp Med Biol. 2003; 524:181-7. 3.   Detel D, Persic M, Varljen J. Serum and Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26) Activity in Children With Celiac Disease. J Ped Gast Nutr. 2007; 45(1):65-70. 4.   Hemmins WA. The entry into the brain of large molecules derived from dietary protein. Proc Roy Soc London Ser B. 1978; 200:175-192. 5.   Marti T, Molberg O, Li Q, et al. Prolyl Endopeptidase-Mediated Destruction of T Cell Epitopes in Whole Gluten: Chemical and Immunological Characterization. J Pharmacol Exp Ther. 2005; 312(1):19-26. 6.   Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol. 2002; 283(4):G996-G1003. 7.   Resta-Lenert S, Barrett KE. Live probiotics prtect intestinal epithelial cells from the effects of infection with enterovasasive Escherichia coli (EIEC). Gut. 2003; 52:988-97. 8.   De Palma G, Cinova J, Stepankova R, et al. Pivotal Advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease. J Leukocyte Biol. 2010; 87(5):765-78. FAQ What is digestive enzyme therapy? Digestive enzyme therapy is the use of plant or animal-based dietary supplements to aid in digestion and promote balanced metabolism. *All of our products are of plant origin, meaning they are 100% vegetarian/vegan.  Although the body is equipped with enzymes that perform digestive actions, certain conditions can affect their production and effectiveness. States of disease and aging are both factors affecting enzyme production and action.   What is a digestive proteolytic enzyme?  Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. The body requires 20 different amino acids, 8 of which are referred to as essential amino acids because they cannot be synthesized by the human body. These essential amino acids must be obtained from the food we eat. Without sufficient proteolytic enzymes, the body is unable to break down and absorb these necessary nutrients. Failure to fully digest proteins can result in undesirable symptoms such as bloating, abdominal cramping, flatulence and diarrhea. What is gluten? Gluten is a protein that is present in wheat, barley and rye products. Gluten is often used in manufacturing food because it provides structural stability and elasticity to the product. Americans are increasingly reporting intolerance to gluten, manifesting as symptoms of gastrointestinal disruption in response to ingestion of offending foods. However, it is difficult to eliminate gluten completely from the diet, as there are several hidden sources.   How long should I take Gluten Relief before feeling results? Gluten Relief should be taken 5-10 minutes prior to eating. The typical, recommended dose is 1 to 2 capsules per meal. There are several variables that may affect the required dosage, for example: Content of meal Size of meal Severity of intolerance Nutritional status Depending on these variables, along with one’s individual response to digestive enzyme therapy, the dose can be as high as 4-5 capsules per meal. It is advisable to experiment with dosage, considering there is no upper limit or adverse effects in exceeding your supplement needs.   What if I miss a dose? Since digestive enzymes aid in digestion of food that is otherwise difficult to tolerate, finding yourself without them may be tricky. If you want to avoid the symptoms that can accompany indigestion, then the best advice would be to avoid the offending foods altogether.  Unlike systemic enzymes, the effects of digestive enzymes can be seen quickly. Adjusting food content and finding an appropriate dosage is an important balance to acheive.   Why is it important to take Gluten Relief with food? Since Gluten Relief aids in digestion, it is contraindicated to use the enzyme without eating. Although it is not harmful to take Gluten Relief on an empty stomach, it is simply a waste of money.  If you take digestive enzymes too soon before a meal, you risk the enzyme becoming inactive. The food and enzyme must be in the stomach together for proper results.   Are there any side effects involved with Gluten Relief? Side effects with Gluten Relief are rare, but not impossible. Mild cramping may occur, as the intestinal lining begins to cleanse. Other rare, but reported side effects include minor gastrointestinal disturbances, like bloating or gas. Starting off at a low dose can minimize any possible side effects. Side effects should clear with regular use, after a tolerance is established.   What does “proprietary blend” mean? Proprietary refers to a patent, or ownership. Applying this concept to our digestive enzyme blend it means that we alone own the rights to the specific blend of enzymes found in Gluten Relief, making our product different from similarly marketed digestive enzyme supplements. Gluten Relief encompasses an all-inclusive digestive aid product that assists in the digestion of several nutrients, not just gluten.   