Sold out
Wizard Sciences Wizard Sciences - Neural Rx (24 servings)
£122.40
Neural RX Neural RX is a premier nootropic supplement, formulated using a Caprylic Acid (C-8) Lipofullerene base with a proprietary Neural blend specifically designed to support cognitive function. As a leading brain health supplement, Neural RX contains a solvent-free C60, also referred to as a C60 supplement, a molecule with great potential because of its antioxidant and anti-inflammatory properties. Wizard Sciences uses a Liposome and proprietary Neural Blend, developed by Ian Mitchell (Wizard Sciences Founder), to enhance the distribution and absorption of fullerenes and constituent ingredients. The increased "availability" to the body supports cognitive function and provides access to antioxidant protection for your body's mitochondria. Higher evoked neural potential - literally more power in your brain, making it one of the best nootropics for enhanced cognitive performance Decrease in neural inflammation Removal of plaques and proteins, key for memory supplements Stimulation of the glymphatic system, important for focus supplements Neurogenesis - new neurons, a fundamental aspect of nootropic supplements Suggested Dose: Adults, take 2 teaspoons daily with or without food in the morning. For best results, take regularly for 5-6 days, then cycle off for 1-2 days before cycling on again. This caprylic acid supplement is designed for optimal dosage and absorption.
Ancestral Supplements Ancestral Supplements - Brain, Memory & Mood Bundle (Wild Caught Fish Eggs, Beef Brain, & Beef Bone & Marrow)
£183.00
Ancestral Supplements - Brain, Memory & Mood Stack (Wild Caught Fish Eggs, Beef Brain, Beef Bone & Marrow) Elevate your focus and vitality with Ancestral Supplements’ Brain, Memory & Mood Stack. This premium stack combines wild-caught fish eggs, grass-fed beef brain, and nutrient-rich beef bone and marrow to provide essential nutrients that support cognitive performance and overall well-being. Wild Caught Fish Eggs: Packed with Omega-3 fatty acids and bioavailable DHA to support cognitive function Grass Fed Beef Brain: A natural source of brain-specific peptides, nutrients, and healthy fats Beef Bone & Marrow: Delivers stem cells, collagen, and essential fats for nourishing the body 100% Natural: Sourced from wild-caught fish and grass-fed, pasture-raised cattle Pure & Clean: Free from GMOs, hormones, fillers, and artificial additives Who It’s For: Ideal for individuals looking to support their mental clarity, focus, and vitality naturally, this stack is perfect for those embracing nutrient-rich, whole-food supplements sourced from the finest ingredients.
Sold out
Bulletproof Bulletproof - MCT Oil 16oz
£15.50
Tired of constantly craving caffeine? Want a thermogenic immune boost with your energy? Say goodbye to coconut oil and say hello to energy that's 6x stronger. Upgraded MCT Oil can provide: Fast Energy - Upgraded MCT oil converts into energy faster than other oils Better Blood Chemistry - Helps maintain healthy cholesterol levels Nutrient Absorption - Improves the body’s absorption and use of vitamin E, calcium, and magnesium Immune System Benefits - Helps lessen harmful bacteria, viruses and fungi inside the body Healthy Cell Membranes - Serves as stable building block of cell membranes Easy Storage - No refrigeration required and liquid at room temperature Make meals more Bulletproof - Flavorless and easy to add into diet. Mix into any smoothie, soup, sushi (my favorite!), or most recipes Upgraded MCT oil is extracted from palm and coconut oil in a time consuming process, making it the most potent MCT on the market. No metal catalysts are used in the manufacturing process, and every batch of our MCT is tested for heavy metals. We only use BPA-free plastic to bottle our Upgraded MCT Oil. The manufacturer of Upgraded MCT Oil is a member of the RSPO, Roundtable on Sustainable Palm Oil. Upgraded MCT Oil acts as a substitute for some of the usual oils in your diet. It should not be used to replace all of the fat in your diet. Begin using MCT 1 tablespoon per day and slowly increase over several days. Too much MCT, especially if consumed on an empty stomach, may result in diarrhea or a stomachache. 1-3 tablespoons per day is recommended for Bulletproof practitioners.The best way to maximize energy is to use Upgraded MCT Oil with Upgraded Coffee to make Bulletproof Coffee. Mix Upgraded MCT oil with grass-fed butter and combine it with Bulletproof Coffee to gain hours of energy and lose inches off your waistline! It may also be used in smoothies, salad dressings, and many recipes. Upgraded MCT oil is suitable to cook at temperatures under 320o F. It does not trigger allergens in the following foods: celery, cereals containing gluten, crustaceans, eggs, fish, lupin, milk or its derivatives, mollusks, mustard, peanuts (including peanut oil), sesame seed or its derivatives, soybean or its derivatives, Sulfur Dioxide, tree nuts, wheat or its derivatives, and more. It is highly, highly purified. Medium-chain triglycerides (MCTs) work directly with cells to give them an extra boost and maximize performance. Very little MCT oil is stored as fat because the body energizes itself very quickly with it. Upgraded MCT is 100% capric and caprylic acid, and has a perfect 8-10 carbon saturated fat level. It's also GMO-free, aflatoxin-free, BSE/TSE-free, and melamine-free.
