Brain Power (22)

Celeryforce® A special blend of Magnesium Glycinate, Inositol, L-Glutamine, L-Taurine, and Choline, which are vitamins, minerals and amino acids that support the health of neurotransmitters, nerves, muscles, cells, the immune system, the cardiovascular system and more. Product info CeleryForce® gives you a simple way to get important vitamins, minerals, and amino acids that many different and vital parts of your body need to function properly. From healthy neurotransmitter signalling to healthy muscular function to healthy nerve transmission to healthy cellular function and more, CeleryForce® can help. Read on to find out how CeleryForce® can support your health! Celeryforce®: Choline is a member of the B vitamin family that supports cellular health Choline is essential for the production of the neurotransmitter acetylcholine Choline supports healthy nerve transmission and is essential for lipid transport and metabolism Inositol supports healthy cellular function Inositol is essential for healthy neurotransmitter signaling Magnesium is an essential cofactor for over 300 enzyme systems. Magnesium is essential for the function of the mitochondrion and is essential for DNA and RNA synthesis Magnesium is essential for the activation of adenylate cyclase, which is an important regulator of cellular activity and is essential for healthy muscular function L-Glutamine supports the function of a healthy immune system L-Taurine is essential for cellular health and also supports cardiovascular health Non-GMO, Gluten-Free, Kosher, Corn-Free, Soy-Free, Vegan, Paleo No Citric Acid and No Gelatin How to Use Serving: As a dietary supplement, take 1 capsule 15 minutes before or after your celery juice, or at anytime, 1 to 2 times daily. Storage: Store in a cool, dark place. Contraindications Consult your physician before use if you are pregnant, lactating, have a medical condition, or are taking any medication. Immediately discontinue use and consult your doctor if you experience any adverse reaction to this product.

Pasture Raised In New Zealand Grass-fed & Grass-Finished Hormone, Pesticide & GMO Free Absolutely No Fillers (or) Flow Agents 100% Freeze Dried & Non-Defatted Third Party Tested For Purity Allergen Free SUPPLEMENT FACTS Serving Size: 6 Capsules Servings Per Container: 30 AMOUNT PER CAPSULE Freeze-Dried New Zealand Grassfed Whole Brain Extract  With Liver 500 MG Grass Fed Whole Brain Extract (Bovine) 250 MG Grass Fed Brain Grass Fed Pituitary Gland Grass Fed Hypothalamus Gland Grass Fed Pineal Gland Grass Fed Liver (Bovine) 250 MG OTHER INGREDIENTS: Collagen (Beef Gelatin) Capsules SUGGESTED USE: Six capsules daily or as directed by a healthcare professional. MANUFACTURED IN THE USA: ANCESTRAL SUPPLEMENTS, LLC FDA STATEMENT: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. WHOLE BRAIN EXTRACT CONTAINS... Proteins Exclusively Found And Expressed In Whole Brain Extract Brain Derived Glandulars Including The Pituitary, Hypothalamus and Pineal Glands Unique Peptides And Neurotrophic Factors Including Brain Derived Neurotrophic Factor (BDNF) Sphingomyelin — Found In High Concentrations In The Myelin Sheath. Brain Cell Activators, Phosphatidylserine & Omega-3 Fats EPA and DHA WHOLE BRAIN EXTRACT SUPPORTS...  Optimal Brain Health Based On "Like Supports Like" Memory, Mood And Cognitive Health  The Survival of Existing Neurons & Encourages The Growth and Differentiation Of New Neurons  Myelin Sheath, Signal Transduction & Apoptosis  NOURISH YOUR WAY TO HEALTH & HAPPINESS WITH GRASS FED BEEF BRAIN For most of human history, we effortlessly consumed (nose-to-tail) the things we needed for strength, health and happiness. Like the fertile ground that we once walked upon, we were a natural extension of this earth. In the modern world, we unknowingly struggle to fulfill our nutritional needs in order to support and sustain a vibrant, disease-free life. We are now part of a world where neurodegenerative conditions, mood disorders and impaired brain functioning run amuck. [ Compounds in whole bovine brain extract may reduce aspects of cellular atrophy, degeneration, decreases in tissue elasticity, and other negative aspects associated with aging.*[2] Brain glandulars contain "specific brain cell activators" [3] and have been advised for slowness of thought, loss of memory, uncontrolled mental activity and epilepsy.*[4,5]  Bovine-brain derived phosphatidylserine was found to improve both behavior and cognition in elderly people with cognitive decline.* [6] "...phosphatidylserine enhances the ability of enzymes in membranes of nerve cells to relay messages in and out of the cells. This product (bovine-brain phosphatidylserine) can improve memory in older adults, and can ameliorate symptoms of depression."*[7] Included in whole brain extract are neurotrophic factors that support the survival of existing neurons and encourages the growth of new neurons as well as sphingomyelin which plays a central role in the myelin sheath and cell signaling.*[9,11] ] Whole food, nutrient dense organs and glands can provide great benefit for those seeking targeted support in harmony with nature — the old fashioned way, the way that our early ancestors did. Grass Fed Beef Brain is a whole brain extract and dietary supplement that provides 100% pure bovine brain with pituitary, hypothalamus and pineal gland in the same balance that exists in nature. Our mission is our purpose... putting back in, what the modern world has left out.  New Zealand Our product is 100% sourced in New Zealand. In agricultural circles, it's known that the clean air, green pastures, and animal husbandry is at a higher level Ultra Pure Our product is 100% pure... This means that you won't see any of the extra stuff that most supplement companies include to save time and money (stearates, silica, etc) Freeze Dried Our product is 100% freeze dried in contrast to the heat processed varieties. This means that you get more of the heat sensitive vitamins, minerals and co-factors that make organ meats so incredibly nourishing Safety There has never been a case of mad cow disease in New Zealand. BSE (mad cow disease), scrapie and other known TSE’s, do not occur in New Zealand. A national surveillance programme is in place to provide comprehensive monitoring CONSIDER THE SOURCE New Zealand seems like it was made for raising healthy animals. Its location and climate produce pristine conditions for cattle and sheep, and the farmers have uncanny expertise handed down for generations. New Zealand is unique among meat-producing regions in the world because its climate is moderate so the grass in the pastures grows fresh and grows green year-round which means the cows and sheep can eat the food that’s healthiest for them every day of the year. Our nose-to-tail product line is always from grassfed, inspected animals born and raised without the use of pesticides, hormones or antibiotics. Health of livestock used for manufacturing in New Zealand is closely monitored by a world leading biosecurity system that is second to none, and is a global exemplar. Strict government licensing, auditing and certification procedures mean that our genuine New Zealand freeze dried products can be used with complete confidence in their origin, safety and efficacy. Freeze-drying preserves the heat sensitive vitamins, minerals and co-factors of components leaving the nutrients in the same balance as found in nature. BENEFITS OF EATING BRAIN WITH LIVER Traditional peoples, Native Americans and early ancestral healers believed that eating the organs from a healthy animal would strengthen and support the health of the corresponding organ of the individual. For instance, the traditional way of treating a person with a weak heart was to feed the person the heart of a healthy animal. Similarly, eating the kidneys of a healthy animal was believed to support urinary ailments and overall kidney health... Pancreas was fed to people with digestive and endocrine problems... and brain was frequently consumed raw and was thought to support clear thinking.*[1,13] Whether from grassfed beef, bison, or lamb, grass fed liver is one of the most nutrient-dense foods you could possibly eat. Hunters all over the world, for uncounted thousands of years, would eat the raw livers of the animals they killed. Lions and other predatory animals will also eat the liver first. Grass fed liver is particularly rich in B vitamins, Vitamin A, Vitamin D, Vitamin K, magnesium, and many other nutrients. Grass fed liver also contains compounds that help the human liver function better. Other substances in liver reduce fatigue and improve brain function.*[1] Organs and glandulars were a staple of our early ancestors' diets as the ultimate superfood, for good reason. It turns out, this nourishing tradition is backed by science... "Radioisotope labeling studies in animals have shown conclusively that, when eaten, organs and glands selectively travel to the corresponding organs and glands in high concentrations. This research, done at the University of Scotland in Edinburgh, lends credence to the ancient practice of eating animal organs to help ensure health in one’s corresponding organs..." - Dr. Ron Schmid, ND.*[10] Our early ancestors knew this, which is why their traditional diets included the frequent and nourishing consumption of nose-to-tail organs and glands. — Based on the ancient ancestral wisdom that "like supports like." Consuming brain may strengthen and support our own brain  — Included in whole brain extract is sphingomyelin which plays a central role in the myelin sheath, cell signaling and apoptosis *[1] — — Included in whole brain extract are neurotrophic factors such as brain-derived neurotrophic factor (BDNF) that support the survival of existing neurons and encourages the growth of new neurons * — SUGGESTED USE (6 CAPSULES A DAY) Six capsules provides the equivalent of one ounce of fresh, raw whole glandulars and organs that you’d get from your local farmer (or) butcher. Our Grass Fed Brain (with liver) is a whole food dietary supplement that provides whole brain extract — including pituitary, hypothalamus, pineal glands in the physiological amounts that exist in harmony with nature. This supplement can be taken with (or) without food (even though it technically is food). The suggested use is 6 capsules a day or as directed by a healthcare professional — for added support, the dose can be doubled. This supplement can be consumed all at once, or divided servings throughout the day. POTENTIAL ISSUES (DETOX REACTION) Most customers tolerate our supplements without incident; however, approximately 5 to 10% of customers (usually with an autoimmune condition) may experience a detoxification reaction. Detoxification reactions go by many different names including healing reactions, healing crises, cleansing reactions (or) Herxheimer reactions with hallmark symptoms of nausea, headache, lethargy, dizziness and other flu like symptoms. In this instance, detoxification reactions are generally an indication that detoxification pathways in the body are back online... cells suddenly have an opportunity to release an even greater than normal quantity of stored toxins, metabolic wastes, pathogens and unwanted material.  A detoxification reaction is more likely to occur when starting with the full suggested serving size of 6 capsules per day. If you know that you are sensitive to supplements and/or you have an autoimmune condition, you may wish to start slow when adding this product to your current regimen. Tolerability can be greatly improved by starting with just 1 (or) 2 capsules a day and increasing by just 1 capsule every couple of days — this method may take a full two weeks to achieve the desired serving size of 6 capsules per day. HIGH QUALITY ORGANS & GLANDS Okay, you're convinced! You're going to start incorporating organ meats in your routine because, well... you're educated now... you understand, just as our early ancestors did, that they provide superlative health benefits that are missing in our modern diets. The next step is sourcing it. It's important that you source the highest quality because not all organs and glands are created equal. Consider the source.  