Can I take Gluten relief with other systemic or digestive enzymes? Although digestive and systemic enzymes arenot contraindicated in terms of ingredients, they should not be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes, and thus should be taken as directed for best results.   Can I open the capsule and pour it onto my food instead of swallowing the capsule? If you find that you have trouble swallowing the capsules, pouring its contents onto food is definitely an option. You may also open the capsule into a glass of water, being sure to drink the entire glass. If you choose to take the enzymes this way, it is best to consume the entire content as soon as possible to ensure you are receiving the full benefits within your body (rather than on your plate).   Supplement Facts Serving Size: 1 CapsuleServings Per Container: 90 Amount Per Serving:                       % DV SEB Gluten-Relief® Proprietary Blend:                                          300 mg *Dippeptidyl Peptidase IV (DPP-IV)SEB-Pro GR™ (Protease I, Protease II,Protease III, Protease IV, Protease V),Amylase I, Amylase II, Glucoamylase,Cellulase, HemiSEB® (Hemicellulase,Alpha-Galactosidase, Xylanase),Lactase, and Lipase *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose, and cellulose. Directions: Take 1 capsule with each meal, or as directed by your healthcare professional. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Lacto-Relief Milk & Cheese Digestion The Difficulties of Dairy Milk is a great source of essential nutrients such as protein and calcium, yet many people struggle with proper digestion of milk and dairy products.  If your digestive system works as it should, the enzyme lactase breaks down the milk sugar lactose into glucose and galactose, two simpler forms of sugar. Glucose and galactose are then absorbed into the bloodstream. In people with lactose intolerance, when the lactase produced is insufficient to digest the amount of lactose consumed, the bowel retains water. Undigested lactose then passes from the small intestine into the colon where it is fermented by bacteria. The resulting symptoms can include cramping, bloating, gas, nausea and diarrhea. Lactose intolerance, characterized by the inability to break down lactase (the sugar found in milk), affects 10 to 16 percent of the entire American population. Lactase deficiency can develop over time, as early as childhood, or later in life due to a variety of conditions. According to the National Institutes of Health, specific populations show higher levels of intolerance: 95 percent of Asians; 60 to 80 percent of African Americans and Ashkenazi Jews; 80 to 100 percent of American Indians; and 50 to 80 percent of Hispanics. For many, milk proteins are an added problem and can cause milk protein intolerance in dairy-sensitive individuals. Digestive enzyme supplementation supports dairy digestion.* Lacto-Relief for Dairy Digestion Lacto-Relief is specifically designed to aid in the digestion of dairy products. Lactase in Lacto-Relief hydrolyzes lactose, thereby relieving the discomfort of lactose intolerance.* Sources of Hidden Lactose You May Not Have Known Bread and other baked goods; waffles, pancakes, biscuits, cookies and mixes to make them; processed breakfast foods such as doughnuts, frozen waffles and pancakes, toaster pastries, and sweet rolls; processed breakfast cereals; instant potatoes, soups, and breakfast drinks; potato chips, corn chips and other processed snacks; processed meats, such as bacon, sausage, hot dogs and lunch meats; margarine; salad dressings; liquid and powdered milk-based meal replacements; protein powders and bars; candies; non-dairy liquid and powdered coffee creamers; and non-dairy whipped toppings. Lacto-Relief Dosage Take 1 or more capsules with each meal, as needed, or as directed by your healthcare professional. *These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure, or prevent any disease.

Product InfoIMMUNE SYSTEM SUPPORT Your immune system is essential to fighting off germs. Immune support is especially vital when everyone around you is sick! Our Immunity Boost Bundles can provide great support for your body to keep healthy. ImmunoSEB™ This powerful enzymatic formula was designed to boost our bodies’ natural resistance against harmful organisms which threaten our life systems.  ImmunoSEB™ is one of the strongest immune system support formulas we offer!  It contains: Enteric-Coated Serrapeptase and Peptidase enzymes that help break down proteins into amino acids needed for healthy immune function. Bromelain and Papain enzymes derived from pineapples and papayas long known to support the body’s natural response to inflammation. Lysozyme, amylases, catalase, lactoferrin proteins to provide natural antimicrobial properties, and natural antioxidant benefits.