Sold out
Bulletproof Bulletproof - MCT OIL 32oz
£29.95
Tired of constantly craving caffeine? Want a thermogenic immune boost with your energy? Say goodbye to coconut oil and say hello to energy that's 6x stronger. Upgraded MCT Oil can provide: Fast Energy - Upgraded MCT oil converts into energy faster than other oils Better Blood Chemistry - Helps maintain healthy cholesterol levels Nutrient Absorption - Improves the body’s absorption and use of vitamin E, calcium, and magnesium Immune System Benefits - Helps lessen harmful bacteria, viruses and fungi inside the body Healthy Cell Membranes - Serves as stable building block of cell membranes Easy Storage - No refrigeration required and liquid at room temperature Make meals more Bulletproof - Flavorless and easy to add into diet. Mix into any smoothie, soup, sushi (my favorite!), or most recipes Upgraded MCT oil is extracted from palm and coconut oil in a time consuming process, making it the most potent MCT on the market. No metal catalysts are used in the manufacturing process, and every batch of our MCT is tested for heavy metals. We only use BPA-free plastic to bottle our Upgraded MCT Oil. The manufacturer of Upgraded MCT Oil is a member of the RSPO, Roundtable on Sustainable Palm Oil. Upgraded MCT Oil acts as a substitute for some of the usual oils in your diet. It should not be used to replace all of the fat in your diet. Begin using MCT 1 tablespoon per day and slowly increase over several days. Too much MCT, especially if consumed on an empty stomach, may result in diarrhea or a stomachache. 1-3 tablespoons per day is recommended for Bulletproof practitioners.The best way to maximize energy is to use Upgraded MCT Oil with Upgraded Coffee to make Bulletproof Coffee. Mix Upgraded MCT oil with grass-fed butter and combine it with Bulletproof Coffee to gain hours of energy and lose inches off your waistline! It may also be used in smoothies, salad dressings, and many recipes. Upgraded MCT oil is suitable to cook at temperatures under 320o F. It does not trigger allergens in the following foods: celery, cereals containing gluten, crustaceans, eggs, fish, lupin, milk or its derivatives, mollusks, mustard, peanuts (including peanut oil), sesame seed or its derivatives, soybean or its derivatives, Sulfur Dioxide, tree nuts, wheat or its derivatives, and more. It is highly, highly purified. Medium-chain triglycerides (MCTs) work directly with cells to give them an extra boost and maximize performance. Very little MCT oil is stored as fat because the body energizes itself very quickly with it. Upgraded MCT is 100% capric and caprylic acid, and has a perfect 8-10 carbon saturated fat level. It's also GMO-free, aflatoxin-free, BSE/TSE-free, and melamine-free.
