Arthur Andrew Medical

Maximize the performance benefits of your protein supplement. Ideal for body builders, runners, fitness enthusiasts, or anyone with an active lifestyle1, Aminolase™ represents a breakthrough in protein nutrition for those using protein supplements or meal replacements to help build or maintain healthy muscle mass and accelerate muscle recovery. (Figure 1) Aminolase™ should be taken with protein rich foods and all protein supplements including the following: whey, milk, casein, soy, pea, rice and hemp. Protein supplements are one of the richest sources of all nine essential amino acids that the body is unable to produce on its own; however all protein must first be processed into a usable form, which includes essential amino acids and beneficial peptides (i.e., Di and Tri-peptides)3. To be effective, protein must be broken down into a smaller particle size within approximately 90 minutes of consumption4. This transit time represents the time from which protein passes from the stomach through the small intestine where digestion/absorption primarily occurs; from there it will be assembled into muscle building protein (a bio-usable form)4. Undigested protein will simply be excreted from the body, resulting in increased kidney stress and wasted amino acids, essentially pouring your expensive protein supplement down the toilet. (Figure 2) Aminolase Suggested Use Suggested Use: Consume 1 capsule of Aminolase™ per 25 grams of protein consumed. Aminolase capsules may also be opened and added directly to your favorite protein supplement. Aminolase is a vegetarian enzyme product which may increase protein bio-availability as much as 1000%. Decreased Stomach Discomfort - An Added Benefit When dietary protein is not broken down into its smallest components, large peptides are created that can cause stomach discomfort such as bloating, nausea and cramping. These symptoms should not be confused with food intolerances; generally, the underlying cause of protein-induced stomach discomfort is peptide sensitivity. Aminolase breaks down these large peptides, reducing the potential for discomfort that often comes from consuming protein supplements or dietary protein. (Figures 3 & 4) C-Reactive Protein (CRP) This study also measured levels of a common marker of inflammation; a protein called C-reactive protein. Elevated levels of this protein in the blood predict the onset of serious illnesses such as cardiovascular disease. Levels of C-reactive protein were measured when the participants consumed only the whey protein drink and again, five days later, when they consumed the whey protein drink with Aminolase™. An increase in C-reactive protein levels was observed for each of the participants when they consumed only the whey protein drink. On the other hand, after consuming the whey protein drink with Aminolase™, a significant decrease in C-reactive protein levels was observed for each individual. These results indicate the ability of Aminolase™ to hydrolyze large amounts of protein, improve the absorption of individual amino acids and significantly reduce inflammation that is associated with undigested proteins. Supplement Facts Acid Stable Protease A patent pending proteolytic enzyme that is capable of digesting every type of consumable protein; protease is responsible for digesting all ingested proteins and is one of the three enzymes found in our body’s natural pancreatic juices. Hundreds of prototypes were developed before the final product was chosen. Aminolase will completely break-down and digest all protein, food or supplement. Amionlase works great with animal and vegetarian dierived proteins. This proprietary blend of proteases is active over a very brough ph range, making it extremely effective in Acid and Alkalain environments. Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Aminolase TPA™Acid Stable Protease Blend 250 mg † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Aminolase™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed.    

Maximize the performance benefits of your protein supplement. Ideal for body builders, runners, fitness enthusiasts, or anyone with an active lifestyle1, Aminolase™ represents a breakthrough in protein nutrition for those using protein supplements or meal replacements to help build or maintain healthy muscle mass and accelerate muscle recovery. (Figure 1) Aminolase™ should be taken with protein rich foods and all protein supplements including the following: whey, milk, casein, soy, pea, rice and hemp. Protein supplements are one of the richest sources of all nine essential amino acids that the body is unable to produce on its own; however all protein must first be processed into a usable form, which includes essential amino acids and beneficial peptides (i.e., Di and Tri-peptides)3. To be effective, protein must be broken down into a smaller particle size within approximately 90 minutes of consumption4. This transit time represents the time from which protein passes from the stomach through the small intestine where digestion/absorption primarily occurs; from there it will be assembled into muscle building protein (a bio-usable form)4. Undigested protein will simply be excreted from the body, resulting in increased kidney stress and wasted amino acids, essentially pouring your expensive protein supplement down the toilet. (Figure 2) Aminolase Suggested Use Suggested Use: Consume 1 capsule of Aminolase™ per 25 grams of protein consumed. Aminolase capsules may also be opened and added directly to your favorite protein supplement. Aminolase is a vegetarian enzyme product which may increase protein bio-availability as much as 1000%. Decreased Stomach Discomfort - An Added Benefit When dietary protein is not broken down into its smallest components, large peptides are created that can cause stomach discomfort such as bloating, nausea and cramping. These symptoms should not be confused with food intolerances; generally, the underlying cause of protein-induced stomach discomfort is peptide sensitivity. Aminolase breaks down these large peptides, reducing the potential for discomfort that often comes from consuming protein supplements or dietary protein. (Figures 3 & 4) C-Reactive Protein (CRP) This study also measured levels of a common marker of inflammation; a protein called C-reactive protein. Elevated levels of this protein in the blood predict the onset of serious illnesses such as cardiovascular disease. Levels of C-reactive protein were measured when the participants consumed only the whey protein drink and again, five days later, when they consumed the whey protein drink with Aminolase™. An increase in C-reactive protein levels was observed for each of the participants when they consumed only the whey protein drink. On the other hand, after consuming the whey protein drink with Aminolase™, a significant decrease in C-reactive protein levels was observed for each individual. These results indicate the ability of Aminolase™ to hydrolyze large amounts of protein, improve the absorption of individual amino acids and significantly reduce inflammation that is associated with undigested proteins. Supplement Facts Acid Stable Protease A patent pending proteolytic enzyme that is capable of digesting every type of consumable protein; protease is responsible for digesting all ingested proteins and is one of the three enzymes found in our body’s natural pancreatic juices. Hundreds of prototypes were developed before the final product was chosen. Aminolase will completely break-down and digest all protein, food or supplement. Amionlase works great with animal and vegetarian dierived proteins. This proprietary blend of proteases is active over a very brough ph range, making it extremely effective in Acid and Alkalain environments. Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Aminolase TPA™Acid Stable Protease Blend 250 mg † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Aminolase™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed.    

If you suffer from occasional bouts of bloating, belching, discomfort or even diarrhea following meals, you may be sensitive to common sugars that easily ferment in the digestive system. These sugars are referred to as FODMAPs. The simplest solution would be to eliminate these foods from your diet, but any type of elimination diet can be difficult. In fact, completely eliminating FODMAPs is likely impossible, or at least improbable to accomplish while maintaining a well-balanced diet. FODMAPs are typically found in some of the most nutritious fruits, vegetables, grains and legumes. Fortunately, FODMAP DPE was created to eliminate the worry of whether or not a meal may result in distress. FODMAP DPE (Digestive Probiotics and Enzymes) is a blend of specialized enzymes and spore-forming probiotics that assists the body in properly digesting highly fermentable foods, commonly known as FODMAPs. Digestive Support What are FODMAPs? FODMAPs are a group of short-chain carbohydrates known as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols and are frequently linked to digestive problems such as bloating, belching, flatulence, and abdominal discomfort. Common High FODMAP Foods Most people experience these digestive issues because FODMAP carbohydrates are poorly digested or remain undigested as they pass through the digestive system. Eventually these undigested foods come into contact with gut bacteria where they undergo fermentation, and produce gas that causes the slew of common symptoms associated with FODMAP foods. Who Can Benefit from FODMAP DPE? The FODMAP Intolerant You have already identified and eliminated high-FODMAP foods.. However, avoiding problematic FODMAPs is difficult when dining out, and sometimes even when preparing meals at home. You want to be able to enjoy eating, without the worry that you may be exposed to foods that may upset your digestion. Incorporate a broader range of foods into the diet Reduce occasional gas & bloating Reduce foodanxiety and enjoy eating again The Vegetarian/Vegan You love your plant-based diet but some of these densely nutritious foods do not always love you back. FODMAP DPE can help digest fruits, vegetables and legumes more completely. This will allow you to release and absorb more nutrients, while preventing uncomfortable and embarrassing gas. Digest & unlock more nutrients Reduce occasional gas & bloating Enjoy a broader variety of FODMAPs The Foodie You live to eat not eat to live, but certain foods you just can’t tolerate without obnoxious side effects. Whether you travel frequently or enjoy eating out, sometimes the best tasting meal just doesn’t sit right. Taking FODMAP DPE before each meal can prevent gas, bloating and distress. Enjoy more of the foods you love, and rest easily knowing you won’t be uncomfortable afterwards. Savor a broader range of foods Reduce occasional gas & bloating Reduce food anxiety and enjoy adventurous eating Fodmap sensitivity Do you already know that you have a FODMAP sensitivity? People who suffer from FODMAP sensitivity are unable to eat certain foods containing either a specific sugar/carbohydrate or a number of them without experiencing gastric distress. Similar to how those suffering from lactose (a common FODMAP) intolerance can enjoy limited levels of dairy by taking the lactase enzyme , those with FODMAP sensitivities can greatly benefit from the addition of a potent digestive enzyme such as FODMAP DPE. Those with severe or even moderate FODMAP sensitivities usually prepare meals at home instead of going out to prevent the risk of accidentally ingesting high-FODMAP foods such as garlic and onion. Unfortunately, avoiding all high-FODMAP foods is nearly impossible, especially when dining out. This makes digestive enzymes such as FODMAP DPE a vital partner in protecting yourself from discomfort due to an accidental exposure to FODMAPs. Forget the worry, get FODMAP DPE today and enjoy eating again.Ingredients Alpha Galactosidase The primary enzyme used in popular gas-relief products, alpha galactosidase is an enzyme responsible for breaking down complex sugars into simple sugars. This allows certain gas-producing foods such as cruciferous vegetables and legumes to become more easily digestible. This enzyme is important for Oligosaccharides, the “O” in FODMAPs. Amylase An enzyme which partially breaks starch down into maltose. Amylase is naturally excreted from the pancreas and saliva. This enzyme is important for Monosaccharides, the “M” in FODMAPs. Glucoamylase Converts starch into sugar like amylase, but is most active in a highly acidic pH. The inclusion of this component allows for many sugars to be broken down prior to exiting the stomach. This enzyme is important for Monosaccharides, the “M” in FODMAPs. Lactase The enzyme responsible for the hydrolysis of the milk sugar lactose into glucose and galactose. This enzyme is important for disaccharides, the “D” in FODMAPs. Cellulase An enzyme that digests cellulose, or plant fiber. Most animals (including humans) do not produce cellulase naturally and are therefore unable to use most of the energy contained in plant material without supplementation of the enzyme. Xylanase An enzyme with the ability to digest the polysaccharide xylan into xylose, which is a primary component of plant cell walls. There is some evidence that xylanase can help support the breakdown of certain artificial sweeteners and preservatives. Hemicellulase Breaks down hemicellulose, a type of polysaccharide that is more complex than simple sugar and present along with cellulose in all plant cell walls. Pectinase Breaks down pectin which is a robust component of plant cell walls. Pectin itself is not a FODMAP, but it is found in many high-FODMAP foods and is fermentable. This enzyme helps break down fermentable foods, the “F” that may not otherwise be classified as high-FODMAP foods. Diastase Breaks down starch into smaller sugar molecules known as maltose and glucose. This enzyme helps support the digestion of both mono and disaccharides, the “D” and “M” of FODMAP. Maltase Breaks down maltose into glucose, which is required for the body to be able to utilize the sugar as energy. This enzyme is important for Disaccharides, the “D” in FODMAPs. Invertase Also known as sucrase, is an enzyme that breaks down sucrose (a disaccharide) into its glucose and fructose building blocks. This enzyme is important for Disaccharides, the “D” in FODMAPs. Beta Glucanase Breaks down glycosidic bonds, which is essentially a bond that holds a molecule of sugar to a molecule of another carbohydrate. This enzyme is important for Disaccharides, the “D” in FODMAPs. FODMAP Probiotic Blend A blend of two powerful spore-based probiotics that can assist in balancing and restoring a healthy microbiome. Although there aren’t any digestive enzymes that directly break down polyols, the “P” in FODMAPs which are primainly contained in “Sugar Free” products, many FODMAP sufferers have gut microbiome imbalances that may contribute to Polyol intolerance. The combination of Bacillus subtilis and Bacillus clausii can help restore gut balance and support regularity by protecting against occasional constipation and diarrhea.

Arthur Andrew Medical FODMAP DPE – Digestive Support for FODMAP Sensitivities Suffer from Digestive Discomfort After Meals?For those who experience bloating, belching, discomfort, or even occasional diarrhoea following otherwise healthy meals, FODMAP DPE is here to help. If you're sensitive to certain sugars found in everyday foods, you're not alone. These sugars, known as FODMAPs, are commonly found in some of the most nutritious fruits, vegetables, grains, and legumes, but can be difficult to digest for many. FODMAP DPE is designed to provide digestive support, so you can enjoy your meals without worry. What are FODMAPs?FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) are a group of short-chain carbohydrates that are poorly digested by the body. When these undigested carbohydrates reach the gut, they ferment and produce gas, which can lead to discomfort such as bloating, flatulence, and occasional digestive upset. FODMAP DPE is a specialised formula that helps break down these hard-to-digest carbohydrates, supporting a more comfortable digestive experience. Why Choose FODMAP DPE? 1. Targeted Digestive Support:FODMAP DPE combines a potent blend of digestive enzymes and probiotics to help break down fermentable carbohydrates (FODMAPs) before they cause discomfort. This blend helps improve the digestion of certain foods, making it easier for your body to absorb nutrients and reducing the risk of bloating, gas, and abdominal discomfort. 2. Enjoy a Broader Range of Foods:FODMAP DPE allows those sensitive to FODMAP-rich foods to enjoy a wider variety of meals without the concern of digestive distress. It helps reduce the need for restrictive eating, allowing you to incorporate more foods into your diet while feeling confident in your digestive health. 3. Convenient and Easy to Use:FODMAP DPE comes in easy-to-take capsules that can be taken with meals containing high-FODMAP foods. This makes it simple to manage occasional digestive discomfort and enjoy dining out, social meals, or new foods with ease. 4. Probiotic Gut Balance:In addition to digestive enzymes, FODMAP DPE also contains spore-forming probiotics like Bacillus subtilis and Bacillus clausii, which help support a healthy gut microbiome. These probiotics can help restore balance to the gut, promote regular digestion, and assist in the digestion of polyols, one of the FODMAP groups. Key Ingredients in FODMAP DPE: Alpha Galactosidase: Helps break down complex sugars in beans, legumes, and cruciferous vegetables. Lactase: Aids in the digestion of lactose, commonly found in dairy products. Amylase & Glucoamylase: Assist in the breakdown of starches found in fruits and certain vegetables. Pectinase & Xylanase: Aid in the digestion of plant fibres, helping to prevent bloating and gas. Spore-Forming Probiotics: Bacillus subtilis and Bacillus clausii support gut balance and assist with the digestion of polyols, a common group of FODMAPs. How FODMAP DPE Works: FODMAP DPE contains a unique blend of digestive enzymes designed to target the specific FODMAP groups that often cause discomfort. Each enzyme plays a role in breaking down oligosaccharides, disaccharides, monosaccharides, and polyols, which are commonly found in high-FODMAP foods. The inclusion of spore-forming probiotics further supports digestive health, balancing the gut microbiome and assisting with digestion and nutrient absorption. Directions for Use: Take one capsule of FODMAP DPE with meals containing high-FODMAP foods or as directed by your healthcare provider. For optimal results, incorporate FODMAP DPE regularly into your digestive routine. Key Features: Digestive enzymes specifically designed for FODMAP digestion. Supports a healthy gut microbiome with probiotics. Reduces digestive discomfort from high-FODMAP foods. Ideal for those with FODMAP sensitivities, vegans, and adventurous eaters. Convenient, easy-to-use capsules. Note:  Consult a healthcare provider before use, particularly if you have a medical condition, are on medication, or are under medical care. Keep out of reach of children. Do not exceed the recommended dosage. This product is not intended to diagnose, treat, cure, or prevent any disease. If any adverse reactions occur, discontinue use and consult your healthcare provider. Get FODMAP DPE Today and Enjoy Your Meals Without the Discomfort!