* A Safe and Natural Regimen We believe in safety first!  Other companies merely buy and repackage someone else’s product.  But, as a true manufacturer, we control safety from the beginning. ImmunoSEB™ is free of pesticides, chemicals, preservatives, animal derivatives, soy, wheat, peanuts, tree nuts, fish and shellfish. All enzyme ingredients are kosher-certified, and suitable for vegetarians. ImmunoSEB™ is manufactured in the USA in an FDA-registered facility that follows cGMP guidelines, and are composed of domestic and international ingredients. FAQ What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of enzymes to support healthy cardiovascular, respiratory, immune systems, among others. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system.  Different systemic enzyme blends offer support to different areas of the body. ImmunoSEB™ is packed with potent proteolytic enzymes at high activities, and antioxidants required for supporting a strong immune system. What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. How long should I take ImmunoSEB™ before feeling results? The length of time to experience the benefits of systemic enzymes varies by individual. Some people notice a difference within days. For others, it’s a week or 10 days. For long-term benefits, it’s important to take systemic enzymes consistently over several months. New systemic enzyme users should start off slow, with one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a 2 capsules, 3 times per day.  onitored, and dosage should be adjusted accordingly.  There are several factors that may affect required dosage, including: Height Weight Age Tolerance Time of administration (Better absorbed on an empty stomach) Adherence to regimen Nutritional state What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up” on one dose. Also remember, systemic enzymes are best absorbed on an empty stomach. Why is it important to take ImmunoSEB™ on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes survive the stomach intact. If enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like ImmunoSEB with food will compromise their absorption, as well as their effectiveness. Are there any side effects involved with ImmunoSEB™? The use of ImmunoSEB™ has not been shown to exhibit detrimental effects, long term or short term. Minor side effects may vary. Gastrointestinal disturbances have been reported by a small percentage of new users, but once the dosage is adjusted, tolerance is maintained. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, particularly if you are on blood-thinning medications, or are pregnant or nursing. Can I take ImmunoSEB™ with other systemic or digestive enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Separate blends or enzymes often work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on supporting the body are more attainable.

Exclzyme The Original Full-Strength Formula Everybody Needs a Healthy Body Elimination of potentially toxic substances from the body is a crucial part in the metabolic processes for optimal health. A variety of health issues can develop if toxins within the body impair enzyme function or availability or without a proper store of enzymes. For instance, the immune system can be overwhelmed with bacteria, fungi, toxins and even food particles that don’t get completely digested in the gastro-intestinal tract. In many instances, proteins created by these distresses found within the body, which the body detects as foreign, can initiate an immune response. Recognized as antigens, the immune system produces antibodies to start the process of the proteins’ degradation and removal. After coupling with one another, these antigens and antibodies form circulating immune complexes (CICs), which induce attack and destruction by the immune system’s macrophages (white blood cells specifically designed to destroy CICs). This process is known as inflammation – the body’s natural healing mechanism In cases where inflammation is prolonged or when CICs are predominant within the body’s tissues and organs, the body may not have enough enzyme potential to begin the next process of renewal and recovery. Moreover, research has demonstrated that a lack of proteolytic enzymes may not cause an adequate response to a large accumulation of CIC’s in the body. Exclzyme® for Total Body Support To address this problem, Exclzyme has been formulated with an ample supply of various proteases to facilitate the body’s immune defenses and breakdown free-roaming CICs that can keep the body in a constant state of inflammation. Enteric-coated serrapeptase highlights this powerful mix of proteolytic enzymes with its scientifically proven fibrinolytic power (to learn more about enteric coating used in AST Enzymes products, please click the "Compare" tab). Exclzyme also contains papain and bromelain, enzymes known for their potent systemic properties. In addition to these systemic and digestive proteases, lipase and amylase also offer their own enzyme activity to bolster the body with extra catalytic energy, especially for the complete digestion of fats, sugar and protein complexes. And for extra synergy, Exclzyme is rounded with anti-oxidant support in the form of rutin and amla, herbs well known for their unique bioflavanoid content, especially useful for tissue rejuvenation and recovery.