Feel Younger Feel Younger - Brain Boost Plus 60caps
£29.00
Would you like… To Focus more Easily Improved Cognition Better Brain Function Improved Memory Sharper Thinking Increased Alertness Improved Mood If so, you may want to give our Brain Boost Plus, Neuro Brain and Focus Formula a try!The combinations of ingredients found in this supplement can potentially also give you: Antioxidant support Anti-inflammatory support Increased energy Improved skin health Improved eye health Blood pressure support Improved heart health Boosted immunity Better bone health Blood sugar regulation Why is it important to support your brain?The brain is arguably the most important organ in your body - without it, we wouldn’t be able to carry out any of our daily functions.The brain controls our motor skills, vision, temperature, hunger, emotions, touch, thought and just about every process that helps to maintain and regulate our bodies [1].There are a variety of factors that can lead to your brain ageing prematurely, or becoming ‘unhealthy’, such as: Lack of good quality sleep [2] Poor diet & overeating [3] Not enough exercise [4] Smoking [5] Obesity [6] High blood pressure [7] High cholesterol levels [8] Social isolation [9] Spending too much time in dimly lit environments [10] Often overlooked, Deficiency or suboptimal levels of nutrients that are important to the brain will also contribute to inferior brain health. Can you test for an ‘unhealthy’ brain?There are a variety of tests that can be used in different situations to help determine if something serious is going on with your brain.Some of these include:Balance testCT scan (computed tomography)EEG (electroencephalography)ElectromyographyMRI (magnetic resonance imaging)MRA (magnetic resonance angiography - a type of MRI scan)And more.However, as these tests are generally expensive and hard to get, most people rely on evaluating symptoms such as decreased memory, focus and clarity of thinking.Speak to your physician to determine the best course of action if you have any concerns.The Top 9 Ways to Support Your Brain:To keep your brain functioning at optimal capacity, there are some lifestyle changes that you can make: Get enough good quality sleep, every night. For most adults, this is 7-8 hours of deep uninterrupted sleep. If sleep is something you struggle with, check out our Sleep Aid Ultra page. Eat an organic diet with plenty of high nutrient density foods. This will provide your brain with most of the nutrients and minerals it needs for optimal function. Exercise regularly. Half an hour of physical activity most days, or around 150 minutes a week. Stop smoking.   Maintain a healthy weight, and don’t overeat. Even too much healthy food can lead to weight gain. Minimize stress and lower your blood pressure. Meditating is a great way to reduce stress, and try natural supplements, such as our 5 HTP, Serenity Anti-Stress Support, Saffron Pure Extract OR Organic Ashwagandha with Black Pepper. Socialize more often. Spend more time in natural light and brighter lit rooms earlier in the day. Provide your brain with minerals and vitamins that are essential for it to function optimally: Vitamin A - Vitamin A is crucial to brain function, behavior and learning [11].Vitamin C - Your brain requires huge amounts of oxygen to function, which means it is extremely susceptible to oxidative stress. Vitamin C is a powerful antioxidant and helps to reduce oxidative stress [12].Calcium - Calcium is essential for optimal blood flow to the brain [13].Vitamin D - Essential for brain health, deficiency in Vitamin D can contribute to brain fog, low mood and can impact cognitive health [14].Magnesium - Optimal levels of magnesium in the body is crucial for brain health. Deficiency of magnesium (or low levels of) is commonly found in people who are stressed [15].Vitamin B1 - A deficiency of thiamine (vitamin B1) can contribute to increased confusion, can be of detriment to your ability to think clearly as well as reducing your awareness of your surroundings [16].Vitamin B2 - Riboflavin vitamin b2) can help to reduce inflammation and oxidative stress to nerves in the brain, both of which can contribute to headaches and migraines [17].Vitamin B3 - Niacin (vitamin B3) is another B vitamin that plays an important role in the health of your brain. It’s involved in making and repairing DNA, cell signaling and acts as an antioxidant [18].Folate - Suboptimal mental function can be linked to low folic acid (folate) levels in the blood.A randomized controlled trial over 2 years showed that 400mg folic acid supplementation improved measures of brain function and decreased blood levels of proteins that are linked to Alzheimer’s disease [19].Selenium - Selenium is a powerful antioxidant [20], and people with Alzheimer’s have been found to have lower levels of selenium in their blood [21].Copper - Essential for brain function, too much or too little copper in the body can be linked with neurodegeneration [22].Manganese - Manganese is required for many functions in the body, which includes normal brain and nervous system function.It’s another powerful antioxidant (potentially one of the most important) [23] that can help to protect your brain against free radicals, as well as improving your brain function [24].Potassium - Potassium plays an important role in the cardiovascular system, helping to get blood to the brain [25].Choline - Choline is needed to produce a neurotransmitter called acetylcholine, which is crucial to regulate intelligence, mood and memory [26].Grape Seed Extract - Grapes contain flavonoids, which possess powerful antioxidants and anti-inflammatory properties. Studies have shown that grape seed extract may help to improve cognitive status and antioxidant levels in the brain, while preventing memory loss [27].GABA - GABA (gamma aminobutyric acid) is an amino acid that functions as a neurotransmitter in the brain. When GABA attaches to a GABA receptor in the brain, it has a calming effect [28].Bilberry Fruit Extract - Bilberry fruit extracts have been shown to help improve memory (both working and long-term) in older adults [29].And many more!We understand that it’s not always easy, nor is it practical to implement a variety of lifestyle changes at once.We’d advise that you make as many of those changes listed further up this page as possible, but to do so 1 or 2 at a time, make sure they stick and then implement a couple more.In the meantime, you can support your body with the essential nutrients and minerals it needs that can help you to boost your brain's function.That’s why we’ve included the above ingredients into our Brain Boost Plus formula, and included other minerals and vitamins that we think are worth taking to support the health of your brain, such as: Vitamin E [30], Iron [31], Biotin [32], Vitamin B5 [33], Vitamin B6 [34], Zinc [35], Chromium [36], Molybdenum [37], DMAE Bitartrate [38], L-glutamine [39], Green Tea Extract [40], Bacopa Extract [41], Inositol [42], N-Acetyl L-Tyrosine [43], Olive Leaf [44], Cinnamon Bark Extract [45], Licorice Root Extract [46], Boron [47], DHA [48], Vanadyl [49], Phosphatidylserine [50], Huperzine A [51]. By combining the ingredients listed on this page, with our unique proprietary blend in an easy to swallow capsule, we’ve taken the stress out of buying each of these ingredients separately, researching and experimenting how much of each you should take and then incorporating them into your diet/supplement regime.Here at Feel younger, we believe in providing strong doses at reasonable prices. Our Brain Boost Plus capsules provide a 1,004 mg dose that will cost you no more than $29, with discounts available on multiple bottle and subscription purchases.How Do You Take Feel Younger® Brain Boost Plus, Neuro Brain and Focus Formula?Take two capsules a day with your morning meal.Any Cautions?ALWAYS consult a healthcare professional before taking any new supplements. Scientific References https://www.ncbi.nlm.nih.gov/books/NBK279302/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143346/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437759/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258000/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543069/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598577/ https://www.health.harvard.edu/heart-health/blood-pressure-and-your-brain https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844833/ https://www.nia.nih.gov/news/social-isolation-loneliness-older-people-pose-health-risks https://pubmed.ncbi.nlm.nih.gov/32933226/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169332/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649700/ https://www.medschool.umaryland.edu/news/2021/University-of-Maryland-School-of-Medicine-Study-Finds-Calcium-Precisely-Directs-Blood-Flow-in-the-Brain.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970300/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761127/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659035/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/ https://pubmed.ncbi.nlm.nih.gov/26828517/ https://pubmed.ncbi.nlm.nih.gov/29255930/ https://pubmed.ncbi.nlm.nih.gov/19033020/ https://pubmed.ncbi.nlm.nih.gov/24668390/ https://www.sciencedirect.com/science/article/pii/S0301008214000124 https://pubmed.ncbi.nlm.nih.gov/22072939/ https://pubmed.ncbi.nlm.nih.gov/12505649/ https://pubmed.ncbi.nlm.nih.gov/23558164/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552/ https://pubmed.ncbi.nlm.nih.gov/21871550/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231020/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024810/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276978/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789770/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728061/ https://pubmed.ncbi.nlm.nih.gov/20423560/ https://pubmed.ncbi.nlm.nih.gov/15207438/ https://pubmed.ncbi.nlm.nih.gov/864168/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760805/ https://pubmed.ncbi.nlm.nih.gov/28899506/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554709/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084775/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074804/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466762/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974064/ https://pubmed.ncbi.nlm.nih.gov/7889884/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772061/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077345/ https://clinicaltrials.gov/ct2/show/NCT04920305 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930088/