Maximize the performance benefits of your protein supplement. Ideal for body builders, runners, fitness enthusiasts, or anyone with an active lifestyle1, Aminolase™ represents a breakthrough in protein nutrition for those using protein supplements or meal replacements to help build or maintain healthy muscle mass and accelerate muscle recovery. (Figure 1) Aminolase™ should be taken with protein rich foods and all protein supplements including the following: whey, milk, casein, soy, pea, rice and hemp. Protein supplements are one of the richest sources of all nine essential amino acids that the body is unable to produce on its own; however all protein must first be processed into a usable form, which includes essential amino acids and beneficial peptides (i.e., Di and Tri-peptides)3. To be effective, protein must be broken down into a smaller particle size within approximately 90 minutes of consumption4. This transit time represents the time from which protein passes from the stomach through the small intestine where digestion/absorption primarily occurs; from there it will be assembled into muscle building protein (a bio-usable form)4. Undigested protein will simply be excreted from the body, resulting in increased kidney stress and wasted amino acids, essentially pouring your expensive protein supplement down the toilet. (Figure 2) Aminolase Suggested Use Suggested Use: Consume 1 capsule of Aminolase™ per 25 grams of protein consumed. Aminolase capsules may also be opened and added directly to your favorite protein supplement. Aminolase is a vegetarian enzyme product which may increase protein bio-availability as much as 1000%. Decreased Stomach Discomfort - An Added Benefit When dietary protein is not broken down into its smallest components, large peptides are created that can cause stomach discomfort such as bloating, nausea and cramping. These symptoms should not be confused with food intolerances; generally, the underlying cause of protein-induced stomach discomfort is peptide sensitivity. Aminolase breaks down these large peptides, reducing the potential for discomfort that often comes from consuming protein supplements or dietary protein. (Figures 3 & 4) C-Reactive Protein (CRP) This study also measured levels of a common marker of inflammation; a protein called C-reactive protein. Elevated levels of this protein in the blood predict the onset of serious illnesses such as cardiovascular disease. Levels of C-reactive protein were measured when the participants consumed only the whey protein drink and again, five days later, when they consumed the whey protein drink with Aminolase™. An increase in C-reactive protein levels was observed for each of the participants when they consumed only the whey protein drink. On the other hand, after consuming the whey protein drink with Aminolase™, a significant decrease in C-reactive protein levels was observed for each individual. These results indicate the ability of Aminolase™ to hydrolyze large amounts of protein, improve the absorption of individual amino acids and significantly reduce inflammation that is associated with undigested proteins. Supplement Facts Acid Stable Protease A patent pending proteolytic enzyme that is capable of digesting every type of consumable protein; protease is responsible for digesting all ingested proteins and is one of the three enzymes found in our body’s natural pancreatic juices. Hundreds of prototypes were developed before the final product was chosen. Aminolase will completely break-down and digest all protein, food or supplement. Amionlase works great with animal and vegetarian dierived proteins. This proprietary blend of proteases is active over a very brough ph range, making it extremely effective in Acid and Alkalain environments. Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Aminolase TPA™Acid Stable Protease Blend 250 mg † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Aminolase™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed.    

Devigest Advanced Digestive Support is more powerful and concentrated than its earlier predecessors. Just one capsule with meals can ease the digestion of even the most troublesome of foods. Now more powerful and concentrated, Devigest can support reduced food irritations and sensitivities as well as reduce occasional abdominal gas and bloating. Devigest now contains a highly potent Peptidase with 500 units of DPP-IV activity per serving. Peptidase breaks down gluten and casein, two digestive irritants. Many formulas today have begun to utilize this amazing enzyme, but rarely is it incorporated in a broad spectrum blend, which leaves many formulas incomplete. Devigest is a complete and broad spectrum formula, making the need for supplementing other digestive enzyme products obsolete. Devigest also includes Alpha Galactosidase which is the active ingredient in the ever-popular product Beano®. Our bodies lack the enzymes that are responsible for breaking down certain carbohydrates in the small intestine. This causes improperly digested food to enter the large intestine where bacteria then begin to break it down, creating large amounts of gas which can lead to flatulence, abdominal bloating and digestive discomfort. Unlike many other gas medicines, Alpha Galactosidase can help prevent gas before it starts by breaking down the complex carbohydrates found in gassy foods into simpler, more easily digestible sugars. A similar phenomenon occurs with those that experience digestive distress when comsuming dairy foods. Lactose intolerance is the inability to break down lactose, which is milk sugar found in most dairy products. Lactose intolerance is the result of lacking the essential enzyme Lactase. Devigest now contains 444% more lactase than its predecessor per serving allowing those with lactose intolerance to enjoy dairy foods without the digestive distress. Proper digestion is a prerequisite for optimal health. Unless digestive physiology is in order, no other self-regulating or self-healing systems are able to perform in normal states. Devigest ADS serves not only in the aiding of the digestive process as a whole, but also therapeutic applications. Too often insufficient digestive enzyme production is overlooked as the culprit of indigestion and other digestive compliactions. Gas, bloating, incomplete digestion, and abdominal discomfort can play a part in the everyday life of many individuals. Properly digested foods add nutrients to our bodies, provide energy, and provide support to the countless other processes that are vital for proper human function. Supplementing with a high-quality digestive enzyme like Devigest ADS may be the answer to many of these concerns. Suggested Use Directions: Take 1 to 2 capsules between meals. Warning: Do not take Devigest without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Devigest safe? No serious or adverse side effects have been reported from taking digestive enzymes such as Devigest. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. When is the best time to take Devigest? For best results, take the product immediately prior to eating, or with your first bite. Devigest can also be taken after meals to alleviate digestive complications such as gas, bloating and indigestion. Can I take Devigest with other supplements? Devigest can be used safely with other dietary supplements. How long does it take for Devigest to work? The effects of digestive enzymes can be felt fairly quickly when taken after meals for indigestion, bloating or heartburn. When taking the product with meals containing foods that typically cause indigestion, the product should help alleviate the onset of these symptoms by assisting the body's digestive process. Supplement Facts Bromelain A proteolytic enzyme derived from pineapple. Bromelain attacks the long chain polypeptides of proteins ingested, breaking them down into shorter chain peptides, which are then able to be broken down further by other enzymes. Protease A proteolytic enzyme that is capable of digesting nearly every type of protein; protease is responsible for digesting the bulk of ingested proteins and is one of the three enzymes found in our body’s natural pancreatic juices. Devigest contains a blend of proteases to broaden the pH range of the product. Dipeptidyl Peptidase A proteolytic enzyme responsible for completing the digestion of peptides to basic amino acids. Dipeptidyl Peptidase is primarily responsible for the breakdown of gluten which is found in food items made from grains such as wheat or rye. Alpha Galactosidase The primary enzyme used in popular gas-relief products such as Beano®, alpha galactosidase is an enzyme responsible for breaking down complex sugars into simple sugars. This allows for certain foods such as cruciferous vegetables and legumes to be more easily digested, reducing intestinal gas. Amylase An enzyme which partially breaks starch down into maltose; amylase is naturally excreted from the pancreas and saliva. Lipase Triggers the breakdown of fat into fatty acids. Lipase is the third enzyme that is found in our body’s natural pancreatic juices along with protease and amylase. Glucoamylase Converts starch into sugar like amylase, but is most active in a highly acidic pH. The inclusion of this component allows for many sugars to be broken down prior to exiting the stomach. Lactase The enzyme responsible for the hydrolysis of the milk sugar lactose into glucose and galactose. Cellulase An enzyme that digests cellulose, or plant fiber. Most animals (including humans) do not produce cellulase naturally and are therefore unable to use most of the energy contained in plant material. Xylanase An enzyme with the ability to digest artificial food dyes and preservatives, and is usually lacking in other digestive formulas. Papain Derived from the papaya, papain hydrolyzes protein peptides into basic amino acids. Potassium and Calcium Bicarbonates Nutrients in the gastrointestinal tract are absorbed most efficiently when the environment is alkaline (pH over 7). Bicarbonates help to alkalize the digestive tract, allowing for optimal absorption of nutrients and can also ease the symptoms of indigestion when taken after meals. Hemicellulase Breaks down hemicellulose, a type of polysaccharide that is more complex than simple sugar and present along with cellulose in all plant cell walls. Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Calcium Carbonate 60 mg † Potassium Bicarbonate 50 mg † Devigest™ Proprietary Blend:Peptidase DPP-IV, Amylase, Glucoamylase, AlphaGalactosidase, Lactase, Bromelain, Acid Stable Protease, Cellulase, Xylanase, Lipase, Hemicellulase, Papain, B. subtilis 638 mg † Devigest™ Protease Blend:(pH Stable Proteases derived from A. oryzae and B. licheniformis) 52 mg † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Capsules) Devigest™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing. Frequently Asked Questions What is Devigest? Devigest ADS was formulated to replace Devacor, the first digestive enzyme blend introduced by Arthur Andrew Medical. Devigest is a broad spectrum digestive enzyme blend that will help restore the body’s digestive enzymes, supporting balanced digestion and complete food assimilation. Devigest includes a much more potent blend of enzymes for breaking down gluten and dairy products. Additionally, our own pancreatic enzymes require an alkaline pH for maximum activity. Sodium and potassium bicarbonates, which are normal components of pancreatic juices, have been added to ensure that a sufficiently alkaline medium is present. How is Devigest Different From its Predecessors? Devigest includes a highly potent Peptidase with 500 units of DPP-IV activity per serving. It also now contains Alpha Galactosidase (the active ingredient in the product Beano®) as well as higher potency enzymes such as Lactase, Acid-Stable Protease, and Glucoamylase. Devigest was formulated to be more effective and provide even more relief for those with sensitivities to gluten, casein, dairy, and much more. Those with a diet high in gassy foods such as legumes and cruciferous vegetables will highly benefit from the addition of Alpha Galactosidase. What are “Digestive Enzymes”? Enzymes are proteins that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and key. Devigest contains several enzymes or “keys” that can “unlock” (or breakdown) many of the typical types of food common in our diets. The enzymes in Devigest ADS are specific to the digestion of fats, carbohydrates, and proteins. Additional enzymes have been added to help digest dairy products as well as gluten and other food additives. How Do I Know if I Need Digestive Enzymes? A healthy body produces enzymes in sufficient quantities to ensure proper digestion of most foods. However, some people do not produce sufficient quantities of these enzymes, and often get the common symptoms of indigestion such as gas, bloating, heartburn, abdominal discomfort and constipation. These symptoms are common indicators that one may benefit from supplementation of a digestive enzyme. However, virtually everyone, even those who are asymptomatic, could benefit from the use of digestive enzymes. Why Devigest? Devigest ADS is the best choice for supporting optimal digestion. Unless digestive physiology is in order, no other self-regulating or self-healing systems are able to perform in optimal states, including immune function. Gas, bloating and abdominal discomfort can play a part in the everyday life of many individuals. Supplementing with a high-quality digestive enzyme may be the answer to many of these problems. How Does Devigest Work? Devigest ADS is an enzyme blend that allows for more complete digestion of fats, carbohydrates and proteins. Unlike Devigest, many digestive enzyme blends are incomplete as they lack the ability to break down common digestive irritants such as lactose and gluten. Devigest also includes an alkalization formula for optimal enzymatic activity. Is Devigest Safe? No serious or adverse side effects have been reported from taking digestive enzymes such as Devigest. Clinical studies have shown that even extremely large doses of these enzymes are not toxic.

Devigest Advanced Digestive Support is more powerful and concentrated than its earlier predecessors. Just one capsule with meals can ease the digestion of even the most troublesome of foods. Now more powerful and concentrated, Devigest can support reduced food irritations and sensitivities as well as reduce occasional abdominal gas and bloating. Devigest now contains a highly potent Peptidase with 500 units of DPP-IV activity per serving. Peptidase breaks down gluten and casein, two digestive irritants. Many formulas today have begun to utilize this amazing enzyme, but rarely is it incorporated in a broad spectrum blend, which leaves many formulas incomplete. Devigest is a complete and broad spectrum formula, making the need for supplementing other digestive enzyme products obsolete. Devigest also includes Alpha Galactosidase which is the active ingredient in the ever-popular product Beano®. Our bodies lack the enzymes that are responsible for breaking down certain carbohydrates in the small intestine. This causes improperly digested food to enter the large intestine where bacteria then begin to break it down, creating large amounts of gas which can lead to flatulence, abdominal bloating and digestive discomfort. Unlike many other gas medicines, Alpha Galactosidase can help prevent gas before it starts by breaking down the complex carbohydrates found in gassy foods into simpler, more easily digestible sugars. A similar phenomenon occurs with those that experience digestive distress when comsuming dairy foods. Lactose intolerance is the inability to break down lactose, which is milk sugar found in most dairy products. Lactose intolerance is the result of lacking the essential enzyme Lactase. Devigest now contains 444% more lactase than its predecessor per serving allowing those with lactose intolerance to enjoy dairy foods without the digestive distress. Proper digestion is a prerequisite for optimal health. Unless digestive physiology is in order, no other self-regulating or self-healing systems are able to perform in normal states. Devigest ADS serves not only in the aiding of the digestive process as a whole, but also therapeutic applications. Too often insufficient digestive enzyme production is overlooked as the culprit of indigestion and other digestive compliactions. Gas, bloating, incomplete digestion, and abdominal discomfort can play a part in the everyday life of many individuals. Properly digested foods add nutrients to our bodies, provide energy, and provide support to the countless other processes that are vital for proper human function. Supplementing with a high-quality digestive enzyme like Devigest ADS may be the answer to many of these concerns. Suggested Use Directions: Take 1 to 2 capsules between meals. Warning: Do not take Devigest without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Devigest safe? No serious or adverse side effects have been reported from taking digestive enzymes such as Devigest. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. When is the best time to take Devigest? For best results, take the product immediately prior to eating, or with your first bite. Devigest can also be taken after meals to alleviate digestive complications such as gas, bloating and indigestion. Can I take Devigest with other supplements? Devigest can be used safely with other dietary supplements. How long does it take for Devigest to work? The effects of digestive enzymes can be felt fairly quickly when taken after meals for indigestion, bloating or heartburn. When taking the product with meals containing foods that typically cause indigestion, the product should help alleviate the onset of these symptoms by assisting the body's digestive process. Supplement Facts Bromelain A proteolytic enzyme derived from pineapple. Bromelain attacks the long chain polypeptides of proteins ingested, breaking them down into shorter chain peptides, which are then able to be broken down further by other enzymes. Protease A proteolytic enzyme that is capable of digesting nearly every type of protein; protease is responsible for digesting the bulk of ingested proteins and is one of the three enzymes found in our body’s natural pancreatic juices. Devigest contains a blend of proteases to broaden the pH range of the product. Dipeptidyl Peptidase A proteolytic enzyme responsible for completing the digestion of peptides to basic amino acids. Dipeptidyl Peptidase is primarily responsible for the breakdown of gluten which is found in food items made from grains such as wheat or rye. Alpha Galactosidase The primary enzyme used in popular gas-relief products such as Beano®, alpha galactosidase is an enzyme responsible for breaking down complex sugars into simple sugars. This allows for certain foods such as cruciferous vegetables and legumes to be more easily digested, reducing intestinal gas. Amylase An enzyme which partially breaks starch down into maltose; amylase is naturally excreted from the pancreas and saliva. Lipase Triggers the breakdown of fat into fatty acids. Lipase is the third enzyme that is found in our body’s natural pancreatic juices along with protease and amylase. Glucoamylase Converts starch into sugar like amylase, but is most active in a highly acidic pH. The inclusion of this component allows for many sugars to be broken down prior to exiting the stomach. Lactase The enzyme responsible for the hydrolysis of the milk sugar lactose into glucose and galactose. Cellulase An enzyme that digests cellulose, or plant fiber. Most animals (including humans) do not produce cellulase naturally and are therefore unable to use most of the energy contained in plant material. Xylanase An enzyme with the ability to digest artificial food dyes and preservatives, and is usually lacking in other digestive formulas. Papain Derived from the papaya, papain hydrolyzes protein peptides into basic amino acids. Potassium and Calcium Bicarbonates Nutrients in the gastrointestinal tract are absorbed most efficiently when the environment is alkaline (pH over 7). Bicarbonates help to alkalize the digestive tract, allowing for optimal absorption of nutrients and can also ease the symptoms of indigestion when taken after meals. Hemicellulase Breaks down hemicellulose, a type of polysaccharide that is more complex than simple sugar and present along with cellulose in all plant cell walls. Supplement Facts Serving Size: 2 Capsules Amount Per Serving* % Daily Value Calcium Carbonate 60 mg † Potassium Bicarbonate 50 mg † Devigest™ Proprietary Blend:Peptidase DPP-IV, Amylase, Glucoamylase, AlphaGalactosidase, Lactase, Bromelain, Acid Stable Protease, Cellulase, Xylanase, Lipase, Hemicellulase, Papain, B. subtilis 638 mg † Devigest™ Protease Blend:(pH Stable Proteases derived from A. oryzae and B. licheniformis) 52 mg † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Capsules) Devigest™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing. Frequently Asked Questions What is Devigest? Devigest ADS was formulated to replace Devacor, the first digestive enzyme blend introduced by Arthur Andrew Medical. Devigest is a broad spectrum digestive enzyme blend that will help restore the body’s digestive enzymes, supporting balanced digestion and complete food assimilation. Devigest includes a much more potent blend of enzymes for breaking down gluten and dairy products. Additionally, our own pancreatic enzymes require an alkaline pH for maximum activity. Sodium and potassium bicarbonates, which are normal components of pancreatic juices, have been added to ensure that a sufficiently alkaline medium is present. How is Devigest Different From its Predecessors? Devigest includes a highly potent Peptidase with 500 units of DPP-IV activity per serving. It also now contains Alpha Galactosidase (the active ingredient in the product Beano®) as well as higher potency enzymes such as Lactase, Acid-Stable Protease, and Glucoamylase. Devigest was formulated to be more effective and provide even more relief for those with sensitivities to gluten, casein, dairy, and much more. Those with a diet high in gassy foods such as legumes and cruciferous vegetables will highly benefit from the addition of Alpha Galactosidase. What are “Digestive Enzymes”? Enzymes are proteins that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and key. Devigest contains several enzymes or “keys” that can “unlock” (or breakdown) many of the typical types of food common in our diets. The enzymes in Devigest ADS are specific to the digestion of fats, carbohydrates, and proteins. Additional enzymes have been added to help digest dairy products as well as gluten and other food additives. How Do I Know if I Need Digestive Enzymes? A healthy body produces enzymes in sufficient quantities to ensure proper digestion of most foods. However, some people do not produce sufficient quantities of these enzymes, and often get the common symptoms of indigestion such as gas, bloating, heartburn, abdominal discomfort and constipation. These symptoms are common indicators that one may benefit from supplementation of a digestive enzyme. However, virtually everyone, even those who are asymptomatic, could benefit from the use of digestive enzymes. Why Devigest? Devigest ADS is the best choice for supporting optimal digestion. Unless digestive physiology is in order, no other self-regulating or self-healing systems are able to perform in optimal states, including immune function. Gas, bloating and abdominal discomfort can play a part in the everyday life of many individuals. Supplementing with a high-quality digestive enzyme may be the answer to many of these problems. How Does Devigest Work? Devigest ADS is an enzyme blend that allows for more complete digestion of fats, carbohydrates and proteins. Unlike Devigest, many digestive enzyme blends are incomplete as they lack the ability to break down common digestive irritants such as lactose and gluten. Devigest also includes an alkalization formula for optimal enzymatic activity. Is Devigest Safe? No serious or adverse side effects have been reported from taking digestive enzymes such as Devigest. Clinical studies have shown that even extremely large doses of these enzymes are not toxic.