*The entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS). The Original Systemic Enzyme Formula Exclzyme is a proven systemic enzyme therapy for overall health. A powerful blend of serrapeptase, proteases and herbs, Exclzyme supports the body’s response to inflammation, metabolic activity, blood, joints and circulation. The Exclzyme formula has been used for more than a decade by thousands of people as a daily dietary supplement. In fact, you may have been using the original formula for years without knowing it (to learn more about Exclzyme vs. Vitalzym®, please click the "Compare" tab).** AST Enzymes’ family of companies is among the largest manufacturers of enzymes in the world. For decades, we have supplied enzymes to marketing companies who have built their businesses on enzyme supplements our experts formulated and manufactured. The Exclzyme formulation has been commercially available since 1999 and is the most successful non-animal derived systemic enzyme blend on the market today. Exclzyme Dosage For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Exclzyme dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit). NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day. Complementing your Exclzyme with additional serrapeptase can increase proteolytic activity, as well as increase positive effects on inflammation and provide faster recovery and healing from injury.*Peptizyme-SP contains 80,000 units of professional-strength serrapeptase per capsule. Exclzyme vs Vitalzym   Exclzyme vs Vitalzym Comparison Chart Brand Enteric Coated Serrapeptase Serrapeptase Manufacturing Source Price Original Vitalzym (2000-2009) Yes India $114.00 "Original" Vitalzym (Current) No Japan $114.00 Vitalzym 360 Liquid Capsules (Current) Yes Japan $149.99 Original Exclzyme Yes India $99.95   If your systemic enzyme supplement recently changed, we have the original formula. Some companies claim to continue to carry the original formula. One easy way to check is to see if the bottle says the enzyme serrapeptase is enteric-coated. Studies show serrapeptase, sourced from the bacterium Serratia marcescens and the key ingredient in the original Full-Strength Exclzyme, must be enteric coated so it can pass through the acid environment of the stomach without being damaged. And as for the new formulas on the market claiming to be stronger or more technologically advanced: the proof is in the results. There is an underlying art when it comes to manufacturing enzyme products. Systemic enzyme blends must be formulated expertly and correctly for maximum effectiveness. In fact, alterations to an already successful systemic enzyme product may not provide the same results you’ve come to expect. Many companies, including ours, use proprietary formulas to protect their products from being copied and used by others. But all companies must list all of the ingredients by name, and rank the ingredients according to the percentage amounts in the formula. For instance, in the original Exclzyme formula, enteric-coated serrapeptase is listed on our ingredient list as the second most prevalent ingredient in our formulation. If your “new and improved” systemic formula does not list serrapeptase as the second ingredient and it doesn’t say enteric-coated, you’re probably not getting the most out of your systemic enzyme formula. Serrapeptase has always been the hallmark of the original Exclzyme formula, making it the choice of companies and consumers alike.   ----------------------------------------------------------------------------------------------   Enteric Coating Comparison   Methacrylic Acid Copolymer (MAAC)*   Cellulose Acetate Phthalate (CAP) Hydroxypropyl Methylcellulose Phthalate (HPMCP) Contains Phthalates NO YES YES Considered Enteric Coating YES YES YES Studies supporting Efficacy as Enteric Coating YES YES YES Gastro-resistance YES YES YES FDA GRAS YES YES YES Time in Use   >50 years   >70 years   ~40 years     *AST Enzymes uses MAAC as enteric coating   What is enteric coating, and why is it needed? Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects. What’s enteric coating made of? At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully. Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, theEuropean Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment. ** Vitalzym® is a registered trademark of World Nutrition Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes.   Research   Inflammation and Fibrin The reality of inflammation is that it affects everyone, men and women alike. However, along with nearly all other tissue and organs, inflammation can affect reproductive tissue and organs particularly. For instance, many women experience painful swelling of the breast as well as uterine fibroids. In men, prostate health is a major concern. Although inflammation in each case may manifest differently in both men and women, inflammation has one thing in common: fibrin. Fibrin is an essential protein that is produced during inflammation. As a blood clotting protein, the body utilizes fibrin to contain blood loss and keep infection at bay after injury. It is the initial step in the body’s attempts at recovery. However, when inflammation has become prolonged, fibrin along with other proteins such as collagen can begin to transform original tissue into a tough fibrous matrix. Differentiated and sometimes sequestered apart from healthy tissue, this fibrous matrix still has the biological markers of inflammation. Nutrients and other building blocks are still needed for healthy and normal tissue. Systemic and proteolytic enzyme research over the years suggests that fibroids in women and swollen prostate glands in men are indications that the body has not been able to get past inflammation. The resulting fibrous tissue usually accumulates toxins that have not been adequately removed by the body. Serrapeptase Research: Anti-inflammatory Activity For nearly 40 years, serrapeptase has been at the heart of systemic enzyme therapy. Systemic enzymes such as serrapeptase have been used for optimal cell, tissue, organ and metabolic function. Likewise, companies, health practitioners and consumers have turned to the original Exclzyme formulation for their systemic enzyme therapy needs. Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). They wanted to determine if a conservative, non-surgical approach would be beneficial. Twenty patients with CTS were evaluated clinically after 6 weeks taking serrapeptase. Sixty five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters. No significant side effects were observed. The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.1 A clinical evaluation of serrapeptase was conducted to determine its efficacy in reducing inflammation in patients with breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving serrapeptase had "Moderate to Marked" improvement. No adverse reactions were reported with the use of serrapeptase. The researchers conclude that serrapeptase is a safe and effective method for the treatment of breast engorgement.2 Moving to another part of the body, a study was conducted in men with amicrobial prostato-vesiculitis (APV is a non-infectious inflammation of the prostate). The researchers wanted to determine if treatment with nonsteroidal anti-inflammatory (NSAIDS) drugs, including serrapeptase, could reduce inflammation and swelling of the prostate. The doctors conclude that in APV patients, the treatment with NSAIDS, including serrapeptase is an effective therapy, producing multiple positive effects.3 Exclzyme Benefits and Sports Nutrition Enzymes are energetic catalysts that push essential chemical reactions in the body in the right direction. In its quest for internal balance, the body always turns to enzymes for help. In this way, Exclzyme helps get inflamed tissue over the hump. Exclzyme’s superior proteolytic action assists the body in removing those larger protein molecules from damaged cells and tissues as well as the inflammatory response itself. In helping breakdown these compounds, the impediments for sustaining healthy cell and tissue growth are removed and the processes for rejuvenation and recovery can move forward. These facets of Exclzyme make it ideal for maintaining healthy tissue repair following strenuous physical training and activity. Sport- and exercise-related muscle pain and inflammation brought on by strong physical tension, excessive training, and heavy competition are decreased with “excellent results” due to the specific activity of systemic enzymes on exercise-induced inflammation.4 Taking systemic enzymes prior activity can also provide protective benefits to athletes who are at risk of injury, resulting in significantly reduced duration of injury symptoms and related absences from training and work. Systemic enzyme support also improves recovery from sprains, as well as shortens recovery from sport injuries severe enough to require surgery.5,6 Enzyme Activity  Enteric Coated Serrapeptase Used by silkworms to digest and emerge from their silken cocoons; studied extensively for more than 50 years; an excellent fibrinolytic (fibrin digesting) and powerful anti-inflammatory enzyme* Protease Hydrolyze (break-down) proteins like casein, steak, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body Bromelain A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its anti-inflammatory properties.  