Sold out
Bulletproof Bulletproof - Neuromaster - 30 Caps
£55.95
Take one capsule in the morning with or without food. Amount Per Serving (1 Capsule): NeuroFactor™ Whole Coffee Fruit Extract – 200mg Coffeeberry® Energy Coffee Fruit Extract – 71mg   Other Ingredients: Rice flour, cellulose capsule, rice concentrate, l-leucine Boost Your Brain NeuroMaster™ contains an ingredient shown to significantly increase BDNF levels - key neuro-proteins for neuron creation and synaptic plasticity, and includes compounds that may improve memory and focus.  BDNF provides gold-standard brain nourishment BDNF, brain-derived neurotrophic factor, is found in the brain – influencing where new neurons grow, and creating denser networks of brain cells. It also helps your brain cells connect with one another, building new neural pathways.  Is Your Brain Growing… Or Shrinking? As we age, many of us normally begin to lose this key protein that supports our brains. In a study of adults between the ages of 59 and 81, lower levels of BDNF were associated with age-related hippocampal shrinkage and memory decline. (source)  Brain health made simple We specifically formulated NeuroMaster™ to boost naturally occurring BDNF, and support brain health, memory and focus. Naturally Sourced From Coffee Berries All ingredients in NeuroMaster™ are laboratory-extracted from high-quality Arabica coffee fruit. One of these extracts alone has been shown in two separate double-blind, placebo-controlled studies to increase levels of BDNF. The other extract has 100% natural caffeine to jump-starts your day.  This Is Your Edge Bulletproof™ supplements are backed by the most cutting-edge research, science, and technology to kick performance into overdrive. Sourced from the best, most bioavailable ingredients possible — all Bulletproof supplements are 100% non-GMO, soy, and gluten-free, with no artificial colors, added preservatives, or any other junk. They undergo strict lab testing to ensure they meet the rigorous quality standards of the Bulletproof Process™ — ensuring purity and potency. So you can focus on being more awesome, in every way.
Natural Stacks Serotonin Brain Food™ - 60 Capsules (Natural Stacks)
£39.95
Serotonin Brain Food™ highlights: ● Happier, more stable moods● Improved gut health, digestion and physical wellbeing● No artificial ingredients, no GMOs, no gluten. What is “brain food”? Neurochemistry - the chemical patterns and processes that cause your brain to function as it does - is highly complex. It varies significantly between individuals, and is heavily influenced by a large range of factors. Your diet, exercise habits, sun exposure, social group and genetics all have a role to play in your brain’s chemical behaviour. Most of us do not get enough of everything we need every day to keep our brain function 100% optimized. That’s why supplementing with brain food can give you such an edge. Brain food are natural nutrients that act as fuel for specific neurotransmitters in the brain. They can be taken daily to boost various states of optimal performance. By addressing any deficiencies or imbalances in the delicate neurological system, you can increase your ability to concentrate, regulate your energy, and balance your mood. The importance of Serotonin Serotonin is a neurotransmitter that is associated with a sense of wellbeing and happiness, as well as a healthy appetite and digestive system, constricting smooth muscles, and transmitting impulses between nerve cells. Abnormal serotonin levels can cause serious problems, such as osteoporosis, poor libido, nausea, migraines, obesity and Parkinson’s disease. Low levels are associated with depression, anxiety, and obsessive compulsive behavior. Getting your serotonin levels balanced and in an optimal range can have a profound influence on your health and quality of life. When your serotonin is being produced at the optimal pace, you will feel calm and healthy. Your mood will be positive, stable, and well balanced. Complete Neurotransmitter Support The best way to optimize serotonin levels is to ensure that the necessary precursors and cofactors are available. These precursors and cofactors pave the way for your brain to produce and then use serotonin at an optimal rate for your particular physiology. Serotonin Brain Food™ provides these essential compounds. It contains an amino acid precursor (L-Tryptophan), serotonin metabolism cofactors (Vitamin B-3, Zinc, & Magnesium), and an herbal extract to reduce cortisol (Rhodiola Rosea). For A Positive Mood SUGGESTED USE: Take a serving of 2-3 capsules to support a positive mood, during situations of stress or irritability, or as directed by a healthcare practitioner. Avoid use in the evening. Do not exceed 2 servings per day. U.S.A manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients. L-Tryptophan As a precursor to serotonin, this essential amino acid is directly converted into 5-HTP. It’s found in many foods such as egg whites, soybean, and turkey. Vitamin B-3 (Niacinamide) An essential vitamin that is also a necessary cofactor for the proper catabolism of fat, carbohydrate, protein, and alcohol. It’s also closely involved in cell signaling and DNA repair. It’s used most extensively in