These symptoms are far too common because of the imbalanced levels of natural hormones and the increasing exposure to dangerous exogenous sources of oestrogen. In fact, many people believe that the signs of hormonal imbalances are the new normal. The good news is that ladies can start to feel at ease with Femesse once more. Women will be back on track to feeling their best and looking their best thanks to this safe and natural solution that is made to normalise hormonal activity and get rid of external influences. Femesse Product Information We learn from eastern and integrative medicine that the exterior characteristics of the human body are influenced by our organ systems. This demonstrates that the hormonal system controls the health of the skin and breasts. Women generally notice an undesirable difference in their skin and breast tissue when their hormonal system is out of balance and not functioning at its best as a result of toxicity and nutritional inadequacies. In order to support strong and attractive breast tissue, healthy, supple skin, and regulated hormone levels, Femesse is a special blend of herbal extracts, vitamins, minerals, and botanicals. Femesse may also help to lessen a number of unpleasant menstrual cycle and menopausal symptoms. Femesse supports internal health and attractiveness so that women can experience the highest level of wellbeing and external beauty. Promoting Healthy Hormone Levels: How Femesse Works Femesse supports the female body by supplying essential nutrients such as maitake mushrooms, evening primrose, vitamin E, selenium, zinc, and other natural herbs that can support the liver and detoxification systems of the body as well as encourage the health of hormones, skin, and glandular tissue. Since the liver serves as the main location for hormone processing, Femesse is essential to the detoxification process. The ability to treat PMS also depends on having a healthy liver (premenstrual syndrome). Since this delicate tissue makes up the breasts and hormone-producing organs in women, maintaining glandular health is crucial. Because of the sharp decline in hormone levels that occurs as women age, their skin and breast tissue become dry and droop. The firmness of a woman’s breast is due to glandular tissue. The glandular tissue starts to shrivel and is replaced by fat when hormone levels are low. The breasts soften and lose their support as a result of this alteration in the breast tissue. Femesse’s patented herbal blend doesn’t actually include any hormones, but it does contain Pueraria Mirifica, a vital nutrient and phytoestrogen that may help the body generate female hormones in a regular, healthy proportion. Femesse offers the resources required to keep these organs feeling, looking, and performing at their peak levels. Women will soon start to notice and experience the difference. Femesse Product Ingredients Vitamin E A potent antioxidant that has a reputation for being a natural anti-aging food. Organs that produce hormones need vitamin E to operate properly and to shield cells in the body from free radical damage. This vitamin makes the skin’s capillaries stronger, which enhances hydration and suppleness. Along with regulating the menstrual cycle and dramatically enhancing immunological function, vitamin E also assists in reducing the cramps, anxiety, and cravings linked to PMS. Vitamin B6 As a vitamin in the B complex family, vitamin B6 plays a major role in maintaining a healthy nervous system and metabolism. Additionally necessary for healthy skin and eyes, it also supports regular liver function. By controlling blood sugar levels, producing antibodies for healthy immunological function, and transporting oxygen in red blood cells, vitamin B6 participates in most of the body’s major physiological processes. Folate Folate, often known as folic acid, is another B vitamin. Folate is a water-soluble vitamin that helps to maintain immune and nervous system health as well as DNA synthesis. People who don’t get enough folate can develop anaemia. Folate promotes healthy glandular tissue, heart health, cognitive function, and pregnancy. Zinc A specific metal that is a crucial trace element. To maintain numerous essential bodily processes, this metal is required in minute amounts each day. Zinc promotes good digestion, a robust immune system, regular liver function, and healthy hormone production. Selenium A little mineral with a significant physiological function. All antioxidants’ capacity and availability are increased by selenium. Antioxidants wouldn’t be able to scavenge free radicals without selenium, and inflammation would become unmanageable. Selenium increases blood flow, controls thyroid function, and strengthens the immune system. Dong Quai Dong Quai, sometimes referred to as “female ginseng,” has been used for generations as a female tonic. It is a natural plant that relaxes the uterine muscles to facilitate comfortable menstruation. Dong Quai is also used to increase sex desire, enhance cardiovascular health, regulate hormones, relieve stress and anxiety, and raise vitality. Damiana Indigenous people in Central and South America traditionally used the leaves of the Damiana plant to make a relaxing/aphrodisiac tea. Damiana is still widely used as an herbal tonic and body cleanser. The active chemical in this herb, known as Damianin, has been shown to balance hormones as an AROMATASE INHIBITOR, as well as a potent herb for lowering blood sugar. This powerful and natural herb is recognized in the PHYSICIAN’S DESK REFERENCE as an herbal medicine for promoting relaxation, weight loss, and for boosting libido. Saw Palmetto Saw Palmetto, which comes from a palm tree with slow growth, is frequently used to treat enlarged prostates in male patients. However, studies have shown that Saw Palmetto can help women balance their hormones quite well. It encourages gorgeous skin by regulating oil production. Saw Palmetto aids in strengthening vaginal and uterine tissue to prevent stretching or tearing as women become older because these tissues can grow weaker. Fenugreek Fenugreek, a perennial herb also known as Greek hay, belongs to the pea family (Fabaceae). It has a long history of use as an ingredient in traditional medicine and is grown in North Africa, the Middle East, Egypt, and India. It offers antioxidant, balanced blood sugar, and long-term digestive health benefits. Fenugreek is a fantastic supporting ingredient for reducing discomfort related to the menstrual cycle since it supports digestive comfort and proper inflammatory response. Blessed Thistle Since the Middle Ages, this plant has been utilised in herbal therapy. Blessed Thistle is a dietary supplement that supports the health of the liver, gallbladder, and intestines. Additionally, it is recognised for its capacity to elevate mood, particularly in menopausal or menstruating women. Fennel Fennel is a natural plant chemical with antioxidant characteristics that functions as a mild female hormone and is one of the most popular herbs used to improve women’s health. Fennel works well to control menstruation and relieve menopausal symptoms because of this. Additionally, this herb is loaded with nutrients, including vitamins, minerals, and dietary fibre. Pueraria Mirifica The main ingredient that gives Femesse its effectiveness is Pueraria Mirifica, sometimes called White Kwao Krua, which has historically been utilised as a vitality booster for older women. This plant supports the body’s capacity to maintain healthy levels of female hormones since it is a potent phytoestrogen. Normal skin elasticity and moisture as well as firm breast tissue are supported by healthy hormone levels. Wild Yam Native Americans have used wild yam to assist the female body’s regular functions. For patients with endometriosis, this herb is frequently used to ease cramping and discomfort during the menstrual cycle. Safely promoting normal digestion and healthy blood sugar levels is wild yam. Additionally, it is well known for easing menopausal symptoms like mood swings, night sweats, and hot flashes. Marshmallow King Tut employed this plant, which is derived from the marshmallow root, to treat stomach issues as well as to support a healthy immune system. This natural herb has been added because it can help maintain healthy skin and reduce fluid retention in people who are going through menopause or PMS. Violet Violet supports liver health and has a long history of use as a calming herb and a mood stabiliser. This plant helps with regular digestion and gets rid of constipation. Women’s menstruation pain has been known to be lessened by violet. Cumin Cumin, a spice that is widely popular in Mexico, India, and the Middle East, has antioxidant characteristics and aids in promoting healthy digestion, blood sugar levels, and sleep. Cumin improves metabolism and helps to curb sugar cravings, making it an ideal supporting food for maintaining a healthy weight. Hops Beer is famous for containing this fragrant flower. Many scientists concur that hops have a calming effect, which may explain why many people report feeling less tense after consuming beer. Additionally, hops can help women balance their hormones. In one study, vaginal gel containing hops was used by 100 postmenopausal women who reported decreased vaginal dryness, itching, and burning as well as less pain during sex. Maitake Mushroom Maitake mushrooms, also known as Grifola frondosa, are indigenous to Japan. A unique kind of fibre found in maitake mushrooms has been demonstrated to support heart health, blood sugar regulation, immunological function, and healthy weight maintenance. Additionally supporting appropriate glandular and lymphatic drainage is this medicinal meal. Lecithin A fatty extract obtained from vegan sources that is the primary constituent of brain tissue and is spontaneously created by body cells. In addition to promoting healthy cell activity, lecithin also helps the heart, liver, and gallbladder work normally. Additionally necessary for skin and breast tissue regeneration is lecithin. Gamma Linoleic Acid Gamma linoleic acid, also referred to as GLA, is an Omega-6 fatty acid obtained from the evening primrose plant. GLA encourages healthy skin and maintains a normal inflammatory response. . Suggested Use Directions: Take four (4) capsules of Femesse two (2) times daily with eight ounces of water or as directed by your healthcare provider. It is recommended that the product be taken for a minimum of three (3) months before assessing results. Individual results may vary. Warning: Temporary soreness of the breast may occur. Do not take this product if pregnant or nursing. Caffeine Warning: Caffeine may disrupt the effectiveness of Femesse. For best results, refrain from consuming caffeinated beverages 30 minutes before and after the consumption of Femesse.