A good substitute for animal-based enzymes a good substitute for pepsin and trypsin for digestive support* Papain Obtained from the latex of the fruit of the Papaya tree; used for centuries as an effective digestive aid* Amylase Breaks down carbohydrates, or more specifically, starches, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants Lipase Catalyzes the break-down of fats into essential fatty acids needed for healthy tissues and cells* Amla Also known as Indian gooseberry (Emblica officinalis); a natural, efficacious antioxidant, and one of the richest sources of absorbable vitamin C Rutin Bioflavonoid; strengthens and tones arteries and veins; provides antioxidant support against free-radicals and inflammation*     References 1. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000 Nov; 48(11):1130. 2. Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb; 30(1):48-54. 3. Vicari E, La Vignera S, Battiato C, Arancio A. Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings[Article in Italian]. Minerva Urol Nefrol. 2005 Mar; 57(1):53-9. 4. Nouza K. Physical activity and immune system. Systemic enzyme therapy in prevention and treatment. Medicina Sportiva Boh Slov. 1997; 6(2):41–45. 5. Zuschlag JM. Prophylactic administration of Wobenzym to reduce consequences of sports injuries in karate fighters. MUCOS Pharma GmbH & Co, Dept. Clinical Research, Geretsried, Germany. 6. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004 Aug; 38(4):431–435. FAQ         What is systemic enzyme therapy? Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing.   What is a systemic proteolytic enzyme? Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to excessive scarring and perpetuated immune responses. Excessive scarring, particularly of the organs, can exacerbate symptoms of the associated disease. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.   What is fibrin? Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.   Are systemic enzymes anti-inflammatory drugs? Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.   Why is it important to take Exclzyme on an empty stomach? Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme with food will compromise their absorption, as well as their effectiveness.   Does Exclzyme have an enteric coating? Yes, the serrapeptase in Exclzyme is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to be active within the bloodstream.   Do you use phthalates in your enteric coating? No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please click the 'Compare" tab.   How long should I take Exclzyme before feeling results? Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-15 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including: ·         Height ·         Weight ·         Age ·         Severity of symptoms ·         Tolerance ·         Time of administration (Better absorbed on an empty stomach) ·         Adherence to regimen ·         Nutritional state   What if I miss a dose? Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.   Are there any side effects involved with Exclzyme? The use of Exclzyme has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.   Can I take Exclzyme with other systemic enzymes? Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.   Can I take Exclzyme with digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.     Supplement Facts Serving Size:  1 CapsulesServings Per Container: 90 Amount Per Serving                          %DV Proprietary Enzyme Blend:                      500 mg *   Protease, Peptizyme SP® EN (Enteric   coated Serrapeptase), Papain,   Bromelain, Amylase, Lipase, Rutin   and Amla. *Daily Value (DV) not established Other ingredients:  Microcrystalline cellulose, and cellulose. Directions: Take 2 capsules three times a day. In three days, if desired benefit is not achieved, take 3 capsules three times a day. Take capsules 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children. Caution If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Introducing Vida Defense by AST Enzymes … As the body’s first line of defense, immune strength is critical to your health. The human immune system functions as a complex network of cells and organs, specialized to defend the body against attacks by foreign invaders. Proper immune responses seek, find and destroy offending pathogens such as bacteria, viruses, fungi and parasites, and also protect the body from