Should Come From An Unpolluted Geographical Region — Isolated, Healthy, Pristine Lands  Should Come From Pasture Raised Animals Should Come From Grass-Fed & Grass-Finished Animals Should Come From Animals That Are Hormone, Pesticide & GMO Free Should Also Be Ultra Pure... Absolutely No Fillers (or) Flow Agents, No Allergens Should Be Non-Defatted Should Be 100% Freeze Dried... Freeze Drying Preserves Heat Sensitive Biological Activity SUGGESTED SUPPLEMENTS (3) If you're going to pick just one ancestral supplement to start with, make it our GRASS FED BEEF LIVER... unless you need targeted support with another specific organ system (see below). If you are going to pick two supplements, our GRASS FED BEEF LIVER and our GRASS FED BEEF ORGANS provide complementary and synergistic nourishment. If you can add a third supplement, GRASS FED BONE MARROW fills fat soluble nutrition gaps and provides the fat soluble activators that nutrition giant Dr. Weston Price extensively wrote about. Grass Fed Beef Liver Grass Fed Beef Organs (liver, heart, kidney, pancreas, spleen) Grass Fed Bone Marrow On the other hand, if you're looking for targeted organ support, you may be interested in our GRASS FED BEEF HEART to support heart health (or) our GRASS FED THYROID to support a struggling thyroid (or) our GRASS FED THYMUS to support thymus function and immune health... you get the picture.* We have a nose-to-tail product line that can be found on our "Products" page. If you can't find what you're looking for (or) you're not sure what you're looking for, send us an email and we'll do everything we can to help. GRASSFED BRAIN SUMMARY Our genome has evolved with the nourishment of nose-to-tail dining since the beginning of time. Grassfed Beef Brain is a whole brain extract that provides brain cell activators, neurotrophic factors, brain derived glandulars and hundreds of other compounds exclusive to brain tissue that regulate memory, mood and cognitive functions.* Based on the concept of "like supports like," consuming brain may strengthen and support our own brain.* Bovine-brain derived phosphatidylserine has been shown to improve both behavior and cognition associated with cognitive decline.*[6] Not all organs and glands are the same. Look for the highest quality brain glandular... It should come from pasture-raised, grass-fed calves that are hormone, pesticide and GMO free. If considering a supplement, look for one that is ultra pure (without binders, fillers (or) flow agents) and look for the freeze dried variety as these have been shown to optimally preserve nutritional factors, growth factors and co-factors. [ FACT: There has never been a case of mad cow disease in New Zealand. BSE (mad cow disease), scrapie and other known TSE’s, do not occur in New Zealand. A national surveillance programme is in place to provide comprehensive monitoring. ] NOTE: Desiccated brain (or) whole brain extract glandular can be found on the market by various names: whole brain, brain extract, desiccated brian, brain glandular, brain PMG belongs to Standard Process and then there's simply bovine brain. SAFETY SUMMARY As it relates to potential microbes and parasites, our product is 100% freeze dried in contrast to the heat processed varieties out there. This process preserves heat sensitive biological activity while removing 98 - 99% of the moisture content. This leaves virtually no moisture; since microbes (viruses, bacteria, parasites etc) can not survive without moisture, this allows for an ultra pure product profile with a very long shelf life — of course, with no need for additives or preservatives. Additional quality controls include the following... 3rd party microbial testing before and after encapsulation 3rd party veterinarian health inspection is performed by the New Zealand Ministry for Primary Industries — for 100% of our animal derived biologics We exclusively harvest Brain, Bone Marrow and Thymus from young calves There has never been a single case of mad cow disease in New Zealand. BSE (mad cow disease); scrapie and other known TSE’s, do not occur in New Zealand. A national surveillance program is in place to provide comprehensive monitoring.   I put the care, attention and quality assurance into my products as if I am giving them to my family... because I am! My young boys, my wife and I all take the Beef Liver, Beef Organs and Bone Marrow everyday. ACTIVATING AN ANCIENT PATHWAY [KETOSIS MAKES YOUR BRAIN WORK BETTER] Nutritional ketosis may have health benefits in conditions such as epilepsy, Alzheimer’s, Parkinson’s, ALS, MS, autism, traumatic brain injuries and much more.*[14] By now you've heard all the rage about ketosis, also known as the ketogenic diet. It's the new diet that everybody's doing, right! Actually, ketosis isn't new at all... it's been around for... well... since we (human beings) have been around. Ketones provided the energy substrate for our brains and bodies when glucose wasn't available, such as in times of famine which was a common occurrence for our early ancestors. Fortunately for us, biology figured out an elegant solution to the problem of inconsistent food sources and a large, hungry brain... ketosis. — Ketosis certainly helps people with neurodegeneration conditions such as Alzheimer’s disease, aging-related cognitive decline, epilepsy, and Parkinson’s disease * — — An outpouring of anecdotes suggest that otherwise healthy people can experience cognitive benefits from brain utilization of ketones. Wife and I belong to this outpouring... love the upgraded mental performance! * — — Ketosis upregulates mitochondrial biogenesis in the brain. It literally creates new power plants in the brain that are good at burning fat-derived fuel and mopping up brain fog * — "People whose brains suffer from impaired glucose utilization see cognitive benefits from ketones. In Alzheimer’s disease, aging-related cognitive decline, epilepsy, and Parkinson’s disease, brain glucose uptake is depressed—even before any actual cognitive decline appears. Despite high glucose availability, the aging, epileptic, Alzheimer’s, or Parkinson’s brain can’t utilize enough of it to handle cognition. Enter ketones. Ketones act as an alternative energy source for the glucose-starved brains. It’s no coincidence that ketogenic diets can improve symptoms (and in some cases abolish them) and cognitive function in all four conditions." [16] For the record, unless there's a neurodegenerative, mood and/or memory condition on board, I don’t think we all need to be on a ketogenic diet, nor do we all need to remain in ketosis for extended periods of time; however, I do think we need to slip in and out of ketosis on a regular basis... just as our early ancestors would have done. After all, we seem to be purpose built for doing it and we derive massive health and happiness benefits from it. We know it seems to stave off neurodegeneration, as well as improve the brains of people already suffering from it.*[16] [ NOTE: Ketosis is a high fat, moderate protein, low carbohydrate way of eating. Medium chain triglycerides (MCT oil), intermittent fasting (IF) and fasting all elevate ketone bodies. Have a look at what I eat (see below) but be careful with too much protein as this can kick you out of ketosis. A typical keto meal should consist of 70% to 75% healthy fats, 20% protein and 5% carbohydrates. The best book, that's also available on Audible, that I've read on ketosis is Keto Clarity. ]  For these reasons, my tribe (my family) and I follow seasonal eating patterns that allow us to slip in and out of ketosis. If we're feeling really good, we may stay in it a little longer. It helps us to think, to perform, and to produce. The following is an idea of how and what we eat... notice that we also go through periods of feast and famine with twenty-four hour fasts and huge refeeds where almost nothing that resembles primal food is off limits. OUR TYPICAL 1ST MEAL IS A DELICIOUS SHAKE AND IT LOOKS LIKE THIS... Wallaby Organic / Grass fed yogurt (2 cups or 150g) NOW Brand MCT oil (1-2 tablespoons; up to 30g- dose to tolerability). NOTE: MCT always produces elevated ketones. Organic raw virgin coconut oil or organic ghee (2 to 3 tablespoons or 30 to 45g) Organic almond butter (2 tablespoons or 30g) Organic unrefined red palm oil (1 tablespoon or 15g) Grassfed Collagen / Gelatin (10-20g) Himalayan sea salt -- 1/4 tsp (2g) Organic cinnamon -- 2g Organic / Grassfed vanilla protein powder (1 scoop) — I like Bluebonnet Grassfed Protein Organic banana (optional when not doing strict keto or if sleep if affected by too low carb consumption) Organic / Pasture raised raw eggs (4 to 6 large eggs) Organic raw milk (1 cup or 150g)... raw is best but Whole Kalona Brand Milk is a good second option if you don't do raw milk This shake takes me about 15 to 20 minutes to make... It's super convenient... and, it's down right delicious. If I don't make a shake, I will have a bunch of pasture-raised eggs (8 or so) that are smothered in butter with a side of avocado, nitrate-free, sugar-free bacon and a dollop of sour cream. OUR TYPICAL SECOND MEAL IS COOKED... IT'S HOT... IT'S BETTER THAN ANY RESTAURANT FOOD... IT LOOKS LIKE THIS... Homemade Bone Soup (simmered for two to three days with tons of marrow) Serving or Kimchi Organic Avocado Grass fed butter or Ghee (2 tablespoons) Organic unrefined red palm oil Salad of dark leafy greens w/ 2 tablespoons of Organic, fresh pressed olive oil and sea salt (I get mine from Apollo Olive Oil) Grass fed beef/organs (6 - 9 oz ground peleo and various organs) Organic almond butter (2 tablespoons) mixed with organic raw coconut oil (2 tablespoons) and a tablespoon of Bluebonnet's grassfed vanilla protein Organic banana with raw local honey (Optional when not doing strict keto or if sleep if affected by too low carb consumption) 100% Cacao block for dessert We generally carb reload on the weekends with plenty of sweet potatoes, raw local honey, the occasional sorghum and various in-season fruits. We also do a twenty-four to thirty hour fast on Sundays... it's not as bad as it sounds. We eat an early dinner as we normally would on early Saturday evening... skip our first meal on Sunday, and eat an amazing fish-based dinner (usually wild caught sardines) with the entire tribe on Sunday. We also do heat and cold exposures together and we go on barefoot hikes every Sunday. Connecting to mother earth creates strong parasympathetic tone for enhanced recovery for the week to come. The basis of how our tribe lives is this... if our early ancestors did it, we do too... or at least we try to. See our most up-to-date tribe life on our "About Us" page. SUPPLEMENTS THAT WE TAKE Transdermal Magnesium Oil - We use magnesium oil every night. Vitamin D3 - Only when we're not able to get adequate sun exposure (this is rare) Vitamin K2 - Only when we're not regularly eating my kimchi (this is also rare)  Grass Fed Liver Grass Fed Beef Organs Grass Fed Bone Marrow Keep in mind that my tribe and I eat a very nutrient dense diet. We consume the whole animal just as our ancestors did... That's right, we eat the liver, kidney, pancreas, spleen, heart, thymus, bones, tendons, ligaments and more... and we eat this way every day (except on vacation we take Liver, Beef Organs and Bone Marrow supplements). We love our bone broth (this is my wife's specialty), and we eat tons of pastured eggs. Wife is awesome enough to sprout chickpeas for us. Then, she turns half of the batch into the best homemade hummus in the world. Super high in folate (NOT SYNTHETIC FOLIC ACID, big diff)!! You never know, ketosis could easily be the missing link to the mood, memory and mental performance benefits that we are all after. Why not give it a try. Send me an email... let me know your thoughts... let me know your questions. I'd love to hear from you. Our mission is our purpose... putting back in, what the modern world has left out.  [ Stay positive... think about the wonderful things in your life that you're grateful for... eat like our early ancestors did... move around like our ancestors did... avoid danger like our ancestors did (think lions, trans fats, sugars, fluoride, excessive wifi, emfs, vaccines, mercury, etc)... slow down... go barefoot, connect to the earth... get sensible sun exposure... get cold (environmental conditioning)... mind your magnesium... sleep like a rock... keep stress in check... and breathe like Wim Hof. ]