FibroVera is a proprietary blend of microbial and botanical components selected to support uterine and breast health. Reproductive health is an important topic for men and women alike. For women however, understanding and feeling confident about the body and the ebb and flow of the menstrual cycle is almost always a daily concern. FibroVera is a gentle option that offers the opportunity of bringing balance back to women’s hormone levels. FibroVera is an all-natural unique blend of hormone balancing botanicals and enzymes designed to help women support health concerns stemming from hormonal irregularities. FibroVera provides fibrinolytic (fibrin eating) enzymes and cofactors that are specifically selected to promote normal fibrin activity. Healthy hormone levels will naturally promote normal fibrin activity as well as support normal premenstrual symptoms. FibroVera is intended to modulate the hormonal response, restoring inherent processes in a woman's body. Each component was carefully selected using only well researched and clinically supported ingredients. Dr. Andrew L. Rubman is a naturopathic physician and founder of the Southbury Clinic for Traditional Medicines in Connecticut. He is a member of the American Association of Naturopathic Physicians and was inducted into the association's elite Founder's Club. He is also a Fellow of the International Association for Medical Preventics and a member of the National Center for Homeopathy, the Orthomolecular Medical Society, and the National Science Honor Society. His most current project has landed him as the primary formulator of Fibrovera AHS, a unique blend of botanical components clinically documented to restore hormonal balance in woman. Hormone modulating ingredients, combined with fibrinolytic enzymes, provides women with a direct defense against uterine and breast abnormalities. Like us on Facebook and stay up to date on all specials and product giveaways.   Estrogen Dominance The phenomenon of Estrogen Dominance has been widely discussed with its relationship to fibroid growth. It is a prime contributor to the deregulation of normal function experienced by not only women approaching, transitioning, and resolving the challenge of menopause, but also those young women experiencing difficulty with menarche (the beginning of fertility). This imbalance is initially characterized by a number of factors: A decrease in DHEA due to stress, aging, poor diet, side effects of prescription drugs etc. A decrease in progesterone effect due to absolute decrease in synthesis secondary to inadequate cholesterol down-conversion and increasing insensitivity of progesterone receptors. The activation of a cross-conversion pathway that forces progesterone to act as a source for the synthesis of estrogens; decreasing both its bioavailability as a hormone, and as a substrate for the formation of adrenal cortical hormones. This concept, unfortunately like most of endocrinology, is difficult for the average person as well as many physicians to fully comprehend. Why is this concept important? It demonstrates that the best way to not only address conditions such as abnormal tissue growth and inflammation, is by providing the body with natural compounds that it can use to enhance processes that it already has in place to decrease symptoms and potentially undo tissue changes. The inclusion of a DHEA supplement may indirectly increase progesterone synthesis and act to alleviate the need for available progesterone scavenged to promote a significant source for the synthesis of estrogen; relying less on progesterone as source for estrogen conversion allowing progesterone to act freely opposing estrogen. [19],[20] This process is further supported by specifically including DIM in FibroVera, to discourage the aromatization of testosterone into estrogens. I have studied the emerging literature and incorporated it into treatment regimes for over a decade and now feel comfortable enough about its metabolism and effects to include it in an OTC formula. Yes, it is a steroidal hormone precursor, however at the dosage levels supplied; it can be regarded as underwriting the proper synthesis of the estrogens and testosterone as well as the balance and effects of a myriad of neurotransmitters in the central nervous system. It is included at synergistic dose levels to help the individual not only do better, but feel better as well. The peer-reviewed research supports the safety and efficacy of DHEA and this inspires our choice and confidence   Suggested Use Directions: Take 1 to 2 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. Warning:Do not take FibroVera without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is FibroVera safe? No serious or adverse side effects have been reported from taking FibroVera. If you are taking blood-thinning medication, you should consult with your physician before taking FibroVera. When is the best time to take FibroVera? For best results, take the product at least one hour prior to eating and/or two hours after a meal. Can I take FibroVera with other supplements? FibroVera can be used safely with other dietary supplements. How long does it take for FibroVera to work? For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, when one is addressing hormonal challenges with a product such as FibroVera, symptoms of hormonal change can occur in a matter of days. This is the first step in the process, and the most important, as hormonal imbalances left in their unbalanced state can lead to a variety of health concerns.   Supplement Facts Fibrinolytic Enzyme Blend Hormonal changes can often trigger excessive fibrin fibrin production. The proprietary fibrinolytic enzyme blend in FibroVera has been added to support healthy fibrin levels. Fibrinolytic enzymes can enhance the normal process of fibrinolysis (fibrin dissolving). Serrapeptase and nattokinase are exceptional fibrinolytic enzymes. Bromelain, an enzyme derived from pineapple, has the potential to soften and digest necrotic (or dead) proteins. Papain, a protease enzyme derived from papaya, is often combined with bromelain to support healthy inflammatory levels. Coenzyme Blend Calcium and magnesium adequacy are essential to pain modulation, as well as cramping and other PMS symptoms, and have been added as active ingredients as well as coenzymes. High doses of systemic enzymes can deplete the body’s coenzyme resources. Coenzymes provide the “fuel” necessary to power the processes of enzymes. Magnesium is a very active coenzyme, and is also essential in proper absorption of calcium. Hormonal Support Blend FibroVera also contains a proprietary blend of hormone modulating compounds that work synergistically to restore hormonal equilibrium. P5P, a vitamin B6 derivative is used by the central nervous system in the synthesis of two important neurotransmitter. Serotonin deficiencies are related to depression, sleep disturbances, and even fatigue. GLA, or gamma-Linolenic acid, is an omega-6 fatty acid that has been shown to support a healthy inflammatory response. Diindolmethane, also known as DIM, is an extract derived from cruciferous vegetables. DIM has been shown to modulate estrogen metabolism. The inclusion of DHEA, Dehydroepiandrosterone, may indirectly increase progesterone synthesis, in turn supporting hormone balance. The female tonic Dong Quai produces a relaxing effect on the muscle of the uterus by decreasing sensitivity to inflammation, making it useful for painful menstruation and tenderness. Liver Cleansing Blend As the primary site of hormone metabolite processing, healthy liver function is essential. Milk Thistle Seed has been studied extensively for its use in supporting healthy liver function. In conjunction with Dandelion Root and Hyssop Flowers, it serves to increase the liver’s ability to bind hormonal metabolites to bile and effectively move them into the intestine for excretion. Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Propretary Blend Fibrovera AHS™ 730 mg † Fibrinolytic Enzyme Blend:Serrapeptase, Protease, Bromelain, Papain, Nattokinase NSK®     Cofactor Blend:Calcium Caprylate, Magnesium Ammoniate     Estromin® Hormonal Support Blend:P5P (Pyridoxal-5-Phosphate), GLA (Gamma- Linolenic Acid), DIM (Diindolylmethane), 5 HTP, DHEA (Dehydroepiandrosterone), Dong Quai Root (Angelica Sinesis)     Liver Cleanse:Milk Thistle Seed, Dandelion Root, Hyssop Flowers     * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (Capsules), Maltodextrin Fibrovera™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed.   Frequently Asked Questions Will FibroVera help me when I become menopausal? The FibroVera formula was specifically formulated to help support many of the symptomatic challenges experienced by women in hormonal transitions. It is well to consider that many of the fluctuations preceding the cessation of menses may begin a full decade before. As many know, symptom clusters may persist many months and even years after the event. We believe that women experiencing difficulty associated with menopause will note substantial improvement with the consistent use of FibroVera. Can I take FibroVera if I am trying to conceive? FibroVera does not contain any ingredients that will negatively impact conception. However, if you become pregnant while taking FibroVera, or are nursing presently, discontinue use and ask your health care provider for advice on how to proceed. We are aware of the special concerns of pregnant women and our role in insuring safety. Unless drugs, OTCs, and supplements are specifically tested for their safety and efficacy while pregnant and nursing, they should not be used unless specifically evaluated and approved by your physician. Is FibroVera right for all women? FibroVera was designed with every woman in mind. FibroVera does not directly impact hormones. FibroVera provides the key ingredients that metabolize unwanted (non-beneficial) hormone metabolites while promoting the secretion and balance of good (beneficial) ones. FibroVera's ingredients are all natural components that work to replenish missing factors from diet, restoring the inherent processes in any woman's body. Can I take FibroVera with other supplements? FibroVera may be safely taken with Neprinol and other dietary supplements. Neprinol can increase the fibrinolytic (fibrin lysing) portion of FibroVera. Syntol can replenish beneficial flora in the body, and Devacor may reduce gastrointestinal stress induced by the process of digesting foods low in natural enzymes. If I am anemic, can I safely take FibroVera? Excessive blood loss can occur during menstruation. For many forms of anemia, we recommend your healthcare provider consider a heme-iron preparation, a B12 supplement, and folic acid with additional multi-B support to address this situation. If you believe that you are or may be anemic, please consult with your health care provider. Does FibroVera contain soy? Soy food products have been a dietary staple for many cultures for centuries and have undeniable benefits. However, we felt it was best not to include these components in the formula at this time. What can I expect from FibroVera? FibroVera has been designed to work as a part of a balanced food and supplement regimen to target those symptoms associated with hormonal imbalances complicated by inflammation and fibrous tissue changes. In the short term, usually within a few weeks, women should expect to feel and function better. Within a few months, they should notice a decrease in the effects of such issues as fibrous tissue abnormalities and endometriosis. FibroVera can be safely used without significant side effects or dangerous interactions with prescription drugs. Is FibroVera safe? No serious or adverse side effects have been reported from taking FibroVera. If you are taking blood-thinning medication, you should consult with your physician before taking FibroVera.

Maximize the strength of any probiotic with the worlds's first supplemented prebiotic “PHAGE." Phage or Bacteriophages are microscopic proteins that target and devour certain harmful bacteria.* When Floraphage dismantles bad bacteria within the gut, nutrients are released turning bad bacteria in the upper GI tract into high-quality food for good bacteria. Based on lab testing with several popular probiotic supplements, this remarkable prebiotic was able to increase the growth rate of supplemented probiotics by 24x compared to control.* Avoid uncomfortable symptoms such as gas and bloating that come along with standard prebiotics and improve the performance of any probiotic formula.* Floraphage for Digestive Health The human digestive tract contains trillions of microorganisms that constantly compete for space and nutrients. This system can be highly susceptible to attacks from harmful bacteria, which can result in digestive discomfort and a weakened immune system. It is therefore important for beneficial bacteria to outperform these harmful bacteria so that proper intestinal balance and overall good health can be achieved. Unfortunately the opposite can sometimes occur, in which aggressive strains of harmful bacteria outgrow and consume more resources than the beneficial bacteria. This phenomenon can be associated with poor health, abdominal discomfort, and bacterial infections. To combat these intestinal imbalances and their damaging effects, Floraphage has been developed to support the restoration and maintenance of the highly sensitive digestive ecosystem. Why Floraphage? Floraphage was designed to support the proliferation of beneficial bacteria throughout the gastrointestinal tract in order to promote optimal digestive and immune health. Floraphage was tested in conjunction with four popular probiotic supplements to determine its ability to increase the growth rate for each respective product. The graph on the right demonstrates the average increase in CFU activity, the measurement of probiotic bacteria growth, for the four products was 2400%, versus control (growth without the use of Floraphage). Floraphage is an excellent product to take in conjunction with a probiotic to maximize the benefits of supplemented beneficial bacteria. It is also helpful for those that do not take probiotics in order to maximize indigenous bacteria growth. What is Floraphage? Floraphage is a bacteriophage (or phage), which is a microscopic protein that can target and destroy one particular type of bacteria. Floraphage is selectively-antimicrobial, specifically attaching to only harmful bacteria. Once a phage has attached itself, these “bad” bacteria essentially burst open, releasing more phage and nutrients, known as prebiotics, for our good bacteria to feed on. Floraphage can only attach itself to harmful bacteria, and can never enter or harm good bacteria or human cells. Phages are everywhere, in our food, in the water we drink, on and in our bodies, and pretty much anywhere else imaginable. They are actually the most abundant naturally occurring organisms on earth. Phages have been safely used for over 90 years in the food supply and as a therapy for antibiotic resistant strains of bacteria. Floraphage is the first dietary supplement formula to utilize these amazing microscopic proteins. How Does Floraphage Work? Floraphage specifically targets bad bacteria and destroys their cell wall, releasing nutrients that provide good bacteria with the food and space that are needed for substantial growth in the digestive tract. In doing so, Floraphage reverses the growth pattern of certain bad bacteria and allows good bacteria to proliferate in their place. Since Floraphage forces the release of nutrients from bad bacteria, it inherently acts as a two-phase super-prebiotic. During the first phase, Floraphage selectively attacks certain bacteria, creating space along the intestinal wall. The second phase occurs organically when these bacteria burst open and release prebiotic nutrients. Prebiotics help beneficial bacteria grow faster than harmful bacteria. More specifically, prebiotics are natural sources of nutrients that provide benefit by stimulating the growth and activity of good bacteria in the digestive tract. Prebiotic supplements have historically been made up of some type of fiber or sugar, which have been known to lead to gas and bloating. Floraphage is not comprised of fiber or sugars, so the potential for digestive distress is eliminated while providing its super-prebiotic benefits. How Safe is Floraphage? Floraphage represents a tiny fraction of the total phages contained in the body, as the gut is a natural habitat for bacteria and phages. Floraphage does not contain genetic elements that are harmful to humans. Furthermore, Floraphage is not constructed in a manner that would enable it to negatively impact any beneficial bacteria. Therefore, Floraphage presents no harm to the natural microbial flora of the intestine. In addition, Floraphage has GRAS status with the FDA. Benefits of Floraphage Include: Increase the potency of any probiotic Does not cause digestive discomfort Selective anti-microbial properties Can be taken alone or in combination with a probiotic Does not contain GMOs 1. Jarro-Dophilus EPS is a registered trademark of Jarrow Formulas, Inc. and has no affiliation with Arthur Andrew Medical. 2. Dr. Ohhira's Probiotics is a registered trademark of Jarrow Formulas, Inc. and has no affiliation with Arthur Andrew Medical. 3. PB-8 is a registered trademark of Jarrow Formulas, Inc. and has no affiliation with Arthur Andrew Medical.