future infections by forming specific antibodies. When the immune system is weakened or malfunctions, the body becomes highly susceptible to infection and is slower to respond. Compromised immune cells can incorrectly identify pathogens and antibodies, as well as other body cells, which may lead to more severe problems. A combination of factors – including stress, fatigue, lack of sleep, toxins in food and the environment, age, and genetics – all contribute to weakened immunity over time, resulting in everything from the common cold or flu to serious illness. Maintaining a healthy immune response is a pivotal to overall health and wellness. Enzymes and Cellular Metabolism Our bodies rely on intricate chemical reactions to function normally. When these biochemical processes are impaired or if toxins accumulate, the body must turn to abnormal metabolic pathways to survive. As a result, the normal immune response is weakened and eventually becomes irresponsive. Systemic enzymes provide the energy needed for metabolic reactions essential to immune health. Enzymes have been shown to stimulate the body’s natural defenses while breaking down offending pathogenic immune complexes. This helps relieve stress on the body and strengthen the immune system, which can speed the healing process. Enzymes can also reduce free radical damage, inhibit pathogens and potentially provide support for the most challenging of health disorders. Vida-Defense is a blend of powerful systemic enzymes and antioxidant herbs designed to support normal cellular metabolism and optimal immune function. The unique blend found in Vida-Defense includes a potent, proprietary blend of plant and microbial proteases SEBPro® V. This is combined with a powerful blend of antioxidant, antimicrobial and immuno-stimulatory enzymes and herbs, including lysozyme, colostrum, chitosanase, catalase, lactoperoxidase, rutin and grapeseed extract for complete, broad-spectrum defense. Benefits of Vida Defense Vida-Defense is an innovative and powerful enzyme blend formulated to maintain and support the body’s immune system by reducing free radical damage, inhibiting pathogens and providing nutritional and enzymatic support. A unique proprietary blend of plant and microbial proteases (SEBPro V) plays the most significant role in Vida-Defense by reducing inflammation, and supporting the body’s natural response to injury or infection. Inflammation is a sign of an abnormal metabolic pathway, used by the body as a reactionary mechanism to injury or illness, which results in a deposit of insoluble proteins. Vida-Defense’s anti-inflammatory proteases help break down these proteins, promoting quicker healing and reducing the severity of the condition. Vida-Defense incorporates multiple potent antioxidants, including catalase, grapeseed extract and rutin. These components aid in the reduction of Reactive Oxygen Species (ROS), or free radicals, which severely damage cells and lessen their integrity. These powerful antioxidants reduce susceptibility to infection and allow cellular processes to remain focused on proper immune functions. Vida-Defense includes several antimicrobial enzymes, giving this powerful formula a multifaceted approach to building immunity. Lysozyme, lactoperoxidase and chitosanase work on invading pathogens by breaking down their cellular wall components, making them more vulnerable to immune responses. With the addition of colostrum, which contains antibodies and additional enzymes, the proprietary blend found in Vida-Defense provides an all-encompassing formula for supporting normal cellular metabolism and optimal immune function. Enzyme Activity in Vida-Defense Proprietary Blend Enzymes How It Works Proteases (SEBPro Vblend Break down proteins and possess significant anti-inflammatory properties; they act systemically, affecting multiple cellular and molecular targets. Lysozyme A naturally occurring protein found in many organisms, including plants and animals; biologically, lysozyme attacks the cell wall of certain pathogenic bacteria. Catalase A natural immune enhancer and powerful antioxidant. Lactoperoxidase A natural antibacterial enzyme which improves immune response; also shown to promote tissue repair and anti-inflammatory activity. Chitosanase Powerful enzyme that breaks down chitin, a component in fungal cell walls. Grapeseed Extract Scientifically proven to be abundant in bioflavonoids, which are known for their tremendous antioxidant properties. Rutin Bioflavonoid; strengthens and tones arteries and veins and provides antioxidant support against free-radicals and inflammation. Colostrum Nutrient-rich, bioactive and immune supporting factor found in breast milk; loaded with several anti-inflammatory, immune, growth and tissue repair factors, including colostral lymphocytes.