Beef Brain is packed with essential fatty acids including the omega-3 fats DHA & EPA, as well as brain-derived neurotrophic factor (BDNF). It’s also a rich source of the micronutrients choline, copper and vitamins B2 (Riboflavin), B5 (Pantothenic Acid), B9 (Folate) and B12. All of these play a key role in either brain health or neurotransmitter production, supporting; focus, memory, mood, speed of thought and slowing brain aging. All the organs we source for our nose-to-tail line come from regenerative farms where the cattle are 100% grass-fed and free to roam on pastures. We gently freeze dry the organs raw to maintain as many of the nutrients and enzymes within them. Each jar contains 180, 500mg capsules (30 day supply).Beef BrainEating whole animals, nose-to-tail, was a way of life for humans for the majority of our existence up until recent history. In the past people believed that consuming the organ of a healthy animal would strengthen and enhance the health of their own corresponding organ. For example, if someone was struggling with with cognitive function such as memory or focus, they would be fed brain. Interestingly, this is just now being validated by science. Research conducted at the University of Edinburgh in animal models has shown conclusively that when eaten, organs and glands selectively travel to the corresponding organs of the consumer in high concentrations. Therefore when the brain of an animal is consumed, the unique fatty acids, growth factors and micronutrients within it, which are key for cognitive function, travel to your own brain. Having a higher concentration of these compounds in your brain gives you the raw materials to support functions such as; focus, memory, mood and speed of thought.Indigenous people also appreciated that animals gave their lives to ensure us as humans could survive and thrive so they left nothing go to waste. And because of their deep connection with the earth and their own bodies they intuitively knew just how nutrient dense organ meat is and would prise this over muscle meats. Fast forward to today and the immense powers of organs have somewhat been forgotten. What was once highly sought after is now rarely consumed and generally people no longer enjoy the taste. We created our nose-to-tail line to help people reintroduce these ancestral superfoods, loaded with nutrients in an easy to consume and flavourless way.HOW TO USEConsume 3- 6 capsules per day (1500-3000mg)WHEN TO USETake 3-6 capsules per day, ideally in the morning to flood your body with micronutrients for the day ahead. Each jar contains 180 capsules and each capsule is 500mg.Ingredients: Grass-Fed Beef Brain (67%), Grass-Fed Beef Liver (33%), Bovine Gelatine (Capsule). *All our organs come from a regenerative farm where the cattle are grass-fed and roam on pastures

WHAT YOU CAN EXPECT FROM ULTRABRAIN Improved mood (combat depressed mood and increase joy) Improved focus and cognitive performance Improved brain energy levels Decreased brain fog (improved clarity) Decreased anxiety Stimulant-free brain boosting action Long-term decreased risk of neurodegenerative diseases DO YOU HAVE ANY (OR ALL) OF THESE SYMPTOMS?Brain-Related fatigue - Feeling fatigued, exhausted, or sleepy after doing something mentally demanding Chronic low-energy - waking up feeling groggy, feeling tired throughout the day, relying on caffeine or stimulants to keep you alert Brain fog - a type of cognitive dysfunction that includes memory problems, lack of ability to concentrate, and lack of mental clarity Anxiety or depression - persistent feelings of sadness, emptiness, guilt, hopelessness, worry, or pessimism Sleep problems - racing thoughts at bedtime or inability to fall asleep quickly, waking up in the night - sometimes repeatedly, insomnia Loss of resiliency - inability to handle and recover from stress Whether you suffer from one or all of these issues, you must understand this critical truth: These symptoms are NOT a normal thing, and they're NOT just a normal part of aging! HERE'S THE REALITY These symptoms are present because you actually have damaged, inflamed, or dysfunctional neurons in your brain more specifically, you have:   Leaky blood-brain barrier – a shockingly common issue where the protective wall between your brain and bloodstream breaks down when it becomes leaky, things get into the brain that shouldn’t be there.   Mitochondrial dysfunction/shutdown –  mitochondria are your cellular energy generators and danger sensors, but, mitochondria cannot be in both energy mode and cell defense mode.  When your mitochondria are weak, they are constantly trying to sense danger and can’t produce energy.   Neuroinflammation – cells in your brain called microglia, which sort of function as your brain’s immune system, are activated too frequently and become stuck in the on position, as a result, they produce inflammatory compounds and oxidative damage.   LET'S FIX THE DAMAGED NEURONS IN YOUR BRAIN! You CAN seal your blood-brain barrier, heal your mitochondria, and reduce the inflammation in your brain! You CAN reverse your brain-related fatigue, brain fog, anxiety and depression, loss of resilience, and sleep issues! To do this you must:   Nourish your imbalanced brain with a wide range of nutrients – nutrients that are scientifically proven to fix your neurons Reverse cellular dysfunction Reduce inflammation Rewire your brain out of fatigue, stress, and depression mode   WHY THESE SPECIFIC NUTRIENTS? The result is a very carefully curated formulation that meets these unparalleled standards:   Absolutely zero pseudo-sciences, facts, or false marketing. Pure science in every serving Each ingredient is in its most potent, bioavailable form. Really nothing else can outperform these brain-boosting compounds. Effective dosages in each and every serving. 6 capsules a day is everything you need to help reverse cellular dysfunction and supercharge your mental capacity   THE PERFECT FORMULATION 15 Premium, carefully sourced ingredients in effective dosages.   RHODIOLA ROSEA   Stabilizes mood Reduces anxiety and depression Improves cognitive performance Reduces feelings of exhaustion, irritability, and burnout Increases resilience (resistance to stress) Functions as an antioxidant and anti-inflammatory Fast-acting Rhodiola is a neuroprotective, cognitive enhancing, and mood stabilizing herb that promotes neuronal regeneration, functions as an antioxidant and anti-inflammatory, facilitates neurotransmission, and regulates several key mediators of the stress response [1–3].   The effects are rapid. In adults with chronic work- and life-related stress, rhodiola significantly reduced feelings of exhaustion, irritability, and anxiety in as little as three days [4].   In a study of working adults suffering from burnout, a third of whom had been unsuccessfully treated for their stress in the past, rhodiola improved every aspect of quality of life and perceived stress after just 1 week, with further improvements seen after 12 weeks [5].   In adults with chronic fatigue syndrome, rhodiola improved every aspect of fatigue after just 1 week, with further improvements seen after 8 weeks [6]. Ultimately, 83% of the participants reported “very much” or “much” improved conditions, with every aspect of fatigue, stress, and global impairment being cut in half.   Improvements in perceived stress, mental fatigue, cognitive performance, anxiety, and depression have also been noted in medical students [7], military cadets [8], and adults with stress-related fatigue [9], mild anxiety [10], and mild-to-moderate depression [11,12].   LION'S MANE POWDER   Reduces anxiety and depression Helps improve memory, concentration, and overall cognitive function Promotes nerve growth and regeneration in the brain Reduces inflammation Stabilizes mood Restores key neurotransmitters Lion’s mane mushroom (Yamabushitake or Hericium erinaceus) is a medicinal mushroom that has been extensively studied for its neurohealth properties [13,14].   Stimulates the production of nerve growth factor [15–17], which promotes neuronal growth, development, and regeneration [18]. Stimulates the production of brain derived neurotrophic factor [19], which has neuroprotective effects, plays a role in neuronal development, and helps in the formation of neuronal connections important for memory and cognition [20]. Restores levels of serotonin, noradrenaline, and dopamine levels in the brain that can be suppressed due to chronic stress [19]. Reduces neuroinflammation [19,21] Clinical trials have shown that lion’s manse improves cognitive function by 12% compared to placebo in older adults with mild cognitive impairment [22], and reduces symptoms of anxiety (by 27%) and depression (by 39%) in adults with obesity [23].   ALPHA-GPC   Protects neurons in the brain and supports neurotransmission Increases dopamine and serotonin signaling in the brain Decreases risk of vascular dementia More effective than Alzheimer drug (Aricept) at improving cognition Alpha-glycerophosphocholine (Alpha-GPC) is a highly bioavailable source of choline for the brain [24], which plays a critical role in neuronal plasticity, membrane stability, signaling events, and neurotransmission [25].     Having adequate brain choline concentrations is neuroprotective against a variety of brain diseases [26], and numerous clinical trials have found that alpha-GPC improves cognitive function and memory in individuals with neurodegenerative disorders, vascular dementia, and stroke — even being more effective than the standard drug therapy for Alzheimer’s disease [27].   CHOLINE (COGNIZIN®)   Promotes the health of cell membranes Improves memory and overall brain cognition Improves motor function Increases focus and reduces impulsive behavior Improves neuroplasticity (helps the brain adapt to new situations) CDP-choline is a bioavailable source of choline for the brain and the direct precursor for the synthesis of phosphatidylcholine [28,29], one of the most abundant and important structural components of cell membranes. Supplementation has been confirmed in humans to increase phosphatidylcholine synthesis within the brain [30,31].   A Cochrane Systematic Review of 14 double-blind, placebo-controlled trials involving older adults with cognitive deficits like dementia reported that CDP-choline was able to improve memory, correct abnormal behaviors, and increase the global impression that physicians have towards the participants [32].   Other studies have found that CDP-choline slows the deterioration of cognition in those with Alzheimer’s disease [33,34], improves motor function and attention in adolescents [35], and improves attention in healthy women [36].   BACOPA   Enhances short-term and long-term memory Enhances learning, visual processing, cognitive performance Improves mood and reduces depression and anxiety Reduces oxidative stress Neuroprotective Reduces β-amyloid deposits Enhances communication between neurons Increases blood flow Bacopa monnieri is an Ayurvedic swamp plant (Brahmi) traditionally used for the enhancement of memory and cognition, as well as a general brain tonic. Its bioactive constituents, the bacosides, have numerous biological effects within the brain that facilitate this use [37–41]:   Reduces oxidative stress and increases antioxidant enzyme activity Reduces inflammation Neuroprotective Reduces β-amyloid deposition Increases the growth of nerve endings to enhance neuronal communication Increase blood flow and the delivery of oxygen and nutrients Numerous clinical trials have found that bacopa supplementation improves working memory, attention, learning rate, information processing, and a variety of other cognitive outcomes in healthy elderly adults [42–44], healthy middle-aged adults [45,46], young medical students [47], and adults with Alzheimer’s disease [48].   GINKGO BILOBA   Neuroprotective Improves memory and cognitive performance Works as an antioxidant Counteracts cognitive impairment Improves neuroplasticity Preserves brain receptors in aging adults Ginkgo biloba possesses neuroprotective and antioxidant effects that preserve brain receptors susceptible to age-related loss, counteract cognitive impairment, enhance neuronal plasticity, and improve memory [49].     A systematic review of 12 meta-analyses found that ginkgo biloba improves cognitive performance, activities of daily living, and clinical global impression in the treatment of dementia [50], provided that at least 240 mg was used daily for several months [51].   COFFEE FRUIT (COGNATIQ™)   Increases Brain-Derived Neurotrophic Factor (BDNF) Powerful antioxidant Improves neuroplasticity Helps to  grow new neurons and prevent neurodegeneration Improves long-term memory CognatiQ™ is a patented extract of the whole coffee fruit, including both the coffee bean and the fruiting body surrounding it, which contains many powerful antioxidant compounds [52,53].   