KD Ultra combines vegan-sourced Vitamin D3, a full-spectrum blend of Vitamin K, and the enzyme lipase to support strong bones, cardiovascular health and immune function. Vitamins K and D have a synergistic relationship that promotes strong bones and cardiovascular health. If you don’t include both in your supplement routine, you could be missing out! According to a research study, health professionals increased testing for Vitamin D sevenfold between 2008 and 2013, and it’s thought that over 1 billion people are deficient in this vital nutrient. In addition, adequate vitamin K is actually necessary to get the health benefits we’ve all come to know about vitamin D. That’s why we formulated KD Ultra to include everything you need for broad-spectrum benefits in a single supplement. KD Ultra combines 2500 IUs of vegan Vitamin D3 with a fullspectrum blend of the available Vitamin K2 chains (referred to as menaquinones) MK4, MK6, MK7 and MK 9 (MKs) as well as Vitamin K1 for the ultimate health benefits of each component. However, because Vitamins D and K are fat-soluble (meaning they dissolve in fat), we added the enzyme [lipase] to break down ingested fats, allowing your body to properly release the vitamins from fat and absorb them efficiently. That means no more missing out on all the perks of taking your vitamins! BONE AND JOINT Everyone knows the importance of calcium for healthy bones, but how important are Vitamins K and D? There are many factors that can impact the bone health of millions of American adults, which can lead to fragile bones and high fracture risk. Vitamin K2 plays an essential role in overall bone health through its involvement in the production of bone proteins. One such protein is osteocalcin (OC), a Vitamin K-dependent protein (VKPD) produced during bone formation by specialized bone cells called osteoblasts. VKDPs are involved in blood coagulation, bone metabolism, and prevention of blood vessel hardening. OC depends on Vitamin K for a vital chemical modification called carboxylation. Low Vitamin K intake results in inadequate levels of carboxylated OC, which is linked to decreased bone health and density. Vitamin D is essential for strong bones as well because it helps the body use calcium from diet and supplementation appropriately. Low levels of Vitamin D have been associated with soft and brittle bones and are likely due to the fact that without D, the body can only absorb between 10-15% of its dietary calcium. Adequate levels of Vitamin D help the body with calcium absorption, bone health, and immune function. HEART HEALTH The Importance of Vitamin K2 in Cardiovascular Health Vitamin K2s various menaquinones (MKs) may also play an essential role in cardiovascular health. The buildup of calcium in blood vessel walls, known as calcification, reduces their flexibility and increases the risk of cardiovascular complications. Matrix Gla-protein (MGP), a critical VitaminK-dependent protein, helps prevent calcium buildup in blood vessels. However, MGP relies on Vitamin K to function properly. Thus, adequate Vitamin K intake is essential for supporting MGP function and its resulting impact on vascular and cardiovascular health. A high intake of Vitamin K is associated with reduced blood vessel calcification and a reduced risk of cardiovascular issues. Accordingly, a high intake of MKs, particularly MK7 and MK9, is thought to protect the heart. MK7 is also specifically associated with decreased blood vessel stiffness. Studies have suggested other potential roles of MKs, as Vitamin K is a crucial component in proper blood clotting. Without enough Vitamin K, excessive bleeding can occur, particularly during injury or surgery. Anticoagulants such as warfarin block the activity of Vitamin K, so individuals taking these medications need to maintain consistent Vitamin K intake through diet or supplement use. Current research suggests that long-chain MKs such as MK7 have a more significant impact on normal blood coagulation than K1 or MK4, while MK4 is thought to be superior for bone health. Therefore, a full-spectrum Vitamin K product is important, as not all Vitamin K is created equally. IMMUNE Essential Vitamins for Effective Immune System Support Vitamin D is often overlooked when it comes to its effects on the immune system. This is largely due to the fact that most people think they have adequate levels under the assumption that they are getting it through sunlight. Although Vitamin D can be obtained naturally through sun exposure, several factors make it challenging to get enough of this vital nutrient from the sun alone. Season, time of day, day length, cloud cover, smog, shade, sunblock, and geographic region all impact UVB exposure and the potential for Vitamin D production. Age and skin color also impact Vitamin D production; dark-skinned individuals produce less Vitamin D than their light-skinned counterparts. Additionally, the skin of older adults does not produce as much Vitamin D when exposed to sunlight as skin in younger people. Due to these numerous issues, over 40% of people are thought to be deficient in Vitamin D. Cod liver oil, a rich source of Vitamin D, has been widely utilized for centuries to increase protection from infections. It is also thought to be the reason why Scandinavian countries have a very low incidence of Vitamin D deficiency despite the fact that they are located in very high latitudes where the sun is less able to provide the proper UVB rays for natural Vitamin D production. Studies have demonstrated that those with healthy Vitamin D levels had a lesser instance of respiratory infections than those with sufficient levels, even after adjusting for variables such as gender, age, season and race. Vitamin D is not very prevalent in foods outside of seafood and dairy products (and dairy products are fortified with D2 (more on that below), so the vitamin D is not even naturally occurring), and until recently was not available from a plant source. KD Ultra offers a broad-spectrum Vitamin K2 blend as well as 2,500 IUs of vegan-friendly sourced D3 per capsule. INGREDIENTS Vitamin D3 Our formula includes vegan vitamin D3 (the natural form produced by the skin upon exposure to sunlight) from reindeer lichen. Vitamin D regulates calcium and phosphorous levels to form and maintain strong bones. It also plays a role in calcium absorption, bone health, immunity, muscular function and inflammation. What is the difference between vitamin D2 and vitamin D3? These two forms of Vitamin D were thought to be equivalent, however, that is far from the truth. Vitamin D2, or ergocalciferol, is inexpensive to produce and almost always what is found in forti-fied foods. It is actually less potent and has a shorter duration of action than its Vitamin D3 counterpart known as cholecalciferol. What are lichens you ask? Lichens are naturally occurring organisms found throughout the world and can best be described as a fungi-algae sandwich, two different organisms that live together as one. The fungi actually protect the algae which allows lichens to grow in some of the most extreme environments the world can offer. A majority of supplemental Vitamin D3 is chemically stripped from lanolin, a yellow waxy oil found in sheep’s wool and then irradiated to produce D3. KD Ultra uses a naturally derived D3 from lichen, a much cleaner and natural form of this vital nutrient. Vitamin K Vitamin K comes in many forms and is essential for proper Vitamin D utilization. Our formula includes Vitamin K1 as well as all available supplemental forms of Vitamin K2 (MK4, MK6, MK7 and MK9) for full-spectrum health benefits. Vitamin K supports proper blood clotting, strong bones and reduced blood vessel calcification for improved cardiovascular health. Lipase Lipase is an enzyme that breaks down lipids (fats) and fat-soluble vitamins. Without enough lipase, fats cannot be fully broken down and properly absorbed by the body. This may limit the benefits you expect to get from taking your vitamins. Lipase is essential for complete vitamin assimilation, which is why we have included it in our proprietary formula. KD Ultra Components Per Capsule Vitamin K2 (Total): 1600 mcg • MK4- 1500 mcg • MK6- 8 mcg • MK7- 60 mcg • MK9- 32mcg Vitamin K1: 100 mcg Vitamin D3 (from reindeer lichen): 2500 IU Lipase: 500 FIP Order KD Ultra today to support strong bones and a healthy cardiovascular system with the convenience of a single supplement! SUGGESTED USE Directions: Take 1-2 capsules daily of KD Ultra, or as directed by your healthcare practitioner. If taking more than one capsule, they may be split up and taken with each meal, or taken all at once. Warning: Do not take this product without the consent of your physician if you are currently taking anti-coagulants, or if you are pregnant or nursing. FAQS How do vitamins K and D work together to provide health benefits? Vitamin D has been found to support bone heath and a well-functioning cardiovascular system. But to get the greatest results from taking Vitamin D, you also need Vitamin K. Vitamin D promotes the production of Vitamin K-dependent proteins (VKDPs), which serve essential roles in bone growth and the vascular system. Vitamin K is necessary for carboxylation, a chemical alteration, of two specific VKDPs: osteocalcin and matrix Gla protein (MGP). According to the International Journal of Endocrinology, carboxylation of MGP helps to mitigate calcium buildup in blood vessels, supporting a healthy cardiovascular system. Osteocalcin carboxylation supports bone density, a key factor in minimizing the likelihood of future bone issues. Studies have also shown that taking Vitamins D and K together results in lower levels of uncarboxylated osteocalcin and increased bone density. This demonstrates that the Vitamin D-K duo are more effective in supporting bone health than supplementing with Vitamin K alone. To ensure bioavailability of both Vitamins D and K, your body needs enough of the enzyme lipase to properly assimilate these fat-soluble vitamins. Thankfully, KD Ultra contains it all! What are the different forms of vitamin K2 in KD Ultra? Vitamin K2 refers to a group of compounds known scientifically as menaquinones (MKs). Several different forms of Vitamin K2 exist, ranging from MK4 to MK13, and each provides unique health benefits. Think of these similar to the different variations of B vitamins, where each vitamin has a different function within the body and the complete complex is important for optimal health. The number following the MK refers to the length of the “chain” in its chemical composition (e.g. MK4 is a 4-chain K2). MK4 is most commonly found in the Western diet while high levels of MK7 are found in the Japanese food natto. KD Ultra includes all four of the currently available supplemental forms of Vitamin K2: MK4, MK6, MK7 and MK9. As if K2 needed to be further complicated, two variations of MK7 (isomers) exist and are known as Trans and Cis. The isomer is basically just the shape of the molecule and impacts the absorbability within the body (among other things). Trans MK7 is what is found in foods and nature, while Cis is not found in nature and may not offer any of the benefits of Trans MK7. KD Ultra contains all-Trans MK7. Why do I need to take Vitamin D, don’t I get it from the sun? Although Vitamin D can be obtained naturally through sunlight exposure, several factors make it challenging to get enough from the sun alone. Season, time of day, day length, cloud cover, smog, shade, and geographic region all impact UVB exposure and the potential for Vitamin D production. Age and skin color also impact Vitamin D production. The skin of older adults does not produce as much Vitamin D when exposed to sunlight as skin in younger people. Also, the kidneys are less capable of converting Vitamin D into its active form as people age. Individuals with dark skin have a lower ability to produce Vitamin D from the sun due to higher melanin levels in the skin, which blocks UVB absorption. In addition, due to the risk of skin cancer, daily sunscreen use and protective clothing are recommended by dermatologists, both of which block UVB exposure and limit Vitamin D production. Does KD Ultra support dental health? It has been shown that Vitamin K2 plays a key role in the development and maintenance of healthy tooth enamel and the immune response within dentin. Without K2, calcium cannot be adequately processed in our bodies, and that includes both bones and teeth. Additionally, Vitamin D3 aids in the absorption of calcium throughout the body. Is KD Ultra safe to use in combination with prescription blood-thinning medications? You should always check with your healthcare provider prior to taking any new dietary supplements in combination with a prescription. However, KD Ultra contains Vitamin K, and since many prescription medications for blood-thinning are designed to block Vitamin K activity, it is imperative you speak with the prescribing physician prior to taking KD Ultra if you are prescribed these types of medications. Is KD Ultra Kosher? The formula is Kosher, and a copy of the certification is available by request . Is KD Ultra vegan friendly? The formula is vegetarian and vegan in accordance with the guidelines of the AMERICAN VEGETAR-IAN ASSOCIATION.

Triple Magnesium Power for Everyday Wellness ✔️ 3 Forms of Highly Bioavailable Magnesium✔️ Nutrient Support for Mood & Stress Balance✔️ Mineral Support for Bone, Joint & Muscle Function Mag3Ultra® combines three advanced, bioavailable forms of magnesium—Sucrosomial Magnesium Oxide, Magnesium Taurate, and Magnesium Bisglycinate—with Potassium Gluconate and Ascorbyl Palmitate (fat-soluble Vitamin C) to support a variety of important physiological processes. Designed to complement your daily routine, Mag3Ultra® offers a comprehensive mineral profile in a thoughtfully formulated blend. How It Works Many magnesium supplements are associated with gastrointestinal discomfort due to low absorption. Mag3Ultra® features Sucrosomial Magnesium, a delivery system that encapsulates magnesium in a sucrosome matrix—helping it pass through the stomach more comfortably and reach the intestines for better uptake. Functional Benefits Well-Tolerated Magnesium The sucrosomial delivery system helps magnesium travel through the digestive tract more gently compared to some conventional forms. Structural Support Magnesium is involved in numerous cellular functions related to the body’s framework and structure. The combination of minerals in Mag3Ultra® is designed to complement these physiological roles. Muscle Function Magnesium and potassium contribute to normal muscle activity. This formula is developed with ingredients known to play a role in muscle-related pathways. Everyday Balance Magnesium participates in enzyme activity and cellular signalling processes. Mag3Ultra® provides forms of magnesium that are bioavailable and well-tolerated to support daily nutritional needs. Ingredients Sucrosomial Magnesium OxideA form of magnesium encapsulated in a lipid matrix to support absorption and digestive comfort. Magnesium TaurateCombines magnesium with taurine, an amino acid-like compound. Magnesium BisglycinateA chelated form of magnesium, known for its solubility and mild profile. Potassium GluconateA source of potassium that contributes to fluid balance and normal muscle function. Ascorbyl PalmitateA fat-soluble form of Vitamin C, often used for its antioxidant properties and stability in formulations. Suggested Use General Use: Take 1–3 capsules per day, or as directed by a healthcare practitioner. Higher Intake: Take 4–6 capsules per day, in divided doses, or as directed by a healthcare practitioner. Always consult your healthcare provider for guidance.  This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your healthcare professional before use. Keep out of reach of children. Do not exceed the recommended daily dose. FAQs Is Sucrosomial Magnesium different from regular magnesium oxide?Yes, Sucrosomial Magnesium differs significantly from regular magnesium oxide. While magnesium oxide is commonly found in supplements due to its high elemental magnesium content (around 61%), Sucrosomial Magnesium utilizes magnesium oxide encapsulated within a sucrosome for improved digestive tolerability and absorption. Despite containing a lower percentage of elemental magnesium (around 31%), Sucrosomial Magnesium has been shown to be more bioavailable than magnesium oxide alone. High elemental magnesium content in magnesium oxide can be harsh on the digestive tract, making the Sucrosomial form a preferable option. Is Mag3Ultra missing calcium?Dietary calcium deficiency is a major problem globally. However, it is not a lack of calcium that creates this deficiency, proper calcium absorption and utilization is the problem. Mag3Ultra supports proper magnesium levels so that calcium is utilized properly. For the most optimal use of calcium, we recommend taking Mag3Ultra with Vitamin D3, and Vitamin K2. The latter two vitamins can be found in KD Ultra, our premier blend of vegan Vitamin D3 and Vitamin K2. When is the best time to take Mag3Ultra?The best time to take Mag3Ultra is with meals to minimize the risk of digestive issues and maximize absorption. If you don't experience the desired benefits with meals, you can try taking it between meals or before bed after ensuring your body tolerates magnesium well. Mag3Ultra contains three highly tolerated forms of magnesium, but starting with meals is advisable to assess your body's response to the product. Is Mag3Ultra Kosher?The product is certified Kosher by Star-K, and a copy of the certification is available upon request. Is Mag3Ultra vegan friendly?The formula is vegan in accordance with the guidelines of the American Vegetarian Association. Note:  This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your healthcare professional before use. Keep out of reach of children. Do not exceed the recommended daily dose.

Triple Magnesium Power for Everyday Wellness ✔️ 3 Forms of Highly Bioavailable Magnesium✔️ Nutrient Support for Mood & Stress Balance✔️ Mineral Support for Bone, Joint & Muscle Function Mag3Ultra® combines three advanced, bioavailable forms of magnesium—Sucrosomial Magnesium Oxide, Magnesium Taurate, and Magnesium Bisglycinate—with Potassium Gluconate and Ascorbyl Palmitate (fat-soluble Vitamin C) to support a variety of important physiological processes. Designed to complement your daily routine, Mag3Ultra® offers a comprehensive mineral profile in a thoughtfully formulated blend. How It Works Many magnesium supplements are associated with gastrointestinal discomfort due to low absorption. Mag3Ultra® features Sucrosomial Magnesium, a delivery system that encapsulates magnesium in a sucrosome matrix—helping it pass through the stomach more comfortably and reach the intestines for better uptake. Functional Benefits Well-Tolerated Magnesium The sucrosomial delivery system helps magnesium travel through the digestive tract more gently compared to some conventional forms. Structural Support Magnesium is involved in numerous cellular functions related to the body’s framework and structure. The combination of minerals in Mag3Ultra® is designed to complement these physiological roles. Muscle Function Magnesium and potassium contribute to normal muscle activity. This formula is developed with ingredients known to play a role in muscle-related pathways. Everyday Balance Magnesium participates in enzyme activity and cellular signalling processes. Mag3Ultra® provides forms of magnesium that are bioavailable and well-tolerated to support daily nutritional needs. Ingredients Sucrosomial Magnesium OxideA form of magnesium encapsulated in a lipid matrix to support absorption and digestive comfort. Magnesium TaurateCombines magnesium with taurine, an amino acid-like compound. Magnesium BisglycinateA chelated form of magnesium, known for its solubility and mild profile. Potassium GluconateA source of potassium that contributes to fluid balance and normal muscle function. Ascorbyl PalmitateA fat-soluble form of Vitamin C, often used for its antioxidant properties and stability in formulations. Suggested Use General Use: Take 1–3 capsules per day, or as directed by a healthcare practitioner. Higher Intake: Take 4–6 capsules per day, in divided doses, or as directed by a healthcare practitioner. Always consult your healthcare provider for guidance.  This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your healthcare professional before use. Keep out of reach of children. Do not exceed the recommended daily dose. FAQs Is Sucrosomial Magnesium different from regular magnesium oxide?Yes, Sucrosomial Magnesium differs significantly from regular magnesium oxide. While magnesium oxide is commonly found in supplements due to its high elemental magnesium content (around 61%), Sucrosomial Magnesium utilizes magnesium oxide encapsulated within a sucrosome for improved digestive tolerability and absorption. Despite containing a lower percentage of elemental magnesium (around 31%), Sucrosomial Magnesium has been shown to be more bioavailable than magnesium oxide alone. High elemental magnesium content in magnesium oxide can be harsh on the digestive tract, making the Sucrosomial form a preferable option. Is Mag3Ultra missing calcium?Dietary calcium deficiency is a major problem globally. However, it is not a lack of calcium that creates this deficiency, proper calcium absorption and utilization is the problem. Mag3Ultra supports proper magnesium levels so that calcium is utilized properly. For the most optimal use of calcium, we recommend taking Mag3Ultra with Vitamin D3, and Vitamin K2. The latter two vitamins can be found in KD Ultra, our premier blend of vegan Vitamin D3 and Vitamin K2. When is the best time to take Mag3Ultra?The best time to take Mag3Ultra is with meals to minimize the risk of digestive issues and maximize absorption. If you don't experience the desired benefits with meals, you can try taking it between meals or before bed after ensuring your body tolerates magnesium well. Mag3Ultra contains three highly tolerated forms of magnesium, but starting with meals is advisable to assess your body's response to the product. Is Mag3Ultra Kosher?The product is certified Kosher by Star-K, and a copy of the certification is available upon request. Is Mag3Ultra vegan friendly?The formula is vegan in accordance with the guidelines of the American Vegetarian Association.

Nattovena is the world’s first ultra-concentrated 4,000 FU pure nattokinase dietary supplement, in easy-to-swallow micro-caps. Nattovena contains ultra-refined, pharmaceutical grade, acid stable nattokinase. Nattovena's potency is unparalleled in its class. The standard for nattokinase manufacturing is a potency of up to 2,000 FU’s, or fibrinolytic units, of fibrin degrading activity per capsule. Nattovéna has broken the mold by providing 4,000 FU’s of activity, or double the ordinary dose, offering the strongest nattokinase activity per capsule, period. Nattovena is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory health concerns. What is Nattokinase? Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting. Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 4,000 units of fibrin per capsule, thereby optimizing its cardiovascular benefits and promoting normal blood viscosity. How Does Nattokinase Work? Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase supplementation can tip the balance back in favor of fibrin removal using two different mechanisms. Firstly, nattokinase is a fibrinolytic enzyme, which means that it can literally dissolve excessive fibrin produced during the healing process. In fact, studies show that nattokinase is actually four times (4x) more potent than the body’s own plasmin in terms of fibrinolytic activity1. Secondly, nattokinase blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal, since PAI-1 blocks the body’s natural production of plasmin. By impeding PAI-1, nattokinase promotes the creation of more plasmin from plasminogen (its building block), increasing the amount of natural fibrinolytic enzymes created within the body2. Suggested Use Suggested Use: Take 1 capsule 2 to 3 times daily on an empty stomach. Higher doses may be taken as needed, but it is recommended to not exceed 15 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner. WARNING: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing. Frequently Asked Questions What does Nattovena do? Studies have demonstrated that nattokinase improves overall circulation, promotes healthy blood viscosity, promotes healthy clotting factors, keeps blood cells from sticking together, and maintains blood pressure levels already within normal range.* How does it work? Nattovena supports normal clot formation by maintaining normal levels of blood coagulation factors.* It also supports normal clot breakdown by maintaining normal fibrinolytic (clot-dissolving) activity, due to its ability to also increase the production of the body's inherent fibrinolytic enzyme plasmin.* Why is fibrinolytic activity important? Fibrin is a vital protein that forms in response to trauma, injury, or even in cases of autoimmune conditions. The body can not only overproduce fibrin in these instances, but can also produce fibrin when there is no trauma or injury, which can lead to a bevy of unwanted symptoms. Fibrinolytic activity is the body’s natural way of breaking up excessive fibrin and unwanted clots. Is Nattovena safe? Nattokinase is derived from natto, which has been a regular food staple within Asian cuisine for centuries. Although nattokinase has many benefits, studies have shown that it also does not have demonstrative side effects, and the ingredient is considered GRAS (generally recognized as safe) within the US. Does Nattovena have value beyond just heart health? Due to the vast array of unhealthy conditions that excessive fibrin can bring, Nattovena has far greater value than a simple cardiovascular support product. Many aspects of health, from muscle recovery, to immune and joint health are directly related to fibrin and blood viscosity.* Is Nattovena safe to use in combination with prescription blood-thinning drug medication? You should always check with your health care provider prior to taking any new dietary supplements in combination with a prescription. However, Nattovena does not contain any vitamin K, so it is assumed to be compatible with these medications since their mode of action is based on inhibiting vitamin K. Nattovena is not contraindicated with aspirin, natural supplements, or antihypertensive medications although medical supervision when implementing any new supplement regimen is always recommended. Supplement Facts   Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Nattovena™ 200 mg † Nattokinase 4,000 FU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Keep out of reach of children. Store in a cool, dry place with lid tightly closed.