the brain, gut and skin, which have a high cellular turnover rate. Our Vitamin B-3 source is a niacinamide, which has been carefully selected to be non-flushing - many other Vitamin B-3 sources are niacin, which can cause uncomfortable skin flushing. Magnesium (Magnesium Glycinate) Magnesium glycinate has a positive impact on attention, memory, and stress reduction. Utilizing the essential amino acid glycine, this form of magnesium has a calming effect on the brain. Zinc (Zinc Glycinate) Zinc glycinate is a critical factor in maintaining a healthy immune system. It supports optimal cell division and replication, improves healing times, and ensures proper growth patterns and sensory development. Rhodiola Rosea An herb native to the Arctic and northernmost parts of Europe and Central Asia, Rhodiola Rosea has been used in herbal medicine for many years. It’s associated with improvements in mood, reduced stress and depression, and overall increases in physical and mental well being and performance. Serotonin Metabolism, by Abelard Lindsay Serotonin is a neurotransmitter responsible for mood[1], fear[2], aggression[3] and anxiety[4]. It plays a large part in the digestive process as it interacts with neurons present in the gut[5]. Healthy serotonin levels allow one to be in the moment instead of becoming drawn into negative thought patterns. Where does serotonin come from? It starts with tryptophan. Tryptophan is an essential amino acid that is a precursor to serotonin. It is found in many foods such as egg whites, soybean and turkey and is also available as a nutritional supplement[6]. It is converted into 5-HTP by the enzyme tryptophan hydroxylase(TH). TH is a key rate limiting enzyme that controls the production of 5-HTP in the body. TH comes in two variants. TPH1, which is present in the gut and the peripheral nervous system, and TPH2, which is primarily expressed in the central nervous system[7]. Serotonin outside the CNS is not particularly interesting for cognitive enhancement. It is however suspected that a lack or excess of serotonin in the digestive tract can lead to irritable bowel syndrome. Some drugs with antidepressant effects are actually used to control certain intractable digestive problems, presumably by having an effect on the neurochemical aspects of digestion[8]. Serotonin is an agonist for many different serotonin receptors in the brain. Many antidepressant drugs developed over the past 30 years, known as SSRIs, have been developed in order to keep serotonin active in the synaptic cleft by reducing the activity of the SERT enzyme[9]. The theory behind this is that stimulating serotonin receptors via increased synaptic serotonin will improve and alleviate depression[10]. Exercise, a well studied treatment for depression[11], has been investigated as a serotonin production enhancer through various mechanisms[12]. Serotonin is broken down and then processed into melatonin via methylation[13]. Melatonin is crucial for sleep. Methylation is also active in the dopamine system and breaks down norepinephrine to epinephrine. Supplementation of melatonin has been shown to increase serotonin in animal models[14]. Seasonal affective disorder, a form of depression caused by lack of sunlight in winter months, is tied to serotonin deficiency[15]. This is possibly due to excess melatonin production from serotonin as melatonin production is controlled by light exposure and the circadian rhythms[16]. Another system that has a profound effect on serotonin metabolism is regulated by the hormone cortisol. Cortisol pathways, which are induced by stress, cause an increase in serotonin reuptake, possibly contributing to depression[17]. Increased cortisol also may increase the production of N-formyl-L-kynurenine by increasing the activity of tryptophan 2,3-dioxygenase[18]. This pathway uses up L-Tryptophan in the eventual production of niacin instead of serotonin. Niacin is produced from tryptophan in competition with the serotonin pathway[19]. Supplementing niacin thus may free up tryptophan to be processed into serotonin. Magnesium is important in processing serotonin[20]. A correlation has been shown between low magnesium levels and depression[21]. Experimental evidence has also shown that magnesium is needed as a cofactor of tryptophan hydroxylase, which converts tryptophan into 5-HTP, a serotonin precursor, and magnesium is also needed for binding serotonin[22]. It also increases activity at the 5-HT1A serotonin receptor.[23] Zinc also enhances outcomes in unipolar depression[24]. The mechanism of action on serotonin is that it modulates uptake of serotonin into cells[25]. Herbs that have exhibited serotonin reuptake inhibition activity like St. John’s Wart[26] and herbs with observed MAO-A inhibition activity like resveratrol[27] are powerful increasers of serotonin and should only be used in situations where there is a significant deficiency. Berberine heavily influences the 5-HTT transporter[28] while having positive health benefits and being well tolerated over long periods of time. Serotonin is a regular and reliable system that responds to supplementation and has positive effects on mood and energy. There’s a huge difference between low levels of serotonin and optimal levels in how you think, feel and perform.