Clinical studies in healthy adults have shown that CognatiQ™ nearly doubles concentrations of brain-derived neurotrophic factor (BDNF) after 1–2 hours [54,55], beating out other forms of coffee bioactives, caffeine, and the phytochemical-rich grape seed extract.     BDNF is a key protein involved in brain health, well established to be critical for:   Neuroplasticity (helps the brain adapt to new situations) [56]. Neurogenesis (the growth, regeneration and creation of new neurons and synapses) [57,58]. Long-term memory [59]. Prevention of neurodegeneration [60]. HUPERZINE A   Promotes learning Used for centuries to treat brain-based illnesses Improves cognition, especially in people with Alzheimer’s and vascular dementia Naturally occurring acetylcholinesterase inhibitor (primary class of drugs for treating Alzheimer’s and dementia) Huperzine-A is a naturally occurring acetylcholinesterase inhibitor, which functions to inhibit the enzyme that degrades acetylcholine, the neurotransmitter responsible for learning new information [61].   A meta-analysis of 20 randomized controlled trials found that huperzine A supplementation improves cognitive function, daily living activity, and global clinical assessments over 8–36 weeks [62]. Other meta-analyses have reported that huperzine A improves cognition in those with vascular dementia [63], as well as in those with major depression [64].   ACETYL-L CARNITINE   Improves brain function, especially memory and attention Reduces oxidative stress Protects against β-amyloid neurotoxicity Reduces mental and physical fatigue Reduces depression – more effective than antidepressant drugs! (And with far fewer side effects) Reduces pain and increases nerve conduction Prevents progression of brain-related disease Acetyl-L-Carnitine (ALCAR) is a special form of carnitine that achieves two goals: (1) it supplies the carnitine your mitochondria need to produce energy, and (2) it provides an acetyl moiety that your mitochondria use to remain youthful and healthy.   ALCAR easily crosses the blood-brain barrier and preserves mitochondrial function within the brain that otherwise deteriorates with aging [65–69]. Notably, ALCAR concentrations slowly decline as cognitive impairment progresses, ultimately being 36% lower in Alzheimer’s patients than healthy adults [70].     A meta-analysis of 21 randomized controlled trials involving patients with mild cognitive impairment or Alzheimer’s disease found that ALCAR significantly improved cognitive function and prevented the progression of Alzheimer’s after as little as 3 months [71].   In elderly adults suffering from excessive fatigue, ALCAR improved cognitive function by 15%, reduced mental and physical fatigue by 43–52%, and improved the ability to function in daily life by 24% [72].   A meta-analysis of 12 randomized controlled trials found 3 g/d of ALCAR to significantly reduce depressive symptoms with an efficacy similar to antidepressant drugs, but with far less side effects [73].   SAFFRON EXTRACT   As effective as prescription drugs (with less side effects) in:   Reducing depression Treating obsessive compulsive disorder (OCD) Improving cognitive function Antioxidant and anti-inflammatory Neuroprotective Saffron is one of the most well-researched antidepressant compounds available, with three separate meta-analyses of randomized controlled trials indicating that 30 mg/d has a potency comparable to prescription drugs but with less side effects [74–76].   Other studies have shown that saffron is as effective as prescription drugs for treating obsessive compulsive disorder (OCD) [77], and boosts cognitive function to the same extent as prescription drugs in those with Alzheimer’s disease [78,79].   L-THEANINE   L-theanine is a naturally occurring amino acid found in tea that alters neurotransmitter signaling within the brain. After consumption, it crosses the blood-brain barrier, interferes with excitatory glutamate signaling, stimulates dopamine release, and promotes inhibitory neurotransmission, thereby helping promote a state of relaxation [80,81].   Electroencephalography (EEG) studies have shown that theanine shifts brain waves towards alpha oscillatory patterns indicative of a relaxed state, particularly in those with high levels of baseline anxiety [82–86]. Accordingly, several studies have found that theanine supplementation improves feelings of relaxation, tension, calmness, and anxiety in the hours following [87,88].   AGMATINE SULFATE   Important neurotransmitter Improves learning and memory Reduces anxiety and depression Protects neurons and enhances cell growth Protects mitochondria More effective at relieving pain than conventional medications Agmatine is a neurotransmitter and neuromodulator (affects neurotransmission of entire neurons) that has anti-seizure, anti-pain, anti-anxiety, and antidepressant effects; modulates some of the processes involved in learning and memory; and interacts with the mechanisms of drug withdrawal [89].   Preliminary research has shown that agmatine supplementation causes a “total/incontrovertible remission of depression” without apparent adverse effects in those who were not responsive to conventional treatments [90].   In a randomized, double-blind, placebo-controlled study of individuals with back pain from herniated lumbar discs, agmatine reduced pain by 25–28% and improved parameters of general health by 65–76% after just two weeks [91].     POLYGALA TENUIFOLIA   Improves memory and combats forgetfulness Supports neurotransmitters required for learning, memory, and mental health Promotes growth of new neurons in the brain Increases neuroplasticity and cognitive function Polygala tenuifolia is one of the fundamental herbs used in traditional Chinese medicine, used to improve memory and combat forgetfulness with aging [92], which it does by:   Inhibiting the breakdown of acetylcholine, dopamine, serotonin, and noradrenaline, neurotransmitters required for learning new information, memory storage, and overall mental health [93,94]. Increasing the expression of brain derived neurotrophic factor (BDNF), which is fundamental for neuroplasticity and neurogenesis [95]. Promoting the growth of new neurons in the brain [96]. In a clinical trial of healthy adults, Polygala tenuifolia improved spatial, verbal, and working memories [97]. In a separate randomized, double-blind, placebo-controlled study of elderly adults, Polygala tenuifolia improved cognitive function by 5–10% [98].   N-ACETYL-L-TYROSINE   Critical for stress management Boosts cognition, alertness, and information processing Improves memory and mental health L-tyrosine is a conditionally essential amino acid that serves as the precursor molecule from which we create the catecholamines: dopamine, adrenaline, and noradrenaline. Your brain needs a steady supply of tyrosine to make the catecholamines and keep your mental health at its peak [99,100], particularly if you are under a lot of stress [101].   Several clinical trials have shown that L-tyrosine supplementation boosts cognition, alertness, and memory in stressful and demanding situations in otherwise healthy adults [102,103], such as those who skimp on their sleep [104], undergo intense physical training [105], or those who endure extreme temperatures [106].   MAGNESIUM TAURATE   Over 300 enzymes require magnesium to function properly! Required for optimal nerve transmission Protects against cell death Prevents mitochondrial dysfunction Prevents migraines Improves anxiety and depression Slows development of and severity of Parkinson’s and Alzheimer’s Reduces risk of stroke Magnesium is required for over 300 enzymes to function properly [107]. Within the brain and nervous system, magnesium is required for optimal nerve transmission and protection against excitotoxicity (excessive excitation leading to cell death) [108,109].   A systematic review of magnesium’s role in neurological disorders found that it plays an important role in the prevention of migraines, treatment of anxiety and depression, severity of Parkinson’s disease, development of Alzheimer’s disease, and protection against stroke [110].   But, not all forms of magnesium are the same. Magnesium taurate demonstrates a superior ability to enter into the brain and increase the brain’s magnesium status compared to other forms [111,112].   References

Sourced purely from coconuts, Brain Octane C8 MCT Oil converts into brain-powering, fat-burning ketone energy. It helps control cravings and improves cognitive performance to keep you sharp.† Bulletproof Brain Octane Oil is flavorless, so add it to smoothies, salad dressings, Bulletproof Coffee and more. MORE BRAIN POWER Improves cognitive performance to give you a rapid, long-lasting brain boost INCREASED ENERGY Brain Octane MCT oil metabolizes quickly and efficiently into ketone energy, which fuels your body without a crash FEWER CRAVINGS Brain Octane oil helps turn cravings off and lets you focus on being awesome INCREASED FAT BURNING Jumpstarts your metabolic rate to increase fat burning WHAT IS BRAIN OCTANE OIL? 100% caprylic acid triglycerides from coconut oil Pure caprylic acid harvested from the most ketogenic part of the coconut Caprylic acid, a medium-chain triglyceride (MCT), is an energizing, easy-to-digest quality fat SUPERCHARGE YOUR BRAIN Rapidly and efficiently converts into brain-boosting, fat-burning ketone energy Ketones power your brain and can't be stored as fat, unlike carbs and sugar GO HARD, ALL DAY WITH BULLETPROOF BRAIN OCTANE OIL Easy-to-digest caprylic acid fuels your cells more efficiently than coconut oil does Converts into energizing ketones that start powering your mind and body within minutes No cravings or energy crashes EASY TO USE BRAIN OCTANE OIL Bulletproof Brain Octane oil is completely flavorless and easy to pour. No coconut flavor means it's a great substitute for other oils. Blend it into Bulletproof Coffee or tea Add to smoothies and shakes Drizzle it over your favorite meals Use to make salad dressings, sauces, and marinades

Product Details Nicotinamide mononucleotide (NMN) is the direct precursor of the essential molecule Nicotinamide Adenine Dinucleotide (NAD+) and is a key component for increased NAD+ levels within all cells. NAD plays a significant role in mitochondrial function, energy, metabolism, and maintenance of healthy gene expression. When we boost NMN levels in the body, we enhance the biosynthesis of NAD and help restore declining levels of NAD as we age.Supplementing NMN as part of your daily regime could offer energy revitalization, protection from the aging process by maintaining healthy DNA, improvements in cognitive health, a decreased risk of cardiovascular complications, and improved cellular metabolism.This formula combines all the health benefits of NMN with added polyphenols and antioxidants resulting in a supplement that can significantly boost NAD levels throughout the body. Ingrediants NMN (Nicotinamide Mononucleotide): A molecule naturally occurring in all life forms. NMN is the direct precursor to the essential molecule NAD and is known to boost NAD levels in cells. Apigenin 98%-Apigenin:  A naturally occurring plant flavonoid, abundantly present in common fruits and vegetables are recognized as a bioactive flavonoid shown to possess immune-stimulating and longevity properties. Green Tea Extract (20% L-Theanine): Improves cognitive function and immunity in studies. Resveratrol (98% Transresveratrol) : Transresveratrol is the more biologically active isomer in Resveratrol, found in the skins of grapes. This powerful polyphenol reduces cellular damage and oxidative stress. Green Coffee Bean (10% Caffeine): Green coffee provides protection against neurological diseases, strengthens heart health, and offers other anti-aging effects associated with longevity. Other Ingredients Veggie Capsule Rice Flour Directions Take two capsules, once a day.  Pro-Tip The science is clear: when supplementing with NAD boosters, it’s critical to support your body’s methylation processes. Our Synergy B12 is the cornerstone of methylation, providing high octane methyl compounds such as Methylcobalamin and L-Methylfolate. Another important compound to include when boosting NAD is Vitamin B6 (Pyridoxine), which lowers homocysteine levels throughout the body. Vitamin B6 is also in our Synergy B-12 formula. The combination of these two formulas makes for a powerful weapon against premature aging, and a laundry list of other ailments.