Nattovena is the world’s first ultra-concentrated 4,000 FU pure nattokinase dietary supplement, in easy-to-swallow micro-caps. Nattovena contains ultra-refined, pharmaceutical grade, acid stable nattokinase. Nattovena's potency is unparalleled in its class. The standard for nattokinase manufacturing is a potency of up to 2,000 FU’s, or fibrinolytic units, of fibrin degrading activity per capsule. Nattovéna has broken the mold by providing 4,000 FU’s of activity, or double the ordinary dose, offering the strongest nattokinase activity per capsule, period. Nattovena is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory health concerns. What is Nattokinase? Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting. Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 4,000 units of fibrin per capsule, thereby optimizing its cardiovascular benefits and promoting normal blood viscosity. How Does Nattokinase Work? Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase supplementation can tip the balance back in favor of fibrin removal using two different mechanisms. Firstly, nattokinase is a fibrinolytic enzyme, which means that it can literally dissolve excessive fibrin produced during the healing process. In fact, studies show that nattokinase is actually four times (4x) more potent than the body’s own plasmin in terms of fibrinolytic activity1. Secondly, nattokinase blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal, since PAI-1 blocks the body’s natural production of plasmin. By impeding PAI-1, nattokinase promotes the creation of more plasmin from plasminogen (its building block), increasing the amount of natural fibrinolytic enzymes created within the body2. Suggested Use Suggested Use: Take 1 capsule 2 to 3 times daily on an empty stomach. Higher doses may be taken as needed, but it is recommended to not exceed 15 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner. WARNING: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing. Frequently Asked Questions What does Nattovena do? Studies have demonstrated that nattokinase improves overall circulation, promotes healthy blood viscosity, promotes healthy clotting factors, keeps blood cells from sticking together, and maintains blood pressure levels already within normal range.* How does it work? Nattovena supports normal clot formation by maintaining normal levels of blood coagulation factors.* It also supports normal clot breakdown by maintaining normal fibrinolytic (clot-dissolving) activity, due to its ability to also increase the production of the body's inherent fibrinolytic enzyme plasmin.* Why is fibrinolytic activity important? Fibrin is a vital protein that forms in response to trauma, injury, or even in cases of autoimmune conditions. The body can not only overproduce fibrin in these instances, but can also produce fibrin when there is no trauma or injury, which can lead to a bevy of unwanted symptoms. Fibrinolytic activity is the body’s natural way of breaking up excessive fibrin and unwanted clots. Is Nattovena safe? Nattokinase is derived from natto, which has been a regular food staple within Asian cuisine for centuries. Although nattokinase has many benefits, studies have shown that it also does not have demonstrative side effects, and the ingredient is considered GRAS (generally recognized as safe) within the US. Does Nattovena have value beyond just heart health? Due to the vast array of unhealthy conditions that excessive fibrin can bring, Nattovena has far greater value than a simple cardiovascular support product. Many aspects of health, from muscle recovery, to immune and joint health are directly related to fibrin and blood viscosity.* Is Nattovena safe to use in combination with prescription blood-thinning drug medication? You should always check with your health care provider prior to taking any new dietary supplements in combination with a prescription. However, Nattovena does not contain any vitamin K, so it is assumed to be compatible with these medications since their mode of action is based on inhibiting vitamin K. Nattovena is not contraindicated with aspirin, natural supplements, or antihypertensive medications although medical supervision when implementing any new supplement regimen is always recommended. Supplement Facts   Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Nattovena™ 200 mg † Nattokinase 4,000 FU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Keep out of reach of children. Store in a cool, dry place with lid tightly closed.

Nattovena is the world’s first ultra-concentrated 4,000 FU pure nattokinase dietary supplement, in easy-to-swallow micro-caps. Nattovena contains ultra-refined, pharmaceutical grade, acid stable nattokinase. Nattovena's potency is unparalleled in its class. The standard for nattokinase manufacturing is a potency of up to 2,000 FU’s, or fibrinolytic units, of fibrin degrading activity per capsule. Nattovéna has broken the mold by providing 4,000 FU’s of activity, or double the ordinary dose, offering the strongest nattokinase activity per capsule, period. Nattovena is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory health concerns. What is Nattokinase? Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting. Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 4,000 units of fibrin per capsule, thereby optimizing its cardiovascular benefits and promoting normal blood viscosity. How Does Nattokinase Work? Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase supplementation can tip the balance back in favor of fibrin removal using two different mechanisms. Firstly, nattokinase is a fibrinolytic enzyme, which means that it can literally dissolve excessive fibrin produced during the healing process. In fact, studies show that nattokinase is actually four times (4x) more potent than the body’s own plasmin in terms of fibrinolytic activity1. Secondly, nattokinase blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal, since PAI-1 blocks the body’s natural production of plasmin. By impeding PAI-1, nattokinase promotes the creation of more plasmin from plasminogen (its building block), increasing the amount of natural fibrinolytic enzymes created within the body2. Suggested Use Suggested Use: Take 1 capsule 2 to 3 times daily on an empty stomach. Higher doses may be taken as needed, but it is recommended to not exceed 15 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner. WARNING: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing. Frequently Asked Questions What does Nattovena do? Studies have demonstrated that nattokinase improves overall circulation, promotes healthy blood viscosity, promotes healthy clotting factors, keeps blood cells from sticking together, and maintains blood pressure levels already within normal range.* How does it work? Nattovena supports normal clot formation by maintaining normal levels of blood coagulation factors.* It also supports normal clot breakdown by maintaining normal fibrinolytic (clot-dissolving) activity, due to its ability to also increase the production of the body's inherent fibrinolytic enzyme plasmin.* Why is fibrinolytic activity important? Fibrin is a vital protein that forms in response to trauma, injury, or even in cases of autoimmune conditions. The body can not only overproduce fibrin in these instances, but can also produce fibrin when there is no trauma or injury, which can lead to a bevy of unwanted symptoms. Fibrinolytic activity is the body’s natural way of breaking up excessive fibrin and unwanted clots. Is Nattovena safe? Nattokinase is derived from natto, which has been a regular food staple within Asian cuisine for centuries. Although nattokinase has many benefits, studies have shown that it also does not have demonstrative side effects, and the ingredient is considered GRAS (generally recognized as safe) within the US. Does Nattovena have value beyond just heart health? Due to the vast array of unhealthy conditions that excessive fibrin can bring, Nattovena has far greater value than a simple cardiovascular support product. Many aspects of health, from muscle recovery, to immune and joint health are directly related to fibrin and blood viscosity.* Is Nattovena safe to use in combination with prescription blood-thinning drug medication? You should always check with your health care provider prior to taking any new dietary supplements in combination with a prescription. However, Nattovena does not contain any vitamin K, so it is assumed to be compatible with these medications since their mode of action is based on inhibiting vitamin K. Nattovena is not contraindicated with aspirin, natural supplements, or antihypertensive medications although medical supervision when implementing any new supplement regimen is always recommended. Supplement Facts   Supplement Facts Serving Size: 1 Capsule Amount Per Serving* % Daily Value Nattovena™ 200 mg † Nattokinase 4,000 FU † * Percent Daily Values based on a 2,000 calorie diet † Daily Value Not Established Other Ingredients: Cellulose (vegetarian Capsules) Keep out of reach of children. Store in a cool, dry place with lid tightly closed.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Neprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.* Neprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications. Recent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.* Systemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.* †Based on 3rd party fibrinolytic assay testing.   Fibrin Defense Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol. Fibrinogen Over-Production Hyper-coagulation & Fibrin Defense Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself. Fibrin Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing. As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8]. Neprinol Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9]. Nattokinase Nattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3]. Researchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13]. Plasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced. Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16]. Bromelain Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17]. Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24]. Serrapeptase Serrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. Other Diseases Linked to Fibrin The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30]. Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1]. Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body. Advanced Fibrin Defense As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.   Suggested Use Directions: Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily. Warning: Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing. Is Neprinol safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. When is the best time to take Neprinol? For best results, take the product atleast one hour prior to eating and/or two hours after a meal. Can I take Neprinol with other supplements? Neprinol can be used safely with other dietary supplements. How long does it take for Neprinol to work? Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.   Supplement Facts Nattokinase A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.SerrapeptaseA proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.LipaseUsed systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.ProteaseA proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.AmlaDerived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.PapainA proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.RutinA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.CoQ10Decreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.MagnesiumPromotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress. Other Ingredients: Cellulose (Acid Amor™ capsules) Neprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives. Keep out of reach of children. Store in a cool, dry place with lid tightly closed. WARNING: Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.   Frequently Asked Questions What is Neprinol? Neprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.* What are Enzymes? Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body. What are "Systemic Enzymes"? When enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin. What is Fibrin? Fibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions. Why Neprinol? As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury. How Does Neprinol Work? By supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.* Is Neprinol Enteric Coated? Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals. Is Neprinol Safe? No serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Neprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.   References: Meletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

Neprofin AVF is a joint supplement for horses that is designed to support the health and function of the horse’s joints and muscles. The blend of systemic enzymes, antioxidants, and bioflavonoids work together to reduce inflammation, promote tissue and muscle healing, and improve joint mobility within equines.  The systemic enzymes, specifically, work by breaking down proteins that can cause inflammation, helping to reduce pain and discomfort for horses.  The antioxidants, on the other hand, protect the horse’s cells from damage caused by free radicals, which are unstable molecules that can cause inflammation and tissue damage.  The bioflavonoids, which are compounds found in fruits and vegetables, are believed to have anti-inflammatory properties and help to strengthen the blood vessels and connective tissue, which is important for maintaining a horse’s joint health.   Some of the major benefits of Neprofin AVF Horse Supplements are:    Boosts a horse’s energy levels, alertness and concentration An Effective equine joint supplement for sprains, fractures, rheumatoid arthritis and osteoarthritis in horses A horse supplement that helps antibiotics to work after surgery Helps in faster tissue repair while preventing exude formation (fluid in the injured area) Promotes joint health in horse’s by relieving inflammation, muscle pain and soreness A Long acting equine joint supplement and can be adopted as a replacement therapy in pathological conditions No known side effects or allergic reactions observed in equine clinical trials A horse supplement that promotes healthy muscle tissue and connective fibre A horse joint supplement that promotes lean body mass and aids with protein utilisation Neprofin AVF reduces systemic fibrin concentrations with a potent fibrinolytic activity in horses An equine joint supplement which is shown to emulsify cholesterol and fibrin Also suitable for any pet suffering from joint pain, injuries or arthritis Supplements enzymes in horses that block the release of pain inducing amines from inflamed tissue Thins mucus secreted by the mucus membranes Works continuously throughout the various pH variations of the digestive tract What Is Neprofin AVF Horse Joint Supplement? Neprofin AVF is a comprehensive joint supplement for horses that is formulated to support the overall health and function of the horse’s joints and muscles. It can be used as an alternative treatment for horse joint problems, and can be found in many joint supplements for horses. It is clinically tested and proven to be safe and efficient for veterinary purposes. The systemic enzymes in Neprofin AVF work by breaking down proteins that can cause inflammation, which can help to reduce pain and discomfort in the joints. These enzymes also help to support the body’s natural healing processes by breaking down damaged tissue and removing it from the body, which can help to speed up the healing process and reduce the risk of chronic pain and stiffness in the joints. Why Most Horses Need An Equine Joint Supplement At Some Point Horse joint supplements, also known as joint supplements for horses or equine joint supplements, are essential for maintaining the health and mobility of horses. As horses are athletic animals and are often used for sports and other activities, they are at an increased risk for joint problems such as inflammation, pain, and arthritis.  Horse joint supplements contain ingredients such as glucosamine, chondroitin, MSM, hyaluronic acid and other anti-inflammatory agents that can help to reduce inflammation and pain, promote cartilage repair, and support the health of the horse’s synovial fluid which is important for the joints to move smoothly. Additionally, they also contain antioxidants and other ingredients to support the overall health of the horse’s joints and muscles. In short, horse joint supplements are an important aspect of maintaining the health and mobility of a horse, especially as they age or if they are heavily used in athletic activities. Why Neprofin AVF The Best Horse Joint Supplement & A Better Horse Supplement Than Bute Neprofin AVF is a powerful joint supplement for horses, created in response to the growing demand for pain relief in athletic and performance animals. Despite its initial purpose, it can be used safely for any pet joint pain, injuries, and conditions including arthritis. Neprofin AVF is a blend of powerful systemic enzymes, antioxidants and bioflavonoids specially formulated to help facilitate movement as well as tissue and muscle healing.  It offers an alternative solution for equine injuries that were previously treated with phenylbutazone (Bute). Neprofin was created primarily to treat inflammation, discomfort, and sore muscles. It works similarly to Bute and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in treating joint problems, however, Bute has been found to have negative effects on white blood cell levels, stomach issues, ulcers, and aplastic anaemia are also very typical side effects with long-term usage, and can be harmful to the liver and kidneys. Neprofin, on the other hand, is a horse joint supplement that digests the pro-inflammatory prostaglandins that are the source of inflammation, instead of blocking Cox Enzymes to suppress inflammation, making it a safer option for horse joint supplements.  Overall, Neprofin AVF is a comprehensive joint supplement for horses that is formulated to support the overall health and function of the horse’s joints and muscles. How Enzymes Provide The Best Joint Supplements For Horses Enzymes can help horses’ joints in several ways. Systemic enzymes, in particular, can help to reduce inflammation and pain in the joints. When a horse experiences an injury or develops a condition such as arthritis, the body produces pro-inflammatory compounds called prostaglandins. These compounds cause inflammation and pain in the affected joint. Systemic enzymes, such as those found in Neprofin AVF, work by breaking down the proteins that make up the prostaglandins, reducing the inflammation and pain in the joint. As well as reducing inflammation and pain, enzymes can also help to promote healing in the joints. Enzymes are essential for the body’s natural healing processes as they help to break down damaged tissue and remove it from the body without it causing any additional damage to the organs which process this. This can help to speed up the healing process and reduce the risk of chronic pain and stiffness in the joints. Enzymes can also help to improve joint mobility. They help to break down and remove any debris that may be blocking the joint, which can improve the joint’s range of motion. This can help to reduce the risk of further injuries and improve a horse’s performance in competitions or races. Overall, enzymes can play a crucial role in maintaining the health of a horse’s joints by reducing inflammation, promoting healing, and improving mobility. They are a safe and effective alternative treatment for horse joint problems, and can be found in many joint supplement for horse, such as Neprofin AVF. How Neprofin AVF Works As Joint Supplements For Horses Neprofin AVF completely changes the course of the healing process by reducing a horse’s joint inflammation. Joint discomfort and functional flexibility are the only issues that glucosamine HCL and chondroitin address.  Neprofin has been demonstrated to considerably alleviate navicular syndrome, tendonitis, muscle tears, arthritis, bowed tendon, colic, foot injuries, bruising, fractures, subluxations, lacerations, and open wounds. Our equine joint supplement is a multi-enzyme blend derived from non-animal sources that combines potent enzymes, proteases, and bioflavonoids to promote movement as well as muscle and tissue regeneration.  Peptizyme SP, a potent peptidase developed from Serratia spp. T1, is coupled with a unique mixture of fungal Protease, Bromelain, and Papain. Due to its anti-inflammatory effects, this peptidase enzyme is used all over the world.  A natural Indian gooseberry supplement called Amla is also included in the recipe, along with doses of lipase and amylase. This unusual fruit works in concert with the enzyme mixture to sustain it.  Our joint supplement for horses, Neprofin, also includes rutin, a vital bioflavonoid that may aid in tissue repair. Neprofin AVF is a great option for joint pain, inflammation, and is ideal for speeding up the healing process after injuries. Using Neprofin AVF As A Horse Supplement In Breeding Neprofin AVF can be an effective supplement for horse breeding as it can help to improve fertility in both male and female horses. In female horses, the treatment can help to reduce the occurrence of pelvic inflammatory disease (PID) which is a condition that can lead to the development of fibroids, which can affect fertility. Neprofin AVF works by reducing inflammation and promoting healing, which can help to reduce the risk of PID and the development of fibroids. This can lead to an increase in fertility, making it easier for female horses to conceive and carry a foal to term. In male horses, Neprofin AVF can also be used to improve fertility. The treatment can help to restore the form of the male erection and reduce testicular irritation. This can help to reduce the risk of infertility and other reproductive problems in male horses. Neprofin AVF works by reducing inflammation and promoting healing in the reproductive system, which can help to improve overall reproductive health.  Additionally, Neprofin also helps to improve the overall health of the horse’s joints and muscles, which can be beneficial for breeding and maintaining the health of any female horse during pregnancy. Neprofin AVF Testimonial Review: Eight weeks ago my horse Justin suffered a serious injury to the brachial plexus (affecting nerves and muscle and possible fractures) and the vet thought best to put her to sleep.  However, there was a slim chance that she might become pasture sound following a period of box rest.  The vest said that it would take on average 7 to 8 months just to get to that stage and she would have terrible muscle wastage.  In desperation I searched the net and found Neprofin. Eight weeks on my mare is pasture sound.  My vet was amazed at the progress, saying she had improved in a third of the time as it would normally take.  She was on Bute for the first two weeks, but after dosing her with Neprofin she is off Bute with no signs of discomfort.  We still have a long way to go but thanks to Neprofin and other natural products I am sure she will make a full recovery. Michele Brady  (U.K.) Neprofin AVF Testimonial Review: Just a quick note to say how fab Neprofin is  –  our eventer (no-one sure how, just appeared overnight after dressage lesson) had a huge cricket ball sized lump right in the hock joint.  A year and 2 operations later, it was still there (fibrin was massing, vets couldn’t find reason) and it was decided to leave it and see what happened, if he went lame we would do final operation to try and resolve. In desperation I searched Fibrin on the internet and after many hours came up with Neprofin as a potential product that may help Valriaan sort himself out; and after 8 weeks of use and a final scan yesterday, it was confirmed the lump is reduced by 75% and he is 100% sound.  Vets sceptical as to why, but I am utterly convinced its the Neprofin and wanted to thank you and the team.  We now have a fit, focused, totally different horse who is back to eventing and jumping clear! S. Young – Happy horsey mum!  (U.K.) Application: Optimum dosage of Neprofin AVF must be determined by the individual animal’s needs. For injured or lame horses, mix 3 scoops (9 grams) of Nerpofin AVF into the horse’s moist or dry food, 3 times per day. After symptoms have dissipated over the course of a several weeks, use the indicated maintenance dosage – (1 scoop (3 grams) 3 times a day. This will ensure a consistent reduction in pain and inflammatory response, while decreasing the time it takes to recover from injury.

