Human Optimization - Sleep 120 Capsules

£53.10 £59.00 -10% OFF
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Human Optimization - Sleep 120 Capsules
Human Optimization - Sleep 120 Capsules

Human Optimization - Sleep 120 Capsules

£53.10 £59.00 -10% OFF

Shipped today from our UK warehouse (If ordered by 2pm.)
Description

Is It Memory Loss?

 

Or sleep loss?

Lack of sleep can lead to...
  • Impaired memory [1]
  • Decreased cognitive ability [2]
  • Poor mood [3]
  • Imbalanced immune function
  • Increased risk of infectious disease [4]
  • Vascular inflammation
  • Increased risk of cardiovascular disease [5]
  • Higher risk of sarcopenia - involuntary loss of muscle mass [6]
  • Emotional dysregulation [7]
  • Low libido [8]
  • Cravings & weight gain [9]
  • Metabolic syndrome [10]
  • Hormonal imbalances [11]
  • Decreased fertility & ability to conceive [12]

 

 

"In addition to elevated risks of chronic diseases, short sleep duration is strongly associated with decreases in cognitive performance...

...impairments in several cognitive domains can be observed even after short-term sleep restriction" [13].

Nature Journal, October 2021

 

 

 

Add 4 Pills To Your Night...And Extra Years To Your Life.

Sleep deprivation has deadly consequences, especially for women.

You might feel tired today, but over time, your health takes an enormous hit.

The most impactful illnesses and disasters of the 21st century are linked to lack of sleep.

Incredibly, a follow-up investigation of the space shuttle Challenger disaster named staff sleep loss as a possible cause [14].

The risk of obesity, metabolic syndrome, hypertension, heart attack, stroke, Alzheimer’s disease, and cancer, particularly the increasingly prevalent colorectal cancer, increase with suboptimal sleep [15, 16].

And women are affected more than men.

Females with disturbed sleep have greater chances of cardiovascular disease, increased insulin, hypertension, and inflammation compared to males [17].

Mental health also suffers—symptoms of depression, anxiety, psychosis, and stress perception worsen with sleep loss. Those with insomnia, for instance, have a two-fold risk of developing depression compared to those without the condition [18, 19].

 

 

Imagine 8 Restful Hours Instead Of 5 Restless Ones. A Calm Mind Instead Of Racing Thoughts.

The best part? No Rx hangover.

Human Optimization Lab's Sleep may support:

  • Non-habit forming REM sleep without the side effects of Rx drugs [20]
  • Healthier balance of non-REM and REM sleep patterns [21]
  • Sounder sleep versus waking up tired before your alarm clock [22, 23]
  • Increased sleep time [22]
  • Faster transition from awake to asleep—no more tossing & turning [22]
  • Alleviation of insomnia, specifically related to age [22, 24, 25]
  • Less chance of waking during the night [26]
  • Reduced symptoms of restless legs syndrome [27]
  • Antioxidant balance and anti-inflammatory effects [28]
  • Reduced anxiety [29]
  • Healthier circadian rhythms, even in the presence of unavoidable light at night [30]
  • Production of your body's own master antioxidant, melatonin [31]
  • Fewer obsessive thoughts that keep you awake [32]

 

 


Sleep's dream team:

Melatonin & your mitochondria

When you think of antioxidants, what comes to mind? Most of us imagine berries, dark chocolate, or vitamins C and E. But the real antioxidant all-star? Melatonin. Melatonin is an incredibly potent and unique antioxidant. Why? Unlike other antioxidants, it's created by your mitochondria and plays enormous roles in optimizing their function...and your energy levels [33].

 

 

Ingredients Based On Science, Not Social Media.

Sleep is formulated with nutrients and doses proved effective in scientific studies…and only those nutrients.

We don’t believe in proprietary blends or hidden excipients.

Learn more about our transparent, evidence-based ingredients.

 

 


Magnesium (Magnesium Glycinate)

Magnesium aids sleep in multiple ways, yet aging is a risk factor for magnesium deficiency. Magnesium relieves muscle tension [35] and is an N-Methyl-D-aspartic acid (NMDA) antagonist and GABA agonist, meaning it gently reduces neuronal excitability and promotes neuronal relaxation.

 

 

Potassium (Potassium Glycinate)

Sleep is divided into two phases, non-rapid eye movement (NREM) and rapid eye movement (REM) and five separate stages! This organization is called sleep architecture, and potassium is best known for supporting these patterns thanks to its role in regulating the intricate physiology of potassium channels in the nervous system [36].

 

 

B6 (Pyridoxal 5’-Phosphate)

Pyridoxal 5′-phosphate (PLP), the biologically active form of vitamin B6, is a cofactor for kynurenine aminotransferase (KAT) and kynureninase (KYNU), two key enzymes in the conversion of kynurenine to tryptophan [38]. In turn, we use tryptophan to make both serotonin and melatonin [39].

 

 

Herbatonin® (Plant Melatonin)

Does melatonin leave you feeling drowsy throughout the morning? Interestingly, a double-blind, placebo-controlled study from MIT found 0.3 mg of melatonin to be the ideal dose for people with insomnia over 50 [24]. When compared to the pharmacological dose of 3 mg, the 0.3 physiological dose restored sleep efficiency without remaining elevated into the daytime.

 

 

L-Theanine

L-theanine is a non-protein amino acid abundant in green tea, well known for its relaxing effects and ability to cross the blood-brain barrier [40]. Once in the brain, l-theanine blocks glutamate receptors and enhances GABA and dopamine, resulting in reduced neuro-excitability and increased feelings of relaxation [41].

 

 

L-Tryptophan

L-tryptophan is an essential amino acid that plays an integral part in nervous system health and is the precursor to serotonin, a key hormone for mood regulation (43). Clinical studies of tryptophan-deficient diets show that low intake of this essential amino acid results in increased depression, anxiety, and poor emotional processing [44].

 

 

L-Serine

L-serine is a non-essential amino acid studied for its remarkable neuroprotective effects [47]. Researchers have hypothesized that dietary L-serine may be responsible for the large centenarian population in Ōgimi, Okinawa, due to their exceptionally high intake of L-serine through foods such as seaweed, tofu, and pork. [48]. The average Ōgimi woman eats over 8 grams of dietary L-serine daily, while her American counterpart only gets 2.5 grams [49].

 

 

5-HTP

5-HTP is an amino acid produced from tryptophan and is a metabolic intermediate to serotonin and melatonin. 5-HTP has been studied for its anti-depressant, anxiolytic, and sleep-promoting effects. Several neurodegenerative diseases have been associated with low levels of 5-HTP, including Parkinson’s, fibromyalgia, and Alzheimer's [54].

 

 

Myo-Inositol

Myo-inositol is a fascinating but commonly underconsumed compound primarily found in organ meats. It was once considered a B vitamin, but its classification changed when endogenous creation from glucose was discovered in the kidneys, liver, and brain.

 

 

Chamomile Extract (Matricaria Recutita)

For hundreds of years, chamomile has been one of the most trusted, aromatic sleep herbs. It's properties include anti-anxiety, stress relieving, and anti-insomnia. It's also beneficial to the immune and digestive systems and the liver [60].

What people say about Sleep

 

 

I have struggled with sleep most of my life, and for the last 10 years have tried many different supplements after finally stopping all sleep medications. Some of these supplements have helped, but I have been using Sleep and find that it combines all the different supplements I have tried into one! It works beautifully, it not only helps me ease into sleep quickly, but when I wake in the middle of the night, I can fall back to sleep. I wake up feeling relaxed but not groggy. I am loving this supplement!!

 

References

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