MCT Oil is a real food derived, rapid source of energy. Unlike other fat sources, it doesn’t need to be broken down on consumption, so is either used as an instant source of ATP energy or turned into ketones. Also C8 and C10 MCTs have been shown to have great antimicrobial properties, which means they help combat gut issues like Candida. Our MCT Oil comes in a 473ml glass bottle, is 100% derived from sustainably sourced organic coconuts and absolutely free of palm oil. ORGANIC 100% derived from sustainably sourced organic coconuts NO PALM OIL We use absolutely no palm oil in the making of this product BRAIN POWER MCT Oil is quickly turned in to ketones, which can easily cross the blood brain barrier aiding cognition BPA FREE Our MCT comes in a BPA free glass bottle ABOUT THE PRODUCT Organic MCT Oil Our MCT Oil is 100% derived from sustainably sourced organic coconuts and contains 60% C8 (Caprylic Acid) and 40% C10 (Capric Acid) Medium Chain Triglycerides. We use absolutely no palm oil in the making of this product. MCT Oil is odourless and flavourless, making it a great for addition to coffee, tea, smoothies, shakes or salads. MCT Oil is one of the key ingredients in Bulletproof coffee. The reason for its inclusion is that when added to coffee the fat slows down caffeine absorption, negating the spike and crash or jitters people often feel and instead providing several hours of steadily released energy. Also C8 and C10 MCTs have been shown to have great antimicrobial properties, which means they help combat gut issues like Candida. Our MCT comes in a BPA free glass bottle to align with our environmental and social responsibility. HOW TO USE Start by using 10ml per ay and steadily increase intake as required. Due to how quickly MCT oil is metabolised it can cause gastric upset if consumed in higher amounts than your body can handle. Therefore it is advisable to increase your intake slowly as tolerance builds. WHEN TO USE Being the key ingredients in Bulletproof Coffee, MCT Oil is most often added to coffee or tea to slow down the caffeine absorption and create a time released energy effect. However, it’s also great to cook with or as an addition to salads for that extra energy boost. Remember to keep temperatures below 160 degrees celsius when cooking to ensure the oil doesn’t saturate. FAQS WHY ORGANIC MCT OIL? Organic food is produced without the use of chemical fertilisers, pesticides or any other artificial chemicals. A number of studies have shown that exposure to these chemicals in high doses, or low does over a long period can have serious detrimental impacts on human health. Find out more here. When consuming any of our products, there’s no danger of you ingesting any of these damaging substances because they are all certified organic by the Soil Association, the UK’s premium organic certification body. CAN I COOK USING MCT OIL? Yes, MCT Oil can be used for cooking. However, aim to keep the cooking temperature below 320 Fahrenheit / 160 Celsius to ensure all the health benefits are maintained. IS MCT OIL MADE FROM COCONUT OR PALM OIL? Our MCT Oil is 100% derived from sustainably sourced organic coconuts and contains absolutely no palm oil. We made this decision for environmental reasons as the rising demand for palm oil is having a devastating impact on the environment. DOES MCT OIL HELP YOU GET IN TO KETOSIS FASTER? Ketosis is a metabolic state in which your body uses primarily fat and ketones for fuel as opposed to carbohydrates. In practical terms, if your blood ketones levels are above 0.5mmol then you can consider yourself in ketosis. MCT Oil is rapidly converted by the body to be used as an instant source of energy or converted in to ketones. Therefore definitely can help you achieve ketosis at a faster rate. However, there’s much more to following a ketogenic diet than just consuming MCT Oil. If you want to find out more, our Keto Transition Guide is a great place to start. HOW MUCH MCT OIL SHOULD I USE? Consuming too much MCT Oil too quickly can cause gastric upset. Therefore we recommend starting out with 5ml per serving and slowly increasing your intake as tolerance builds. WHAT ARE THE BENEFITS OF MCT OIL? Brain Power - MCT Oil is quickly turned in to ketones, which can easily cross the blood brain barrier aiding cognition. Increased Energy - Cultivating the fat burning state of ketosis creates a noticeable impact on energy levels. Instead of the post lunch energy crash a lot of people have grown accustomed to, expect energy to build throughout the day. Less Cravings - No more snacking will be required to top up carbohydrate levels. WILL MCT OIL BREAK MY FAST? It depends. If you’re fasting for weight loss then MCT Oil can be great tool to help curb cravings to your first meal. However, as MCT Oil contains calories it will technically break your fast and mitigate some of the weight loss and autopaghy benefits. IS MCT OIL GOOD FOR BRAIN HEALTH? MCT Oil is quickly turned in to ketones which can cross the blood-brain barrier to be used as fuel for your brain. People in ketosis often report high levels of focus and energy. WHAT’S THE DIFFERENCE BETWEEN C8 & C10 MCTS? C8 MCTs convert to ketones at a slightly quicker rate than C10 MCTs. However, due to how quickly C8 MCT Oil converts, some people find that taking it in isolation can cause gastric upset. Also, C8 and C10 MCTs have a slightly different micronutrient profile. Therefore we opted for a combination of both to ensure a wider variety of micronutrients and no gastric discomfort when consuming our product.

Brain Octane Oil, when encapsulated, slows the digestion of Caprylic acid and spends more time in your gut, balancing beneficial bacteria and helping maintain normal yeast levels. Studies have shown that Caprylic fatty acids have gut biome balancing and potent microbial balancing effects that help to support healthy digestion and immune function.  Travel friendly Brain Octane Softgels go with you everywhere to support healthy digestion, cognitive function and provide a boost of energy from Bulletproof fats. Brain Octane Softgels were created using the most upgraded methods and ingredients.  Made with Bulletproof Brain Octane Oil, our most effective C8 medium chain triglyceride found in the heart of the coconut. Brain Octane Oil undergoes the rigorous Bulletproof Process® and is extracted, cleaned and refined without the use of harsh chemicals. Brain Octane Softgels contain the lowest particle size possible to support optimal absorption. The Caprylic fatty acid particles do not separate, but because it is a fat particle, it will change size and translucency depending on its temperature. It will be solid white at cool temperatures, and liquid clear in warmer temperatures. A cloudy or whiter appearance can be normal depending on environmental temperatures. Optimum storage conditions for Brain Octane Softgels is 59 to 86 °F (15-30°C). Protect from extreme temperatures. Freezing & excessive heat may damage softgels. Brain Octane Softgels Ingredients: Caprylic Acid Triglycerides (Brain Octane Oil), Bovine Gelatin, Glycerin, Oleic Acid (Derived from Olive Oil), Vitamin E (TPGS), Purified Water, Natural Flavor.