Neprofin AVF is a joint supplement for horses that is designed to support the health and function of the horse’s joints and muscles. The blend of systemic enzymes, antioxidants, and bioflavonoids work together to reduce inflammation, promote tissue and muscle healing, and improve joint mobility within equines.  The systemic enzymes, specifically, work by breaking down proteins that can cause inflammation, helping to reduce pain and discomfort for horses.  The antioxidants, on the other hand, protect the horse’s cells from damage caused by free radicals, which are unstable molecules that can cause inflammation and tissue damage.  The bioflavonoids, which are compounds found in fruits and vegetables, are believed to have anti-inflammatory properties and help to strengthen the blood vessels and connective tissue, which is important for maintaining a horse’s joint health.   Some of the major benefits of Neprofin AVF Horse Supplements are:    Boosts a horse’s energy levels, alertness and concentration An Effective equine joint supplement for sprains, fractures, rheumatoid arthritis and osteoarthritis in horses A horse supplement that helps antibiotics to work after surgery Helps in faster tissue repair while preventing exude formation (fluid in the injured area) Promotes joint health in horse’s by relieving inflammation, muscle pain and soreness A Long acting equine joint supplement and can be adopted as a replacement therapy in pathological conditions No known side effects or allergic reactions observed in equine clinical trials A horse supplement that promotes healthy muscle tissue and connective fibre A horse joint supplement that promotes lean body mass and aids with protein utilisation Neprofin AVF reduces systemic fibrin concentrations with a potent fibrinolytic activity in horses An equine joint supplement which is shown to emulsify cholesterol and fibrin Also suitable for any pet suffering from joint pain, injuries or arthritis Supplements enzymes in horses that block the release of pain inducing amines from inflamed tissue Thins mucus secreted by the mucus membranes Works continuously throughout the various pH variations of the digestive tract What Is Neprofin AVF Horse Joint Supplement? Neprofin AVF is a comprehensive joint supplement for horses that is formulated to support the overall health and function of the horse’s joints and muscles. It can be used as an alternative treatment for horse joint problems, and can be found in many joint supplements for horses. It is clinically tested and proven to be safe and efficient for veterinary purposes. The systemic enzymes in Neprofin AVF work by breaking down proteins that can cause inflammation, which can help to reduce pain and discomfort in the joints. These enzymes also help to support the body’s natural healing processes by breaking down damaged tissue and removing it from the body, which can help to speed up the healing process and reduce the risk of chronic pain and stiffness in the joints. Why Most Horses Need An Equine Joint Supplement At Some Point Horse joint supplements, also known as joint supplements for horses or equine joint supplements, are essential for maintaining the health and mobility of horses. As horses are athletic animals and are often used for sports and other activities, they are at an increased risk for joint problems such as inflammation, pain, and arthritis.  Horse joint supplements contain ingredients such as glucosamine, chondroitin, MSM, hyaluronic acid and other anti-inflammatory agents that can help to reduce inflammation and pain, promote cartilage repair, and support the health of the horse’s synovial fluid which is important for the joints to move smoothly. Additionally, they also contain antioxidants and other ingredients to support the overall health of the horse’s joints and muscles. In short, horse joint supplements are an important aspect of maintaining the health and mobility of a horse, especially as they age or if they are heavily used in athletic activities. Why Neprofin AVF The Best Horse Joint Supplement & A Better Horse Supplement Than Bute Neprofin AVF is a powerful joint supplement for horses, created in response to the growing demand for pain relief in athletic and performance animals. Despite its initial purpose, it can be used safely for any pet joint pain, injuries, and conditions including arthritis. Neprofin AVF is a blend of powerful systemic enzymes, antioxidants and bioflavonoids specially formulated to help facilitate movement as well as tissue and muscle healing.  It offers an alternative solution for equine injuries that were previously treated with phenylbutazone (Bute). Neprofin was created primarily to treat inflammation, discomfort, and sore muscles. It works similarly to Bute and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in treating joint problems, however, Bute has been found to have negative effects on white blood cell levels, stomach issues, ulcers, and aplastic anaemia are also very typical side effects with long-term usage, and can be harmful to the liver and kidneys. Neprofin, on the other hand, is a horse joint supplement that digests the pro-inflammatory prostaglandins that are the source of inflammation, instead of blocking Cox Enzymes to suppress inflammation, making it a safer option for horse joint supplements.  Overall, Neprofin AVF is a comprehensive joint supplement for horses that is formulated to support the overall health and function of the horse’s joints and muscles. How Enzymes Provide The Best Joint Supplements For Horses Enzymes can help horses’ joints in several ways. Systemic enzymes, in particular, can help to reduce inflammation and pain in the joints. When a horse experiences an injury or develops a condition such as arthritis, the body produces pro-inflammatory compounds called prostaglandins. These compounds cause inflammation and pain in the affected joint. Systemic enzymes, such as those found in Neprofin AVF, work by breaking down the proteins that make up the prostaglandins, reducing the inflammation and pain in the joint. As well as reducing inflammation and pain, enzymes can also help to promote healing in the joints. Enzymes are essential for the body’s natural healing processes as they help to break down damaged tissue and remove it from the body without it causing any additional damage to the organs which process this. This can help to speed up the healing process and reduce the risk of chronic pain and stiffness in the joints. Enzymes can also help to improve joint mobility. They help to break down and remove any debris that may be blocking the joint, which can improve the joint’s range of motion. This can help to reduce the risk of further injuries and improve a horse’s performance in competitions or races. Overall, enzymes can play a crucial role in maintaining the health of a horse’s joints by reducing inflammation, promoting healing, and improving mobility. They are a safe and effective alternative treatment for horse joint problems, and can be found in many joint supplement for horse, such as Neprofin AVF. How Neprofin AVF Works As Joint Supplements For Horses Neprofin AVF completely changes the course of the healing process by reducing a horse’s joint inflammation. Joint discomfort and functional flexibility are the only issues that glucosamine HCL and chondroitin address.  Neprofin has been demonstrated to considerably alleviate navicular syndrome, tendonitis, muscle tears, arthritis, bowed tendon, colic, foot injuries, bruising, fractures, subluxations, lacerations, and open wounds. Our equine joint supplement is a multi-enzyme blend derived from non-animal sources that combines potent enzymes, proteases, and bioflavonoids to promote movement as well as muscle and tissue regeneration.  Peptizyme SP, a potent peptidase developed from Serratia spp. T1, is coupled with a unique mixture of fungal Protease, Bromelain, and Papain. Due to its anti-inflammatory effects, this peptidase enzyme is used all over the world.  A natural Indian gooseberry supplement called Amla is also included in the recipe, along with doses of lipase and amylase. This unusual fruit works in concert with the enzyme mixture to sustain it.  Our joint supplement for horses, Neprofin, also includes rutin, a vital bioflavonoid that may aid in tissue repair. Neprofin AVF is a great option for joint pain, inflammation, and is ideal for speeding up the healing process after injuries. Using Neprofin AVF As A Horse Supplement In Breeding Neprofin AVF can be an effective supplement for horse breeding as it can help to improve fertility in both male and female horses. In female horses, the treatment can help to reduce the occurrence of pelvic inflammatory disease (PID) which is a condition that can lead to the development of fibroids, which can affect fertility. Neprofin AVF works by reducing inflammation and promoting healing, which can help to reduce the risk of PID and the development of fibroids. This can lead to an increase in fertility, making it easier for female horses to conceive and carry a foal to term. In male horses, Neprofin AVF can also be used to improve fertility. The treatment can help to restore the form of the male erection and reduce testicular irritation. This can help to reduce the risk of infertility and other reproductive problems in male horses. Neprofin AVF works by reducing inflammation and promoting healing in the reproductive system, which can help to improve overall reproductive health.  Additionally, Neprofin also helps to improve the overall health of the horse’s joints and muscles, which can be beneficial for breeding and maintaining the health of any female horse during pregnancy. Neprofin AVF Testimonial Review: Eight weeks ago my horse Justin suffered a serious injury to the brachial plexus (affecting nerves and muscle and possible fractures) and the vet thought best to put her to sleep.  However, there was a slim chance that she might become pasture sound following a period of box rest.  The vest said that it would take on average 7 to 8 months just to get to that stage and she would have terrible muscle wastage.  In desperation I searched the net and found Neprofin. Eight weeks on my mare is pasture sound.  My vet was amazed at the progress, saying she had improved in a third of the time as it would normally take.  She was on Bute for the first two weeks, but after dosing her with Neprofin she is off Bute with no signs of discomfort.  We still have a long way to go but thanks to Neprofin and other natural products I am sure she will make a full recovery. Michele Brady  (U.K.) Neprofin AVF Testimonial Review: Just a quick note to say how fab Neprofin is  –  our eventer (no-one sure how, just appeared overnight after dressage lesson) had a huge cricket ball sized lump right in the hock joint.  A year and 2 operations later, it was still there (fibrin was massing, vets couldn’t find reason) and it was decided to leave it and see what happened, if he went lame we would do final operation to try and resolve. In desperation I searched Fibrin on the internet and after many hours came up with Neprofin as a potential product that may help Valriaan sort himself out; and after 8 weeks of use and a final scan yesterday, it was confirmed the lump is reduced by 75% and he is 100% sound.  Vets sceptical as to why, but I am utterly convinced its the Neprofin and wanted to thank you and the team.  We now have a fit, focused, totally different horse who is back to eventing and jumping clear! S. Young – Happy horsey mum!  (U.K.) Application: Optimum dosage of Neprofin AVF must be determined by the individual animal’s needs. For injured or lame horses, mix 3 scoops (9 grams) of Nerpofin AVF into the horse’s moist or dry food, 3 times per day. After symptoms have dissipated over the course of a several weeks, use the indicated maintenance dosage – (1 scoop (3 grams) 3 times a day. This will ensure a consistent reduction in pain and inflammatory response, while decreasing the time it takes to recover from injury.