CILTEP® is a natural dietary supplement designed to improve and maintain brain performance, especially memory, focus, and motivation. It is a new natural nootropic created from the combination of artichoke extract and forskolin, and it works synergistically with choline-boosting nootropic stacks like Alpha BRAIN™.CILTEP, which stands for 'Chemically Induced Long-Term Potentiation,' improves healthy learning and memory in the brain by supporting and optimizing levels of intracellular second messengers.Many users say it produces a powerful effect similar to Modafinil. CILTEP works best for people who need to learn a lot of new material, focus intently on a task or series of tasks over a period of several hours.Warning:Do not consume nicotine or prescription stimulants with CILTEP. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you have or suspect a medical condition, are taking any medications, or other non-Natural Stacks™ dietary supplements. Do not use if safety seal is broken or missing. Store in a cool dry place. KEEP OUT OF THE REACH OF CHILDREN. For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day. Users typically experience results for 8-14 hours. Unlike other nootropics on the market, a CILTEP stack works inside the cell to naturally induce Long-Term Potentiation (LTP), a state of increased neuron connectivity. For biohackers, here are the primary mechanisms by which CILTEP induces LTPLong-Term Potentiation (LTP) is a long-lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time. LTP is one of the major cellular mechanisms behind learning and memory. Memories are formed or 'encoded' in the brain by creating LTP.ARTSKOLIN achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP). 1. PDE4 InhibitionPDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain.Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition , improved long term memory, increased wakefulness, and neuroprotection. Artichoke Extract is known to be the safest and most effective PDE4 Inhibitor.There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of high quality Artichoke Extract in each serving. 2. Increasing cAMPAn herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It has been used for thousands of years in traditional Indian Aryuvedic medicine. Forskolin activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP.CILTEP features premium Coleus Forskohlii that is standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP. Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is an overall improvement of cognitive function, especially memory formation and retention of new information. 3. LTP & DopamineThis regimen makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes. Meanwhile, the chemical dynamics of the dopamine system are preserved, which avoids all negative side effects associated with using traditional dopamine stimulation (such as Adderall or Ritalin). Research has shown that increased intracellular cAMP increases the rate of dopamine synthesis. We include Vitamin B6 and the natural dopamine precursor L-Phenylalanine to the CILTEP formula to keep your brain well stocked with the building blocks of dopamine. L-Phenylalanine (pronounced feen-ull-AL-uh-neen) is an amino acid found in some foods that the brain uses to make dopamine and it synergizes perfectly with Artichoke Extract and Forskolin, reducing fatigue and creating long lasting results with a lift in mood References:1.http://www.ncbi.nlm.nih.gov/pubmed/166722922.http://www.ncbi.nlm.nih.gov/pubmed/84214943.http://www.ncbi.nlm.nih.gov/pubmed/166722924.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704616/5.http://www.ncbi.nlm.nih.gov/pubmed/98440086.http://www.ncbi.nlm.nih.gov/pubmed/97009667.http://www.ncbi.nlm.nih.gov/pubmed/113884388.http://www.ncbi.nlm.nih.gov/pubmed/173980019.http://www.ncbi.nlm.nih.gov/pubmed/2096957310.http://www.ncbi.nlm.nih.gov/pubmed/1706435211.http://www.ncbi.nlm.nih.gov/pubmed/2761676 For more resources on the science of CILTEP, please visit:CILTEP Whitepaper by Abelard Lindsay

Cerebra-GPC is 100% Purified PhosChol with the fatty acids removed. It is a simple formulation of purified GPC and water, which comes together as a clear, concentrated, sweet tasting solution that is easy to administer to adults and children. What is Cerebra GPC? GPC is a safe, stable, and rapidly absorbed source of free choline, which easily enters the brain and has many functions in the body. It is important for the structural integrity of cell membranes, cholinergic neurotransmission, transmembrane signalling, methyl metabolism, and lipid-cholesterol transport and metabolism. Choline is a precursor for phosphatidylcholine, sphingomyelin, platelet-activating factor, betaine, and other phospholipids. A Positive Influence on Neurotransmission Acetylcholine decline coincides with advancing age, and is a hallmark of neurodegenerative disease. Even in the absence of diseases such as Alzheimer's and vascular dementia, aging brains lose cholinergic receptors; structures within the nerves that receive and propagate the messages transmitted by acetylcholine. Evidence suggests that by increasing levels of acetylcholine in the brain, cognitive deficits and brain structure changes related to ageing may be reversed. GPC is believed to prevent and ameliorate dementia, memory loss and learning difficulties because it accelerates the biosynthesis of acetylcholine and phosphatidylcholine. Additionally, GPC may protect and facilitate communication between nerves through its effect on receptors for nerve growth factor. GPC has been shown to stimulate the release of the neurotransmitter, GABA (gamma-aminobutyric acid). And, administration of GPC was influential in making more GABA available to brain cells. In various studies, GPC has been directly compared to some popular nootropic substances such as oxiracetam and acetyl-L-carnitine. Cognitive improvement among GPC patients was similar to those seen in patients taking oxiracetam. Tests directly comparing the GPC to acetyl-L-carnitine demonstrated that GPC delivers superior cognitive benefits. Conclusions Supplementation of GPC provides a good source of safe, stable, and readily absorbed choline for enhancing cholinergic metabolic functions such as neurological and mental performance. GPC should be considered as an essential nutrient in any integrated anti-ageing and/or brain restoration protocol. At this time there are no known side effects, contraindications or interactions. Ingredients are GRAS and should be well tolerated even with long term use. GPC is a nutrient present in all mammalian cells and other life forms. It is a rapidly absorbed source of choline, which easily enters the brain and has many functions in the body. Choline is important for the structural integrity of cell membranes, cholinergic neurotransmission, transmembrane signalling, methyl metabolism, and lipid-cholesterol transport and metabolism [1]. Choline is a precursor for phosphatidylcholine, sphingomyelin, platelet-activating factor, betaine, and other phospholipids (Food and Nutrition Board (FNB) 1998). Choline speeds the synthesis and release of acetylcholine, an important neurotransmitter involved in numerous important functions in the body. Choline is an essential nutrient since the de novo synthesis of choline is not always sufficient to meet human requirements for choline. The FNB established various Adequate Intake levels (AI) for choline based on gender/age groups. Table 1 lists the AI levels established by the Food and Nutritional Board. The Adequate Intake for pregnancy and lactation was established as 450 mg/day and 550 mg/day, respectively (FNB, 1998). Table 1 shows that the Adequate Intake of choline is about 550 mg/day for men and 425 mg/day for women. Choline in the diet is available as free choline or is bound as esters such as phosphocholine, GPC, sphingomyelin, or phosphatidylcholine. It should be noted that foods that are good sources of choline and choline esters are typically higher in fat and/or cholesterol. Many Americans, in view of recommendations from various private and government public health organizations, are decreasing fat, saturated fat, and cholesterol in their diet. The consumption of less fat, saturated fat, and cholesterol will lead to a concomitant decrease in choline intake. The de facto intake of choline and choline compounds were examined during the Framingham Offspring Study in several thousand men and women and showed that the general dietary intake of choline as free form and as compounds is about 312 mg/day for men and 314 mg/day for women [2]. Total choline intake was calculated as the sum of intake from free choline, phosphocholine, glycerophosphocholine, phosphatidylcholine and lecithin. Thus, the addition of choline and choline precursors to certain foods may compensate for a possible deficit in choline. Choline is a vitamin-like, essential nutrient. But free choline is poorly bioavailable and unstable in the water phase. GPC is a physiological form of choline in the body. Figure 2 shows the metabolic pathway of choline and GPC. Cerebra GPC is water soluble and able to efficiently increase choline levels in the blood and the brain. Cerebra GPC is recommended at 500mg to 1000mg of pure GPC per day, which is equivalent to 200 - 400 mg free choline. Safety of GPC GPC is a choline precursor like lecithin and choline salts. Commercial lecithin, phosphatidylcholine, choline bitartrate, and choline chloride are also precursors of choline and are all generally recognized as safe (GRAS) (21 CFR � 182,184). GPC is a naturally occurring food component. Table 2 lists the content of free choline, GPC, and other naturally present choline esters in common foods (mg choline moiety per 100 g food) [6]. Table 2 shows that GPC is the predominant choline component in foods such as milk, dairy products (e.g., cheese), olive oil, oat bran, and bananas. The average intake of GPC in the subjects participating in the Framingham Offspring Study was 54�21 mg/day [2]. Additional GPC is formed in the body by hydrolysis of phosphatidylcholine from food by phospholipase A in the gut mucosa. GPC is also an important component in human milk, with a concentration of 362�70 �mol/l as derived by the mean of 16 women [3]. GPC is a nutrient present in all mammalian cells and other life forms. It is a rapidly absorbed source of choline, which easily enters the brain and has many functions in the body. Choline is important for the structural integrity of cell membranes, cholinergic neurotransmission, transmembrane signalling, methyl metabolism, and lipid-cholesterol transport and metabolism [1]. Choline is a precursor for phosphatidylcholine, sphingomyelin, platelet-activating factor, betaine, and other phospholipids (Food and Nutrition Board (FNB) 1998). Choline speeds the synthesis and release of acetylcholine, an important neurotransmitter involved in numerous important functions in the body. Choline is an essential nutrient since the de novo synthesis of choline is not always sufficient to meet human requirements for choline. The FNB established various Adequate Intake levels (AI) for choline based on gender/age groups. Table 1 lists the AI levels established by the Food and Nutritional Board. The Adequate Intake for pregnancy and lactation was established as 450 mg/day and 550 mg/day, respectively (FNB, 1998). Table 1 shows that the Adequate Intake of choline is about 550 mg/day for men and 425 mg/day for women. Choline in the diet is available as free choline or is bound as esters such as phosphocholine, GPC, sphingomyelin, or phosphatidylcholine. It should be noted that foods that are good sources of choline and choline esters are typically higher in fat and/or cholesterol. Many Americans, in view of recommendations from various private and government public health organizations, are decreasing fat, saturated fat, and cholesterol in their diet. The consumption of less fat, saturated fat, and cholesterol will lead to a concomitant decrease in choline intake. The de facto intake of choline and choline compounds were examined during the Framingham Offspring Study in several thousand men and women and showed that the general dietary intake of choline as free form and as compounds is about 312 mg/day for men and 314 mg/day for women [2]. Total choline intake was calculated as the sum of intake from free choline, phosphocholine, glycerophosphocholine, phosphatidylcholine and lecithin. Thus, the addition of choline and choline precursors to certain foods may compensate for a possible deficit in choline. Choline is a vitamin-like, essential nutrient. But free choline is poorly bioavailable and unstable in the water phase. GPC is a physiological form of choline in the body. Figure 2 shows the metabolic pathway of choline and GPC. Figure 2: Metabolic pathway of GPC [3]. Cerebra GPC is water soluble and able to efficiently increase choline levels in the blood and the brain. Cerebra GPC is recommended at 500mg to 1000mg of pure GPC per day, which is equivalent to 200 - 400 mg free choline. Safety of GPC GPC is a choline precursor like lecithin and choline salts. Commercial lecithin, phosphatidylcholine, choline bitartrate, and choline chloride are also precursors of choline and are all generally recognized as safe (GRAS) (21 CFR � 182,184). GPC is a naturally occurring food component. Table 2 lists the content of free choline, GPC, and other naturally present choline esters in common foods (mg choline moiety per 100 g food) [6]. Table 2: Choline concentrations in common food in mg choline moiety/100 g food [6]. food Choline GPC Phospho- choline Phosphatidyl- choline Total choline 2 % milk 2.82 9.98 1.58 1.15 16.40 Cheese half & half 3.92 8.48 1.17 1.71 16.82 Sour cream 4.73 8.08 1.26 3.51 20.33 Yoghurt, plain 2.32 9.10 1.65 1.04 15.20 Olive oil 0.02 0.28 ND ND 0.29 Bananas 3.20 5.60 0.51 0.44 9.76 Fin fish � Atlantic cod 17.73 30.04 1.57 32.90 83.63 Oat bran, raw 4.41 33.25 0.68 20.23 58.57 Beef liver 56.67 77.93 11.77 247.75 418.22 Table 2 shows that GPC is the predominant choline component in foods such as milk, dairy products (e.g., cheese), olive oil, oat bran, and bananas. The average intake of GPC in the subjects participating in the Framingham Offspring Study was 54�21 mg/day [2]. Additional GPC is formed in the body by hydrolysis of phosphatidylcholine from food by phospholipase A in the gut mucosa. GPC is also an important component in human milk, with a concentration of 362�70 �mol/l as derived by the mean of 16 women [3].Metabolic Studies The bioavailability of choline and choline esters from milk was studied in a rat-pup model [7]. 