Neprofin PET is one of the best joint supplements for pets that is designed specifically to be a natural alternative to provide immune and joint support for household pets. These enzyme pet supplements aim to promote a normal inflammatory response in pets and assist them in pain free movement. Containing a blend of essential enzymes, antioxidants and bioflavonoids that are formulated to help assist movement and support the healing process in household pets.  The proteolytic enzymes help to promote a healthy immune system and improve circulatory health in household pets. The antioxidants work by neutralising free radicals, and help protect cells and tissues from damage. They also work to reduce inflammation in your pets. Bioflavonoids which are found in fruits and vegetables, in supplements they provide a range of health benefits. They also help to improve cardiovascular health in your pets and alleviate inflammation.  Some Of The Benefits Of Neprofin PET Supplements Are: Reduces inflammation in pets Improves immune health in pets Helps to improve pets’ dental health Assists digestion in pets Improves joint motions in pets Increases pets’ flexibility A supplement for pets that provides blood cleansing Supplement for pets that provides healthy non-degenerative ageing Suitable for any pet that’s suffering from joint pain, injuries or arthritis  Improve circulatory health Reduces pain in household pets Reduce swelling in household pets Increase speed recovery from pets who have recently experienced an injury Promote healthy skin conditions in household pets What Are Neprofin PET Supplements   Neprofin PET is a supplement for pets that is formulated to support the healthy function of the immune system and the joints in household pets. It can be used as a natural alternative to treating joint problems in dogs and cats as well as improving your pet’s health and longevity. Neprofin PET offers a wide range of health benefits for your household pets including joint support, digestive health, immune system support and many more health benefits. Whether you’ve spotted problems in your pets’ health or you want to prevent any problems from occurring in the future, supplementing Neprofin PET is a great option to add into your pets diet in order to ensure that they’re in good health and help to prevent any future conditions from developing.   Neprofin PET is 100% natural, as well as being a non-GMO (Genetically Modified Organism). Regular testing is also conducted in order to determine whether any GMO material is present in the product. Making sure you receive one of the highest quality, and most importantly, natural pet supplements.   How Do Neprofin PET Supplements Work   Neprofin PET works by supporting the joints in household pets. Containing serrapeptase, a proteolytic enzyme that reduces swelling and speeds up recovery after injury. When taken, serrapeptase works to gently break down proteins that can hinder the health of your pets. This enzyme plays a vital role in supporting joint comfort and mobility in household pets by promoting a balanced inflammatory response, to reduce swelling and improve the overall function of the joints.    As one of the best supplements for pets, Neprofin PET also works to improve circulatory health in your household pets. With the use of protease, another proteolytic enzyme that works to digest the excess blood proteins found in their body, which, when given to your pets, is introduced to the blood serum – playing a vital role in blood clotting. This enzyme also works to improve circulatory health and improve the immune system in your pets.    Designed to be a natural alternative for joint support for pets; other more well known joint supplements such as glucosamine, chondroitin sulphate and methylsulfonylmethane (MSM) only work by providing lubrication to the joint. Neprofin PET enzymes are a more long term solution for joint discomfort in your pets as they address pain from overuse systemically before it affects the joints. For horses, see the best joint supplements here.   How Long Does It Take Neprofin PET Supplements To Work Although every pet is different, depending on things like the size of your animal, some pet owners have reported seeing Neprofin PET supplements work within the first day of adding this supplement to their diet. As every animal is different and varies in size and breed, the speed of which it takes for your pet to experience the benefits will vary, being slow for some animals and faster for others. Normally, supplementing for a month is the minimum recommended amount of time, for noticeable results one to three months will see the best results. For larger animals try Neprofin.  Why Neprofin PET Is The Best Joint Supplement For Cats   Using Neprofin PET as a joint supplement for cats, will help support your cats joints and overall health and well being. Containing a combination of powerful enzymes, antioxidants and bioflavonoids specifically formulated to help assist movement making it the best joint supplement for cats.  Serrapeptase reduces swelling in your feline pet and plays a vital role in speeding up recovery, therefore reducing inflammation. Cats are agile animals, and as they age the excessive stress put on their joints over the years takes a toll. Arthritis is common in older cats, therefore they require more joint support than other pets. With the supplements fast acting nature it ensures quick relief for cats experiencing joint discomfort, allowing them to regain normal joint movement. Neprofin PET is a great option for older cats and active agile felines, working to support their joint function all throughout their lives. Why Neprofin PET Is The Best Joint Supplement For Dogs Taking joint supplements for dogs can provide many benefits for your pet. When dogs experience any form of pain it can be difficult to tell, as they are very good at hiding any signs of illness or discomfort, therefore health problems may go unnoticed. This is the best supplement for dogs as this enzyme prompts regular anti-inflammatory response and will help your pet have pain-free movement. Containing a unique combination of natural anti-inflammatory agents, essential vitamins, and joint supporting compounds that work together to alleviate pain in dogs. This enzyme relieves pain by reducing inflammation and supporting cartilage repair, which helps to treat any joint pain your dog may be experiencing. What makes Neprofin PET the best joint supplement for dogs is its fast-acting nature, with some people reporting seeing benefits within one day of implementing this supplement in their dogs diet, therefore providing quick relief for dogs who are suffering from joint discomfort.  This enzyme is beneficial for older dogs who’ve experienced wear a tear on their joints over the years, and experience joint pain from their lifestyle and other factors such as ageing, and need that extra support. However, younger athletic dogs who are regularly active will also benefit from taking Neprofin PET, as their lifestyle requires more joint support, therefore this enzyme will help maintain normal joint function and mobility. Helping to enhance joint health and restoring vitality in dogs, this enzyme is the best joint supplement for dogs.  How Do I Know If My Dog Needs Supplements? It can be difficult to know whether your dog needs to take Neprofin PET, as dogs are generally good at hiding their pain and discomfort from their owners. However, there are certain signs to look out for that could indicate that your pet is in need of some extra support. One sign to look out for is if you start to notice your dog experiencing joint stiffness or  physical discomfort after playing. This could be a sign that their joints are playing up and may need some support. Another sign that your dog would benefit from taking Neprofin PET is if you’ve noticed that their health has started to decline. This could be due to lifestyle or ageing, and could mean that your dog needs some extra support. With the addition of Neprofin PET to your dogs diet, this can help them live a long, happy and pain free life. Noticing signs of ageing from slower movements, frequent napping or shorter playtime can cause pet owners to be concerned with worry. That’s why it’s important to spot these signs early, so you can make the healthy decision for your pet.  Do Dogs Need Joint Supplements? Neprofin PET can be extremely beneficial to dogs experiencing joint issues or at risk of developing them. As dogs age, they are more prone to developing health conditions, such as arthritis, hip dysplasia, and joint inflammation. Did you know that 1 in 5 dogs will experience arthritis in their lifetime? Larger breeds are also more at risk of developing this health problem as their excessive weight puts more stress on their joints than smaller breeds. By taking Neprofin PET it will treat the pain in your dog before it reaches their joints, making it a more effective supplement than other options that only work to lubricate the joints. Therefore, taking Neprofin PET is a long term solution for your dogs suffering from joint problems. Application: For optimal results of Neprofin PET the dosage should be determined by your pet’s size and needs by the recommended dosage chart, or with guidance from your veterinarian. For small pets under 5 lbs add ¼ – ½ scoop to wet or dry food 1-2 times daily, or for animals weighing between 6 – 25 lbs add ½ – 1 scoop. If your pet weighs 26-75 lbs add 1-2 scoops to their food mixture 2-3 times a day. For larger pets that weigh 76-150 lbs add 2-3 scoops 2-4 times daily.

Novequin PET is one of the best digestive supplements for pets, specifically formulated to improve their gut health. This blend of probiotics and digestive enzymes are designed to support your pets immune and digestive health. If you’ve noticed that your pet is experiencing shedding, bad breath, regular yeast infections or occasional constipation, then Novequin PET is the perfect solution to keep your pet’s sensitive digestive system healthy and happy.   Digestive problems in household pets are more common than you would think and can be difficult to spot. Factors such as stress, physical strain and ageing can all lead to unpleasant symptoms in your four legged furry friend. If you believe your pet is experiencing problems in their digestive tract, then try Novequin PET today.   Benefits of Novequin PET:   Digestion support in pets Healthy Immune Function In Pets Improved gut health Reduce shedding in pets Relieves constipation in pets Pre and probiotic enhancement in pets Healthy yeast and fungal levels Optimal nutrient absorption What Is Novequin PET? Novequin PET is a natural supplement that’s a crucial addition to your pets’ diet in order to improve their gut health and overall wellbeing. This is because they contain a combination of digestive enzymes and probiotics that are required to ensure a healthy and happy life for your furry companion. By introducing probiotics for pets you will be providing your beloved four legged friend with the essential nutrients to support intestinal and gut health, as well as improving their immune function and overall well being. Whether you’re looking for digestive enzymes for dogs or probiotics for cats, you can introduce Novequin PET at any stage of their life no matter how old they are. How Does Novequin PET Supplements Work? Specifically designed to support the immune and digestive health in your pets, Novequin PET probiotics for dogs helps to improve this function. The same way we experience stress from our day to day lives; animals too are confronted with stress and physical strain while living their lives, which can negatively affect their digestive function. Factors that can contribute to this can be anywhere from changes in their environments, changes in their diet or nutritional deficiencies. Your pets can even experience additional stress and anxiety if they are left home alone for many hours of the day, causing an intestinal imbalance resulting in a decline in their heath and happiness. By providing them with probiotics for pets with Novequin PET, you can be confident that their sensitive digestive system is functioning at its best. Novequin PET contains beneficial bacteria and enzymes that your pet needs in order to feel their best. By introducing Novequin PET to your furry friend’s diet, they will be provided with the good bacteria and supportive enzymes that work to protect their sensitive digestive system. How Does Novequin PET Supplements Improve Digestion   Novequin PET supplements are the perfect option if your pet is suffering from digestive issues. Because they contain a combination of digestive enzymes and probiotics, they work together to ensure a healthier pet. But how does introducing this into your pet improve digestion? Digestive enzymes are essentially proteins that act as catalysts in biochemical reactions. What sets Novequin PET apart from other supplements for pets is that it contains a variety of different enzymes that help break down many common foods in a typical animal’s diet. Specifically, Novequin PET enzymes help digest fibre, protein, fat and carbohydrates.  How long does it take Novequin PET to work? The time it takes for Novequin PET supplements to work will vary from pet to pet. From dogs to cats and every pet in between, as every animal is different it can take longer for the effects to kick in depending on the pet. Weight, size and species are all factors that determine how quickly Novequin PET takes to work. However, some pet owners reported seeing the benefits within one day of supplementing. As results will differ with some working slower and some seeing benefits faster, the general rule is you will need to wait at least a month to see the desired outcome and up to three months for optimal results. Why Novequin PET Are The Best Probiotics For Dogs By introducing digestive enzymes for dogs you can ensure the health and happiness of your four legged friend. Dogs are known for being happy and loyal animals, but when their health is on the decline it can be difficult to spot as they can’t communicate when something is wrong. This can lead to them suffering for a long time before receiving treatment, causing their condition to worsen overtime. Therefore, if you spot any of the following symptoms: shedding fur, unpleasant breath or unusual bowel movements, you may want to try implementing digestive enzymes for dogs. Novequin PET works to restore gut health within our furry companion, as these supplements for pets contain beneficial microorganisms, which help assist your dog’s overall digestive system. Containing prebiotic isomalto-oligosaccharide (IMO), an all natural, non-GMO prebiotic fibre which is responsible for promoting digestive health in your canine companion. As IMO is a prebiotic, when it enters your dogs intestines, it’s consumed by the probiotics already present in their gut, which allows for the good bacteria to flourish. As dogs have sensitive digestive systems, introducing Novequin PET can help make sure everything is well balanced. There are many contributing factors that can lead to something becoming unbalanced leading to an array of uncomfortable symptoms in your pup. From excessive stress, nutritional deficiencies or even dietary changes. It’s common for dogs to eat food they find on their walk, which can disrupt the digestive system. Moreover, supplementing Novequin PET can prevent issues with digestion in your dog and improve their overall gut health. Why Novequin PET Are The Best Probiotics For Cats By introducing probiotics for cats with Novequin PET, you can secure optimal gut health in your fur companion. Containing a combination of digestive enzymes and probiotics for cats, they work together to relieve digestive problems in your beloved pet. The enzyme amylase works to break down starches, helping to ease the digestion of excess starches processed in the large intestine. This is important as cats are unpredictable; if you own an outdoor cat you can’t control what they eat outside and often catch, kill and eat things they shouldn’t. If they have digestive issues, this could lead to problems with their gut health. Therefore, by introducing this enzyme into your cat’s diet, it will assist in easing any digestive discomfort, leading to a happy cat. Suggested Use: In order to achieve the desired result from Novequin PET, it’s essential that you follow the dosage recommendation which will determine the amount to add to either wet or dry food. Or if you’re unsure, speak to your vet. For small pets weighing under 5 lbs, simply add ½ to 1 scoop 1-2 times per day – or 1-3 times if they weigh 6-25 lbs. Animals that weigh 26-75 lbs will require 1-2 scoops 2-3 times a day. For larger pets weighing 76-150 lbs, you will need to add 2-3 scoops between 2-4 times per day.

Novequin PET is one of the best digestive supplements for pets, specifically formulated to improve their gut health. This blend of probiotics and digestive enzymes are designed to support your pets immune and digestive health. If you’ve noticed that your pet is experiencing shedding, bad breath, regular yeast infections or occasional constipation, then Novequin PET is the perfect solution to keep your pet’s sensitive digestive system healthy and happy.   Digestive problems in household pets are more common than you would think and can be difficult to spot. Factors such as stress, physical strain and ageing can all lead to unpleasant symptoms in your four legged furry friend. If you believe your pet is experiencing problems in their digestive tract, then try Novequin PET today.   Benefits of Novequin PET:   Digestion support in pets Healthy Immune Function In Pets Improved gut health Reduce shedding in pets Relieves constipation in pets Pre and probiotic enhancement in pets Healthy yeast and fungal levels Optimal nutrient absorption What Is Novequin PET? Novequin PET is a natural supplement that’s a crucial addition to your pets’ diet in order to improve their gut health and overall wellbeing. This is because they contain a combination of digestive enzymes and probiotics that are required to ensure a healthy and happy life for your furry companion. By introducing probiotics for pets you will be providing your beloved four legged friend with the essential nutrients to support intestinal and gut health, as well as improving their immune function and overall well being. Whether you’re looking for digestive enzymes for dogs or probiotics for cats, you can introduce Novequin PET at any stage of their life no matter how old they are. How Does Novequin PET Supplements Work? Specifically designed to support the immune and digestive health in your pets, Novequin PET probiotics for dogs helps to improve this function. The same way we experience stress from our day to day lives; animals too are confronted with stress and physical strain while living their lives, which can negatively affect their digestive function. Factors that can contribute to this can be anywhere from changes in their environments, changes in their diet or nutritional deficiencies. Your pets can even experience additional stress and anxiety if they are left home alone for many hours of the day, causing an intestinal imbalance resulting in a decline in their heath and happiness. By providing them with probiotics for pets with Novequin PET, you can be confident that their sensitive digestive system is functioning at its best. Novequin PET contains beneficial bacteria and enzymes that your pet needs in order to feel their best. By introducing Novequin PET to your furry friend’s diet, they will be provided with the good bacteria and supportive enzymes that work to protect their sensitive digestive system. How Does Novequin PET Supplements Improve Digestion   Novequin PET supplements are the perfect option if your pet is suffering from digestive issues. Because they contain a combination of digestive enzymes and probiotics, they work together to ensure a healthier pet. But how does introducing this into your pet improve digestion? Digestive enzymes are essentially proteins that act as catalysts in biochemical reactions. What sets Novequin PET apart from other supplements for pets is that it contains a variety of different enzymes that help break down many common foods in a typical animal’s diet. Specifically, Novequin PET enzymes help digest fibre, protein, fat and carbohydrates.  How long does it take Novequin PET to work? The time it takes for Novequin PET supplements to work will vary from pet to pet. From dogs to cats and every pet in between, as every animal is different it can take longer for the effects to kick in depending on the pet. Weight, size and species are all factors that determine how quickly Novequin PET takes to work. However, some pet owners reported seeing the benefits within one day of supplementing. As results will differ with some working slower and some seeing benefits faster, the general rule is you will need to wait at least a month to see the desired outcome and up to three months for optimal results. Why Novequin PET Are The Best Probiotics For Dogs By introducing digestive enzymes for dogs you can ensure the health and happiness of your four legged friend. Dogs are known for being happy and loyal animals, but when their health is on the decline it can be difficult to spot as they can’t communicate when something is wrong. This can lead to them suffering for a long time before receiving treatment, causing their condition to worsen overtime. Therefore, if you spot any of the following symptoms: shedding fur, unpleasant breath or unusual bowel movements, you may want to try implementing digestive enzymes for dogs. Novequin PET works to restore gut health within our furry companion, as these supplements for pets contain beneficial microorganisms, which help assist your dog’s overall digestive system. Containing prebiotic isomalto-oligosaccharide (IMO), an all natural, non-GMO prebiotic fibre which is responsible for promoting digestive health in your canine companion. As IMO is a prebiotic, when it enters your dogs intestines, it’s consumed by the probiotics already present in their gut, which allows for the good bacteria to flourish. As dogs have sensitive digestive systems, introducing Novequin PET can help make sure everything is well balanced. There are many contributing factors that can lead to something becoming unbalanced leading to an array of uncomfortable symptoms in your pup. From excessive stress, nutritional deficiencies or even dietary changes. It’s common for dogs to eat food they find on their walk, which can disrupt the digestive system. Moreover, supplementing Novequin PET can prevent issues with digestion in your dog and improve their overall gut health. Why Novequin PET Are The Best Probiotics For Cats By introducing probiotics for cats with Novequin PET, you can secure optimal gut health in your fur companion. Containing a combination of digestive enzymes and probiotics for cats, they work together to relieve digestive problems in your beloved pet. The enzyme amylase works to break down starches, helping to ease the digestion of excess starches processed in the large intestine. This is important as cats are unpredictable; if you own an outdoor cat you can’t control what they eat outside and often catch, kill and eat things they shouldn’t. If they have digestive issues, this could lead to problems with their gut health. Therefore, by introducing this enzyme into your cat’s diet, it will assist in easing any digestive discomfort, leading to a happy cat. Suggested Use: In order to achieve the desired result from Novequin PET, it’s essential that you follow the dosage recommendation which will determine the amount to add to either wet or dry food. Or if you’re unsure, speak to your vet. For small pets weighing under 5 lbs, simply add ½ to 1 scoop 1-2 times per day – or 1-3 times if they weigh 6-25 lbs. Animals that weigh 26-75 lbs will require 1-2 scoops 2-3 times a day. For larger pets weighing 76-150 lbs, you will need to add 2-3 scoops between 2-4 times per day.