15-day-old rat pups were fed infant formula, labeled with approximately 15,725 Bq of either 14C-choline, 14C-phosphocholine, 14C-GPC, or 14C-phosphatidylcholine. Stomach content, blood, and tissues were analyzed for the different choline species at different time points. The disappearance of the radiolabel in the stomach was similar for choline, phosphocholine and GPC. There was a 3-fold decrease in all labels at 30 min post incubation. At 4 h post incubation there was essentially no label present in the stomach contents. Disappearance of phosphatidylcholine-derived label in stomach contents was slower than for the other three labels. It took 8 h before a 3-fold decrease was observed and more than 12 h before this label disappeared from the stomach contents. In the GI tract, choline-, GPC-, and phosphocholine-derived labels were similar, and the total area under the curves were significantly different from the phosphatidylcholine-derived label. The labeled choline compounds were absorbed and distributed to the GI tract, liver, blood, and brain of the rat pups. The appearance and disappearance of choline-, GPC-, and phosphatidylcholine-derived labels were similar. In the liver, phosphocholine appeared and disappeared more rapidly than did the other labels. Labels from all of the water-soluble forms of choline reached maximum levels within 4 h; phosphocholine label did so by 1 h. Phosphatidylcholine appeared much more slowly than did the other labels and was still accumulating at 24 h post dose. In the liver, the total area under the curve was significantly different for each label over the time periods studied. Different choline-containing compounds were formed in liver from choline-, phosphocholine-, GPC-, and phosphatidylcholine-radio labeled infant formula. In liver at 4 h post treatment, choline (Table 3), phosphocholine-, and GPC-derived label were present in the greatest amount as betaine, with phosphocholine being the next most common metabolite formed. Phosphatidylcholine-derived label was principally associated with phosphatidylcholine in liver. By 24 h in liver (Table 4), choline and phosphocholine label was mainly present as betaine, with a small amount of phosphatidylcholine formed. No choline- and phosphocholine-derived label was present as choline, GPC, or phosphocholine. GPC-derived label was present as betaine, with some choline, GPC and phosphatidylcholine also being formed. Phosphatidylcholine-derived label was present mainly as phosphatidylcholine in liver with some betaine and phosphocholine formed. These data indicate that in liver GPC was metabolized differently than free choline and phosphatidylcholine. GPC seems to offer a sustained liberation of choline for further metabolism. The absorption, distribution, and excretion after single doses of radio labeled GPC ([14G]-GPC, labeled in the glycerol part of the molecule, and [14C]-GPC, labeled in the choline-part of the molecule) were also extensively studied in rats [8]. The blood and plasma kinetics and the excretion and tissue distribution of GPC were investigated after oral (100-300 mg GPC/kg) and i.v. (10 mg GPC/kg) uptake. The blood and plasma concentration of [14G]-GPC reached a maximum between 2-4 h after oral intake of 100 mg/kg. For [14C]-GPC, the peak concentration was obtained after 24 h. The GPC concentrations for both labeled forms stayed above the baseline during the 72 h of investigation. The tissue distribution of radioactivity was examined 3 h and 72 h after oral administration. After 3 h the radioactivity of [14G]-GPC peaked in the gut, corresponding to 18-20 % of the administered dose. The concentration in liver and kidney were respectively about twice the concentration of the blood levels, equivalent to 2-6 % of the dose. Furthermore, 3 h after oral intake of [14C]-GPC, the liver contained the highest level of radioactivity (5-11 % of the dose). Other tissues with radioactivity levels higher than blood were the kidneys (1-1.5% of the dose), spleen and lung. The total radioactivity in the gut was 2-3 % of the administered dose. Brain radioactivity was about half that found in blood. After 72 h the total remaining radioactivity for both labeled GPC-forms was spread over most tissues and organs, but values higher than blood levels were found in liver, kidneys, lung, and spleen. The brain-to-blood distribution of radioactivity was also measured time-dependently. After [14G]-GPC, the time courses of blood and brain concentrations were almost parallel within 32 h of dosing. For [14C]-GPC, brain radioactivity increased slowly up 24 h and then remained constant up to the end of the experiment. Within this plateau it amounted about 50 % of blood radioactivity. Another experiment, with 300 mg/kg GPC orally administrated showed that the radioactivity was registered in the brain as phosphatidylcholine. This suggests that choline from GPC enters the brain and is reused for biosynthesis of phospholipids. The excretion of labeled GPC during 72 h was also investigated. Renal and fecal excretion was comparable to the G- and C-labeled compounds, but low (10 % of the dose). By far the largest part of the administered radioactivity was exhaled as 14CO2, in accordance with established catabolic pathways of glycerol and choline degradation. This study showed that in the rat, GPC is hydrolyzed to choline and glycerol-3-phosphate. Some metabolic studies in men from the literature will be described:A comparative study of free plasma choline levels following intramuscular administration of l-alpha-glycerylphosphorylcholine and citicoline in normal volunteers [9] l-alpha-glycerylphosphorylcholine (alpha-GPC) is a recently developed cognitive enhancer whose mode of action is considered to involve the release of free choline, which is then utilized for acetylcholine and phosphatidylcholine biosynthesis in the brain. The purpose of this study was to evaluate the profile of free plasma choline levels following a single i.m. dose of alpha-GPC in 12 normal volunteers. Citicoline (CTC), which also acts as a choline precursor, was included for comparison purposes. Each subject was studied on three randomized occasions, (i) on a control day in the absence of drug administration (to evaluate the plasma level profile of endogenous choline); (ii) after i.m. alpha-GPC (1,000 mg); and (iii) after i.m. CTC (1,000 mg), respectively, with a washout period of at least 1-week between sessions. Blood samples for plasma choline HPLC determinations were collected at regular intervals over a 6-h period. In the control session, plasma choline levels remained stable during the sampling period. The administration of alpha-GPC was associated with a rapid rise in plasma choline, peak levels being usually observed at the first (0.25 h) or second (0.5 h) sampling time after the injection. Thereafter, the concentration of choline declined gradually and returned to near baseline values at the end of the observation period. After the administration of CTC, plasma choline levels showed a similar time course, but were considerably lower than those observed after the administration of alpha-GPC.Pharmacokinetics of choline alfoscerate in the healthy volunteer [10] This was a pharmacokinetic study of i.m., i.v., and oral dosing with GPC. Four healthy volunteers aged 19-24 years received GPC 1000 mg i.v., then subsequently i.m., then by mouth, then received a placebo by mouth, in four separate sessions separated by 1-week washouts. During each session blood was sampled periodically over 10 hours. With i.v. administration of GPC, plasma total choline peaked at 5 minutes and returned to baseline by 4 hours. With i.m. administration, plasma total choline peaked at 0.5 hours and returned to baseline by 6 hours. With oral GPC, plasma total choline peaked at 3 hours, at a concentration slightly less than half that reached by i.m. administration. But with oral GPC, the plasma total choline remained above baseline at 10 hours. The investigators concluded that i.v. and i.m. GPC both delivered virtually identical total plasma doses (AUC, area under the curve), and that oral administration delivered about half this amount. Clinical Studies Several clinical studies showed that the tolerability of GPC was very good, even when administered in very high doses for a long term. Numerous clinical studies have described the effects of high oral or parenteral doses of GPC on several neuronal disorders:Multi-center study of l-alpha-glyceryl-phosphorylcholine vs. ST200 among patients with probable senile dementia of Alzheimer's type [11] A multi-center, randomized, controlled study compared the efficacy of l-alpha-glyceryl-phosphorylcholine (alpha-GPC) and ST200 (acetyl-l-carnitine) among 126 patients with probable senile dementia of Alzheimer's type (SDAT) of mild to moderate degree. Efficacy was evaluated by means of behavioural scales and psychometric tests. The results showed significant improvements in most neuropsychological parameters in the alpha-GPC recipients. Improvements also occurred in the ST200 recipients, but to a lesser extent. Tolerability was good in both groups. These positive findings require replication in larger, double-blind, longitudinal studies coupling clinical and biological evaluations.Multi-center clinical study of efficacy and tolerability of choline alfoscerate in patients with deficits in higher mental function arising after an acute ischemic cerebrovascular attack [12] A total of 320 patients suffering mental decline after a cerebral ischemic attack received GPC 1000 mg i.m. once daily for 28 days, then 1200 mg by mouth for another 20 weeks. GPC significantly improved neurologic measures by week 4 (p<0.0001). By week 24, the various cognitive and global clinical assessment scales showed a �large improvement� of the mental status of the patients.Clinical study of the therapeutic effectiveness and tolerability of choline alfoscerate in 15 subjects with compromised cognitive functions subsequent to acute focal cerebral ischemia [13] This was a small open trial that followed the usual GPC stroke protocol. Eleven patients of average age 74 years received GPC 1000 mg i.m. once daily for 28 days, then 1200 mg orally daily for at least another 20 weeks. On various rating scales (Mathew, MMSE, SCAG, the Psychic Evaluation Scale), GPC significantly improved results with regard to memory, anxiety, emotional lability, sociability, spatial orientation, aspects of language, eye deviation, confusion, vigilance, and general mental sharpness. Two patients complained of slight, transitory heartburn but did not withdraw from the trial. At 6 months the physicians judged 10/11 of the patients as showing results excellent to fairly good, while 10/10 patients judged themselves as having excellent to fairly good. Thus, in 5 open trials completed with 2,972 patients variously afflicted by stroke, a regimen of 1 month of intramuscular GPC followed by 5 months of oral intake produced clinically remarkable improvement. Given that the patients were generally too ill to be given placebos, the degrees of clinical improvement over the 6-month trial periods were well above those predictable as placebo effects. Many patients showed accelerated improvement within the first 2-4 weeks and continued to improve over the remaining 5 months. The physicians as well as the patients uniformly judged GPC to be very well tolerated.Effect of l-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine [14] The present study was carried out to test the effects of l-alpha-glycerylphosphorylcholine (l-alpha-GFC) on memory impairment induced by scopolamine in human subjects. Thirty-two healthy young volunteers were randomly allocated to four different groups. They were given a ten-day pre-treatment with either l-alpha-GFC or placebo, p.o., and on the eleventh day either scopolamine or placebo, i.m. Before and 0.5, 1, 2, 3, and 6 h after injection, the subjects were given attention and mnemonic tests. The findings of this study indicate that the drug is able to antagonize impairment of attention and memory induced by scopolamine.Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by l-alpha-glycerylphosphorylcholine, a cholinomimetic drug [15] The present study investigates the cholinomimetic properties of the drug l-alpha-glycerylphosphorylcholine (alpha-GPC) at the CNS level. Experiments using tritium-labelled alpha-GPC indicate that the drug reaches the brain after i.p. and p.o. administration. In order to study the cholinomimetic properties of this drug, an indirect functional index of cholinergic activation was used. In fact cholinergic agonists induce an activation of striatal dopaminergic output. Administration of alpha-GPC, both i.p. and p.o., increased striatal dihydroxyphenylacetic acid (DOPAC) content. In addition, the in vitro K+-stimulated dopamine release was increased in rats treated in vivo with alpha-GPC. Since alpha-GPC has a weak displacing activity in QNB binding, the in vivo cholinergic activity might be due to the fact that this drug may increase the availability of choline for acetylcholine synthesis leading to increased acetylcholine production. This activity may be useful in those situations such as aging in which cholinergic activity is deficient.Choline alfoscerate in the treatment of mental disorder after acute cerebrovascular accident [16] An Italian multi-center trial involved 425 patients aged 45-85 years, who were recruited from 44 centers distributed throughout the country. All the patients had suffered cerebral ischemic attacks (stroke, TIA, or acute cerebral ischemia) within the previous 10 days. It was another open trial, since the patients were too severely afflicted to be subjected to placebo treatment. Patients who scored 35 or below on the Mathew Scale were eligible for the trial, but comatose patients were not, nor were those not expected to live or judged unable to comply over the 6-month period of the trial. As per the typical GPC stroke protocol, treatment proceeded in two phases, first by giving GPC 1000 mg i.m. in-hospital daily for 28 days, then switching to GPC 1200 mg by mouth for 5 more months (400 mg 3 times per day). Upon completion of the GPC i.m. phase, there was an average improvement on the Mathew Scale of 18.56 % (11.5 points, from 62.02 to 73.53). This was statistically highly significant over baseline. A 20 % or greater improvement was seen in 168 (39.5 %) of the patients. By this measure the more impaired, older patients (65-85 years) were more likely to benefit than were the younger patients 45-64 years). During the second phase, after discharge (GPC oral, for 5 months), evaluation was based on clinical interviews and three assessment scales were used. On the MMSE for cognitive functions, there was a 12.3 % improvement (from 21.53 at week 5 to 24.19 at 6 months). A 20 % or greater improvement was seen in 126 patients (29.7 %). On the Global Deterioration Scale, there was an average 20.2 % improvement. A 20 % or greater improvement was seen in 180 patients (42.3 %). On the Crichton Geriatric Rating Scale, which assesses mainly behavioural functioning, there was an average 19.5 % improvement. A 20 % or greater improvement was seen in 166 patients (39.1 %). The researchers judged GPC to be effective and well tolerated both parenterally and orally. They noted that despite the many drugs with which GPC was co-administered, no single GPC-drug interaction was observed clinically or in laboratory tests. GPC's benefits were consistent, and spanned functional state as well as performance and social behavior. With the possible exception of the MMSE (at 12.3 %), the degrees of improvement from GPC on the various scales were well above that expected from a placebo, namely 12 % in at least 20 % of such patients.Conclusion Glycerophosphocholine is a natural, physiological, water-soluble and stable precursor of choline. It is part of the daily nutrition and its levels are reduced on account of changed dietary composition. The fortification of different foods with GPC can supply GPC and choline as readily absorbed nutrients for enhancing cholinergenic metabolic functions such as neurological and mental performance. References: [1] Canty D.J., Zeisel S.H., Jolitz A.J., Lecithin and Choline � Research Update on Health and Nutrition. [2] Cho E., Zeisel S.H., Jaques P., Selhub J., Dougherty L., Colditz G.A., Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study, Am. J. Clin. Nutr. 2006, 83: 905-911. [3] Holmes-McNary M.Q., Cheng W.-L., Nar M.-H., Fussell S., Zeisel S.H., Choline and choline esters in human and rat milk and in infant formulas. Am. J. Clin. Nutr. 1996, 64: 572-576. [4] Howe J.C., Williams J.R., Holden J.M., Zeisel S.H., Mar M.-H., USDA Database for the Choline Content of Common Foods, March 2004. [5] Koc H., Mar M.-H., Ranasinghe A., Swenberg J.A., Zeisel S.H., Quantitation of Choline and Its Metabolites in Tissues and Foods by Liquid Chromatography(Electrospray Ionization-Isotope Dilution Mass Spectrometry, Analytical Chemistry 2002, 74(18): 4734-4740. [6] Zeisel S.H., Mar M.-H., Hove J.C., Holden J.M., Concentrations of Choline-Containing Compounds and Betaine in Common Foods. Human Nutrition and Metabolism 2003: 1302-1307. [7] Cheng W.-L., Holmes-McNary M.Q., Mar M.-H., Lien E.L. Zeisel S.H., Bioavailability of choline and choline esters from milk in rat pups, Nutritional Biochemistry 1996, 7: 457-464. [8] Abbiati G., Fossati T., Lachmann G., Bergamaschi M., Castiglioni C., Absorption, tissue distribution and excretion of radiolabeled compounds in rats after administration of [14C]-l-a-glycerylohosphorylcholine, Euro. J. Drug Metabol. Pharma 1993, 18(2): 173-180. [9] Gatti J. et al., A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers, Int. J. Clin. Pharmacol. Ther. Toxicol. 1992, 30(9): 331-335. [10] De Moliner et al., Pharmacokinetics of choline alsphscerate in the healthy volunteer, Le Basi Raz. Ter. 1993, 23, Suppl. 3, 75. [11] Parnetti L,. Avate G., Bartorelli L., Cucinotta D., Cuzzupoli M., Maggioni M., Villardita C., Senin U., Multicenter Study of l-a-Glyceryl-Phosphorylcholine vs ST200 among Patients with Probable Senile Dementia of Alzheimer�s Type, Drugs & Aging 1993, 3(2): 159-164. [12] Gambi D., Onofrj M., Multicenter clinical study of efficacy and tolerability of choline alfoscerate in patients with deficits in higher mental function arising after an acute ischemic cerebrovascular attack, Geriatrica 1994, 6:91. [13] Tomasina C. et al., Clinical study of the therapeutic effectiveness and tolerability of choline alfoscerate in 15 subjects with compromised cognitive functions subsequent to acute focal cerebral ischemia, Rivista Neuropsi. Sci. Affini. 1996, 3(7): 21. [14] Canal et al., Effect of L-alpha-glycerylphosphorylcholine on amnesia caused by scopolamine. Int. J. Clin. Pharmacol. Ther. Toxico. 1991, 29(3): 103-107. [15] Trabucchi et al., Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by l-alpha-glycerylphosphorylcholine, a cholinomimetic drug, Farmaco. Sci. 1986, 41(4): 325-334. [16] Aguglia E. et al., Choline alfoscerate in the treatment of mental pathology following acute cerebrovascular accident. Funct. Neurol. 1993; 8 (Suppl):5.

BENEFITS OF Helps maintain healthy brain inflammation levels* Encourages new brain cell growth* Supports healthy neurons for better memory power* Protects the brain from free radical damage* Aids healthy blood flow & oxygen levels* Promotes a calm, focused mind & balanced moods* PRODUCT DETAILS 8-in-1 complete brain health supplement Made from wild-sourced and organic brain-boosting botanicals Formulated by natural health visionary “Amazon John” Easterling Ingredients responsibly sourced from a nature preserve in the Amazon rainforest Non-GMO; No artificial flavors, preservatives, colors, fillers, or additives  3rd-Party Tested to ensure free from pesticides, glyphosate, and heavy metals Ingredients Organic Cat’s Claw Powder This ancient herbal remedy has been used for 2,000 years as a potent antioxidant and anti-inflammatory. Studies show it can help repair damaged DNA and strengthen the communication (synapses) between neurons. Plus, it can also help grow new brain cells by boosting brain-derived neurotrophic factor (BDNF).   Organic Bacopa Monnieri Powder An amazing natural brain booster that speeds up reaction time and improves memory, bacopa also helps improve mood by decreasing feelings of anxiety and depression. It’s been shown to help increase BDNF for new brain cell growth and reduce amyloid plaque (a hallmark of Alzheimer’s disease) in the brain.   Organic Pau d’Arco A powerful antifungal, pau d’arco contains a compound called lapachol that can be deadly against certain viruses, bacteria, fungi (including Candida), parasites, and more. It’s also a major anti-inflammatory that helps protect brain cells by blocking key enzymes that can contribute to brain inflammation.   Dragon’s Blood Resin Extract Beneficial for banishing brain fog and improving memory recall, dragon’s blood is a dark red, thick tree sap that’s one of the most powerful antioxidants in the world. Research shows it’s an amazing brain protector and neurogenic inflammation fighter, meaning it helps keep brain inflammation levels low.   Organic Camu Camu Powder Camu camu contains one of the highest levels of vitamin C of any plant. Not only is vitamin C a powerful antioxidant that helps prevent free radical damage, it’s also essential for the “synthesis” of other important substances in the body – including brain neurotransmitters.   Organic Cinnamon Not just a flavorful culinary spice, cinnamon is a real antioxidant powerhouse that is best known for helping to normalize blood sugar and reducing inflammation and pain. It contains two unique compounds: epicatechin and cinnamaldehyde, which have been shown to protect against age-related memory loss.   Organic Cacao Powder Cacao is considered a mood-lifter as well as a “brain-builder” as it contains neurotransmitters that are associated with pleasure as well as motivation. It’s also a rich source of resveratrol, a powerful antioxidant that helps to remove amyloid plaque from the brain.   Organic Guayusa Extract With twice as many antioxidants as green tea and containing the neuroprotective amino acid L-theanine, guayusa improves age-related cognitive decline, protects brain cells against free radical damage, and reduces anxiety. It also contains small amounts of caffeine, which can produce a “calm focus” in individuals.

Acetylcholine Brain Food™ is designed to promote the production of acetylcholine, a neurotransmitter essential to mental processing. Research suggests that the natural compounds in Acetylcholine Brain Food™ are associated with memory and cognitive function.† Improved attention to detail† Better mental clarity† Faster thinking† Cuts through brain fog† Suggested Use Take a serving of 2-4 capsules to support mental processing speed, or as directed by a healthcare practitioner. Do not exceed 8 capsules per day. U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients. Details: To make acetylcholine, the brain needs two elements: an acetyl group and a choline molecule. An acetyl group is a type of simple molecular building block of organic chemistry with a chemical formula of C2H30. The acetyl group is usually present in the brain as Acetyl-CoA. Choline and the acetyl group are grouped together by the enzyme Choline Acetyltransferase (ChAT). They are both stored in neurons, released, and then broken down by another enzyme called acetylcholinesterase (AchE). To increase levels of acetylcholine, we use the following approach: Create more acetyl-CoA molecules to provide acetyl groups to ChAT for acetylcholine production. Provide more choline in choline producing (cholinergic) neurons for use by ChAT. Increase or upregulate the activity of ChAT. Decrease the activity of AchE. Acetylcholine Brain Food™ contains the essential raw materials for the brain to increase production, achieve balance, and maintain prolonged activity of the neurotransmitter acetylcholine -- the Learning Molecule. Research: De jesus moreno moreno M. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther. 2003;25(1):178-93. PMID 12637119 Szutowicz A, Bielarczyk H, Jankowska-kulawy A, Pawełczyk T, Ronowska A. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Neurochem Res. 2013;38(8):1523-42. PMID 23677775 Houten SM, Wanders RJ. A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation. J Inherit Metab Dis. 2010;33(5):469-77. 20195903 Arsenio L, Bodria P, Magnati G, Strata A, Trovato R. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clin Ther. 1986;8(5):537-45. PMID 3094958 Malaguarnera M, Gargante MP, Cristaldi E, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46(2):181-90. PMID 17658628